metronidazole has been researched along with Pocket, Periodontal in 201 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In generalized periodontitis stage III/grade C, a clinically relevant lower percentage of disease progression after adjunctive systemic amoxicillin/metronidazole was observed compared to placebo (PLAC: 9." | 9.69 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis stage and grade: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Göde, M; Harks, I; Kaner, D; Kim, TS; Koch, R; Kocher, T; Lorenz, K; Meyle, J; Nickles, K; Schlagenhauf, U, 2023) |
| "Systemically healthy patients, with stages III-IV, grades B-C periodontitis, were randomly assigned to receive metronidazole or placebo adjunctive to periodontal surgery, after subgingival instrumentation." | 9.51 | Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial. ( Collins, JR; Figuero, E; González, R; Herrera, D; Marín, MJ; Ogando, G; Sanz, M, 2022) |
| " We hypothesize, if variables fall below or exceed these threshold levels, systemic amoxicillin/metronidazole may contribute to reducing progression of periodontitis." | 9.30 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Harks, I; Harmsen, D; Hoffmann, T; Kaner, D; Kim, TS; Koch, R; Kocher, T; Meyle, J; Schlagenhauf, U, 2019) |
| " The aim of this study was to compare interleukin-1β (IL-1β) and chemokine (C-C motif) ligand 28 (CCL28) levels following a topical application of curcumin (CRM), chlorhexidine (CHX) and chlorhexidine-metronidazole (CHX-MTZ) in an experimental gingivitis human model." | 9.20 | Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis. ( Nath, S; Pulikkotil, SJ, 2015) |
| " forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP)." | 9.19 | Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: an exploratory analysis from a randomized controlled clinical trial. ( Griffiths, GS; Guerrero, A; Lambertenghi, R; Nibali, L; Ready, D; Suvan, J; Tonetti, MS; Wilson, M, 2014) |
| "The aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (AM) when performing full-mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment." | 9.16 | The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. ( Casarin, RC; Casati, MZ; Gonçalves, RB; Nociti, FH; Peloso Ribeiro, ED; Sallum, EA, 2012) |
| "The aim of this study is to evaluate the effects of metronidazole-amoxicillin combination on clinical and microbiologic parameters in patients with generalized aggressive periodontitis." | 9.14 | Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. ( Cintan, S; Issever, H; Kantarci, A; Kulekci, G; Topcuoglu, N; Yek, EC, 2010) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 9.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "The aims of the present study were to evaluate the clinical efficacy of, and to monitor microbiologically, repeated oral hygiene instructions alone or in combination with metronidazole 25% gel or subgingival scaling with or without metronidazole gel in treatment of new, residual or recurrent periodontal pockets in previously treated adult periodontitis patients." | 9.12 | Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study. ( Corbet, EF; Lee, DH; Zee, KY, 2006) |
| "Subgingival application of chlorhexidine via a controlled-delivery device (CHX chip) improves the clinical outcome of scaling/root planing (SRP) in therapy for chronic periodontitis." | 9.12 | Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. ( Bernimoulin, JP; Friedmann, A; Hopfenmüller, W; Kaner, D; Kleber, BM, 2007) |
| "The objective of this study was to assess the adjunctive clinical effect of the administration of systemic amoxicillin and metronidazole in the non-surgical treatment of generalized aggressive periodontitis (GAP)." | 9.11 | Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. ( Griffiths, GS; Guerrero, A; Laurell, L; Moles, DR; Nibali, L; Suvan, J; Tonetti, MS, 2005) |
| "To evaluate the efficacy of metronidazole on cyclosporine-induced gingival overgrowth (GO), a prospective intra-subject double-blind longitudinal study was performed on six heart transplant patients with GO." | 9.10 | Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients. ( Montebugnoli, L; Prati, C; Servidio, D, 2002) |
| "The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25% metronidazole dental gel as an adjunct to scaling and root planing (SRP) in the treatment of adult periodontitis." | 9.09 | Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results. ( Bilgiç, A; Buduneli, E; Evrenosoglu, E; Tünger, A, 2001) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 9.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "In this article the clinical and microbiological effects of systemic metronidazole in the treatment of refractory periodontitis in adult patients is discussed." | 9.09 | [Metronidazole in the treatment of refractory periodontitis]. ( van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 2000) |
