metronidazole has been researched along with Bejel in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 1977 swine dysentery was made a notifiable disease in the German Democratic Republic, with the intention of eradicating it by the systematic treatment of clinically affected herds using intensive medication and hygiene control programmes." | 5.27 | Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme. ( Blaha, T; Burch, DG; Erler, W, 1987) |
| "In 1977 swine dysentery was made a notifiable disease in the German Democratic Republic, with the intention of eradicating it by the systematic treatment of clinically affected herds using intensive medication and hygiene control programmes." | 1.27 | Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme. ( Blaha, T; Burch, DG; Erler, W, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ehmke, B | 1 |
| Beikler, T | 1 |
| Riep, B | 1 |
| Flemmig, T | 1 |
| Göbel, U | 1 |
| Moter, A | 1 |
| Loesche, WJ | 1 |
| Giordano, J | 1 |
| Hujoel, PP | 1 |
| Blaha, T | 1 |
| Erler, W | 1 |
| Burch, DG | 1 |
| Lerner, PI | 1 |
2 trials available for metronidazole and Bejel
| Article | Year |
|---|---|
Intraoral dissemination of treponemes after periodontal therapy.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidi | 2004 |
The utility of the BANA test for monitoring anaerobic infections due to spirochetes (Treponema denticola) in periodontal disease.
Topics: Analysis of Variance; Benzoylarginine-2-Naphthylamide; Dental Plaque; Double-Blind Method; Humans; M | 1990 |
2 other studies available for metronidazole and Bejel
| Article | Year |
|---|---|
Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme.
Topics: Animals; Anti-Bacterial Agents; Diterpenes; Dysentery; Female; Follow-Up Studies; Germany, East; Leu | 1987 |
Antimicrobial considerations in anaerobic infections.
Topics: Actinomycetales Infections; Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Bacteroides I | 1974 |