Page last updated: 2024-10-31

metronidazole and Intestinal Obstruction

metronidazole has been researched along with Intestinal Obstruction in 21 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Intestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.

Research Excerpts

ExcerptRelevanceReference
"Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy."5.27Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983)
"Patients with colorectal cancer treated from May 6, 2004, to April 25, 2005."2.73Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics. ( Fujita, S; Ikeda, E; Kondo, K; Moriya, Y; Ohue, M; Saito, N; Takii, Y; Yamada, T, 2007)
"There was no recurrence of the volvulus at 1 to 6 years follow up but 8 patients (9."2.68Extraperitonealization for sigmoid volvulus: a reappraisal. ( Khanna, AK; Kumar, K; Misra, MK, 1995)
"Whilst colonic amoebiasis and its complications are well-documented, ileal amoebiasis has not been described in the literature."1.30Ileal amoebiasis. ( Haffejee, AA; Moodley, J; Ramdial, P; Singh, B, 1997)
"Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy."1.27Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983)
"Pneumatosis cystoides intestinalis was a sequal in two patients."1.26Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications. ( Ament, ME; Drenick, EJ; Finegold, SM; Passaro, E, 1977)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19909 (42.86)18.7374
1990's8 (38.10)18.2507
2000's1 (4.76)29.6817
2010's3 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Haumann, A1
Ongaro, S1
Detry, O1
Meunier, P1
Meurisse, M1
Zhu, KJ1
Winn, R1
Farahmand, F1
Khodadad, A1
Fallahi, G1
Motaharizad, D1
Sabery Nejad, J1
Fujita, S1
Saito, N1
Yamada, T1
Takii, Y1
Kondo, K1
Ohue, M1
Ikeda, E1
Moriya, Y1
Berenguer, J1
Kraft-Kinz, J1
Kronberger, L1
Keshavarzian, A1
Isaacs, P1
McColl, I1
Sladen, GE1
Khanna, AK1
Misra, MK1
Kumar, K1
Rau, BK1
Harikrishnan, KM1
Krishna, S1
Iacono, G1
Carroccio, A1
Montalto, G1
Cavataio, F1
Lo Cascio, M1
Notarbatolo, A1
Luchsinger, A1
Martinez, J1
Singh, B1
Moodley, J1
Ramdial, P1
Haffejee, AA1
Moesgaard, F1
Jensen, LS1
Christiansen, PM1
Thorlacius-Ussing, O1
Nielsen, KT1
Rasmussen, NR1
Bardram, L1
Nielsen, HJ1
Horiki, N1
Kaneda, Y1
Maruyama, M1
Fujita, Y1
Tachibana, H1
Antonelli, D1
Kustrup, JF1
Barry, RE2
Chow, AW1
Billesdon, J1
Drenick, EJ1
Ament, ME1
Finegold, SM1
Passaro, E1
Benfield, JR1
Nicell, P1
Bray, GA1
Brower, RA1
Axelsson, CK1
Otkjaer, S1
Andersen, ST1
Arnold, E1
Balikian, JP1
Uthman, SM1
Khouri, NF1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Multicenter Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery: Single-Dose Vs. Three Doses of Second-Generation Cephalosporin[NCT00292708]Phase 3500 participants Interventional2004-05-31Completed
ERAS Lazio Network Clinical Registry[NCT03353311]1,000 participants (Actual)Observational [Patient Registry]2014-09-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for metronidazole and Intestinal Obstruction

ArticleYear
Large bowel obstruction due to intrauterine device: associated pelvic inflammatory disease.
    The American surgeon, 1999, Volume: 65, Issue:12

    Topics: Actinomycosis; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Colostomy; Diagnosis, Diffe

1999

Trials

4 trials available for metronidazole and Intestinal Obstruction

ArticleYear
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
    Archives of surgery (Chicago, Ill. : 1960), 2007, Volume: 142, Issue:7

    Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic

2007
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
    Archives of surgery (Chicago, Ill. : 1960), 2007, Volume: 142, Issue:7

    Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic

2007
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
    Archives of surgery (Chicago, Ill. : 1960), 2007, Volume: 142, Issue:7

    Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic

2007
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
    Archives of surgery (Chicago, Ill. : 1960), 2007, Volume: 142, Issue:7

    Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic

2007
Extraperitonealization for sigmoid volvulus: a reappraisal.
    The Australian and New Zealand journal of surgery, 1995, Volume: 65, Issue:7

    Topics: Adolescent; Adult; Aged; Ampicillin; Colectomy; Drug Therapy, Combination; Elective Surgical Procedu

1995
The effect of ranitidine on postoperative infectious complications following emergency colorectal surgery: a randomized, placebo-controlled, double-blind trial.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cefuroxime; Colonic Diseases; Double-Blind Method; Femal