| "The present study describes results on selected clinical and microbiological parameters obtained by treatment with local (Elyzol) and systemic (Flagyl) use of metronidazole alone and/or mechanical subgingival debridement in adult periodontitis." | 9.08 | A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. ( Acar, O; Büget, E; Kadir, T; Kuru, B; Noyan, U; Yilmaz, S, 1997) |
| "The Effect on the subgingival microflora of a single topical administration of a 95% collagen and 5% metronidazole device in combination with debridement was investigated in 30 adult periodontitis patients in comparison with mechanical treatment alone." | 9.08 | Effects of combined topical metronidazole and mechanical treatment on the subgingival flora in deep periodontal pockets in cuspids and bicuspids. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C, 1997) |
| "The present study was performed to assess and compare the clinical healing and the microbiological findings following local application of metronidazole or tetracycline to augment subgingival scaling in previously untreated adult periodontitis sites." | 9.08 | Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. ( Böe, OE; Bruun, G; Lie, T, 1998) |
| "The purpose of this study was to evaluate the clinical effects of a single application of a 5% metronidazole collagen device in periodontal pockets deeper than 5 mm, in association with debridement and without reinforcement of home care and hygiene as practiced by the patient at any time." | 9.07 | Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C; Teboul, M; Varonne, R, 1994) |
| "The aim of the study was to compare the clinical and microbiological effects of topical application of a metronidazole gel and a single session of subgingival scaling in the treatment of adult periodontitis." | 9.07 | Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. ( Karring, T; Kilian, M; Pedrazzoli, V, 1992) |
| "A newly developed metronidazole 25% dental gel was compared with subgingival scaling in the treatment of adult periodontitis." | 9.07 | Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. ( Ainamo, J; Ellingsen, BH; Hansen, BF; Johansson, LA; Karring, T; Kisch, J; Lie, T; Paunio, K; Stoltze, K, 1992) |
| "The efficacy of metronidazole and doxycycline in preventing recurrent periodontitis was studied in 23 patients." | 9.07 | Serial doxycycline and metronidazole in prevention of recurrent periodontitis in high-risk patients. ( Aitken, S; Birek, P; Kulkarni, GV; Lee, WL; McCulloch, CA, 1992) |
| "The effect of adjunctive systemic metronidazole was studied in patients with moderate and advanced periodontitis recalcitrant to comprehensive non-surgical treatment." | 9.06 | The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. ( Engström, PE; Frithiof, L; Nedlich, U; Rubin, B; Söder, B; Söder, PO; Wikner, S; Wouters, F, 1990) |
| "Meta-analysis was used to assess the effectiveness of local delivery of metronidazole alone or as an adjunct to mechanical therapy in patients with chronic periodontitis." | 8.82 | Meta-analysis of local metronidazole in the treatment of chronic periodontitis. ( Angelillo, IF; Bianco, A; Nobile, CG; Pavia, M, 2004) |
| "The purpose of this meta-analysis was to provide a quantitative overview of clinical trials assessing the use of systemic metronidazole (S-MET) as an adjunct to scaling and root planning (S&RP) in the treatment of adult periodontitis." | 8.79 | Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis. ( Beck, JD; Elter, JR; Lawrence, HP; Offenbacher, S, 1997) |
| "Metronidazole (MZ) and levofloxacin (LF) are widely employed for treatment of periodontitis, but high oral dose and resistance development after long-term oral administration limit their use." | 7.83 | Development and Evaluation of Biodegradable Chitosan Films of Metronidazole and Levofloxacin for the Management of Periodontitis. ( Bansal, M; Khan, G; Mishra, B; Nath, G; Patel, RR; Yadav, SK, 2016) |
| "This study was performed to obtain prolonged drug release with biodegradable in situ forming implants for the local delivery of metronidazole to periodontal pockets." | 7.80 | In situ forming implants for the delivery of metronidazole to periodontal pockets: formulation and drug release studies. ( Bodmeier, R; Kilicarslan, M; Koerber, M, 2014) |
