metronidazole has been researched along with Nausea in 39 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anecdotal reports suggest that metronidazole may have disease modifying activity in the treatment of rheumatoid arthritis." | 9.07 | Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis. ( Capell, HA; Hunter, JA; Marshall, DA, 1992) |
| " pylori-positive peptic ulcer received omeprazole 20 mg twice daily in combination with metronidazole 400 mg twice daily and clarithromycin 500 mg twice daily for seven days." | 5.08 | One week triple therapy for Helicobacter pylori: does high-dose clarithromycin confer additional benefit? ( Bhutta, AS; Bindel, H; Cunnane, K; Loane, J; O'Connor, HJ, 1997) |
| " pylori-positive peptic ulcer received lansoprazole 30 mg twice daily in combination with metronidazole 400 mg twice daily and clarithromycin 250 mg twice daily for 5 days." | 5.08 | Lansoprazole triple therapy for Helicobacter pylori--is 5 days enough? ( Cunnane, K; Kelly, S; Laundon, J; McLoughlin, R; O'Connor, HJ, 1998) |
| "Anecdotal reports suggest that metronidazole may have disease modifying activity in the treatment of rheumatoid arthritis." | 5.07 | Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis. ( Capell, HA; Hunter, JA; Marshall, DA, 1992) |
| " Adverse events considered by the investigator to be related to study drug occurred in only 20." | 2.84 | A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis. ( Koltun, W; Morgan, FG; Nyirjesy, P; Schwebke, JR, 2017) |
| "Patients with locoregional advanced laryngeal cancer (stage T3-4,N0-3,M0) were included: group 1(control, n=30)were not administered of sodium glycididazole; group 2 (test, n=30) received sodium glycididazole at a dose of 700 mg/m(2) intravenous infusion 30 minutes before radiotherapy three times a week." | 2.75 | Safety and radiation-enhancing effect of sodium glycididazole in locoregionally advanced laryngeal cancers previously treated with platinum-containing chemotherapy regimens: A preliminary report. ( Chen, W; Chen, XD; Chi, F; Dong, XQ; Fan, GL; Hao, SH; Jia, MX; Jin, XY; Li, X; Li, Y; Wang, EY; Wang, SL; Wang, YM; Wu, LN; Wu, R; Xia, HH; Xiao, FD; Xu, ZG; Zeng, YC; Zhang, HB; Zhang, LB; Zhang, XY; Zhang, ZY; Zheng, W, 2010) |
| " In addition, the number and the type of adverse events induced by the two regimens were compared, assuming better tolerability of the intravaginal application." | 2.73 | Intravaginally applied metronidazole is as effective as orally applied in the treatment of bacterial vaginosis, but exhibits significantly less side effects. ( Abels, C; Brandt, M; Hoyme, UB; Lohmann, K; May, T; Schmidts-Winkler, I, 2008) |
| " The incidence of adverse effects was significantly lower in the group given satranidazole (P < ." | 2.72 | Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess. ( Kar, P; Madan, K; Muzaffar, J; Sharma, MP, 2006) |
| " Drug-related adverse events occurred in 18." | 2.71 | Safety and efficacy of sequential i.v. to p.o. moxifloxacin versus conventional combination therapies for the treatment of community-acquired pneumonia in patients requiring initial i.v. therapy. ( Choudhri, S; Fogarty, CM; Hamed, K; Katz, E; Larsen, LS; Song, J, 2004) |
