metronidazole has been researched along with Fasciitis, Necrotizing in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Fasciitis, Necrotizing: A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When located in the face necrotizing fasciitis is associated with severe cosmetic and functional restrictions due to the invasive infection and often to the necessary surgical treatment." | 1.35 | Management of facial necrotizing fasciitis. ( Burghartz, M; Hoang, N; Kesting, M; Miethke, T; Schurr, C; Staudenmaier, R, 2009) |
| "To report a case of necrotizing fasciitis after cosmetic blepharoplasty." | 1.30 | Necrotizing fasciitis after cosmetic blepharoplasty. ( Johnson, TE; Meldrum, ML; Suñer, IJ; Tse, DT, 1999) |
| "We report a case of cervical necrotizing fasciitis arising from a dental infection and review the cause, pathophysiology, diagnosis and treatment of this potentially lethal entity." | 1.29 | Management of necrotizing fasciitis in the neck. ( Bossuyt, M; De Backer, T; Schoenaers, J, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schurr, C | 1 |
| Burghartz, M | 1 |
| Miethke, T | 1 |
| Kesting, M | 1 |
| Hoang, N | 1 |
| Staudenmaier, R | 1 |
| Lodha, A | 1 |
| Wales, PW | 1 |
| James, A | 1 |
| Smith, CR | 1 |
| Langer, JC | 1 |
| Jensen, SL | 1 |
| Amato, JE | 1 |
| Hartstein, ME | 1 |
| Breer, WA | 1 |
| De Backer, T | 1 |
| Bossuyt, M | 1 |
| Schoenaers, J | 1 |
| Suñer, IJ | 1 |
| Meldrum, ML | 1 |
| Johnson, TE | 1 |
| Tse, DT | 1 |
5 other studies available for metronidazole and Fasciitis, Necrotizing
| Article | Year |
|---|---|
Management of facial necrotizing fasciitis.
Topics: Adult; Anti-Bacterial Agents; Antifungal Agents; Clindamycin; Disease Progression; Drug Combinations | 2009 |
Acute appendicitis with fulminant necrotizing fasciitis in a neonate.
Topics: Acute Disease; Appendectomy; Appendicitis; Clindamycin; Combined Modality Therapy; Debridement; Drug | 2003 |
Bilateral periorbital necrotizing fasciitis.
Topics: Aged; Anti-Bacterial Agents; Arthritis, Rheumatoid; Bacteremia; Bronchopneumonia; Ceftriaxone; Debri | 2004 |
Management of necrotizing fasciitis in the neck.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Cilastatin; Combined Modality Therapy; Debridem | 1996 |
Necrotizing fasciitis after cosmetic blepharoplasty.
Topics: Aged; Blepharoplasty; Debridement; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Eyelids; Fa | 1999 |