Collagenous Colitis

Synonym
Collagenous Colitis

Excerpt	Reference
"Collagenous colitis is typified by chronic watery diarrhoea and characteristic histological alterations of the colonic mucosa without endoscopic abnormalities."	( DeWitt, JE; Feyen, B; Finnerty, EP; Reyes, RS; Wall, GC, 2004)
"Collagenous colitis is an idiopathic microscopic colitis characterised by watery diarrhoea."	( Bästlein, E; Bayerdörffer, E; Bethke, B; Heymer, P; Madisch, A; Meier, E; Miehlke, S; Schimming, W; Stolte, M; Voss, C; Wigginghaus, B, 2005)
"Collagenous colitis is generally regarded as a benign disease with few serious complications."	( Bohr, J; Eriksson, S; Järnerot, G; Larsson, LG; Tysk, C, 2005)
"Clinically, collagenous colitis is characterized by long-standing diarrhea."	( Elaprolu, K; Khalife, W; Khurana, A; Mahmoud, F, 2005)
"Collagenous colitis is characterised by watery diarrhoea, normal colonic mucosa on endoscopy, diffuse colitis with surface epithelial injury, and a distinctive thickening of the subepithelial collagen table on histology."	( Bennett, AE; Fazio, VW; Lashner, BA; Remzi, FH; Shen, B; Sherman, KK; Sun, J, 2006)
"Collagenous colitis is an idiopathic inflammatory colonic disease that is included in the microscopic colitides."	( Alomar, A; Busquets, D; Corella, F; Dalmau, J; Delgado, E; García-Navarro, X; Monfort, D; Ribé, A; Roé, E, 2006)
"Collagenous colitis is a disorder that is recognized as a cause of chronic diarrhea."	( Chande, N; MacDonald, JK; McDonald, JW, 2006)
"Collagenous colitis is increasingly recognized as a common diarrheal disorder of inflammatory origin."	( Münch, A; Ost, A; Söderholm, JD; Ström, M, 2009)
"Colonic mucosa of collagenous colitis is known to be endoscopically normal."	( Abe, T; Chiba, M; Ono, I; Sugawara, T; Tokairin, T; Tozawa, H; Tsuda, H; Ushiyama, E, 2009)
"Moreover, collagenous colitis is associated with bile acid malabsorption."	( Carlsson, AH; Magnusson, KE; Münch, A; Ost, A; Söderholm, JD; Ström, M, 2011)
"Collagenous colitis is a chronic inflammatory bowel disease of unknown etiology."	( Cooper, DK; Dons, EM; Echeverri, GJ; Ijzermans, JN; Klein, E; Montoya, C; Rigatti, LH; Wagner, R; Wolf, RF, 2012)
""Pseudomembranous collagenous colitis" is a morphologic variant of collagenous colitis in which active inflammation with pseudomembrane formation is prominent and which has been associated with infectious, toxic, and ischemic etiologies."	( Ammon, H; Ferrer, MS; Fons, ME; Komorowski, RA; Mackinnon, AC; Patel, A; Stein, DJ; Yan, BC, 2013)
"Pseudomembranous collagenous colitis is a rare pathological condition, not related to infectious agents, and characterized by thickening of the subepithelial collagen and formation of pseudomembranes."	( Antonelli, E; Bassotti, G; Broglia, L; Cristina, S; Muscarà, M; Occhipinti, P; Saettone, S; Salemme, M; Villanacci, V, 2013)
"Collagenous colitis is a common cause of non-bloody, watery diarrhea."	( Fujii, K; Fujiwara-Tani, R; Kadochi, Y; Kishi, S; Kuniyasu, H; Luo, Y; Mori, S; Nishiguchi, Y; Ohmori, H, 2017)
"Collagenous colitis is a cause of chronic diarrhea."	( Chande, N; Kafil, TS; MacDonald, JK; McDonald, JW; Nguyen, TM; Patton, PH, 2017)

