metronidazole has been researched along with Dermatitis, Perioral in 18 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Dermatitis, Perioral: A papular eruption of unknown etiology that progresses to residual papular erythema and scaling usually confined to the area of the mouth, and almost exclusively occurring in young women. It may also be localized or extend to involve the eyelids and adjacent glabella area of the forehead (periocular dermatitis). (Dorland, 28th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Perioral dermatitis is a common cutaneous condition characterized by acneiform facial eruptions often with an eczematous appearance." | 2.72 | Perioral dermatitis: Diagnosis, proposed etiologies, and management. ( Al-Niaimi, F; Ali, FR; Searle, T, 2021) |
| "Metronidazole is a synthetic nitroimidazole derivative with antimicrobial and antiinflammatory properties." | 2.46 | Innovative use of topical metronidazole. ( Zip, CM, 2010) |
| "Oral tetracyclines have been considered the first line treatment for years." | 2.46 | Evidence based review of perioral dermatitis therapy. ( Hall, CS; Reichenberg, J, 2010) |
| "Perioral dermatitis is a unique skin disorder of childhood." | 2.40 | Perioral dermatitis in children. ( Laude, TA; Salvemini, JN, 1999) |
| "Perioral dermatitis is a relatively important and often enigmatic type of eczema." | 1.35 | Periorificial dermatitis in children: an update and description of a child with striking features. ( Cruz, MA; Kihiczak, GG; Schwartz, RA, 2009) |
| "Perioral dermatitis has to be considered as differential diagnosis in children presenting with erythematous papules and papulovesicles in typical locations." | 1.30 | Perioral dermatitis in children--clinical presentation, pathogenesis-related factors and response to topical metronidazole. ( Abeck, D; Boeck, K; Ring, J; Werfel, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 5 (27.78) | 2.80 |
| Authors | Studies |
|---|---|
| Parker, J | 1 |
| Neill, B | 1 |
| Whitsitt, J | 1 |
| Rajpara, A | 1 |
| Aires, D | 1 |
| Ramirez, J | 1 |
| Lee, H | 1 |
| Kim, KH | 1 |
| Fakih, A | 1 |
| Makhoul, R | 1 |
| Grozdev, I | 1 |
| Searle, T | 1 |
| Ali, FR | 1 |
| Al-Niaimi, F | 1 |
| Parke, L | 1 |
| Diernaes, J | 1 |
| Bygum, A | 1 |
| Lee, GL | 1 |
| Zirwas, MJ | 1 |
| Mayor-Ibarguren, A | 1 |
| Maseda-Pedrero, R | 1 |
| Feito-Rodríguez, M | 1 |
| Kihiczak, GG | 1 |
| Cruz, MA | 1 |
| Schwartz, RA | 1 |
| Palomo, A | 1 |
| Cervigón, I | 1 |
| Torres-Iglesias, LM | 1 |
| Kumar, P | 1 |
| Parashette, KR | 1 |
| Noronha, P | 1 |
| Zip, CM | 1 |
| Hall, CS | 1 |
| Reichenberg, J | 1 |
| Jensen, SL | 1 |
| Amato, JE | 1 |
| Hartstein, ME | 1 |
| Breer, WA | 1 |
| Weber, K | 1 |
| Thurmayr, R | 1 |
| Nguyen, V | 1 |
| Eichenfield, LF | 1 |
| Boeck, K | 1 |
| Abeck, D | 1 |
| Werfel, S | 1 |
| Ring, J | 1 |
| Laude, TA | 1 |
| Salvemini, JN | 1 |
7 reviews available for metronidazole and Dermatitis, Perioral
| Article | Year |
|---|---|
Childhood granulomatous periorificial dermatitis: case report and review of the literature.
Topics: Administration, Topical; Anti-Infective Agents; Biopsy; Child; Dermatitis, Perioral; Drug Therapy, C | 2020 |
Perioral dermatitis: Diagnosis, proposed etiologies, and management.
Topics: Anti-Bacterial Agents; Dermatitis, Perioral; Dermatologic Agents; Humans; Isotretinoin; Metronidazol | 2021 |
Granulomatous Rosacea and Periorificial Dermatitis: Controversies and Review of Management and Treatment.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Benzoyl Peroxide; Dermatitis, Perioral; Dermatologic | 2015 |
Innovative use of topical metronidazole.
Topics: Acute Generalized Exanthematous Pustulosis; Administration, Cutaneous; Adult; Anti-Infective Agents; | 2010 |
Evidence based review of perioral dermatitis therapy.
Topics: Administration, Topical; Dermatitis, Perioral; Erythromycin; Evidence-Based Medicine; Humans; Metron | 2010 |
Critical appraisal of reports on the treatment of perioral dermatitis.
Topics: Administration, Oral; Administration, Topical; Adult; Dermatitis, Perioral; Dose-Response Relationsh | 2005 |
Perioral dermatitis in children.
Topics: Administration, Topical; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antifungal Agents; Child; D | 1999 |
11 other studies available for metronidazole and Dermatitis, Perioral
| Article | Year |
|---|---|
Exacerbation of Pediatric Periorificial Dermatitis: A Novel Adverse Reaction.
Topics: Administration, Cutaneous; Administration, Oral; Anti-Bacterial Agents; Boron Compounds; Bridged Bic | 2020 |
Recurrent Facial Rash.
Topics: Administration, Cutaneous; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; De | 2020 |
Treatment of pediatric periorificial dermatitis with topical calcineurin inhibitor and topical/oral metronidazole.
Topics: Administration, Topical; Anti-Bacterial Agents; Calcineurin Inhibitors; Child; Dermatitis, Perioral; | 2021 |
Papulopustular Facial Eruption in a Child: A Quiz.
Topics: Administration, Oral; Administration, Topical; Child, Preschool; Dermatitis, Perioral; Diagnosis, Di | 2019 |
Periorificial Lesions in a Young Girl.
Topics: Adrenal Cortex Hormones; Age of Onset; Child; Contraindications; Dermatitis, Perioral; Drug Substitu | 2016 |
Periorificial dermatitis in children: an update and description of a child with striking features.
Topics: Administration, Cutaneous; Anti-Infective Agents; Child; Dermatitis, Perioral; Diagnosis, Differenti | 2009 |
[Symptomatic perioral, perinasal, and periocular papules].
Topics: Child; Dermatitis, Perioral; Diagnosis, Differential; Facial Dermatoses; Female; Granuloma; Humans; | 2009 |
Letter: Perioral dermatitis in a child associated with an inhalation steroid.
Topics: Administration, Inhalation; Adolescent; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Cl | 2010 |
Bilateral periorbital necrotizing fasciitis.
Topics: Aged; Anti-Bacterial Agents; Arthritis, Rheumatoid; Bacteremia; Bronchopneumonia; Ceftriaxone; Debri | 2004 |
Periorificial dermatitis in children and adolescents.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adrenal Cortex Hormones; Anti-Infective A | 2006 |
Perioral dermatitis in children--clinical presentation, pathogenesis-related factors and response to topical metronidazole.
Topics: Administration, Topical; Anti-Inflammatory Agents; Child; Child, Preschool; Dermatitis, Perioral; Fe | 1997 |