metronidazole has been researched along with ENT Diseases in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole also has been used either alone or in combination, most frequently with amoxicillin, to treat many other anaerobic infections: head and neck, pleuropulmonary, genital tract, bone and joint, skin and soft tissue, and cases of fusobacterial septicemia (necrobacillosis)." | 1.27 | The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital. ( Eykyn, SJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marchiori, C | 1 |
| Tonon, E | 1 |
| Boscolo Rizzo, P | 1 |
| Vaglia, A | 1 |
| Meyding-Lamadé, U | 1 |
| Levorato, M | 1 |
| Da Mosto, MC | 1 |
| Dietz, A | 1 |
| Dovzhanskiĭ, SI | 1 |
| Grashkina, IG | 1 |
| Iaksanova, EM | 1 |
| Eykyn, SJ | 1 |
| Mann, W | 2 |
| Pelz, K | 1 |
| Murdoch, DA | 1 |
| Telfer, MR | 1 |
| Irvine, GH | 1 |
| Maurer, J | 1 |
| Wolfensberger, M | 1 |
| Riechelmann, H | 1 |
| Daschner, F | 1 |
| Morton, RP | 1 |
| Mellow, CG | 1 |
| Dorman, EB | 1 |
1 review available for metronidazole and ENT Diseases
| Article | Year |
|---|---|
[Anerobic infections in otolaryngology (author's transl)].
Topics: Adult; Anaerobiosis; Bacteria; Bacterial Infections; Carcinoma, Squamous Cell; Cephalosporins; Chron | 1981 |
2 trials available for metronidazole and ENT Diseases
| Article | Year |
|---|---|
[Perioperative preventive use of antibiotics in head and neck surgery].
Topics: Anti-Bacterial Agents; Azlocillin; Cephalosporins; Clindamycin; Drug Therapy, Combination; Humans; M | 1990 |
Chest infection following head and neck surgery: a pilot study.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Clavulanic Acids; Drug Thera | 1990 |
4 other studies available for metronidazole and ENT Diseases
| Article | Year |
|---|---|
[Brain abscesses after extracranial infections of the head and neck area].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic | 2003 |
[Pathogenesis and treatment of rosacea and perioral dermatitis].
Topics: Adolescent; Adult; Aged; Calcium Gluconate; Drug Therapy, Combination; Facial Dermatoses; Female; Ga | 1980 |
The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital.
Topics: Adult; Aged; Bacterial Infections; Bone Diseases; Empyema; Female; Fusobacterium Infections; Gastroi | 1983 |
Audit of antibiotic policy and wound infection in neck surgery.
Topics: Anti-Bacterial Agents; Cefuroxime; Clinical Protocols; Drug Therapy, Combination; Head and Neck Neop | 1993 |