| "The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis." | 7.78 | Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. ( De Micheli, G; Hirata, MH; Hirata, RD; Lima Neto, LG; Lotufo, RF; Lourenção, DS; Pannuti, CM; Rodrigues, AS, 2012) |
| "Topical metronidazole benzoate preparations, applied directly into the space between the teeth and, periodontal tissue, are the treatment of choice for periodontal pockets." | 7.73 | [Assessment of feasibility of formulation of a preparation for growth inhibition of metronidazole-resistant strains isolated from periodontal pockets]. ( Loncar, I; Nonković, Z; Toskić-Radojicić, M; Varjacić, M, 2005) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 7.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 7.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "We report on the microbiological and clinical effects of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with Actinobacillus actinomycetemcomitans-associated periodontitis." | 7.68 | Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. ( de Graaff, J; Tijhof, CJ; van Winkelhoff, AJ, 1992) |
| "The metronidazole concentration was monitored in gingival crevicular fluid (GCF) of inflamed periodontal pockets after 1 application of a 25% gel." | 7.68 | Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. ( Stoltze, K, 1992) |
| "The present study was performed to assess the effect of topical metronidazole therapy on ligature-induced periodontitis in beagle dogs." | 7.68 | The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. ( Attström, R; Edwardsson, S; Kalfas, S; Klinge, B; Kuvatanasuhati, J, 1992) |
| " This study attempts to measure changes in flora by a number of methods following the placement of 40% metronidazole acrylic strips into periodontal pockets." | 7.67 | Simple bacteriological methods to assess changes in subgingival microflora produced by metronidazole-containing acrylic strips placed into periodontal pockets. ( Addy, M; Alam, L; Rawle, L, 1984) |
| "5%) and the other high (40%) dose metronidazole locally in periodontal pockets once a week for 4 weeks." | 7.67 | Slow release metronidazole and a simplified mechanical oral hygiene regimen in the control of chronic periodontitis. ( Addy, M; Newman, HN; wan Yusof, WZ; Yeung, FI, 1984) |
| "5% metronidazole solutions on the clinical and microbiologic parameters of adult periodontitis as compared with scaling and root planing." | 7.67 | Clinical and microbiologic changes following the irrigation of periodontal pockets with metronidazole or stannous fluoride. ( Bissada, NF; Lazzaro, AJ, 1989) |
| "The present study evaluated the effect of systemic metronidazole on advanced periodontitis in 10 patients with inadequate oral hygiene." | 7.67 | Systemic metronidazole in the treatment of periodontitis. ( Gilmour, WH; Jenkins, WM; MacFarlane, TW; MacKenzie, D; Ramsay, I, 1989) |
| "The aim of this study was to evaluate the effects of a gel containing 4% metronidazole and collagen in periodontal pockets deeper than 4 mm." | 7.67 | [Experimental study of a metronidazole gel inserted in periodontal pockets]. ( Bitton-Sebag, C; Charbit, Y; Hitzig, C; Lapougeas, JC; Teboul, M, 1989) |
| "The potential use of an adjunctive therapy of metronidazole plus amoxycillin for the subgingival elimination of Actinobacillus actinomycetemcomitans in periodontitis patients was investigated." | 7.67 | Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. ( Abbas, F; de Graaff, J; Goené, RJ; Rodenburg, JP; van Winkelhoff, AJ; Winkel, EG, 1989) |
| "Niridazole, metronidazole and tetracycline were compared for their activity against subgingival bacteria from patients with chronic periodontitis." | 7.67 | Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. ( Addy, M; Wade, WG, 1987) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 6.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| "In generalized periodontitis stage III/grade C, a clinically relevant lower percentage of disease progression after adjunctive systemic amoxicillin/metronidazole was observed compared to placebo (PLAC: 9." | 5.69 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis stage and grade: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Göde, M; Harks, I; Kaner, D; Kim, TS; Koch, R; Kocher, T; Lorenz, K; Meyle, J; Nickles, K; Schlagenhauf, U, 2023) |
| "Systemically healthy patients, with stages III-IV, grades B-C periodontitis, were randomly assigned to receive metronidazole or placebo adjunctive to periodontal surgery, after subgingival instrumentation." | 5.51 | Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial. ( Collins, JR; Figuero, E; González, R; Herrera, D; Marín, MJ; Ogando, G; Sanz, M, 2022) |
