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metronidazole and Diseases of Pharynx

metronidazole has been researched along with Diseases of Pharynx in 13 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the use of metronidazole as a prophylactic agent against pharyngocutaneous fistula (PCF) formation."9.15Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help? ( Dimaka, K; Kourousis, C; Mallis, A; Margaritis, V; Mastronikolis, NS; Naxakis, SS; Panogeorgou, T; Papadas, TA; Stathas, T; Stavrou, S, 2011)
" An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed."5.27Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988)
"To evaluate the use of metronidazole as a prophylactic agent against pharyngocutaneous fistula (PCF) formation."5.15Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help? ( Dimaka, K; Kourousis, C; Mallis, A; Margaritis, V; Mastronikolis, NS; Naxakis, SS; Panogeorgou, T; Papadas, TA; Stathas, T; Stavrou, S, 2011)
"The majority of patients with PPA were effectively managed by abscess incision, tonsillectomy, and penicillin G ± metronidazole."4.12Clinical evaluation of antibiotic regimens in patients with surgically verified parapharyngeal abscess: a prospective observational study. ( Andersen, C; Christensen, AL; Danstrup, CS; Døssing, H; Greve, T; Hahn, P; Kjeldsen, A; Klug, TE; Mikkelsen, S; Petersen, NK; Rusan, M, 2022)
"All patients with acute tonsillitis, peritonsillar abscess (PTA), and parapharyngeal abscess admitted to the Ear-Nose-Throat Department, Aarhus University Hospital, in the 2001-2014 period were included in the study."1.51Adherence to antibiotic guidelines in the treatment of acute pharyngeal infections. ( Danstrup, CS; Klug, TE; Øhrstrøm, MT, 2019)
" An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed."1.27Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19903 (23.08)18.7374
1990's2 (15.38)18.2507
2000's2 (15.38)29.6817
2010's5 (38.46)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Klug, TE2
Andersen, C1
Hahn, P1
Danstrup, CS2
Petersen, NK1
Mikkelsen, S1
Døssing, H1
Christensen, AL1
Rusan, M1
Kjeldsen, A1
Greve, T1
Del Carmen Martínez-Herrero, M1
González-González, F1
López-Márquez, I1
García-Peña, FJ1
Sansano-Maestre, J1
Martínez-Díaz, RA1
Ponce-Gordo, F1
Garijo-Toledo, MM1
Gómez-Muñoz, MT1
Øhrstrøm, MT1
Bali, R1
Sharma, P1
Gaba, S1
Aladag, I1
Eyibilen, A1
Guven, M1
Erkokmaz, U1
Stathas, T1
Mallis, A1
Mastronikolis, NS1
Naxakis, SS1
Dimaka, K1
Panogeorgou, T1
Stavrou, S1
Margaritis, V1
Kourousis, C1
Papadas, TA1
Scotton, W1
Cobb, R1
Pang, L1
Nixon, I1
Joshi, A1
Jeannon, JP1
Oakley, R1
French, G1
Hemsley, C1
Simo, R1
Sathia, L1
Ellis, B1
Phillip, S1
Winston, A1
Smith, A1
Innes, AJ1
Windle-Taylor, PC1
Harrison, DF1
Bates, G1
Tucker, RL1
Ford, S1
Mattix, ME1
Sethi, DS1
Chew, CT1
Barrett, AP1
Johansen, LV1
Overgaard, J1
Elbrønd, O1

Trials

2 trials available for metronidazole and Diseases of Pharynx

ArticleYear
Use of metronidazole as part of an empirical antibiotic regimen after incision and drainage of infections of the odontogenic spaces.
    The British journal of oral & maxillofacial surgery, 2015, Volume: 53, Issue:1

    Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Bacteriological Techniq

2015
Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help?
    ORL; journal for oto-rhino-laryngology and its related specialties, 2011, Volume: 73, Issue:6

    Topics: Aged; Anti-Infective Agents; Combined Modality Therapy; Cutaneous Fistula; Female; Humans; Incidence

2011

Other Studies

11 other studies available for metronidazole and Diseases of Pharynx

ArticleYear
Clinical evaluation of antibiotic regimens in patients with surgically verified parapharyngeal abscess: a prospective observational study.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022, Volume: 279, Issue:4

    Topics: Abscess; Adult; Anti-Bacterial Agents; Humans; Metronidazole; Pharyngeal Diseases; Tonsillectomy

2022
Oropharyngeal Trichomonosis Due to Trichomonas gypaetinii in a Cinereous Vulture ( Aegypius monachus) Fledgling in Spain.
    Journal of wildlife diseases, 2019, Volume: 55, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Falconiformes; Metronidazole; Mouth Diseases;

2019
Adherence to antibiotic guidelines in the treatment of acute pharyngeal infections.
    Danish medical journal, 2019, Volume: 66, Issue:2

    Topics: Acute Disease; Adult; Anti-Bacterial Agents; Denmark; Drug Prescriptions; Female; Guideline Adherenc

2019
Effects of helicobacter pylori eradication on chronic nonspecific pharyngeal symptoms.
    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2008, Volume: 37, Issue:5

    Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Breath Tests; Chronic Disease; Cohort

2008
Post-operative wound infection in salvage laryngectomy: does antibiotic prophylaxis have an impact?
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2012, Volume: 269, Issue:11

    Topics: Administration, Intravenous; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefuroxime; Cohort Studi

2012
Pharyngeal gonorrhoea - is dual therapy the way forward?
    International journal of STD & AIDS, 2007, Volume: 18, Issue:9

    Topics: Anti-Bacterial Agents; Azithromycin; Cefixime; Chlamydia Infections; Doxycycline; Drug Therapy, Comb

2007
The role of metronidazole in the prevention of fistulae following total laryngectomy.
    Clinical oncology, 1980, Volume: 6, Issue:1

    Topics: Bacterial Infections; Fistula; Humans; Laryngeal Neoplasms; Laryngectomy; Metronidazole; Pharyngeal

1980
Thyroid adenocarcinoma in a bald eagle (Haliaeetus leukocephalus).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 1999, Volume: 30, Issue:3

    Topics: Adenocarcinoma; Animals; Antitrichomonal Agents; Bird Diseases; Eagles; Female; Hemorrhage; Metronid

1999
Retropharyngeal abscess--the foreign body connection.
    Annals of the Academy of Medicine, Singapore, 1991, Volume: 20, Issue:5

    Topics: Abscess; Adult; Aged; Airway Obstruction; Female; Foreign Bodies; Humans; Male; Metronidazole; Middl

1991
Metronidazole in the management of anaerobic neck infection in acute leukemia.
    Oral surgery, oral medicine, and oral pathology, 1988, Volume: 66, Issue:3

    Topics: Adult; Bacteria, Anaerobic; Bacterial Infections; Humans; Leukemia, Myeloid; Male; Metronidazole; Ne

1988
Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole.
    Cancer, 1988, Feb-15, Volume: 61, Issue:4

    Topics: Fistula; Humans; Laryngeal Neoplasms; Laryngectomy; Metronidazole; Pharyngeal Diseases; Radiation In

1988