metronidazole has been researched along with Lymphoma, B-Cell, Marginal Zone in 32 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Lymphoma, B-Cell, Marginal Zone: Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nine patients with low-grade gastric MALT lymphoma were treated with amoxicillin, metronidazole, and omeprazole for 14 days in a prospective study." | 2.68 | Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: follow-up together with sequential molecular studies. ( Alvarez, I; Bellas, C; Boixeda, D; Calleja, JL; Manzanal, A; Montalban, C; Redondo, C, 1997) |
| "All patients with peptic ulcer disease, gastric cancer, and MALT lymphoma should be tested for Hp." | 2.47 | Diagnosis and treatment of Helicobacter pylori infection. ( Bytzer, P; Dahlerup, JF; Eriksen, JR; Jarbøl, DE; Rosenstock, S; Wildt, S, 2011) |
| "pylori treatment on MALT lymphoma and chronic gastritis at the histologic and molecular levels." | 1.31 | Mucosal change of the stomach with low-grade mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: follow-up study of 48 cases. ( Begum, S; Endo, H; Kawamata, H; Sano, T; Urakami, Y, 2000) |
| "pylori eradication on low-grade gastric MALT lymphoma and to investigate the whitish mucosa that appeared with regression of the lesions." | 1.31 | Endoscopic characteristics of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori. ( Begum, S; Endo, H; Kawamata, H; Oki, Y; Sano, T; Urakami, Y, 2000) |
| "We report a case of Mediterranean lymphoma treated with antibiotics." | 1.29 | "Mediterranean lymphoma" treated with antibiotics. ( Asahara, M; Chiba, T; Fujimori, T; Fukuda, H; Kawanami, C; Kinoshita, Y; Matsumoto, S; Matsushima, Y; Waki, S, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (28.13) | 18.2507 |
| 2000's | 17 (53.13) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Guevara, B | 1 |
| Cogdill, AG | 1 |
| Kim, SG | 1 |
| Jung, HK | 1 |
| Lee, HL | 1 |
| Jang, JY | 1 |
| Lee, H | 1 |
| Kim, CG | 1 |
| Shin, WG | 1 |
| Shin, ES | 1 |
| Lee, YC | 1 |
| Grgov, S | 1 |
| Katić, V | 1 |
| Krstić, M | 1 |
| Nagorni, A | 1 |
| Radovanović-Dinić, B | 1 |
| Tasić, T | 1 |
| Rosmaninho, A | 1 |
| Alves, R | 1 |
| Lima, M | 1 |
| Lobo, I | 1 |
| Amorim, I | 1 |
| Selores, M | 1 |
| Smith, PT | 1 |
| Bytzer, P | 1 |
| Dahlerup, JF | 1 |
| Eriksen, JR | 1 |
| Jarbøl, DE | 1 |
| Rosenstock, S | 1 |
| Wildt, S | 1 |
| Fischbach, W | 2 |
| Goebeler-Kolve, M | 1 |
| Starostik, P | 1 |
| Greiner, A | 3 |
| Müller-Hermelink, HK | 1 |
| Schuster, MJ | 1 |
| Goebeler-Kolve, ME | 1 |
| Dragosics, B | 1 |
| Stolte, M | 2 |
| Malfertheiner, P | 1 |
| Schuster, M | 1 |
| Chen, LT | 2 |
| Lin, JT | 2 |
| Tai, JJ | 1 |
| Chen, GH | 1 |
| Yeh, HZ | 1 |
| Yang, SS | 1 |
| Wang, HP | 1 |
| Kuo, SH | 1 |
| Sheu, BS | 1 |
| Jan, CM | 2 |
| Wang, WM | 1 |
| Wang, TE | 1 |
| Wu, CW | 1 |
| Chen, CL | 2 |
| Su, IJ | 2 |
| Whang-Peng, J | 1 |
| Cheng, AL | 2 |
| Pai, RK | 1 |
| Snider, WK | 1 |
| Starkey, CR | 1 |
| Viswanatha, D | 1 |
| Foucar, MK | 1 |
| Wilson, CS | 1 |
| Blecker, U | 1 |
| McKeithan, TW | 1 |
| Hart, J | 1 |
| Kirschner, BS | 1 |
| tho Pesch, S | 1 |
| Müller, W | 1 |
| Borchard, F | 1 |
| Peters, U | 1 |
| Montalban, C | 2 |
| Manzanal, A | 2 |
| Boixeda, D | 2 |
| Redondo, C | 2 |
| Bellas, C | 2 |
| Alkan, S | 1 |
| Karcher, DS | 1 |
| Newman, MA | 1 |
| Cohen, P | 1 |
| Matsumoto, S | 1 |
| Kinoshita, Y | 1 |
| Fukuda, H | 1 |
| Waki, S | 1 |
| Asahara, M | 1 |
| Matsushima, Y | 1 |
| Kawanami, C | 1 |
| Fujimori, T | 1 |
| Chiba, T | 1 |
