Abscess, Epidural

Circumscribed collections of suppurative material occurring in the spinal or intracranial EPIDURAL SPACE. The majority of epidural abscesses occur in the spinal canal and are associated with OSTEOMYELITIS of a vertebral body; ANALGESIA, EPIDURAL; and other conditions. Clinical manifestations include local and radicular pain, weakness, sensory loss, URINARY INCONTINENCE, and FECAL INCONTINENCE. Cranial epidural abscesses are usually associated with OSTEOMYELITIS of a cranial bone, SINUSITIS, or OTITIS MEDIA. (From Adams et al., Principles of Neurology, 6th ed, p710 and pp1240-1; J Neurol Neurosurg Psychiatry 1998 Aug;65(2):209-12)

Synonym
Epidural Abscess, Spinal
Intracranial Extradural Abscess
Cranial Extradural Abscess
Spinal Extradural Abscess
Epidural Abscess, Intracranial
Epidural Abscess
Abscess, Extradural
Abscess, Epidural
Cranial Epidural Abscess

Excerpt	Reference
"Spinal epidural abscess is rare in children."	( Barbadillo Izquierdo, F; Carpintero Martín, I; González De La Rosa, JB; Merino Arribas, J; Rodrigo Palacios, J, 2001)
"Spinal epidural abscess is a rare but devastating disorder that has previously been reported to have a mean incidence during sixth or seventh decade."	( Burke, M; Choma, T; Kakarlapudi, R; Kim, C, 2008)
"Spinal epidural abscess is a rare but potentially fatal disease."	( Chang, FY; Lin, JC; Wang, CW; Xiao, BR, 2008)
"Spinal epidural abscess is a very uncommon infection that requires prompt recognition and proper management to avoid potentially disastrous complications."	( Abduljabar, A; Elsamaloty, H; Elzawawi, M, 2010)
"Ventral cervical spinal epidural abscess is a very rare clinical condition with a relatively high morbidity and mortality."	( Arnautovic, KI; Olinger, RG, 2012)

Excerpt	Reference
"Treatment of spinal epidural abscess has been based on surgical debridement."	( Holtom, PD; Savage, K; Zalavras, CG, 2005)
"The incidence of spinal epidural abscess has increased in the past decades."	( Burton, AW; Hamid, B; Koyyalagunta, D; Perez-Toro, MR, 2009)

Excerpt	Reference
"Development of epidural abscess affects the duration and success of treatment."	( Akbal, A; Gökmen, F; Inceer, BŞ; Reşorlu, H; Saçar, S; Savaş, Y; Zateri, C, 2016)

Excerpt	Reference
"We describe a case of a posterior spinal epidural abscess that was successfully treated with percutaneous, computed tomography-guided, needle aspiration and parenteral antibiotic therapy."	( Chen, CJ; Chen, ST; Lyu, RK; Tang, LM, 2002)
"The spinal epidural abscess completely resolved after 6 weeks of antibiotic treatment."	( Chen, CJ; Chen, ST; Lyu, RK; Tang, LM, 2002)
"We report the conservative treatment of a spinal epidural abscess (SEA) caused by escherichia coli and affecting the anterior epidural space from C2 to L4 in a diabetic, obese patient presenting with tetraparesis."	( de las Heras, P; Wessling, H, 2003)
"We report the occurrence of an epidural abscess and meningitis in a 70-year-old man after 2 epidural corticosteroid injections for treatment of acute radicular lumbar back pain."	( Hooten, WM; Huntoon, MA; Kinney, MO, 2004)
"Treatment of spinal epidural abscess has been based on surgical debridement."	( Holtom, PD; Savage, K; Zalavras, CG, 2005)
"Treatment of SMG spinal-epidural abscess with neurologic manifestations should include prompt and aggressive surgical decompression coupled with targeted anti-infective therapy."	( Bearman, G; Lampen, R, 2005)
"Although the epidural abscess was initially treated with antibiotic (cefozopran) for 5 days, he subsequently developed motor weakness, paresthesia and urinary retention."	( Abe, H; Kohshi, K; Mizoguchi, Y; Shimokobe, M, 2005)
"Posterior spinal epidural abscesses may be successfully treated by way of the two Touhy needle and catheter technique for drainage and irrigation."	( Burton, AW; Hamid, B; Koyyalagunta, D; Perez-Toro, MR, 2009)
"A case of staphylococcal epidural abscess associated with infliximab and methotrexate therapy in a patient with psoriatic arthropathy is presented."	( Agustin, T; Gurnani, P; Lee, J; Singh, K; Vasoo, S, 2009)
"A MRSA epidural abscess in a 48-year-old woman was successfully treated with ceftaroline fosamil 600 mg every 12 hours as salvage therapy."	( Bucheit, J; Collins, R; Joshi, P, 2014)
"Spinal epidural abscesses are difficult to diagnose and could have high morbidity and mortality if left untreated."	( Abla, AA; Agarwal, N; George, HK; Khattar, NK; Zussman, BM, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	7 (3.47)	23.3326
1990's	1 (0.50)	12.5806
2000's	90 (44.55)	18.1394
2010's	85 (42.08)	28.8240
2020's	19 (9.41)	9.53

