metronidazole and cefepime

metronidazole has been researched along with cefepime in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.70)18.7374
1990's4 (14.81)18.2507
2000's12 (44.44)29.6817
2010's8 (29.63)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bradbury, BJ; Buechter, DD; Cheng, J; Deshpande, M; Mushtaq, G; Podos, SD; Pucci, MJ; Thanassi, JA; Thoma, CL; Vigliotti, GA1
Lombardo, F; Obach, RS; Waters, NJ1
Amsler, KM; Bush, K; Davies, TA; Jacobs, MR; Shang, W1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Appleman, MD; Berne, TV; Chin, A; Gill, MA; Heseltine, PN; Knupp, CA; Okamoto, MP; Sclar, DA; Yellin, AE1
Barry, AL; Jones, RN; Packer, RR1
Appleman, MD; Berne, TV; Gill, MA; Heseltine, PN; Yellin, AE1
Barie, PS; Baumgartner, TF; Dellinger, EP; Rotstein, OD; Solomkin, JS; Vogel, SB; Yang, JY1
Alekseeva, EA; BelotserkovskiÄ­, BZ; Gel'fand, BR; Gel'fand, EB; Karabak, VI; Tsedenzhapov, ETs1
Rulli, F; Zanella, E1
Cincin, TG; Gezen, CF; Kurt, N; Olcay, E; Oncel, M; Remzi, FH; Sensu, SS; Vural, S1
Blijlevens, N; de Pauw, B; Donnelly, P; Levenga, H; Shirango, H; Verweij, P1
Barie, PS; Dellinger, EP; Grasela, TH; Rotstein, OD; Walawander, CA1
Lambert, DA; Nolin, TD; Owens, RC1
Caviezel, A; Garbino, J; Lew, D; Matulionyte, R; Morel, P; Uckay, I; Villiger, P1
Abbas, M; Elsebae, M; Farouk, Y; Nafeh, AE1
Cox, RM; El Jamal, SM; Lorsbach, RB; Malak, SF1
Barshikar, S; Baylor, AE; Dolman, HS; Glowniak, J; Hong, K; Lavery, T; Nailor, M; Singla, R; Stassinopoulus, J; Tyburski, JG; Wilson, RF; Zimmerman, LH1
Buppajarntham, S; Junpaparp, P; Madueno, FV; Varadi, G1
Hung, YP; Ko, WC; Lee, CI; Lee, JC; Lin, HJ; Liu, HC; Tsai, PJ; Wan, L; Wu, TC; Wu, YH1
Anderson, KT; Kao, LS; Lally, KP; Mueck, KM; Putnam, LR; Tsao, K1
Demirci, T; O'Brien, S1
Bergoza, L; da Silva Fonseca, G; Dos Anjos, MV; Dos Santos, PR; Moura E Silva, S; Possa, E; Tasso, L1
Deng, T; Kong, W; Li, S; Shu, Y; Wu, Y1

Reviews

3 review(s) available for metronidazole and cefepime

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Fatal hemorrhagic pneumonia caused by infection due to Kytococcus sedentarius--a pathogen or passenger?
    Annals of hematology, 2004, Volume: 83, Issue:7

    Topics: Actinomycetales; Actinomycetales Infections; Acyclovir; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Bacterial Translocation; Cefepime; Cephalosporins; Clostridium Infections; Colistin; Cytarabine; Daunorubicin; Drug Therapy, Combination; Etoposide; Fatal Outcome; Hemoptysis; Humans; Hydroxyurea; Immunocompromised Host; Intestinal Mucosa; Leukemia, Myeloid, Acute; Male; Metronidazole; Middle Aged; Neutropenia; Pneumonia, Bacterial; Superinfection; Teicoplanin; Trimethoprim, Sulfamethoxazole Drug Combination

2004
Efficacy, safety, and tolerability of antimicrobial agents for complicated intra-abdominal infection: a systematic review and network meta-analysis.
    BMC infectious diseases, 2023, Apr-21, Volume: 23, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Cefepime; Humans; Intraabdominal Infections; Meropenem; Metronidazole; Network Meta-Analysis; Tazobactam; Tigecycline

2023

Trials

7 trial(s) available for metronidazole and cefepime

ArticleYear
In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Anti-Bacterial Agents; Cephalosporins; Enterobacteriaceae; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Skin Diseases, Bacterial; Staphylococcus