1998
Role of intestinal microflora in colonic pseudoobstruction complicating jejunoileal bypass.
    Gut, 1977, Volume: 18, Issue:5

    Topics: Bacteria; Clinical Trials as Topic; Colonic Diseases; Dilatation, Pathologic; Drug Therapy, Combinat

1977

Other Studies

16 other studies available for metronidazole and Intestinal Obstruction

ArticleYear
Acute pelvic inflammatory disease as a rare cause of acute small bowel obstruction.
    Acta chirurgica Belgica, 2019, Volume: 119, Issue:5

    Topics: Abdomen, Acute; Acute Disease; Adult; Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachom

2019
Pseudomembranous colitis presenting as a mechanical large bowel obstruction.
    ANZ journal of surgery, 2018, Volume: 88, Issue:9

    Topics: Administration, Intravenous; Administration, Oral; Anastomosis, Surgical; Anti-Bacterial Agents; Clo

2018
Hyperammonemic Induced Coma by Bacterial Overgrowth in a Child With Hirschsprung's Disease.
    Acta medica Iranica, 2016, Volume: 54, Issue:9

    Topics: Adolescent; Colon, Sigmoid; Coma; Female; Hirschsprung Disease; Humans; Intestinal Obstruction; Metr

2016
[Crohn's disease. Has there been progress in its treatment?].
    Medicina clinica, 1984, Jun-09, Volume: 83, Issue:2

    Topics: Crohn Disease; Drug Combinations; Female; Glucocorticoids; Glucosamine; Humans; Intestinal Obstructi

1984
[Diagnosis and therapy of cancer of the large intestine (author's transl)].
    Wiener klinische Wochenschrift, 1982, Apr-02, Volume: 94, Issue:7

    Topics: Aged; Colonic Neoplasms; Colostomy; Female; Humans; Intestinal Obstruction; Male; Metronidazole; Mid

1982
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin.
    The American journal of gastroenterology, 1983, Volume: 78, Issue:9

    Topics: Adult; Body Weight; Constipation; Humans; Ileostomy; Indomethacin; Intestinal Obstruction; Intestina

1983
Nd-YAG laser therapy for palliation of obstructed colorectal carcinomas.
    Indian journal of cancer, 1994, Volume: 31, Issue:4

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Fema

1994
Extreme short bowel syndrome: a case for reviewing the guidelines for predicting survival.
    Journal of pediatric gastroenterology and nutrition, 1993, Volume: 16, Issue:2

    Topics: Acidosis; Bacterial Infections; Bicarbonates; Breast Feeding; Catheters, Indwelling; Diarrhea, Infan

1993
A multiplicity of bowel problems.
    Hospital practice (1995), 1996, Jul-15, Volume: 31, Issue:7

    Topics: Aeromonas hydrophila; Ampicillin; Diagnosis, Differential; Drug Therapy, Combination; Enterocolitis,

1996
Ileal amoebiasis.
    Journal of the Royal College of Surgeons of Edinburgh, 1997, Volume: 42, Issue:3

    Topics: Adult; Amebiasis; Amebicides; Colitis; Constriction, Pathologic; Female; Humans; Ileal Diseases; Int

1997
Intestinal blockage by carcinoma and Blastocystis hominis infection.
    The American journal of tropical medicine and hygiene, 1999, Volume: 60, Issue:3

    Topics: Adolescent; Adult; Aged; Animals; Antitrichomonal Agents; Blastocystis hominis; Blastocystis Infecti

1999
Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications.
    The American journal of clinical nutrition, 1977, Volume: 30, Issue:1

    Topics: Adult; Albumins; Arthritis; Body Weight; Dermatitis; Diarrhea; Female; Humans; Ileum; Inflammation;

1977
Colonic pseudo-obstruction: a new complication of jejunoileal bypass.
    Gut, 1975, Volume: 16, Issue:11

    Topics: Adult; Clindamycin; Colon; Colonic Diseases; Diagnosis, Differential; Dilatation, Pathologic; Humans

1975
Hydrostatic balloon dilation of a terminal ileal stricture secondary to Crohn's disease.
    Gastrointestinal endoscopy, 1986, Volume: 32, Issue:1

    Topics: Adult; Crohn Disease; Dilatation; Female; Follow-Up Studies; Humans; Ileal Diseases; Intestinal Obst

1986
Absorption of metronidazole suppositories in patients with postoperative ileus.
    Danish medical bulletin, 1985, Volume: 32, Issue:2

    Topics: Absorption; Adult; Aged; Bacterial Infections; Female; Humans; Intestinal Obstruction; Male; Metroni

1985
Intestinal amebiasis. A roentgen analysis of 19 cases including 2 case reports.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1974, Volume: 122, Issue:2

    Topics: Abscess; Aged; Cecal Diseases; Colitis, Ulcerative; Colonic Diseases; Colonic Neoplasms; Diagnosis,

1974