Drug	Relationship Strength	Studies	Trials
beta-alanine	low	1	0
salicylic acid	low	3	0
lactic acid	low	1	0
methanol	low	1	0
nitrous oxide	low	1	0
pyrazinamide	low	2	0
azathioprine	low	1	0
baclofen	low	1	0
bupivacaine	low	3	0
ciprofloxacin	low	4	0
clofazimine	low	1	0
fentanyl	low	2	0
fluconazole	low	4	0
gabapentin	low	1	0
gentamicin	low	5	0
lidocaine	low	3	0
iohexol	low	1	0
isoniazid	low	4	0
mepivacaine	low	1	0
methadone	low	1	0
metronidazole	low	4	0
ofloxacin	low	2	0
phenobarbital	low	1	0
sevoflurane	low	1	0
sulfamethoxazole	low	1	0
trimethoprim	low	1	0
prednisone	low	3	0
chloramphenicol	low	3	0
methicillin	low	3	0
cloxacillin	low	4	0
colchicine	low	2	0
oxacillin	low	9	0
ampicillin	low	1	0
methylmethacrylate	low	1	0
methylprednisolone	low	2	0
penicillanic acid	low	1	0
benzoyl peroxide	low	1	0
framycetin	low	1	0
nafcillin	low	1	0
oxazoles	medium	1	1
hydrazine	low	1	0
betamethasone	low	2	0
fusarium	low	2	0
erythromycin	low	3	0
ethambutol	low	2	0
durapatite	low	2	0
vancomycin	low	21	0
methylprednisolone hemisuccinate	low	1	0
streptomycin	low	5	0
floxacillin	low	4	0
vidarabine	low	1	0
titanium	low	1	0
gadolinium	low	9	0
calcium sulfate	low	1	0
ozone	low	2	0
trolamine salicylate	low	1	0
fludrocortisone	low	1	0
cefazolin	low	7	0
amoxicillin	low	3	0
ticarcillin	low	1	0
amikacin	low	4	0
propiconazole	low	6	0
piperacillin	low	2	0
itraconazole	low	4	0
cephalosporin c	low	10	0
triazoles	low	4	0
fluorodeoxyglucose f18	low	1	0
voriconazole	low	6	0
oxazolidin-2-one	medium	5	1
clarithromycin	low	1	0
fibrinogen	low	1	0
levobupivacaine	low	1	0
cobalt	low	1	0
tazobactam	low	1	0
technetium tc 99m hydroxymethylene diphosphonate	low	1	0
methotrexate	low	4	0
beta-lactams	low	1	0
levofloxacin	low	1	0
moxifloxacin	low	1	0
temocillin	low	1	0
ropivacaine	low	2	0
dabigatran	low	1	0
cortisone	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	6	0
meropenem	low	5	0
cefoxitin	low	1	0
netilmicin	low	1	0
linezolid	medium	8	1
clindamycin	low	4	0
fosfomycin	low	1	0
fludarabine	low	1	0
fusidic acid	low	1	0
isepamicin	low	1	0
amphotericin b	low	4	0
clavulanic acid	low	2	0
phenylephrine hydrochloride	low	1	0
hydromorphone	low	1	0
levetiracetam	low	1	0
morphine	low	1	0
heroin	low	1	0
cefepime	low	1	0
cefotaxime	low	6	0
brl 28500	low	1	0
gadolinium dtpa	low	1	0
ppi-0903	low	1	0
virginiamycin	low	1	0
enfuvirtide	low	1	0
ro13-9904	low	23	0
quinupristin-dalfopristin	low	1	0
tetracycline	low	1	0
oxytetracycline, anhydrous	low	1	0
daptomycin	low	4	0
cyclosporine	low	1	0
technetium tc 99m medronate	low	2	0
rifampin	low	11	0
dactinomycin	low	1	0

