metronidazole has been researched along with Bed Sores in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malodor associated with each of 13 wounds was decreased following the initial treatment with topical metronidazole." | 1.29 | Case study: eliminating odors from wounds. ( Poteete, V, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Gethin, G | 1 |
| Vellinga, A | 1 |
| McIntosh, C | 1 |
| Sezgin, D | 1 |
| Probst, S | 1 |
| Murphy, L | 1 |
| Carr, P | 1 |
| Ivory, J | 1 |
| Cunningham, S | 1 |
| Oommen, AM | 1 |
| Joshi, L | 1 |
| Ffrench, C | 1 |
| Guo, J | 1 |
| Ji, F | 1 |
| Zhang, X | 1 |
| Han, J | 1 |
| Zhang, J | 1 |
| Lyvers, E | 1 |
| Elliott, DP | 1 |
| Pierleoni, EE | 1 |
| Gomolin, IH | 1 |
| Brandt, JL | 1 |
| Herman, J | 1 |
| Baker, PG | 1 |
| Haig, G | 1 |
| Poteete, V | 1 |
| Jones, PH | 1 |
| Willis, AT | 1 |
| Ferguson, IR | 1 |
| Motta, GJ | 1 |
| Witkowski, JA | 1 |
| Parish, LC | 1 |
| Soriano, F | 1 |
| Aguado, JM | 1 |
| Tornero, J | 1 |
| Fernandez-Guerrero, ML | 1 |
| Gómez-Garcés, JL | 1 |
3 reviews available for metronidazole and Bed Sores
| Article | Year |
|---|---|
Systematic review of topical interventions for the management of odour in patients with chronic or malignant fungating wounds.
Topics: Adolescent; Adult; Humans; Metronidazole; Odorants; Pressure Ulcer; Quality of Life; Silver | 2023 |
Combination of metronidazole and pearl powders for the treatment of stage 2 pressure injury wounds: Case report and literature review.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Humans; Metronidazole; Powders; Pressure Ulc | 2021 |
Topical Metronidazole for Odor Control in Pressure Ulcers.
Topics: Administration, Topical; Anti-Infective Agents; Humans; Metronidazole; Odorants; Pressure Ulcer | 2015 |
2 trials available for metronidazole and Bed Sores
| Article | Year |
|---|---|
Metronidazole in the treatment of chronic pressure sores and ulcers. A comparison with standard treatment in general practice.
Topics: Adult; Aged; Anti-Infective Agents; Bandages; Borates; Clinical Trials as Topic; Female; Humans; Mal | 1981 |
Does metronidazole help leg ulcers and pressure sores?
Topics: Clinical Trials as Topic; Humans; Leg Ulcer; Metronidazole; Pressure Ulcer | 1982 |
8 other studies available for metronidazole and Bed Sores
| Article | Year |
|---|---|
Topical metronidazole therapy for infected decubitus ulcers.
Topics: Administration, Topical; Aged; Female; Humans; Male; Metronidazole; Pressure Ulcer; Wound Infection | 1984 |
Topical metronidazole therapy for pressure sores of geriatric patients.
Topics: Administration, Topical; Aged; Bacterial Infections; Feces; Female; Humans; Male; Metronidazole; Pre | 1983 |
Metronidazole for a malodorous pressure sore.
Topics: Aged; Bacteria, Anaerobic; Bacterial Infections; Humans; Male; Metronidazole; Odorants; Pressure Ulc | 1983 |
Case study: eliminating odors from wounds.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Clinical Nursing Research; Gels; Humans; Me | 1993 |
Treatment of anaerobically infected pressure sores with topical metronidazole.
Topics: Administration, Topical; Aged; Bacterial Infections; Humans; Metronidazole; Pressure Ulcer; Ulcer | 1978 |
Topical metronidazole. Part I.
Topics: Administration, Topical; Humans; Metronidazole; Odorants; Pressure Ulcer | 1992 |
Topical metronidazole gel. The bacteriology of decubitus ulcers.
Topics: Administration, Topical; Aged; Aged, 80 and over; Bacteria; Gels; Humans; Metronidazole; Pressure Ul | 1991 |
Bacteroides fragilis meningitis successfully treated with metronidazole after a previous failure with thiamphenicol.
Topics: Aged; Bacteroides fragilis; Bacteroides Infections; Female; Humans; Meningitis; Metronidazole; Micro | 1986 |