| "The most cost-effective treatment for bacterial vaginosis was generic metronidazole." | 2.69 | Oral metronidazole vs. Metrogel Vaginal for treating bacterial vaginosis. Cost-effectiveness evaluation. ( Greenberg, R; McComish, JF; Ransom, SB; Tolford, DA, 1999) |
| "Metronidazole is an antimicrobial, antiprotozoal agent that has been widely used in the treatment of a variety of infections." | 2.69 | Evaluation of metronidazole toxicity: a prospective study. ( Chandra, M; Gupta, RC; Kapoor, K; Nag, D; Paliwal, JK; Saxena, RC, 1999) |
| "Metronidazole, used for prevention and treatment of infections in oral and maxillofacial surgery is frequently prescribed three times daily, but research into its pharmacokinetics has shown that a twelve hourly dosage regimen achieves and maintains therapeutic serum concentrations." | 2.67 | Metronidazole: two or three times daily--a comparative controlled clinical trial of the efficacy of two different dosing schedules of metronidazole for chemoprophylaxis following third molar surgery. ( Earl, PD; Lloyd, CJ, 1994) |
| "To evaluate two triple-therapy (TT) regimens of colloidal bismuth subcitrate (CBS), metronidazole, and tetracycline HCl in eradicating Helicobacter pylori, with particular attention to the frequency of resulting adverse effects of the two therapies." | 2.67 | Use of high efficacy, lower dose triple therapy to reduce side effects of eradicating Helicobacter pylori. ( Andrews, P; Borody, TJ; Brandl, S; Ferch, N; Hyland, L; Jankiewicz, E, 1994) |
| "Seventy-eight patients with active Crohn's disease participated in a randomized, double-blind, cross-over trial." | 2.65 | A comparative study of metronidazole and sulfasalazine for active Crohn's disease: the cooperative Crohn's disease study in Sweden. II. Result. ( Alm, T; Bárány, F; Bergelin, I; Ganrot-Norlin, K; Hoevels, J; Huitfeldt, B; Järnerot, G; Krause, U; Krook, A; Lindström, B; Nordle, O; Rosén, A; Ursing, B, 1982) |
| " In the recommended dosage nitrimidazine is inferior to metronidazole, but is sufficiently effective to be useful in cases of intolerance to metronidazole." | 2.64 | Nitrimidazine compared with metronidazole in the treatment of vaginal trichomoniasis. ( Catterall, RD; Evans, BA, 1971) |
| "Three drugs have been advocated for the treatment of giardiasis; furazolidone (Furoxone), metronidazole (Flagyl), and quinacrine (Atabrine)." | 2.36 | Treatment of giardiasis: literature review and recommendations. ( Lerman, SJ; Walker, RA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (46.15) | 18.7374 |
| 1990's | 8 (20.51) | 18.2507 |
| 2000's | 7 (17.95) | 29.6817 |
| 2010's | 6 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| García Carretero, R | 1 |
| Lopez-Lomba, M | 1 |
| Vazquez-Gomez, O | 1 |
| Rodriguez-Maya, B | 1 |
| Schwebke, JR | 1 |
| Morgan, FG | 1 |
| Koltun, W | 1 |
| Nyirjesy, P | 1 |
| Çekin, AH | 1 |
| Şahintürk, Y | 1 |
| Akbay Harmandar, F | 1 |
| Uyar, S | 1 |
| Yolcular, BO | 1 |
| Çekin, Y | 1 |
| Brandt, M | 1 |
| Abels, C | 1 |
| May, T | 1 |
| Lohmann, K | 1 |
| Schmidts-Winkler, I | 1 |
| Hoyme, UB | 1 |
| Zeng, YC | 1 |
| Wu, R | 1 |
| Xu, ZG | 1 |
| Zhang, XY | 1 |
| Fan, GL | 1 |
| Wu, LN | 1 |
| Wang, YM | 1 |
| Hao, SH | 1 |
| Zheng, W | 1 |
| Chen, XD | 1 |
| Chi, F | 1 |