Excerpt	Reference
"Collagenous colitis has been associated with autoimmune diseases."	( Coban, S; Ekiz, F; Ensari, A; Gören, D; Ormeci, N; Savas, B, 2007)
"Patients with collagenous colitis have an impaired mucosal barrier."	( Carlsson, AH; Magnusson, KE; Münch, A; Ost, A; Söderholm, JD; Ström, M, 2011)
"Collagenous colitis has occasionally been reported in patients with organ transplants."	( Cooper, DK; Dons, EM; Echeverri, GJ; Ijzermans, JN; Klein, E; Montoya, C; Rigatti, LH; Wagner, R; Wolf, RF, 2012)

Excerpt	Reference
"Five randomized trials assessing treatments for collagenous colitis were identified."	( Chande, N; Macdonald, JK; McDonald, JW, 2004)
"Budesonide is effective in the treatment of collagenous colitis."	( Bethke, B; Heymer, P; Kuhlisch, E; Madisch, A; Miehlke, S; Morgner, A; Stolte, M; Voss, C, 2005)
"Budesonide is effective for the treatment of collagenous colitis."	( Chande, N; MacDonald, JK; McDonald, JW, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	49 (38.89)	18.1394
2010's	64 (50.79)	28.8240
2020's	13 (10.32)	9.53

Drug	Relationship Strength	Studies	Trials
azathioprine	low	5	0
ciprofloxacin	low	2	0
diclofenac	low	2	0
lansoprazole	low	18	0
leflunomide	low	1	0
loperamide	low	5	0
mesalamine	medium	14	3
metronidazole	low	1	0
nimesulide	low	1	0
omeprazole	low	1	0
pentoxifylline	low	1	0
rizatriptan	low	1	0
sulfasalazine	low	4	0
ticlopidine	low	1	0
tinidazole	low	1	0
prednisolone	low	6	0
penicillamine	low	1	0
prednisone	low	3	0
mannitol	low	1	0
thiophenes	low	1	0
fluocortolone	low	1	0
isoxazoles	low	1	0
chenodeoxycholic acid	low	1	0
barium sulfate	low	1	0
duloxetine hydrochloride	low	1	0
triazoles	low	1	0
methotrexate	medium	7	1
olmesartan	low	1	0
technetium tc 99m pentetate	low	1	0
deoxycholic acid	low	1	0
tacrolimus	low	1	0
dimethyl fumarate	low	1	0
mercaptopurine	low	1	0
indigo carmine	low	2	0
pulmicort	medium	64	11
isotretinoin	low	1	0
bismuth	low	7	0
fumarates	low	1	0
mocetinostat	medium	3	2
gastrins	low	1	0
bismuth subsalicylate	low	5	0
salicylates	low	6	0
transforming growth factor beta	low	2	0
cyclosporine	low	2	0
lactoferrin	low	1	0
muramidase	low	1	0
exudates	low	1	0
cholestyramine resin	medium	8	1

