metronidazole has been researched along with Intestinal Obstruction in 21 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Intestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 5.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| "Patients with colorectal cancer treated from May 6, 2004, to April 25, 2005." | 2.73 | Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics. ( Fujita, S; Ikeda, E; Kondo, K; Moriya, Y; Ohue, M; Saito, N; Takii, Y; Yamada, T, 2007) |
| "There was no recurrence of the volvulus at 1 to 6 years follow up but 8 patients (9." | 2.68 | Extraperitonealization for sigmoid volvulus: a reappraisal. ( Khanna, AK; Kumar, K; Misra, MK, 1995) |
| "Whilst colonic amoebiasis and its complications are well-documented, ileal amoebiasis has not been described in the literature." | 1.30 | Ileal amoebiasis. ( Haffejee, AA; Moodley, J; Ramdial, P; Singh, B, 1997) |
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 1.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| "Pneumatosis cystoides intestinalis was a sequal in two patients." | 1.26 | Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications. ( Ament, ME; Drenick, EJ; Finegold, SM; Passaro, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (42.86) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haumann, A | 1 |
| Ongaro, S | 1 |
| Detry, O | 1 |
| Meunier, P | 1 |
| Meurisse, M | 1 |
| Zhu, KJ | 1 |
| Winn, R | 1 |
| Farahmand, F | 1 |
| Khodadad, A | 1 |
| Fallahi, G | 1 |
| Motaharizad, D | 1 |
| Sabery Nejad, J | 1 |
| Fujita, S | 1 |
| Saito, N | 1 |
| Yamada, T | 1 |
| Takii, Y | 1 |
| Kondo, K | 1 |
| Ohue, M | 1 |
| Ikeda, E | 1 |
| Moriya, Y | 1 |
| Berenguer, J | 1 |
| Kraft-Kinz, J | 1 |
| Kronberger, L | 1 |
| Keshavarzian, A | 1 |
| Isaacs, P | 1 |
| McColl, I | 1 |
| Sladen, GE | 1 |
| Khanna, AK | 1 |
| Misra, MK | 1 |
| Kumar, K | 1 |
| Rau, BK | 1 |
| Harikrishnan, KM | 1 |
| Krishna, S | 1 |
| Iacono, G | 1 |
| Carroccio, A | 1 |
| Montalto, G | 1 |
| Cavataio, F | 1 |
| Lo Cascio, M | 1 |
| Notarbatolo, A | 1 |
| Luchsinger, A | 1 |
| Martinez, J | 1 |
| Singh, B | 1 |
| Moodley, J | 1 |
| Ramdial, P | 1 |
| Haffejee, AA | 1 |
| Moesgaard, F | 1 |
| Jensen, LS | 1 |
| Christiansen, PM | 1 |
| Thorlacius-Ussing, O | 1 |
| Nielsen, KT | 1 |
| Rasmussen, NR | 1 |
| Bardram, L | 1 |
| Nielsen, HJ | 1 |
| Horiki, N | 1 |
| Kaneda, Y | 1 |
| Maruyama, M | 1 |
| Fujita, Y | 1 |
| Tachibana, H | 1 |
| Antonelli, D | 1 |
| Kustrup, JF | 1 |
| Barry, RE | 2 |
| Chow, AW | 1 |
| Billesdon, J | 1 |
| Drenick, EJ | 1 |
| Ament, ME | 1 |
| Finegold, SM | 1 |
| Passaro, E | 1 |
| Benfield, JR | 1 |
| Nicell, P | 1 |
| Bray, GA | 1 |
| Brower, RA | 1 |
| Axelsson, CK | 1 |
| Otkjaer, S | 1 |
| Andersen, ST | 1 |
| Arnold, E | 1 |
| Balikian, JP | 1 |
| Uthman, SM | 1 |
| Khouri, NF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Multicenter Trial of Antibiotic Prophylaxis in Elective Colorectal Surgery: Single-Dose Vs. Three Doses of Second-Generation Cephalosporin[NCT00292708] | Phase 3 | 500 participants | Interventional | 2004-05-31 | Completed | ||
| ERAS Lazio Network Clinical Registry[NCT03353311] | 1,000 participants (Actual) | Observational [Patient Registry] | 2014-09-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Intestinal Obstruction
| Article | Year |
|---|---|
Large bowel obstruction due to intrauterine device: associated pelvic inflammatory disease.