| Zhang, ZY | 1 |
| Li, X | 1 |
| Jin, XY | 1 |
| Chen, W | 1 |
| Wang, SL | 1 |
| Xiao, FD | 1 |
| Wang, EY | 1 |
| Dong, XQ | 1 |
| Zhang, LB | 1 |
| Jia, MX | 1 |
| Xia, HH | 1 |
| Zhang, HB | 1 |
| Li, Y | 1 |
| Rehman Alvi, A | 1 |
| Rizvi, F | 1 |
| Kazim, SF | 1 |
| Ejaz, K | 1 |
| Zafar, H | 1 |
| Chawla, T | 1 |
| Bibi, S | 1 |
| Ur Rehman, Z | 1 |
| Moraes, ME | 1 |
| Cunha, GH | 1 |
| Bezerra, MM | 1 |
| Fechine, FV | 1 |
| Pontes, AV | 1 |
| Andrade, WS | 1 |
| Frota Bezerra, FA | 1 |
| Moraes, MO | 1 |
| Cavalcanti, PP | 1 |
| Katz, E | 1 |
| Larsen, LS | 1 |
| Fogarty, CM | 1 |
| Hamed, K | 1 |
| Song, J | 1 |
| Choudhri, S | 1 |
| Dore, MP | 1 |
| Maragkoudakis, E | 1 |
| Pironti, A | 1 |
| Tadeu, V | 1 |
| Tedde, R | 1 |
| Realdi, G | 1 |
| Delitala, G | 1 |
| Muzaffar, J | 1 |
| Madan, K | 1 |
| Sharma, MP | 1 |
| Kar, P | 1 |
| Aijaz, B | 1 |
| Beckman, TJ | 1 |
| Stewart, DJ | 1 |
| Benoit, B | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Dennery, J | 1 |
| Russell, N | 1 |
| Peterson, E | 1 |
| Grahovac, Z | 1 |
| Belanger, G | 1 |
| Maroun, JA | 1 |
| Ursing, B | 1 |
| Alm, T | 1 |
| Bárány, F | 1 |
| Bergelin, I | 1 |
| Ganrot-Norlin, K | 1 |
| Hoevels, J | 1 |
| Huitfeldt, B | 1 |
| Järnerot, G | 1 |
| Krause, U | 1 |
| Krook, A | 1 |
| Lindström, B | 1 |
| Nordle, O | 1 |
| Rosén, A | 1 |
| Pfeffer, MR | 1 |
| Sulkes, A | 1 |
| Peretz, TY | 1 |
| Fuks, Z | 1 |
| Catane, R | 1 |
| Harkness, JA | 1 |
| Griffin, AJ | 1 |
| Heinrich, I | 1 |
| Gibson, T | 1 |
| Grahame, R | 1 |
| Lerman, SJ | 1 |
| Walker, RA | 1 |
| Thomas, GM | 1 |
| Rauth, AM | 1 |
| Bush, RS | 1 |
| Black, BE | 1 |
| Cummings, BJ | 1 |
| Lloyd, CJ | 1 |
| Earl, PD | 1 |
| Borody, TJ | 1 |
| Brandl, S | 1 |
| Andrews, P | 1 |
| Ferch, N | 1 |
| Jankiewicz, E | 1 |
| Hyland, L | 1 |
| O'Connor, HJ | 2 |
| Loane, J | 1 |
| Bindel, H | 1 |
| Bhutta, AS | 1 |
| Cunnane, K | 2 |
| McLoughlin, R | 1 |
| Kelly, S | 1 |
| Laundon, J | 1 |
| Ransom, SB | 1 |
| McComish, JF | 1 |
| Greenberg, R | 1 |
| Tolford, DA | 1 |
| Ahmed, DS | 1 |
| Fecik, S | 1 |
| Dammann, HG | 1 |
| Fölsch, UR | 1 |
| Hahn, EG | 1 |
| von Kleist, DH | 1 |
| Klör, HU | 1 |
| Kirchner, T | 1 |
| Strobel, S | 1 |
| Kist, M | 1 |
| Calvet, X | 1 |
| Titó, L | 1 |
| Comet, R | 1 |
| García, N | 1 |
| Campo, R | 1 |
| Brullet, E | 1 |
| Kapoor, K | 1 |
| Chandra, M | 1 |
| Nag, D | 1 |
| Paliwal, JK | 1 |
| Gupta, RC | 1 |
| Saxena, RC | 1 |
| Fleury, FJ | 1 |
| Van Bergen, WS | 1 |
| Prentice, RL | 1 |
| Russell, JG | 1 |
| Singleton, JA | 1 |
| Standard, JV | 1 |
| Fowler, JF | 1 |
| Adams, GE | 1 |
| Marshall, DA | 1 |
| Hunter, JA | 1 |
| Capell, HA | 1 |
| Jones, DI | 1 |
| Kale, OO | 1 |
| Everett, ED | 1 |
| Kettis, AA | 1 |
| Thorén, G | 1 |
| Naoemar, SA | 1 |
| Rukmono, B | 1 |
| Seinson, RP | 1 |
| Evans, BA | 1 |
| Catterall, RD | 1 |
| Kanani, SR | 1 |
| Knight, R | 1 |
| Khambatta, RB | 1 |
| de Mattos, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 4, Prospective, Randomized and Comparative Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice[NCT01273441] | Phase 4 | 338 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Nausea
| Article | Year |
|---|---|
Treatment of giardiasis: literature review and recommendations.