| Alvarez, I | 1 |
| Calleja, JL | 1 |
| Lévy, M | 2 |
| Hammel, P | 1 |
| Lamarque, D | 2 |
| Marty, O | 1 |
| Chaumette, MT | 1 |
| Haioun, C | 1 |
| Blazquez, M | 1 |
| Delchier, JC | 3 |
| van der Hulst, RW | 1 |
| van 't Hoff, BW | 1 |
| van der Ende, A | 1 |
| Tytgat, GN | 1 |
| Furusyo, N | 1 |
| Kanamoto, K | 1 |
| Nakamura, S | 3 |
| Yao, T | 1 |
| Suekane, H | 1 |
| Yano, Y | 1 |
| Ariyama, I | 1 |
| Hayashi, J | 1 |
| Kashiwagi, S | 1 |
| Raderer, M | 1 |
| Pfeffel, F | 1 |
| Pohl, G | 1 |
| Mannhalter, C | 1 |
| Valencak, J | 1 |
| Chott, A | 1 |
| Ng, WW | 1 |
| Lam, CP | 1 |
| Chau, WK | 1 |
| Fen-Yau Li, A | 1 |
| Huang, CC | 1 |
| Chang, FY | 1 |
| Lee, SD | 1 |
| Begum, S | 2 |
| Sano, T | 2 |
| Endo, H | 2 |
| Kawamata, H | 2 |
| Urakami, Y | 2 |
| Oki, Y | 1 |
| Tankovic, J | 1 |
| Lascols, C | 1 |
| Soussy, CJ | 1 |
| Timm, S | 1 |
| Sailer, M | 1 |
| Fuchs, KH | 1 |
| Shyu, RY | 1 |
| Chiang, IP | 1 |
| Liu, SM | 1 |
| Matsumoto, T | 1 |
| Kusano, Y | 1 |
| Esaki, M | 1 |
| Kurahara, K | 1 |
| Fukuda, T | 1 |
| Alpen, B | 1 |
| Röbbecke, J | 1 |
| Wündisch, T | 1 |
| Neubauer, A | 1 |
| Copie-Bergman, C | 1 |
| Traulle, C | 1 |
| Lavergne-Slove, A | 1 |
| Brousse, N | 1 |
| Flejou, JF | 1 |
| de Mascarel, A | 1 |
| Hemery, F | 1 |
| Gaulard, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Eradication of Helicobacter Pylori in the Management of Stage IE & IIE-1 Primary Low-grade B Cell Lymphoma of Mucosa-associated Lymphoid Tissue Type of The Stomach[NCT00201422] | 70 participants (Actual) | Interventional | 1996-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for metronidazole and Lymphoma, B-Cell, Marginal Zone
| Article | Year |
|---|---|
Helicobacter pylori: A Review of Current Diagnostic and Management Strategies.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Antigens, Bacterial; Biopsy; Bismuth; Breath | 2020 |
Diagnosis and treatment of Helicobacter pylori infection.
Topics: Amoxicillin; Anti-Bacterial Agents; Antidiarrheals; Bismuth; Clarithromycin; Denmark; Drug Therapy, | 2011 |
[Helicobacter pylori. Update 2002].
Topics: Adenocarcinoma; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Therapy, Combination; Duode | 2002 |
[Guidelines for the diagnosis and treatment of H. pylori infection].
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Drug Therapy, Combination; Duodenal Ulcer; Dysp | 2003 |
[Helicobacter pylori: reasons for eradication].
Topics: Adenocarcinoma; Amoxicillin; Anti-Ulcer Agents; Clarithromycin; Drug Therapy, Combination; Gastritis | 2004 |
[Treatment of Helicobacter pylori infections].
Topics: Clarithromycin; Clinical Protocols; Drug Resistance; Drug Therapy, Combination; Duodenal Ulcer; Fema | 1999 |
5 trials available for metronidazole and Lymphoma, B-Cell, Marginal Zone
| Article | Year |
|---|---|
Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Infective Agents; Clarithromycin; Drug Therapy, Co | 2004 |
Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: follow-up together with sequential molecular studies.
Topics: Aged; Amoxicillin; Drug Therapy, Combination; Follow-Up Studies; Gastrointestinal Neoplasms; Genes, | 1997 |
Endoscopic ultrasonography for the initial staging and follow-up in patients with low-grade gastric lymphoma of mucosa-associated lymphoid tissue treated medically.
Topics: Adult; Aged; Amoxicillin; Anti-Infective Agents; Antineoplastic Agents, Alkylating; Clarithromycin; | 1997 |
Helicobacter pylori eradication therapy in gastric high grade non Hodgkin's lymphoma (NHL).
