cp 70429 profile

sulopenem: a penem antibiotic [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	9950244
CHEMBL ID	1908305
SCHEMBL ID	2256409
MeSH ID	M0220733

Synonym
sulopenem
cp-70429
cp-65207-s
sulopenem (usan/inn)
120788-07-0
D05969
cp-70,429
xx514bj1xw ,
CHEMBL1908305
sulopenem [inn]
(5r,6s)-6-[(1r)-1-hydroxyethyl]-7-oxo-3-[[(3s)-tetrahydro-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, (r)-s-oxide
sulopenem [usan]
4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-((1r)-1-hydroxyethyl)-7-oxo-3-(((1r,3s)-tetrahydro-1-oxido-3-thienyl)thio)-, (5r,6s)-
(5r,6s)-6-((1r)-1-hydroxyethyl)-7-oxo-3-(((1r,3s)-1-oxotetrahydro-1h-1.lamba.(sup 4)-thiophen-3-yl)sulfanyl)-4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-((tetrahydro-3-thienyl)thio)-, s-oxide, (5r-(3(1r,3s),5.alpha.,6.alpha.(r*)))-
SCHEMBL2256409
AC-33244
cp 70429
sulopenem, >=98% (hplc)
DTXSID20869656
DB15284
(5r,6s)-6-[(1r)-1-hydroxyethyl]-7-oxo-3-[(1r,3s)-1-oxothiolan-3-yl]sulfanyl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
cp70429
gtpl10862
Q27294038
EX-A4518
MS-25396
HY-105284
CS-0025618
AKOS040745084

Bioassays (101)