Protein Targets (552)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Ferritin light chain	5	0	0	5
interleukin 8	1	0	0	1
acetylcholinesterase	5	0	0	5
thioredoxin reductase	7	0	0	7
phosphopantetheinyl transferase	9	0	0	9
RAR-related orphan receptor gamma	14	0	0	14
SMAD family member 2	5	0	0	5
ATAD5 protein, partial	10	0	0	10
Fumarate hydratase	4	0	0	4
SMAD family member 3	5	0	0	5
TDP1 protein	19	0	0	19
GLI family zinc finger 3	12	0	0	12
Microtubule-associated protein tau	8	0	0	8
AR protein	19	0	0	19
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
EWS/FLI fusion protein	12	0	0	12
glucocorticoid receptor [Homo sapiens]	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	14	0	0	14
estrogen-related nuclear receptor alpha	18	0	0	18
farnesoid X nuclear receptor	10	0	0	10
pregnane X nuclear receptor	13	0	0	13
estrogen nuclear receptor alpha	24	0	0	24
G	11	0	0	11
polyprotein	4	0	0	4
P53	2	0	0	2
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	12	0	0	12
arylsulfatase A	4	0	0	4
IDH1	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
aryl hydrocarbon receptor	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
thyroid stimulating hormone receptor	7	0	0	7
activating transcription factor 6	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
Histone H2A.x	7	0	0	7
Bloom syndrome protein isoform 1	5	0	0	5
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	5	0	0	5
thyroid hormone receptor beta isoform 2	12	0	0	12
heat shock protein beta-1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
DNA polymerase iota isoform a (long)	8	0	0	8
geminin	14	0	0	14
peripheral myelin protein 22	7	0	0	7
survival motor neuron protein isoform d	10	0	0	10
cytochrome P450 3A4 isoform 1	9	0	0	9
M-phase phosphoprotein 8	4	0	0	4
muscleblind-like protein 1 isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	5	0	0	5
lamin isoform A-delta10	14	0	0	14
Gamma-aminobutyric acid receptor subunit pi	9	1	0	10
ATP-binding cassette sub-family C member 3	0	16	0	16
Multidrug resistance-associated protein 4	0	16	0	17
Bile salt export pump	0	5	0	5
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Bile salt export pump	0	23	0	23
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	11	0	0	11
Cellular tumor antigen p53	14	0	0	14
Gamma-aminobutyric acid receptor subunit beta-1	9	1	0	10
Gamma-aminobutyric acid receptor subunit delta	9	1	0	10
Gamma-aminobutyric acid receptor subunit gamma-2	9	1	0	10
Glutamate receptor 2	11	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	9	1	0	10
Gamma-aminobutyric acid receptor subunit alpha-3	9	1	0	10
Gamma-aminobutyric acid receptor subunit gamma-1	9	1	0	10
Gamma-aminobutyric acid receptor subunit alpha-2	9	1	0	10
Gamma-aminobutyric acid receptor subunit alpha-4	9	1	0	10
Gamma-aminobutyric acid receptor subunit gamma-3	9	1	0	10
Gamma-aminobutyric acid receptor subunit alpha-6	9	1	0	10
Nuclear receptor ROR-gamma	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	9	1	0	10
Gamma-aminobutyric acid receptor subunit beta-3	9	1	0	10
Gamma-aminobutyric acid receptor subunit beta-2	9	1	0	10
GABA theta subunit	9	1	0	10
Inositol hexakisphosphate kinase 1	11	0	0	11
Canalicular multispecific organic anion transporter 1	0	15	0	15
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	11	0	0	11
Gamma-aminobutyric acid receptor subunit epsilon	9	1	0	10
Protein-arginine deiminase type-4	0	4	0	4
cytochrome P450 2C9, partial	11	0	0	11
Luciferase	13	0	0	13
Spike glycoprotein	12	0	1	13
caspase 7, apoptosis-related cysteine protease	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
caspase-3	4	0	0	4
Caspase-7	2	0	0	2
chromobox protein homolog 1	7	0	0	7
caspase-3	2	0	0	2
Alpha-2A adrenergic receptor	0	2	1	3
Vitamin D3 receptor	0	2	2	4
Alpha-2B adrenergic receptor	0	6	1	7
Alpha-2C adrenergic receptor	0	2	1	3
Retinoic acid receptor RXR-alpha	0	1	1	2
Guanine nucleotide-binding protein G	1	0	0	1
Ileal sodium/bile acid cotransporter	0	2	0	2
TAR DNA-binding protein 43	6	0	0	6
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	2	2
Bile acid receptor	0	0	2	2
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, Cruzipain	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
cytochrome P450 2C9 precursor	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
Cytochrome P450 1A2	0	2	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Cytochrome P450 3A4	0	5	0	5
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
Cytochrome P450 2D6	0	5	0	5
DNA topoisomerase 2-alpha	0	1	0	4
Cytochrome P450 2C9	0	9	0	10
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	6	0	7
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	8	0	0	9
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	5
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Steroid Delta-isomerase	0	0	1	1
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	3	0	4
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	1	4
Fatty acid-binding protein, liver	0	2	0	2
Transthyretin	0	0	1	3
Albumin	0	2	1	3
Prostaglandin G/H synthase 1	0	3	0	3
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	4
UDP-glucuronosyltransferase 1-6	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	2	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	4
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2J2	0	7	0	7
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Kelch-like ECH-associated protein 1	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	1
glp-1 receptor, partial	5	0	0	5
Smad3	1	0	0	1
estrogen receptor 2 (ER beta)	9	0	0	9
progesterone receptor	11	0	0	11
cytochrome P450 2D6	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Alpha-synuclein	2	0	0	2