Topics: Aged; Anti-Ulcer Agents; Clarithromycin; Combined Modality Therapy; Drug Therapy, Combination; Gastr | 2001 |
Conservative treatment of primary gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue: predictive factors of response and outcome.
Topics: Adult; Aged; Amoxicillin; Antineoplastic Agents, Alkylating; Biopsy, Needle; Chlorambucil; Clarithro | 2002 |
21 other studies available for metronidazole and Lymphoma, B-Cell, Marginal Zone
| Article | Year |
|---|---|
[Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition].
Topics: Amoxicillin; Anti-Bacterial Agents; Aspirin; Bismuth; Breath Tests; Clarithromycin; Gastroesophageal | 2013 |
Treatment of low-grade gastric MALT lymphoma using Helicobacter pylori eradication.
Topics: Adult; Aged; Amoxicillin; Anti-Infective Agents; Clarithromycin; Disease-Free Survival; Female; Heli | 2015 |
Red nose: primary cutaneous marginal zone B-cell lymphoma.
Topics: Administration, Topical; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Antineopla | 2010 |
Case of the month. MALT lymphoma.
Topics: Anemia; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Cyclophosphamide; Drug Therapy, Co | 2010 |
Minimal residual low-grade gastric MALT-type lymphoma after eradication of Helicobacter pylori.
Topics: Adult; Aged; Clarithromycin; Drug Therapy, Combination; Female; Helicobacter Infections; Helicobacte | 2002 |
Long-term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Progression; Disease-Fre | 2005 |
Nonsecretory variant of immunoproliferative small intestinal disease: a case report with pathologic, immunophenotypic, and molecular findings.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Amoxicillin; Anti-Bacterial Agents; Benzimidazoles; | 2005 |
Resolution of Helicobacter pylori-associated gastric lymphoproliferative disease in a child.
Topics: Adolescent; Amoxicillin; Bismuth; Chronic Disease; Drug Therapy, Combination; Female; Follow-Up Stud | 1995 |
[Low malignancy MALT lymphoma of the stomach: H. pyloric eradication as a therapeutic concept?].
Topics: Amoxicillin; Drug Therapy, Combination; Follow-Up Studies; Gastric Mucosa; Gastritis; Helicobacter I | 1994 |
Treatment of low-grade gastric MALT lymphoma with Helicobacter pylori eradication.
Topics: Amoxicillin; Biopsy; Gastrectomy; Helicobacter Infections; Helicobacter pylori; Humans; Lymphoma, B- | 1995 |
Regression of salivary gland MALT lymphoma after treatment for Helicobacter pylori.
Topics: Bismuth; Doxycycline; Female; Helicobacter Infections; Helicobacter pylori; Humans; Lymphoma, B-Cell | 1996 |
"Mediterranean lymphoma" treated with antibiotics.
Topics: Aged; Amoxicillin; Drug Therapy, Combination; Duodenoscopy; Duodenum; Female; Humans; Immunoprolifer | 1996 |
Rapidly growing primary gastric B-cell lymphoma after eradication of Helicobacter pylori.
Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Gastrointestinal Neoplasms; Helicobacter I | 1999 |
Regression of colonic low grade B cell lymphoma of the mucosa associated lymphoid tissue type after eradication of Helicobacter pylori.
Topics: Aged; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Colonic Neoplasms; Drug Therapy, Com | 2000 |
Regression of high-grade gastric mucosa-associated lymphoid tissue lymphoma with Helicobacter pylori after triple antibiotic therapy.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Drug Therapy, Combination; Helicobacter | 2000 |
Mucosal change of the stomach with low-grade mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: follow-up study of 48 cases.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Drug Therapy, Combination; Female | 2000 |
Endoscopic characteristics of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer | 2000 |
Clarithromycin resistance of Helicobacter pylori has a major impact on the efficacy of the omeprazole-amoxicillin-clarithromycin therapy.
Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Ulcer Agents; Biopsy; Clarithromycin; DNA, Bacterial; Dru | 2001 |
First successful treatment of a primary high-grade gastric MALT lymphoma by eradication therapy for Helicobacter pylori.
Topics: Biopsy; Clarithromycin; Drug Therapy, Combination; Female; Helicobacter Infections; Helicobacter pyl | 2001 |
Prospective study of Helicobacter pylori eradication therapy in stage I(E) high-grade mucosa-associated lymphoid tissue lymphoma of the stomach.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Female; Follo | 2001 |
Duodenal mucosa-associated lymphoid tissue lymphoma treated by eradication of Helicobacter pylori: report of 2 cases including EUS findings.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Amoxicillin; Benzimidazoles; Biopsy, Needle; Clarithr | 2001 |