2008
Analysis of cefepime tissue penetration into human appendix.
    Pharmacotherapy, 1991, Volume: 11, Issue:5

    Topics: Adolescent; Adult; Appendectomy; Appendicitis; Appendix; Ascitic Fluid; Cefepime; Cephalosporins; Clindamycin; Female; Gangrene; Gentamicins; Humans; Injections, Intravenous; Intestinal Perforation; Male; Metronidazole; Rupture, Spontaneous

1991
A clinical comparison of cefepime and metronidazole versus gentamicin and clindamycin in the antibiotic management of surgically treated advanced appendicitis.
    Surgery, gynecology & obstetrics, 1993, Volume: 177 Suppl

    Topics: Adolescent; Adult; Appendicitis; Cefepime; Cephalosporins; Clindamycin; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Gentamicins; Humans; Male; Metronidazole; Middle Aged; Treatment Outcome

1993
A randomized, double-blind clinical trial comparing cefepime plus metronidazole with imipenem-cilastatin in the treatment of complicated intra-abdominal infections. Cefepime Intra-abdominal Infection Study Group.
    Archives of surgery (Chicago, Ill. : 1960), 1997, Volume: 132, Issue:12

    Topics: Abdomen; Abdominal Abscess; Adult; Aged; Antitrichomonal Agents; Appendicitis; Cefepime; Cephalosporins; Cilastatin; Double-Blind Method; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Imipenem; Infections; Male; Metronidazole; Middle Aged; Peritonitis; Treatment Outcome

1997
[The efficacy of cefepime (Maxipime) in the treatment of abdominal sepsis in surgical patients].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1999, Volume: 44, Issue:11

    Topics: Abdomen; Aged; Anti-Infective Agents; APACHE; Cefepime; Cephalosporins; Drug Therapy, Combination; Female; Humans; Male; Metronidazole; Middle Aged; Peritonitis; Prospective Studies; Sepsis; Surgical Wound Infection; Time Factors

1999
A multicenter randomized trial of prophylaxis with intravenous cefepime + metronidazole or ceftriaxone + metronidazole in colorectal surgery. The 230 Study Group.
    Journal of chemotherapy (Florence, Italy), 2000, Volume: 12, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Antibiotic Prophylaxis; Cefepime; Ceftriaxone; Cephalosporins; Colorectal Surgery; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Male; Metronidazole; Middle Aged; Surgical Wound Infection

2000
A randomized prospective study of cefepime plus metronidazole with imipenem-cilastatin in the treatment of intra-abdominal infections.
    Infection, 2007, Volume: 35, Issue:3

    Topics: Abdominal Cavity; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; APACHE; Bacterial Infections; Cefepime; Cephalosporins; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Hospitals, University; Humans; Imipenem; Male; Metronidazole; Middle Aged

2007

Other Studies

17 other study(ies) available for metronidazole and cefepime

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Animals; Anti-Infective Agents; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Mice; Microbial Sensitivity Tests; Quinolones; Thiazoles

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
BMY28142, cefbuperazone (T-1982), and Sch 34343. Antimicrobial activity against 94 anaerobes compared to seven other antimicrobial agents.
    Diagnostic microbiology and infectious disease, 1985, Volume: 3, Issue:3

    Topics: Anti-Bacterial Agents; Bacteroides; Cefepime; Cefoperazone; Cefoxitin; Cephalosporins; Cephamycins; Chloramphenicol; Clindamycin; Clostridium; Lactams; Metronidazole; Microbial Sensitivity Tests; Piperacillin

1985
The effectiveness of systemic antibiotics in preventing postoperative, intraabdominal adhesions in an animal model.
    The Journal of surgical research, 2001, Volume: 101, Issue:1

    Topics: Animals; Anti-Infective Agents; Cefepime; Cephalosporins; Fibrosis; Injections, Intramuscular; Metronidazole; Peritoneal Diseases; Postoperative Complications; Rats; Rats, Wistar; Severity of Illness Index; Tissue Adhesions

2001
The cost-effectiveness of cefepime plus metronidazole versus imipenem/cilastatin in the treatment of complicated intra-abdominal infection.
    Surgical infections, 2004,Fall, Volume: 5, Issue:3