| " We hypothesize, if variables fall below or exceed these threshold levels, systemic amoxicillin/metronidazole may contribute to reducing progression of periodontitis." | 5.30 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Harks, I; Harmsen, D; Hoffmann, T; Kaner, D; Kim, TS; Koch, R; Kocher, T; Meyle, J; Schlagenhauf, U, 2019) |
| " Eighty participants with Aggregatibacter actinomycetemcomitans-associated moderate to advanced periodontitis were randomized into two treatment groups: group A, antibiotics (500 mg metronidazole plus 375 mg amoxicillin three times per day for 7 days) during the first, non-surgical phase of periodontal therapy (T1) and placebo during the second, surgical phase (T2); and group B, placebo during T1 and antibiotics during T2." | 5.20 | Differential benefits of amoxicillin-metronidazole in different phases of periodontal therapy in a randomized controlled crossover clinical trial. ( Almaghlouth, A; Cionca, N; Courvoisier, DS; Giannopoulou, C; Mombelli, A, 2015) |
| " The aim of this study was to compare interleukin-1β (IL-1β) and chemokine (C-C motif) ligand 28 (CCL28) levels following a topical application of curcumin (CRM), chlorhexidine (CHX) and chlorhexidine-metronidazole (CHX-MTZ) in an experimental gingivitis human model." | 5.20 | Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis. ( Nath, S; Pulikkotil, SJ, 2015) |
| " forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP)." | 5.19 | Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: an exploratory analysis from a randomized controlled clinical trial. ( Griffiths, GS; Guerrero, A; Lambertenghi, R; Nibali, L; Ready, D; Suvan, J; Tonetti, MS; Wilson, M, 2014) |
| "A total of 184 patients with moderate-to-severe periodontitis were randomly allocated to one of four treatment groups: 1) FDIS+metronidazole; 2) FDIS+placebo; 3) SRP+metronidazole; or 4) SRP+placebo." | 5.17 | A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results. ( Baelum, V; Gjermo, P; Gunleiksrud, TM; Preus, HR; Sandvik, L, 2013) |
| "The aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (AM) when performing full-mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment." | 5.16 | The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. ( Casarin, RC; Casati, MZ; Gonçalves, RB; Nociti, FH; Peloso Ribeiro, ED; Sallum, EA, 2012) |
| "To compare the effects of systemic amoxicillin (AMX) plus metronidazole (MET) or placebos combined with anti-infective mechanical debridement on the sub-gingival microbiota of generalized aggressive periodontitis (GAP)." | 5.15 | Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT. ( Colombo, AP; Feres-Filho, EJ; Heller, D; Silva-Senem, MX; Torres, MC; Varela, VM, 2011) |
| "To assess the clinical benefit of either metronidazole and amoxicillin or doxycycline administered immediately after completion of full-mouth scaling and root planing (FRP) for treatment of generalized aggressive periodontitis." | 5.15 | Analysis of clinical results of systemic antimicrobials combined with nonsurgical periodontal treatment for generalized aggressive periodontitis: a pilot study. ( Aslan, M; Baltacioglu, E; Saraç, Ö; Saybak, A; Yuva, P, 2011) |
| "The aim of this study is to evaluate the effects of metronidazole-amoxicillin combination on clinical and microbiologic parameters in patients with generalized aggressive periodontitis." | 5.14 | Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. ( Cintan, S; Issever, H; Kantarci, A; Kulekci, G; Topcuoglu, N; Yek, EC, 2010) |
| "To compare the therapeutic effects of minocycline, metronidazole and iodine glycerin on periodontitis." | 5.14 | [Therapeutic effects of three topical remedies on periodontitis]. ( Fu, XY; Li, GF, 2010) |
| "To evaluate and compare the effects of adjunctive metronidazole plus amoxicillin, doxycycline and metronidazole on clinical and microbiological parameters in patients with generalized aggressive periodontitis." | 5.12 | Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. ( Baka, A; Konstantinidis, A; Sakellari, D; Slini, T; Xajigeorgiou, C, 2006) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 5.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "The aims of the present study were to evaluate the clinical efficacy of, and to monitor microbiologically, repeated oral hygiene instructions alone or in combination with metronidazole 25% gel or subgingival scaling with or without metronidazole gel in treatment of new, residual or recurrent periodontal pockets in previously treated adult periodontitis patients." | 5.12 | Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study. ( Corbet, EF; Lee, DH; Zee, KY, 2006) |