histone deacetylase 9 isoform 3	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
regulator of G-protein signaling 4	4	0	0	4
67.9K protein	2	0	0	2
Parkin	3	0	0	3
vitamin D3 receptor isoform VDRA	9	0	0	9
thyroid hormone receptor beta isoform a	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
serine/threonine-protein kinase PLK1	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Adenosine receptor A3	0	4	0	4
Retinoic acid receptor alpha	0	1	0	1
Alpha-1B adrenergic receptor	0	4	0	4
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Alpha-1A adrenergic receptor	0	4	0	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Mitogen-activated protein kinase 14	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Olfactory receptor 51E2	0	1	0	1
Chain A, Beta-lactamase	5	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
15-lipoxygenase, partial	4	0	0	4
USP1 protein, partial	9	0	0	9
GLS protein	4	0	0	4
apical membrane antigen 1, AMA1	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
thyroid stimulating hormone receptor	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
alpha-galactosidase	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Replicase polyprotein 1ab	0	1	2	3
cytochrome P450 2D6 isoform 1	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
cytochrome P450 2C19 precursor	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
nuclear receptor ROR-gamma isoform 1	7	0	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Amyloid-beta precursor protein	1	0	0	1
ATP-dependent translocase ABCB1	0	3	1	5
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Replicase polyprotein 1ab	0	2	1	3
Microtubule-associated protein tau	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	0	1
Fatty acid synthase	0	6	0	6
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
WD repeat-containing protein 5	0	3	0	3
Histone-lysine N-methyltransferase 2A	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Cytosolic endo-beta-N-acetylglucosaminidase	0	3	0	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
ATP-dependent phosphofructokinase	4	0	0	4
matrix metalloproteinase 1, partial	0	0	1	1
PPM1D protein	4	0	0	4
Thrombopoietin	3	0	0	3
nonstructural protein 1	2	0	0	2
pyruvate kinase	1	0	0	1
huntingtin isoform 2	3	0	0	3
histone acetyltransferase KAT2A isoform 1	7	0	0	7
neuropeptide S receptor isoform A	1	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Integrin beta-3	3	0	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Integrin alpha-IIb	3	0	0	3
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin receptor type B	1	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Endothelin-1 receptor	1	0	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Spike glycoprotein	0	0	1	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Menin	0	1	0	1
Cocaine esterase	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Transmembrane protease serine 2	0	0	1	1
Beta-2 adrenergic receptor	0	2	0	2
Procathepsin L	0	1	1	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
D(2) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Histamine H2 receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	4	0	4
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	0	2
Nociceptin receptor	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Calmodulin	0	1	1	2
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Mu-type opioid receptor	0	0	1	1
Inositol monophosphatase 1	2	0	0	2
Angiopoietin-1 receptor	0	0	1	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
Angiotensin-converting enzyme 2	0	0	1	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
DNA polymerase kappa isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	2	0	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Tumor necrosis factor	0	2	1	3
Neuraminidase	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	2	0	2
Caspase-7	2	0	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	5
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	5
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	2	0	0	2
ClpP	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
flap endonuclease 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Thioredoxin reductase	0	1	0	1
mitogen-activated protein kinase 1	2	0	0	2
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	2	0	2
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Interstitial collagenase	0	2	0	2
Myeloperoxidase	0	1	0	1
Aromatase	0	1	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Platelet glycoprotein VI	0	0	1	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Glutathione S-transferase omega-1	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
endonuclease IV	1	0	0	1
NFKB1 protein, partial	2	0	0	2
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
Cholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A2b	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chitotriosidase-1	0	2	1	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Endochitinase B1	0	2	1	3
luciferase	0	0	0	1
Estrogen receptor	0	3	0	3
Glucocorticoid receptor	0	6	3	14
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	3	2	5
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	5	0	5
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	0	3
pregnane X receptor	1	0	0	1
glucocerebrosidase	1	0	0	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Insulin-degrading enzyme	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	1	0	1
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
GALC protein	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (126)

Protein Targets (552)

Collagenous Colitis

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (126)

Drugs Studied (53)

Protein Targets (552)