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metronidazole and Histoplasmosis

metronidazole has been researched along with Histoplasmosis in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Histoplasmosis: Infection resulting from exposure to the fungus HISTOPLASMA. It is worldwide in distribution and particularly common in the central and eastern states, especially areas around the Ohio and Mississippi River valleys.

Research Excerpts

ExcerptRelevanceReference
"Histoplasmosis is a frequent complication of HIV infection and is usually the result of reactivation."2.39Oral histoplasmosis in a patient infected with HIV. A case report. ( Durham, T; Johansson, SL; Kaufman, L; Swindells, S, 1994)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Swindells, S1
Durham, T1
Johansson, SL1
Kaufman, L1
Coss, KC1
Wheat, LJ1
Conces, DJ1
Brashear, RE1
Hull, MT1

Reviews

1 review available for metronidazole and Histoplasmosis

ArticleYear
Oral histoplasmosis in a patient infected with HIV. A case report.
    Oral surgery, oral medicine, and oral pathology, 1994, Volume: 77, Issue:2

    Topics: Adult; AIDS-Related Opportunistic Infections; Fluconazole; Histoplasmosis; Humans; Male; Metronidazo

1994

Other Studies

1 other study available for metronidazole and Histoplasmosis

ArticleYear
Esophageal fistula complicating mediastinal histoplasmosis. Response to amphotericin B.
    The American journal of medicine, 1987, Volume: 83, Issue:2

    Topics: Adult; Amphotericin B; Ceftriaxone; Drug Therapy, Combination; Esophageal Fistula; Hemoptysis; Histo

1987
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