| "To compare clinical changes occurring in chronic periodontitis subjects receiving SRP alone or with systemically administered azithromycin, metronidazole or a sub-antimicrobial dose of doxycycline." | 5.12 | Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results. ( Haffajee, AD; Socransky, SS; Torresyap, G, 2007) |
| "Subgingival application of chlorhexidine via a controlled-delivery device (CHX chip) improves the clinical outcome of scaling/root planing (SRP) in therapy for chronic periodontitis." | 5.12 | Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. ( Bernimoulin, JP; Friedmann, A; Hopfenmüller, W; Kaner, D; Kleber, BM, 2007) |
| "The present controlled, single-blind study was performed to assess and compare the clinical healing and the microbiological findings following repeated intrasulcular applications of 1% metronidazole or 1% chlorhexidine gels in persistent periodontal pockets previously treated by scaling and root planing (SRP)." | 5.11 | Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. ( Cordella, C; D'Ercole, S; Paolantonio, M; Perinetti, G; Piccolomini, R; Serra, E, 2004) |
| "The objective of this study was to assess the adjunctive clinical effect of the administration of systemic amoxicillin and metronidazole in the non-surgical treatment of generalized aggressive periodontitis (GAP)." | 5.11 | Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. ( Griffiths, GS; Guerrero, A; Laurell, L; Moles, DR; Nibali, L; Suvan, J; Tonetti, MS, 2005) |
| "Several studies have reported adjunctive benefits to scaling and root planing (SRP) of systemic amoxycillin and metronidazole in the treatment of periodontal diseases." | 5.10 | Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study. ( Addy, M; Newcombe, RG; Rooney, J; Sprague, SV; Wade, WG, 2002) |
| "To evaluate the efficacy of metronidazole on cyclosporine-induced gingival overgrowth (GO), a prospective intra-subject double-blind longitudinal study was performed on six heart transplant patients with GO." | 5.10 | Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients. ( Montebugnoli, L; Prati, C; Servidio, D, 2002) |
| "The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25% metronidazole dental gel as an adjunct to scaling and root planing (SRP) in the treatment of adult periodontitis." | 5.09 | Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results. ( Bilgiç, A; Buduneli, E; Evrenosoglu, E; Tünger, A, 2001) |
| "The effect of topical application of a metronidazole gel (ELYZOL DENTAL GEL), and adjunctive therapy in the treatment of adult periodontitis was assessed clinically." | 5.09 | Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy. ( Al-Mubarak, SA; Ho, A; Karring, T, 2000) |
| "A single-blind, randomised clinical trial of 28 smokers and 56 non-smokers, stratified for periodontitis disease severity and randomly allocated to 3 treatment groups: (1) Scaling and root planing using an ultrasonic scaler with local anaesthesia (SRP), (2) SRP+ metronidazole tabs 200 mg tds for 7 days, (3) SRP + 2 subgingival applications of 25% metronidazole gel." | 5.09 | Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers. ( Matthews, JP; Palmer, RM; Wilson, RF, 1999) |
| "The aim of this study was to examine the effect of periodontal surgery on PGE2 levels in patients treated for advanced adult periodontitis, with and without application of a 25% metronidazole gel over 12 months follow-up." | 5.09 | Periodontal flap surgery with 25% metronidazole gel. (2). Effect on gingival crevicular fluid PGE2. ( Collins, AM; Moles, DR; Needleman, IG, 2000) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 5.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "The aim of this study was to examine the effect of doxycycline, metronidazole, and clindamycin used adjunctively in a 2-step nonsurgical procedure in patients with rapidly progressive periodontitis (RPP)." | 5.09 | A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis. ( Beier, M; Glockmann, E; Klinger, G; Pfister, W; Sigusch, B, 2001) |
| "In this article the clinical and microbiological effects of systemic metronidazole in the treatment of refractory periodontitis in adult patients is discussed." | 5.09 | [Metronidazole in the treatment of refractory periodontitis]. ( van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 2000) |