    Topics: Adult; Aged; APACHE; Bacterial Infections; Cefepime; Cephalosporins; Cilastatin; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Imipenem; Male; Metronidazole; Middle Aged; Probability; Retrospective Studies; Treatment Outcome

2004
Stability of cefepime and metronidazole prepared for simplified administration as a single product.
    Diagnostic microbiology and infectious disease, 2006, Volume: 56, Issue:2

    Topics: Anti-Bacterial Agents; Cefepime; Cephalosporins; Drug Combinations; Drug Stability; Metronidazole

2006
Dose related effect of systemic antibiotics in prevention of postoperative intra-abdominal adhesion formation in experimental animals.
    Journal of the Egyptian Society of Parasitology, 2008, Volume: 38, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Cefepime; Cephalosporins; Cricetinae; Disease Models, Animal; Injections, Intramuscular; Laparotomy; Mesocricetus; Metronidazole; Postoperative Complications; Random Allocation; Time Factors; Tissue Adhesions; Treatment Outcome

2008
Extragenitourinary malakoplakia in a patient with myeloma clinically mimicking extramedullary myelomatous disease.
    Human pathology, 2011, Volume: 42, Issue:4

    Topics: Aged; Anti-Bacterial Agents; Cefepime; Cephalosporins; Escherichia coli Infections; Humans; Malacoplakia; Male; Metronidazole; Multiple Myeloma; Neoplasm Metastasis; Soft Tissue Neoplasms; Stem Cell Transplantation

2011
Impact of evaluating antibiotic concentrations in abdominal abscesses percutaneously drained.
    American journal of surgery, 2011, Volume: 201, Issue:3

    Topics: Abdominal Abscess; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cefepime; Cephalosporins; Ciprofloxacin; Exudates and Transudates; Female; Fluconazole; Humans; Male; Metronidazole; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Suction; Treatment Outcome; Vancomycin

2011
Concomitant typhlitis and Clostridium difficile colitis developed after first R-CHOP chemotherapy in a non-Hodgkin lymphoma patient.
    BMJ case reports, 2013, Apr-17, Volume: 2013

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cefepime; Cephalosporins; Clostridioides difficile; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Enterocolitis, Pseudomembranous; Humans; Lymphoma, Non-Hodgkin; Male; Metronidazole; Middle Aged; Polymerase Chain Reaction; Prednisone; Radiography; Rituximab; Typhlitis; Vancomycin; Vincristine

2013
Risk factors of fecal toxigenic or non-toxigenic Clostridium difficile colonization: impact of Toll-like receptor polymorphisms and prior antibiotic exposure.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Cefepime; Cefuroxime; Cephalosporins; Clostridioides difficile; Enterocolitis, Pseudomembranous; Feces; Female; Humans; Male; Metronidazole; Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk Factors; Toll-Like Receptor 4; Vancomycin

2013
Does compliance with antibiotic prophylaxis in pediatric simple appendicitis matter?
    The Journal of surgical research, 2017, Volume: 216

    Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendectomy; Appendicitis; Cefepime; Cephalosporins; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; Guideline Adherence; Humans; Infant; Infant, Newborn; Logistic Models; Male; Metronidazole; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Practice Guidelines as Topic; Preoperative Care; Retrospective Studies; Surgical Wound Infection; Treatment Outcome

2017
Complicated Necrotizing Otitis Externa Progressing to Coalescent Mastoiditis and Temporal Lobe Abscess.
    The American journal of medicine, 2019, Volume: 132, Issue:2

    Topics: Aged; Anti-Bacterial Agents; Brain Abscess; Cefepime; Gram-Positive Bacterial Infections; Humans; Male; Mastoiditis; Metronidazole; Otitis Externa; Peptostreptococcus; Temporal Lobe

2019
Development and validation of an LC-ESI-QTOF-MS method to measure cefepime in the plasma and peritoneal fluid of rats using microdialysis: Application in a pilot pharmacokinetic study.
    Biomedical chromatography : BMC, 2022, Volume: 36, Issue:11

    Topics: Acetonitriles; Animals; Ascitic Fluid; Cefepime; Gallic Acid; Metronidazole; Microdialysis; Rats; Rats, Wistar; Reproducibility of Results; Tandem Mass Spectrometry; Water

2022