Topics: Animals; Child; Diarrhea; Drug Evaluation; Female; Fever; Furazolidone; Giardiasis; Humans; Metronid | 1982 |
25 trials available for metronidazole and Nausea
| Article | Year |
|---|---|
A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis.
Topics: Administration, Oral; Adolescent; Adult; Antiprotozoal Agents; Candidiasis, Vulvovaginal; Diarrhea; | 2017 |
Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Abdominal Pain; Adult; Amoxicillin; Anorexia; Anti-Bacteria | 2017 |
Intravaginally applied metronidazole is as effective as orally applied in the treatment of bacterial vaginosis, but exhibits significantly less side effects.
Topics: Abdominal Pain; Administration, Intravaginal; Administration, Oral; Adult; Double-Blind Method; Fema | 2008 |
Safety and radiation-enhancing effect of sodium glycididazole in locoregionally advanced laryngeal cancers previously treated with platinum-containing chemotherapy regimens: A preliminary report.
Topics: Carcinoma, Squamous Cell; Female; Humans; Laryngeal Neoplasms; Male; Metronidazole; Middle Aged; Nau | 2010 |
Efficacy of the Mentha crispa in the treatment of women with Trichomonas vaginalis infection.
Topics: Adult; Antitrichomonal Agents; Double-Blind Method; Dyspareunia; Dysuria; Female; Humans; Male; Ment | 2012 |
Safety and efficacy of sequential i.v. to p.o. moxifloxacin versus conventional combination therapies for the treatment of community-acquired pneumonia in patients requiring initial i.v. therapy.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aza Compounds; Azithromycin; Ceftriaxone; Com | 2004 |
Twice-a-day quadruple therapy for eradication of Helicobacter pylori in the elderly.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Breath Tests; Dyspepsia; Esomeprazole; Female; Helic | 2006 |
Randomized, single-blind, placebo-controlled multicenter trial to compare the efficacy and safety of metronidazole and satranidazole in patients with amebic liver abscess.
Topics: Adult; Antiprotozoal Agents; Drug Tolerance; Female; Humans; Incidence; Liver Abscess, Amebic; Male; | 2006 |
A comparative study of metronidazole and sulfasalazine for active Crohn's disease: the cooperative Crohn's disease study in Sweden. II. Result.
Topics: Adult; Anorexia; Blood Sedimentation; Clinical Trials as Topic; Crohn Disease; Double-Blind Method; | 1982 |
A double-blind comparative study of metronidazole and placebo in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Humans; Metronidazole; | 1982 |
Metronidazole: two or three times daily--a comparative controlled clinical trial of the efficacy of two different dosing schedules of metronidazole for chemoprophylaxis following third molar surgery.
Topics: Adolescent; Adult; Chi-Square Distribution; Drug Administration Schedule; Female; Humans; Male; Mand | 1994 |
Use of high efficacy, lower dose triple therapy to reduce side effects of eradicating Helicobacter pylori.
Topics: Abdominal Pain; Anti-Bacterial Agents; Constipation; Diarrhea; Drug Administration Schedule; Drug Th | 1994 |
One week triple therapy for Helicobacter pylori: does high-dose clarithromycin confer additional benefit?
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Ulcer Agents; Antitrichomonal Agents; Cl | 1997 |
Lansoprazole triple therapy for Helicobacter pylori--is 5 days enough?
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial | 1998 |
Oral metronidazole vs. Metrogel Vaginal for treating bacterial vaginosis. Cost-effectiveness evaluation.
Topics: Administration, Intravaginal; Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Cost-B | 1999 |
Eradication of H. pylori with pantoprazole, clarithromycin, and metronidazole in duodenal ulcer patients: a head-to-head comparison between two regimens of different duration.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Abdominal Pain; Adult; Aged; Anti-Bacterial Agents; Anti-Ul | 2000 |
Four-day, twice daily, quadruple therapy with amoxicillin, clarithromycin, tinidazole and omeprazole to cure Helicobacter pylori infection: a pilot study.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Diarrhea; Drug A | 2000 |
Evaluation of metronidazole toxicity: a prospective study.