Protein Targets (790)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
estrogen nuclear receptor alpha	30	0	0	30
peripheral myelin protein 22	7	0	0	7
histone acetyltransferase KAT2A isoform 1	9	0	0	9
lamin isoform A-delta10	18	0	0	18
ATP-binding cassette sub-family C member 3	0	31	0	31
Multidrug resistance-associated protein 4	0	31	0	33
Bile salt export pump	0	44	0	44
Canalicular multispecific organic anion transporter 1	0	30	0	30
Aminoglycoside 3'-phosphotransferase	0	0	0	2
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, Beta-lactamase	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Beta-lactamase	0	2	0	6
Beta-lactamase	0	2	0	8
Beta-lactamase	0	0	0	7
Beta-lactamase	0	3	0	10
AR protein	25	0	0	25
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	10	0	0	10
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
DNA polymerase kappa isoform 1	5	0	0	5
Bile salt export pump	0	14	0	14
Beta-lactamase SHV-1	0	2	0	7
Beta-lactamase SHV-1	0	5	0	12
Cytochrome P450 2C9	0	8	0	9
Beta-lactamase	0	3	0	10
Kappa-type opioid receptor	0	4	0	10
Solute carrier family 15 member 1	0	12	0	12
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	5
Solute carrier family 15 member 2	0	7	0	7
Beta-lactamase	0	2	0	7
Beta-lactamase	0	1	0	7
Solute carrier family 15 member 2	0	7	0	7
Beta-lactamase	0	2	0	7
Beta-lactamase	0	0	0	6
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, Cruzipain	4	0	0	4
interleukin 8	7	0	0	7
phosphopantetheinyl transferase	10	0	0	10
GLS protein	7	0	0	7
glucocorticoid receptor [Homo sapiens]	21	0	0	21
farnesoid X nuclear receptor	12	0	0	12
peroxisome proliferator-activated receptor delta	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	20	0	0	20
Cytochrome P450 1A2	0	4	0	5
Cytochrome P450 3A4	0	14	1	16
Cytochrome P450 2D6	0	4	0	5
Cytochrome P450 2C19	0	5	0	6
Nuclear receptor ROR-gamma	4	0	0	4
Potassium voltage-gated channel subfamily H member 2	0	18	0	20
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	5
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Beta-lactamase	0	3	0	7
acid sphingomyelinase	3	0	0	3
GLI family zinc finger 3	19	0	0	19
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
Beta-lactamase	0	3	0	7
Beta-lactamase	0	1	0	8
Metallo-beta-lactamase type 2	0	0	1	8
Metallo-beta-lactamase VIM-11	0	0	0	6
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
Metallo-beta-lactamase VIM-2	0	0	0	6
Beta-lactamase	0	1	0	8
Metallo-beta-lactamase	0	0	0	7
Beta-lactamase	0	3	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
chromobox protein homolog 1	14	0	0	14
thyroid hormone receptor beta isoform 2	15	0	0	15
DNA polymerase beta	4	0	0	4
geminin	26	0	0	26
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	1	4
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-lactamase OXA-7	0	0	0	4
Spike glycoprotein	12	0	0	12
10 kDa heat shock protein, mitochondrial	0	4	0	4
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	2	0	6
Beta-lactamase	0	2	0	6
Beta-lactamase	0	2	0	6
Thiosulfate sulfurtransferase	0	4	0	4
Metallo-beta-lactamase VIM-13	0	0	0	6
Efflux transporter	0	1	0	3
Beta-lactamase	0	1	0	7
Beta-lactamase Toho-1	0	0	0	3
Beta-lactamase	0	1	0	3
Class D beta-lactamase	0	3	0	6
60 kDa chaperonin	0	4	0	4
Metallo-beta-lactamase	0	0	0	6
Beta-lactamase	0	3	0	9
Beta-lactamase	0	0	1	4
10 kDa chaperonin	0	4	0	4
Metallo-b-lactamase	0	0	0	11
Carbapenem-hydrolyzing beta-lactamase KPC	0	5	0	11
Histamine H3 receptor	0	0	0	6
Beta-lactamase class B VIM-2	0	0	1	12
Beta-lactamase VIM-1	0	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Ferritin light chain	5	0	0	5
acetylcholinesterase	6	0	0	6
thioredoxin reductase	15	0	0	15
RAR-related orphan receptor gamma	13	0	0	13
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	7	0	0	7
Fumarate hydratase	4	0	0	4
SMAD family member 3	2	0	0	2
TDP1 protein	21	0	0	21
Microtubule-associated protein tau	7	0	0	7
thioredoxin glutathione reductase	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