| "The present study describes results on selected clinical and microbiological parameters obtained by treatment with local (Elyzol) and systemic (Flagyl) use of metronidazole alone and/or mechanical subgingival debridement in adult periodontitis." | 5.08 | A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. ( Acar, O; Büget, E; Kadir, T; Kuru, B; Noyan, U; Yilmaz, S, 1997) |
| "The Effect on the subgingival microflora of a single topical administration of a 95% collagen and 5% metronidazole device in combination with debridement was investigated in 30 adult periodontitis patients in comparison with mechanical treatment alone." | 5.08 | Effects of combined topical metronidazole and mechanical treatment on the subgingival flora in deep periodontal pockets in cuspids and bicuspids. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C, 1997) |
| "The present study compared the effectiveness of two antimicrobials, tetracycline and metronidazole, in reducing subgingival microorganisms in periodontal pockets using an ethyl cellulose strip as the delivery medium." | 5.08 | Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery system. ( Dudhani, RV; Jariwala, U; Jayachandran, P; Somayaji, BV; Vidyalakshmi, K, 1998) |
| "The present study was performed to assess and compare the clinical healing and the microbiological findings following local application of metronidazole or tetracycline to augment subgingival scaling in previously untreated adult periodontitis sites." | 5.08 | Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. ( Böe, OE; Bruun, G; Lie, T, 1998) |
| "The purpose of this study was to evaluate the clinical effects of a single application of a 5% metronidazole collagen device in periodontal pockets deeper than 5 mm, in association with debridement and without reinforcement of home care and hygiene as practiced by the patient at any time." | 5.07 | Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C; Teboul, M; Varonne, R, 1994) |
| "The aim of the study was to compare the clinical and microbiological effects of topical application of a metronidazole gel and a single session of subgingival scaling in the treatment of adult periodontitis." | 5.07 | Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. ( Karring, T; Kilian, M; Pedrazzoli, V, 1992) |
| "This report presents the findings from an open randomized multicentre clinical trial designed to compare the clinical efficacy of scaling with application of 3 different preparations/dose frequencies of topical metronidazole in the treatment of adult periodontitis." | 5.07 | 3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. ( Attström, R; Karring, T; Kisch, J; Klinge, B; Lewin, B; Stoltze, K, 1992) |
| "A newly developed metronidazole 25% dental gel was compared with subgingival scaling in the treatment of adult periodontitis." | 5.07 | Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. ( Ainamo, J; Ellingsen, BH; Hansen, BF; Johansson, LA; Karring, T; Kisch, J; Lie, T; Paunio, K; Stoltze, K, 1992) |
| "The efficacy of metronidazole and doxycycline in preventing recurrent periodontitis was studied in 23 patients." | 5.07 | Serial doxycycline and metronidazole in prevention of recurrent periodontitis in high-risk patients. ( Aitken, S; Birek, P; Kulkarni, GV; Lee, WL; McCulloch, CA, 1992) |
| "The effect of adjunctive systemic metronidazole was studied in patients with moderate and advanced periodontitis recalcitrant to comprehensive non-surgical treatment." | 5.06 | The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. ( Engström, PE; Frithiof, L; Nedlich, U; Rubin, B; Söder, B; Söder, PO; Wikner, S; Wouters, F, 1990) |
| "The influence of a systemic metronidazole therapy in case of marked marginal periodontitis on clinical parameter and the subjective pocket flora was examined." | 5.06 | [Influence of systemic metronidazole therapy on the flora of the periodontal gingival pocket]. ( Gäbler, K, 1989) |
| " This study evaluated chlorhexidine, metronidazole, and tetracycline delivered into periodontal pockets in an acrylic resin vehicle and compared the results with root planed and untreated sites over a three-month follow-up period." | 5.06 | Use of antimicrobial containing acrylic strips in the treatment of chronic periodontal disease. A three month follow-up study. ( Addy, M; Hassan, H; Moran, J; Newcombe, R; Wade, W, 1988) |
| "This double-blind cross-over study was undertaken to assess the effect of systemically administered metronidazole when used as an adjunct to periodontal surgery for the treatment of moderate and advanced periodontitis." | 5.06 | The value of systemically administered metronidazole in the modified Widman flap procedure. ( Dolby, AE; Mahmood, MM, 1987) |