Assay ID	Title	Year	Journal	Article
AID557718	Antimicrobial activity in Fusobacterium mortiferum by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557742	Antimicrobial activity in Anaerococcus tetradius by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557420	Antimicrobial activity in Bacteroides vulgatus by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558590	Antimicrobial activity against Streptococcus pneumoniae 2 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557964	Antimicrobial activity in Clostridium difficile by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557714	Antimicrobial activity in Fusobacterium necrophorum by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558583	Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557730	Antimicrobial activity in Micromonas micros by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558630	Antimicrobial activity against Streptococcus pneumoniae isolate 4747 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558004	Antimicrobial activity in Clostridium hastiforme by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557952	Antimicrobial activity in Actinomyces by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557412	Antimicrobial activity in Bacteroides thetaiotaomicron by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557698	Antimicrobial activity in Prevotella loescheii by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558000	Antimicrobial activity in Clostridium clostridioforme by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557452	Antimicrobial activity in Prevotella intermedia by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557960	Antimicrobial activity in Clostridium perfringens by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557436	Antimicrobial activity in Prevotella bivia by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557738	Antimicrobial activity in Peptoniphilus asaccharolyticus by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558582	Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557424	Antimicrobial activity in Bacteroides distasonis by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558601	Antimicrobial activity against Streptococcus pneumoniae isolate 24 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558607	Antimicrobial activity against Streptococcus pneumoniae isolate 1384 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557956	Antimicrobial activity in Eggerthella lenta by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558620	Antimicrobial activity against Streptococcus pneumoniae isolate 3282 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557448	Antimicrobial activity in Prevotella denticola by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558622	Antimicrobial activity against Streptococcus pneumoniae isolate 3374 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557428	Antimicrobial activity in Bacteroides uniformis by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557734	Antimicrobial activity in Peptostreptococcus anaerobius by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557968	Antimicrobial activity in Clostridium sp. by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557746	Antimicrobial activity in Anaerococcus prevotii by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557416	Antimicrobial activity in Bacteroides ovatus by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557750	Antimicrobial activity in Lactobacillus by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557710	Antimicrobial activity in Fusobacterium nucleatum by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557460	Antimicrobial activity in Prevotella corporis by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557976	Antimicrobial activity in Clostridium ramosum by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558623	Antimicrobial activity against Streptococcus pneumoniae isolate 3412 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557432	Antimicrobial activity in Bacteroides stercoris by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557682	Antimicrobial activity in Prevotella oralis group by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557456	Antimicrobial activity in Prevotella nigrescens by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558612	Antimicrobial activity against Streptococcus pneumoniae isolate 2617 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557996	Antimicrobial activity in Clostridium butyricum by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557948	Antimicrobial activity in Propionibacterium acnes by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558589	Antimicrobial activity against Streptococcus pneumoniae 1 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557722	Antimicrobial activity in Fusobacterium varium by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557726	Antimicrobial activity in Finegoldia magna by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558608	Antimicrobial activity against Streptococcus pneumoniae isolate 1394 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557944	Antimicrobial activity in Bifidobacterium by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558587	Antimicrobial activity against Streptococcus pneumoniae 19A by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558631	Antimicrobial activity against Streptococcus pneumoniae isolate 4755 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558581	Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558606	Antimicrobial activity against Streptococcus pneumoniae isolate 1147 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557992	Antimicrobial activity in Clostridium sordellii by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558619	Antimicrobial activity against Streptococcus pneumoniae isolate 3275 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558599	Antimicrobial activity against Streptococcus pneumoniae 11 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558618	Antimicrobial activity against Streptococcus pneumoniae isolate 3263 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557988	Antimicrobial activity in Clostridium innocuum by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558609	Antimicrobial activity against Streptococcus pneumoniae isolate 1397 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557980	Antimicrobial activity in Clostridium cadaveris by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557694	Antimicrobial activity in Prevotella salivae by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558625	Antimicrobial activity against Streptococcus pneumoniae isolate 3458 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557690	Antimicrobial activity in Prevotella bergensis by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557706	Antimicrobial activity in Porphyromonas asaccharolytica by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558613	Antimicrobial activity against Streptococcus pneumoniae isolate 2686 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557408	Antimicrobial activity in Bacteroides fragilis by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558624	Antimicrobial activity against Streptococcus pneumoniae isolate 3455 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557444	Antimicrobial activity in Prevotella melaninogenica by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558596	Antimicrobial activity against Streptococcus pneumoniae 8 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558591	Antimicrobial activity against Streptococcus pneumoniae 3 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557972	Antimicrobial activity in Clostridium tertium by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557702	Antimicrobial activity in Prevotella sp.by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557440	Antimicrobial activity in Prevotella buccae by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558604	Antimicrobial activity against Streptococcus pneumoniae isolate 1055 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558626	Antimicrobial activity against Streptococcus pneumoniae isolate 3481 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558614	Antimicrobial activity against Streptococcus pneumoniae isolate 2688 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557464	Antimicrobial activity in Prevotella disiens by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558627	Antimicrobial activity against Streptococcus pneumoniae isolate 3587 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558592	Antimicrobial activity against Streptococcus pneumoniae 4 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558611	Antimicrobial activity against Streptococcus pneumoniae isolate 1564 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558593	Antimicrobial activity against Streptococcus pneumoniae 5 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558010	Antimicrobial activity in Eggerthella lenta ATCC 43055 by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558595	Antimicrobial activity against Streptococcus pneumoniae 7 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558603	Antimicrobial activity against Streptococcus pneumoniae isolate 37 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558617	Antimicrobial activity against Streptococcus pneumoniae isolate 3260 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557686	Antimicrobial activity in Prevotella veroralis by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558009	Antimicrobial activity in Bacteroides thetaiotaomicron ATCC 29741 by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID557678	Antimicrobial activity in Prevotella baroniae by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558598	Antimicrobial activity against Streptococcus pneumoniae 10 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558014	Antimicrobial activity in Porphyromonas gingivalis by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558621	Antimicrobial activity against Streptococcus pneumoniae isolate 3346 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558008	Antimicrobial activity in Bacteroides fragilis ATCC 25285 by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558629	Antimicrobial activity against Streptococcus pneumoniae isolate 3791 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID557984	Antimicrobial activity in Clostridium bifermentans by CLSI agar dilution method	2009	Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5	Antianaerobic activity of sulopenem compared to six other agents.