EWS/FLI fusion protein	17	0	0	17
retinoid X nuclear receptor alpha	13	0	0	13
estrogen-related nuclear receptor alpha	15	0	0	15
pregnane X nuclear receptor	15	0	0	15
G	10	0	0	10
polyprotein	4	0	0	4
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	10	0	0	10
arylsulfatase A	3	0	0	3
IDH1	8	0	0	8
aryl hydrocarbon receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
thyroid stimulating hormone receptor	4	0	0	4
activating transcription factor 6	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	5	0	0	5
Bloom syndrome protein isoform 1	6	0	0	6
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
heat shock protein beta-1	5	0	0	5
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	9	0	0	9
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	9	2	0	12
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Interferon beta	12	0	0	12
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Cellular tumor antigen p53	14	0	0	14
Gamma-aminobutyric acid receptor subunit beta-1	9	2	0	12
Gamma-aminobutyric acid receptor subunit delta	9	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	9	2	1	13
Glutamate receptor 2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	9	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	9	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-1	9	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	9	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	9	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	9	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	9	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-1	9	2	1	13
Gamma-aminobutyric acid receptor subunit beta-3	9	2	0	12
Gamma-aminobutyric acid receptor subunit beta-2	9	2	1	13
GABA theta subunit	9	2	0	12
Inositol hexakisphosphate kinase 1	10	0	0	10
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit epsilon	9	2	0	12
Protein-arginine deiminase type-4	0	8	0	8
cytochrome P450 2C9, partial	10	0	0	10
NFKB1 protein, partial	2	0	0	2
regulator of G-protein signaling 4	5	0	0	5
67.9K protein	8	0	0	8
D(1A) dopamine receptor	1	0	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
thyroid hormone receptor beta isoform a	7	0	0	7
lethal factor (plasmid)	5	0	0	5
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
pregnane X receptor	5	0	0	5
progesterone receptor	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	8	1	9
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Potassium channel subfamily K member 3	0	4	0	4
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Luciferase	5	0	0	5
Smad3	3	0	0	3
cytochrome P450 2D6	8	0	0	8
Solute carrier family 22 member 6	0	4	0	4
Solute carrier family 22 member 6	0	4	0	5
Solute carrier family 22 member 8	0	4	0	6
Solute carrier family 22 member 11	0	3	0	5
Solute carrier family 22 member 8	0	3	0	3
Beta-lactamase	0	4	0	8
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	5
Beta-lactamase	0	3	0	7
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	3	0	5
Beta-lactamase	0	4	0	8
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	7	0	11
Beta-lactamase	0	1	0	2
Beta-lactamase	0	3	0	7
Metallo-beta-lactamase VIM-2	0	0	0	6
Beta-lactamase	0	0	0	2
BlaVIM-1	0	0	0	5
Beta-lactamase	0	0	0	2
Beta-lactamase	0	2	0	5
Beta-lactamase	0	3	0	5
Albumin	0	1	6	7
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 7	0	2	0	3
Solute carrier family 22 member 7	0	2	0	3
Solute carrier family 22 member 8	0	7	0	7
endonuclease IV	4	0	0	4
WRN	2	0	0	2
DNA (cytosine-5)-methyltransferase 1 isoform b	0	1	0	1
importin subunit beta-1 isoform 1	5	0	0	5
flap endonuclease 1	8	0	0	8
serine/threonine-protein kinase PLK1	3	0	0	3
snurportin-1	5	0	0	5
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Beta-lactamase OXA-1	0	3	0	5
Beta-lactamase	0	1	0	4
phosphoglycerate kinase	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	16	0	0	16
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
streptokinase A precursor	0	0	9	9
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	6	1	7
