metronidazole has been researched along with Abscess, Epidural in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was administrated for 5 weeks and symptoms were completely resolved." | 1.39 | Bacteroides fragilis vertebral osteomyelitis complicated by percutaneous epidural adhesiolysis. ( Choi, BK; Han, IH; Kim, SY; Nam, KH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mittal, MK | 1 |
| Zimmerman, RA | 1 |
| ter Avest, E | 1 |
| Uyttenboogaart, M | 1 |
| Dorgelo, J | 1 |
| ter Maaten, JC | 1 |
| Han, IH | 1 |
| Choi, BK | 1 |
| Nam, KH | 1 |
| Kim, SY | 1 |
| Abdlslam, K | 1 |
| Thumbikat, P | 1 |
| Gibson, RJ | 1 |
4 other studies available for metronidazole and Abscess, Epidural
| Article | Year |
|---|---|
Meningitis and epidural abscess related to pansinusitis.
Topics: Bacteroidaceae Infections; Cefotaxime; Ceftriaxone; Child; Combined Modality Therapy; Consciousness | 2009 |
A patient with neck pain and fever. Combined prevertebral and intraspinal abscess in a patient with a de novo HIV infection.
Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Cervical Vertebrae; Epidural Abscess; Fever; HIV Infectio | 2009 |
Bacteroides fragilis vertebral osteomyelitis complicated by percutaneous epidural adhesiolysis.
Topics: Adult; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infections; Ceftazidime; Combined Mo | 2013 |
Anaerobic infection of the lumbar spine in an intravenous drug abuser.
Topics: Adult; Anaerobiosis; Anti-Bacterial Agents; Ciprofloxacin; Clindamycin; Epidural Abscess; Female; Hu | 2002 |