Page last updated: 2024-11-12

methyl 4-(adenin-9-yl)-2-hydroxybutanoate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

methyl 4-(adenin-9-yl)-2-hydroxybutanoate: suppresses antigen-induced specific immune responses, particularly Th1 responses, through inhibition of AdoHcy hydrolase and elevation of endogenous AdoHcy [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11658872
CHEMBL ID484587
SCHEMBL ID982326
MeSH IDM0496775

Synonyms (21)

Synonym
C15594
CHEMBL484587
CS-3510
SCHEMBL982326
dz2002
HY-18620
9h-purine-9-butyric acid, 6-amino-.alpha.-hydroxy-, methyl ester
9h-purine-9-butyric acid, 6-amino-alpha-hydroxy-, methyl ester
9h-purine-9-butanoic acid, 6-amino-alpha-hydroxy-, methyl ester
9h-purine-9-butanoic acid, 6-amino-.alpha.-hydroxy-, methyl ester
dz-2002, (+/-)-
58408S5CB9 ,
33231-14-0
unii-58408s5cb9
dz-2002
AKOS030526782
methyl 4-(adenin-9-yl)-2-hydroxybutanoate
methyl 4-(6-aminopurin-9-yl)-2-hydroxybutanoate
Q27261550
MS-23549
methyl 4-(6-amino-9h-purin-9-yl)-2-hydroxybutanoate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID538978Antiparasitic activity against Trichomonas vaginalis T1 at 10 uL after 24 hrs by hemocytometric analysis2010Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
AdoHcy hydrolase of Trichomonas vaginalis: studies of the effects of 5'-modified adenosine analogues and related 6-N-cyclopropyl derivatives.
AID388635Cytotoxicity against BALB/c mouse splenic lymphocytes co-cultured with C57BL/6 mouse splenic lymphocytes assessed as reduction of cell viability after 72 hrs2008Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers.
AID388634Immunosuppressive activity in BALB/c mouse splenic lymphocytes co-cultured with C57BL/6 mouse splenic lymphocytes assessed as inhibition of cell proliferation after 72 hrs by mixed lymphocyte reaction assay2008Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers.
AID388633Inhibition of rabbit erythrocyte SAHase by DTNB-coupled assay2008Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (33.33)29.6817
2010's7 (58.33)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.05 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.61 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]