Page last updated: 2024-10-31

metronidazole and Bejel

metronidazole has been researched along with Bejel in 4 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"In 1977 swine dysentery was made a notifiable disease in the German Democratic Republic, with the intention of eradicating it by the systematic treatment of clinically affected herds using intensive medication and hygiene control programmes."5.27Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme. ( Blaha, T; Burch, DG; Erler, W, 1987)
"In 1977 swine dysentery was made a notifiable disease in the German Democratic Republic, with the intention of eradicating it by the systematic treatment of clinically affected herds using intensive medication and hygiene control programmes."1.27Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme. ( Blaha, T; Burch, DG; Erler, W, 1987)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ehmke, B1
Beikler, T1
Riep, B1
Flemmig, T1
Göbel, U1
Moter, A1
Loesche, WJ1
Giordano, J1
Hujoel, PP1
Blaha, T1
Erler, W1
Burch, DG1
Lerner, PI1

Trials

2 trials available for metronidazole and Bejel

ArticleYear
Intraoral dissemination of treponemes after periodontal therapy.
    Clinical oral investigations, 2004, Volume: 8, Issue:4

    Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidi

2004
The utility of the BANA test for monitoring anaerobic infections due to spirochetes (Treponema denticola) in periodontal disease.
    Journal of dental research, 1990, Volume: 69, Issue:10

    Topics: Analysis of Variance; Benzoylarginine-2-Naphthylamide; Dental Plaque; Double-Blind Method; Humans; M

1990

Other Studies

2 other studies available for metronidazole and Bejel

ArticleYear
Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme.
    The Veterinary record, 1987, Oct-31, Volume: 121, Issue:18

    Topics: Animals; Anti-Bacterial Agents; Diterpenes; Dysentery; Female; Follow-Up Studies; Germany, East; Leu

1987
Antimicrobial considerations in anaerobic infections.
    The Medical clinics of North America, 1974, Volume: 58, Issue:3

    Topics: Actinomycetales Infections; Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Bacteroides I

1974