metronidazole and Histoplasmosis
metronidazole has been researched along with Histoplasmosis in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Histoplasmosis: Infection resulting from exposure to the fungus HISTOPLASMA. It is worldwide in distribution and particularly common in the central and eastern states, especially areas around the Ohio and Mississippi River valleys.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Histoplasmosis is a frequent complication of HIV infection and is usually the result of reactivation." | 2.39 | Oral histoplasmosis in a patient infected with HIV. A case report. ( Durham, T; Johansson, SL; Kaufman, L; Swindells, S, 1994) |
Research
Studies (2)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (50.00) | 18.7374 |
1990's | 1 (50.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Swindells, S | 1 |
Durham, T | 1 |
Johansson, SL | 1 |
Kaufman, L | 1 |
Coss, KC | 1 |
Wheat, LJ | 1 |
Conces, DJ | 1 |
Brashear, RE | 1 |
Hull, MT | 1 |
Reviews
1 review available for metronidazole and Histoplasmosis
Article | Year |
---|---|
Oral histoplasmosis in a patient infected with HIV. A case report.
Topics: Adult; AIDS-Related Opportunistic Infections; Fluconazole; Histoplasmosis; Humans; Male; Metronidazo | 1994 |
Other Studies
1 other study available for metronidazole and Histoplasmosis
Article | Year |
---|---|
Esophageal fistula complicating mediastinal histoplasmosis. Response to amphotericin B.
Topics: Adult; Amphotericin B; Ceftriaxone; Drug Therapy, Combination; Esophageal Fistula; Hemoptysis; Histo | 1987 |