metronidazole has been researched along with Embryopathies in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No antimicrobial regimen has been shown to be superior to ampicillin and gentamicin in decreasing mortality and preventing clinical deterioration in NEC." | 5.41 | Empirical Antimicrobial Therapy of Neonates with Necrotizing Enterocolitis: A Systematic Review. ( Aluvaala, J; Barbieri, E; Bonadies, L; Donà, D; English, M; Gastaldi, A, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Germano, C | 1 |
| Messina, A | 1 |
| Massaro, A | 1 |
| Attini, R | 1 |
| Leo, L | 1 |
| Manzoni, P | 1 |
| Masturzo, B | 1 |
| Donà, D | 1 |
| Gastaldi, A | 1 |
| Barbieri, E | 1 |
| Bonadies, L | 1 |
| Aluvaala, J | 1 |
| English, M | 1 |
| SCOTT-GRAY, M | 1 |
| LOCK, FR | 1 |
| Hawkins, DF | 1 |
| Korelitz, BI | 1 |
2 reviews available for metronidazole and Embryopathies
| Article | Year |
|---|---|
Maternal Origins of Neonatal Infections: What Do Obstetrician-Gynecologist Should/Could Do?
Topics: Ampicillin; Anti-Bacterial Agents; Bacteriuria; Cesarean Section; Chorioamnionitis; Clindamycin; Com | 2022 |
Empirical Antimicrobial Therapy of Neonates with Necrotizing Enterocolitis: A Systematic Review.
Topics: Ampicillin; Anti-Bacterial Agents; Clinical Deterioration; Enterocolitis, Necrotizing; Female; Fetal | 2023 |
4 other studies available for metronidazole and Embryopathies
| Article | Year |
|---|---|
METRONIDAZOLE IN OBSTETRIC PRACTICE.
Topics: Abnormalities, Drug-Induced; Fetal Diseases; Imidazoles; Infant, Newborn; Metronidazole; Pregnancy; | 1964 |
GYNECOLOGY AND OBSTETRICS.
Topics: Congenital Abnormalities; Endometriosis; Female; Fetal Diseases; Gynecology; Humans; Maternal-Fetal | 1964 |
Teratogens in the human: current problems.
Topics: Abnormalities, Drug-Induced; Barbiturates; Contraceptives, Oral; Ethanol; Female; Fetal Diseases; Hu | 1976 |
Pregnancy, fertility, and inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Fe | 1985 |