Topics: Actinomycosis; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Colostomy; Diagnosis, Diffe | 1999 |
4 trials available for metronidazole and Intestinal Obstruction
| Article | Year |
|---|---|
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics.
Topics: Administration, Oral; Anti-Infective Agents; Antibiotic Prophylaxis; Cefmetazole; Colectomy; Colonic | 2007 |
Extraperitonealization for sigmoid volvulus: a reappraisal.
Topics: Adolescent; Adult; Aged; Ampicillin; Colectomy; Drug Therapy, Combination; Elective Surgical Procedu | 1995 |
The effect of ranitidine on postoperative infectious complications following emergency colorectal surgery: a randomized, placebo-controlled, double-blind trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cefuroxime; Colonic Diseases; Double-Blind Method; Femal | 1998 |
Role of intestinal microflora in colonic pseudoobstruction complicating jejunoileal bypass.
Topics: Bacteria; Clinical Trials as Topic; Colonic Diseases; Dilatation, Pathologic; Drug Therapy, Combinat | 1977 |
16 other studies available for metronidazole and Intestinal Obstruction
| Article | Year |
|---|---|
Acute pelvic inflammatory disease as a rare cause of acute small bowel obstruction.
Topics: Abdomen, Acute; Acute Disease; Adult; Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachom | 2019 |
Pseudomembranous colitis presenting as a mechanical large bowel obstruction.
Topics: Administration, Intravenous; Administration, Oral; Anastomosis, Surgical; Anti-Bacterial Agents; Clo | 2018 |
Hyperammonemic Induced Coma by Bacterial Overgrowth in a Child With Hirschsprung's Disease.
Topics: Adolescent; Colon, Sigmoid; Coma; Female; Hirschsprung Disease; Humans; Intestinal Obstruction; Metr | 2016 |
[Crohn's disease. Has there been progress in its treatment?].
Topics: Crohn Disease; Drug Combinations; Female; Glucocorticoids; Glucosamine; Humans; Intestinal Obstructi | 1984 |
[Diagnosis and therapy of cancer of the large intestine (author's transl)].
Topics: Aged; Colonic Neoplasms; Colostomy; Female; Humans; Intestinal Obstruction; Male; Metronidazole; Mid | 1982 |
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin.
Topics: Adult; Body Weight; Constipation; Humans; Ileostomy; Indomethacin; Intestinal Obstruction; Intestina | 1983 |
Nd-YAG laser therapy for palliation of obstructed colorectal carcinomas.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Fema | 1994 |
Extreme short bowel syndrome: a case for reviewing the guidelines for predicting survival.
Topics: Acidosis; Bacterial Infections; Bicarbonates; Breast Feeding; Catheters, Indwelling; Diarrhea, Infan | 1993 |
A multiplicity of bowel problems.
Topics: Aeromonas hydrophila; Ampicillin; Diagnosis, Differential; Drug Therapy, Combination; Enterocolitis, | 1996 |
Ileal amoebiasis.
Topics: Adult; Amebiasis; Amebicides; Colitis; Constriction, Pathologic; Female; Humans; Ileal Diseases; Int | 1997 |
Intestinal blockage by carcinoma and Blastocystis hominis infection.
Topics: Adolescent; Adult; Aged; Animals; Antitrichomonal Agents; Blastocystis hominis; Blastocystis Infecti | 1999 |
Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications.
Topics: Adult; Albumins; Arthritis; Body Weight; Dermatitis; Diarrhea; Female; Humans; Ileum; Inflammation; | 1977 |
Colonic pseudo-obstruction: a new complication of jejunoileal bypass.
Topics: Adult; Clindamycin; Colon; Colonic Diseases; Diagnosis, Differential; Dilatation, Pathologic; Humans | 1975 |
Hydrostatic balloon dilation of a terminal ileal stricture secondary to Crohn's disease.
Topics: Adult; Crohn Disease; Dilatation; Female; Follow-Up Studies; Humans; Ileal Diseases; Intestinal Obst | 1986 |
Absorption of metronidazole suppositories in patients with postoperative ileus.
Topics: Absorption; Adult; Aged; Bacterial Infections; Female; Humans; Intestinal Obstruction; Male; Metroni | 1985 |
Intestinal amebiasis. A roentgen analysis of 19 cases including 2 case reports.
Topics: Abscess; Aged; Cecal Diseases; Colitis, Ulcerative; Colonic Diseases; Colonic Neoplasms; Diagnosis, | 1974 |