Topics: Adult; Anti-Infective Agents; Female; Headache; Humans; Male; Metronidazole; Middle Aged; Nausea; Pr | 1999 |
Single dose of two grams of metronidazole for Trichomonas vaginalis infection.
Topics: Administration, Oral; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Ma | 1977 |
Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Metronidazole; Middle | 1992 |
The effect of metronidazole on exophthalmos in man.
Topics: Antithyroid Agents; Clinical Trials as Topic; Exophthalmos; Feeding and Eating Disorders; Humans; Hy | 1968 |
A controlled field trial of the treatment of dracontiasis with metronidazole and niridazole.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dracunculiasis; Gastrointestinal Diseases; Humans; | 1974 |
Clinical trial of Ro7-0207, a nitroimidazole derivative in amoebic dysentery.
Topics: 1-Propanol; Administration, Oral; Adolescent; Adult; Antiprotozoal Agents; Child; Child, Preschool; | 1973 |
Long term trial of metronidazole in male alcoholics.
Topics: Alcoholism; Anorexia Nervosa; Clinical Trials as Topic; Follow-Up Studies; Humans; Male; Metronidazo | 1971 |
Nitrimidazine compared with metronidazole in the treatment of vaginal trichomoniasis.
Topics: Administration, Oral; Adolescent; Adult; Candidiasis; Clinical Trials as Topic; Female; Gonorrhea; H | 1971 |
13 other studies available for metronidazole and Nausea
| Article | Year |
|---|---|
Bacteraemia and liver abscess due to
Topics: Abdominal Pain; Anti-Bacterial Agents; Bacteremia; Ceftriaxone; Fusobacterium Infections; Fusobacter | 2017 |
Amoebic liver abscess: experience in a south Asian country.
Topics: Abdominal Pain; Animals; Anti-Infective Agents; Combined Modality Therapy; Female; Fever; Hepatomega | 2010 |
25-year-old man with abdominal pain, nausea, and fatigue.
Topics: Abdominal Pain; Adult; Antiprotozoal Agents; Diagnosis, Differential; Fatigue; Giardiasis; Humans; M | 2007 |
Treatment of malignant gliomas in adults with BCNU plus metronidazole.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Female; Gliobl | 1984 |
Phase I study of the combination of iv mitomycin and oral metronidazole.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; | 1984 |
A toxicity study of daily dose metronidazole with pelvic irradiation.
Topics: Administration, Oral; Adolescent; Adult; Aged; Carcinoma; Diarrhea; Dose-Response Relationship, Drug | 1980 |
The fatigue factor. When long shifts harm patients.
Topics: Adult; Alcohol Drinking; Anti-Infective Agents; Drug Interactions; Fatigue; Female; Humans; Medicati | 1999 |
Proceedings: Radiosensitization of hypoxic cells in solid tumours in mice.
Topics: Animals; Fast Neutrons; Guinea Pigs; Humans; Hypoxia; Metronidazole; Mice; Nausea; Neoplasms, Experi | 1975 |
Metronidazole and amebiasis.
Topics: Administration, Oral; Adolescent; Adult; Carrier State; Dysentery, Amebic; Entamoeba histolytica; Fe | 1974 |
Inter- and intrafamilial distribution of giardia lamblia infection.
Topics: Adult; Child; Child, Preschool; Diarrhea; Female; Flatulence; Giardia; Giardiasis; Humans; Male; Met | 1974 |
Experiences with the use of metronidazole in the treatment of non dysenteric intestinal amoebiasis.
Topics: Adolescent; Adult; Africa; Asia; Black People; Carrier State; Child; Dysentery, Amebic; Europe; Huma | 1972 |
Metronidazole in giardiasis.
Topics: Adult; Electrocardiography; Fatigue; Feeding and Eating Disorders; Giardiasis; Humans; Metronidazole | 1971 |
[Relations between alcoholism and the gastrointestinal system. Experience using Metronidazole].
Topics: Adolescent; Adult; Alcoholism; Child; Ethanol; Gastrointestinal Diseases; Humans; Metronidazole; Mid | 1968 |