30S ribosomal protein S7	0	6	1	7
50S ribosomal protein L15	0	6	1	7
50S ribosomal protein L10	0	6	1	7
50S ribosomal protein L11	0	6	1	7
50S ribosomal protein L7/L12	0	6	1	7
50S ribosomal protein L19	0	6	1	7
50S ribosomal protein L1	0	6	1	7
50S ribosomal protein L20	0	6	1	7
50S ribosomal protein L27	0	6	1	7
50S ribosomal protein L28	0	6	1	7
50S ribosomal protein L29	0	6	1	7
50S ribosomal protein L31	0	6	1	7
50S ribosomal protein L31 type B	0	6	1	7
50S ribosomal protein L32	0	6	1	7
50S ribosomal protein L33	0	6	1	7
50S ribosomal protein L34	0	6	1	7
50S ribosomal protein L35	0	6	1	7
50S ribosomal protein L36	0	6	1	7
30S ribosomal protein S10	0	6	1	7
30S ribosomal protein S11	0	6	1	7
30S ribosomal protein S12	0	6	1	7
30S ribosomal protein S13	0	6	1	7
30S ribosomal protein S16	0	6	1	7
30S ribosomal protein S18	0	6	1	7
30S ribosomal protein S19	0	6	1	7
30S ribosomal protein S20	0	6	1	7
30S ribosomal protein S2	0	6	1	7
30S ribosomal protein S3	0	6	1	7
30S ribosomal protein S4	0	6	1	7
30S ribosomal protein S5	0	6	1	7
30S ribosomal protein S8	0	6	1	7
30S ribosomal protein S9	0	6	1	7
50S ribosomal protein L13	0	6	1	7
50S ribosomal protein L14	0	6	1	7
50S ribosomal protein L16	0	6	1	7
50S ribosomal protein L23	0	6	1	7
30S ribosomal protein S15	0	6	1	7
50S ribosomal protein L17	0	6	1	7
50S ribosomal protein L21	0	6	1	7
50S ribosomal protein L30	0	6	1	7
50S ribosomal protein L6	0	6	1	7
30S ribosomal protein S14	0	6	1	7
30S ribosomal protein S17	0	6	1	7
30S ribosomal protein S1	0	6	1	7
50S ribosomal protein L18	0	6	1	7
50S ribosomal protein L2	0	6	1	7
50S ribosomal protein L3	0	6	1	7
50S ribosomal protein L24	0	6	1	7
50S ribosomal protein L4	0	6	1	7
50S ribosomal protein L22	0	6	1	7
50S ribosomal protein L5	0	6	1	7
30S ribosomal protein S21	0	6	1	7
50S ribosomal protein L25	0	6	1	7
50S ribosomal protein L36 2	0	6	1	7
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9 precursor	2	0	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	5	0	9
DNA gyrase subunit B	0	5	0	9
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	2	0	3
DNA topoisomerase 2-alpha	0	1	0	5
DNA gyrase subunit A	0	2	0	3
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	4	0	0	4
DNA gyrase subunit B	0	5	0	7
DNA gyrase subunit A	0	6	0	8
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
mitogen-activated protein kinase 1	5	0	0	5
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
ATP-dependent translocase ABCB1	0	9	0	11
Solute carrier organic anion transporter family member 1B3	0	3	0	5
Solute carrier organic anion transporter family member 1B1	0	3	0	4
Beta-lactamase	0	3	0	3
Beta-lactamase	0	4	0	4
Neutrophil elastase	0	1	0	1
Cytochrome P450 2B6	0	4	1	5
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	2	0	2
USP1 protein, partial	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
cytochrome P450 2D6 isoform 1	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
transcriptional regulator ERG isoform 3	4	0	0	4
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Estrogen receptor	0	0	3	3
Spike glycoprotein	0	0	1	1
5-hydroxytryptamine receptor 1A	0	2	1	3
Cruzipain	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Estrogen receptor beta	0	0	3	3
PAX8	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
PPM1D protein	2	0	0	2
Thrombopoietin	1	0	0	1
thyroid stimulating hormone receptor	8	0	0	8
estrogen receptor 2 (ER beta)	9	0	0	9
glucocerebrosidase	1	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	3	2	6
ATP-dependent translocase ABCB1	0	5	0	5
Tubulin beta chain	0	3	2	6
Tubulin alpha-3C chain	0	3	2	6
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Tubulin alpha-1B chain	0	3	2	6
Tubulin alpha-4A chain	0	3	2	6
Tubulin beta-4B chain	0	3	2	6
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	3	2	6
Tubulin beta-2A chain	0	3	2	6
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	2	6
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	3	2	6
Tubulin alpha-1A chain	0	3	2	6