AID558605	Antimicrobial activity against Streptococcus pneumoniae isolate 1146 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558616	Antimicrobial activity against Streptococcus pneumoniae isolate 2880 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558610	Antimicrobial activity against Streptococcus pneumoniae isolate 1424 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558594	Antimicrobial activity against Streptococcus pneumoniae 6 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558628	Antimicrobial activity against Streptococcus pneumoniae isolate 3681 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558615	Antimicrobial activity against Streptococcus pneumoniae isolate 2874 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558600	Antimicrobial activity against Streptococcus pneumoniae 12 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558602	Antimicrobial activity against Streptococcus pneumoniae isolate 33 by agar dilution method	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
AID558597	Antimicrobial activity against Streptococcus pneumoniae 9 by time-kill analysis	2009	Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6	Comparative antipneumococcal activities of sulopenem and other drugs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	6 (37.50)	18.2507
2000's	3 (18.75)	29.6817
2010's	0 (0.00)	24.3611
2020's	7 (43.75)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (18.75%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (81.25%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
cefuroxime Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.. cefuroxime : A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain.	2.41	1	0	carbamate ester; cephalosporin
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	5.74	3	2	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.	2.05	1	0	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic
gatifloxacin Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.. gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.	2.05	1	0	N-arylpiperazine; organofluorine compound; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antiinfective agent; antimicrobial agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	2.05	1	0	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	2.42	2	0	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
amoxicillin Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.	2.78	3	0	penicillin allergen; penicillin	antibacterial drug
piperacillin Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.. piperacillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group.	2.05	1	0	penicillin allergen; penicillin	antibacterial drug
cefoperazone Cefoperazone: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections.. cefoperazone : A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.	1.99	1	0	cephalosporin	antibacterial drug
cephalosporin c cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.	2.68	3	0	cephalosporin	fungal metabolite
flomoxef flomoxef: structure given in first source; RN given refers to sodium salt. flomoxef : A second-generation oxacephem antibiotic in which the oxazine ring is substituted at C-3 with a hydroxyethyl-substituted tetrazolylthiomethyl group and the azetidinone ring carries 7alpha-methoxy and 7beta-{2-[(difluoromethyl)thiomethyl]acetamido} substituents.	2.39	2	0	N-acyl-amino acid; organonitrogen heterocyclic antibiotic; oxacephem	antibacterial drug
fropenem [no description available]	2.6	1	0	faropenem
clarithromycin Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.. clarithromycin : The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.	2.05	1	0	macrolide antibiotic	antibacterial drug; environmental contaminant; protein synthesis inhibitor; xenobiotic
imipenem, anhydrous Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.	3.25	6	0	beta-lactam antibiotic allergen; carbapenems; zwitterion	antibacterial drug
sulbactam [no description available]	1.99	1	0	penicillanic acids
carbapenems [no description available]	2.9	2	0
beta-lactams 2-azetidinone: structure in first source. azetidin-2-one : An unsubstituted beta-lactam compound.. beta-lactam : A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.	3.1	5	0	beta-lactam antibiotic allergen; beta-lactam
levofloxacin Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.	2.05	1	0	9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; fluoroquinolone antibiotic; quinolone antibiotic	antibacterial drug; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; topoisomerase IV inhibitor
ertapenem Ertapenem: A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of Gram-positive and Gram-negative bacterial infections including intra-abdominal infections, acute gynecological infections, complicated urinary tract infections, skin infections, and respiratory tract infections. It is also used to prevent infection in colorectal surgery.. ertapenem : Meropenem in which the one of the two methyl groups attached to the amide nitrogen is replaced by hydrogen while the other is replaced by a 3-carboxyphenyl group. The sodium salt is used for the treatment of moderate to severe susceptible infections including intra-abdominal and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract.	4.84	2	1	carbapenemcarboxylic acid; pyrrolidinecarboxamide	antibacterial drug
moxifloxacin Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.	2.05	1	0	aromatic ether; cyclopropanes; fluoroquinolone antibiotic; pyrrolidinopiperidine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug
meropenem Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.	3.2	5	0	alpha,beta-unsaturated monocarboxylic acid; carbapenemcarboxylic acid; organic sulfide; pyrrolidinecarboxamide	antibacterial agent; antibacterial drug; drug allergen
sultamicillin sultamicillin: contains ampicillin & sulbactam	1.99	1	0	penicillanic acid ester
clindamycin Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.	2.05	1	0
zithromax Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.	2.05	1	0	macrolide antibiotic	antibacterial drug; environmental contaminant; xenobiotic
hmr 3647 [no description available]	2.05	1	0
cefuroxime [no description available]	2.05	1	0	3-(carbamoyloxymethyl)cephalosporin; furans; oxime O-ether	drug allergen
ceftriaxone [no description available]	2.05	1	0	1,2,4-triazines; 1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen; EC 3.5.2.6 (beta-lactamase) inhibitor
cefotaxime Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.	1.99	1	0	1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen
cefpodoxime [no description available]	2.05	1	0	carboxylic acid; cephalosporin	antibacterial drug
cefuzonam cefuzonam: article gives L-105 as synonym, however L 105 is a rifamycin derivative according to Chemline. cefuzonam : A second generation cephalosporin antibiotic.	2.39	2	0	cephalosporin	antibacterial drug
cefdinir [no description available]	2.05	1	0	cephalosporin; ketoxime	antibacterial drug
tebipenem tebipenem: an oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae; structure in first source	2.9	2	0
avibactam avibactam : A member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) in combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis.	2.9	2	0	azabicycloalkane; hydroxylamine O-sulfonic acid; monocarboxylic acid amide; ureas	antibacterial drug; antimicrobial agent; EC 3.5.2.6 (beta-lactamase) inhibitor

Condition	Indicated	Relationship Strength	Studies	Trials
Disease, Pulmonary [description not available]	0	2.45	2	0
Lung Diseases Pathological processes involving any part of the LUNG.	0	2.45	2	0
Bacteriuria The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the URINARY TRACT and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection.	0	4.91	1	1
Necrotizing Pyelonephritis [description not available]	0	4.91	1	1
Pyelonephritis Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.	0	4.91	1	1
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	1	8.87	5	3
E coli Infections [description not available]	0	2.39	2	0
Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI.	0	2.39	2	0
Infections, Klebsiella [description not available]	0	1.99	1	0
Bacteroides Infections Infections with bacteria of the genus BACTEROIDES.	0	1.99	1	0
Klebsiella Infections Infections with bacteria of the genus KLEBSIELLA.	0	1.99	1	0
Bacterial Disease [description not available]	0	1.99	1	0
Bacterial Infections Infections by bacteria, general or unspecified.	0	1.99	1	0

cp 70429

Description

Cross-References

Synonyms (30)

Bioassays (101)

Research

Studies (16)

Study Types

cp 70429

Description

Cross-References

Synonyms (30)

Bioassays (101)

Research

Studies (16)

Study Types

Related Drugs (33)

Related Conditions (13)