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	3	2	6
Tubulin beta-6 chain	0	3	2	6
Tubulin beta-2B chain	0	3	2	6
Tubulin beta-1 chain	0	3	2	6
dopamine D1 receptor	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Multidrug and toxin extrusion protein 1	0	5	0	5
Solute carrier family 22 member 2	0	1	0	1
Prothrombin	0	2	0	2
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Coagulation factor XII	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Trypsin-3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Env polyprotein	0	0	2	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
60 kDa chaperonin	0	1	0	1
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	4	1	5
Pantothenate synthetase	0	2	0	2
Solute carrier family 22 member 1	0	4	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
D(2) dopamine receptor	0	2	0	2
Amine oxidase [flavin-containing] A	0	3	0	3
D(4) dopamine receptor	0	2	0	2
Amine oxidase [flavin-containing] B	0	2	0	2
Delta-type opioid receptor	0	3	0	4
Delta-type opioid receptor	0	5	1	7
Mu-type opioid receptor	0	5	2	10
Kappa-type opioid receptor	0	4	1	6
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	7	3	11
D(3) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	6	1	8
Kappa-type opioid receptor	0	6	2	9
Mu-type opioid receptor	0	3	1	6
Mu-type opioid receptor	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	2	3
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	1	0	1
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	2	2
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
5'-nucleotidase	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine deaminase	0	0	0	2
GALC protein	3	0	0	3
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	1	1
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
Chain A, Type Iii Chloramphenicol Acetyltransferase	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	3
large T antigen	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	2	0	3
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Endonuclease 8-like 1	0	1	0	1
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Synaptic vesicle glycoprotein 2A	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Replicase polyprotein 1ab	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	0	6
Amine oxidase [flavin-containing] B	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Renin	0	1	0	1
Adenosine transporter 1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
Mas-related G-protein coupled receptor member X2	0	0	2	2
Aldehyde oxidase 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	3	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	4	2	6
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	5	0	6
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Dihydrofolate reductase	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Dihydrofolate reductase	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
nonstructural protein 1	2	0	0	2
Androgen receptor	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	1	1	2
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
STE24	0	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
MecA	0	1	0	1
Vpr	2	0	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Valosin-containing protein	0	1	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
glp-1 receptor, partial	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Metallo-beta-lactamase type 2	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protease	0	1	1	2
B2 bradykinin receptor	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase L1 type 3	0	1	0	1
Beta-lactamase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Histamine H1 receptor	0	0	1	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(9)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (202)

Protein Targets (790)

Abscess, Epidural

Synonyms(9)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (202)

Drugs Studied (129)

Protein Targets (790)