| "Meta-analysis was used to assess the effectiveness of local delivery of metronidazole alone or as an adjunct to mechanical therapy in patients with chronic periodontitis." | 4.82 | Meta-analysis of local metronidazole in the treatment of chronic periodontitis. ( Angelillo, IF; Bianco, A; Nobile, CG; Pavia, M, 2004) |
| "Controlled release devices containing tetracyclines or metronidazole are now commercially available for use in periodontal pockets." | 4.79 | The role of antibiotics in the treatment of periodontitis. (Part I--Systemic delivery. ( Foyle, DM; Needleman, IG; Pandya, NV; Smith, SR, 1994) |
| "The purpose of this meta-analysis was to provide a quantitative overview of clinical trials assessing the use of systemic metronidazole (S-MET) as an adjunct to scaling and root planning (S&RP) in the treatment of adult periodontitis." | 4.79 | Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis. ( Beck, JD; Elter, JR; Lawrence, HP; Offenbacher, S, 1997) |
| "Twenty (20) patients with severe periodontitis underwent a single session of One-Stage Full-Mouth Instrumentation (OSFMI) involving supra- and sub-gingival air-polishing with erythritol and chlorhexidine powder and ultrasonic root surface debridement and calculus removal, in association with systemic amoxicillin and metronidazole." | 3.96 | One-Stage Full Mouth Instrumentation (OSFMI): Clinical Outcomes of an Innovative Protocol for the Treatment of Severe Periodontitis. ( Calza, S; Feres, M; Garzetti, G; Mensi, M; Scotti, E; Sordillo, A, 2020) |
| "Metronidazole (MZ) and levofloxacin (LF) are widely employed for treatment of periodontitis, but high oral dose and resistance development after long-term oral administration limit their use." | 3.83 | Development and Evaluation of Biodegradable Chitosan Films of Metronidazole and Levofloxacin for the Management of Periodontitis. ( Bansal, M; Khan, G; Mishra, B; Nath, G; Patel, RR; Yadav, SK, 2016) |
| "This study was performed to obtain prolonged drug release with biodegradable in situ forming implants for the local delivery of metronidazole to periodontal pockets." | 3.80 | In situ forming implants for the delivery of metronidazole to periodontal pockets: formulation and drug release studies. ( Bodmeier, R; Kilicarslan, M; Koerber, M, 2014) |
| "The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis." | 3.78 | Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. ( De Micheli, G; Hirata, MH; Hirata, RD; Lima Neto, LG; Lotufo, RF; Lourenção, DS; Pannuti, CM; Rodrigues, AS, 2012) |
| "Topical metronidazole benzoate preparations, applied directly into the space between the teeth and, periodontal tissue, are the treatment of choice for periodontal pockets." | 3.73 | [Assessment of feasibility of formulation of a preparation for growth inhibition of metronidazole-resistant strains isolated from periodontal pockets]. ( Loncar, I; Nonković, Z; Toskić-Radojicić, M; Varjacić, M, 2005) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 3.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| " actinomycetemcomitans-associated periodontitis during successive non-surgical and adjunctive metronidazole plus amoxicillin (or ciprofloxacin) (AB) therapy." | 3.70 | Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis. ( Borneff, M; Heinecke, A; Kiencke, C; Knopf, A; Müller, HP; Pohl, S, 1998) |
| "Elyzo 25% Dentalgel (EDG) which is developed for use in the treatment of periodontitis is a suspension of metronidazole benzoate (40%) in a mixture of glyceryl mono-oleate (GMO) and triglyceride (sesame oil)." | 3.69 | Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets. ( Stoltze, K, 1995) |
| "The peripheral distribution of spiramycin and metronidazole, which are combined in the proprietary drug "Rodogyl", has been studied in gingival fluid, saliva and blood after a single administration to 12 healthy volunteers and after repeated administration to 4 patients with recurring severe periodontitis." | 3.69 | Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood. ( Cimasoni, G; Le Liboux, A; Pichard, E; Rotzetter, PA, 1994) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 3.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "We report on the microbiological and clinical effects of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with Actinobacillus actinomycetemcomitans-associated periodontitis." | 3.68 | Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. ( de Graaff, J; Tijhof, CJ; van Winkelhoff, AJ, 1992) |
| "The metronidazole concentration was monitored in gingival crevicular fluid (GCF) of inflamed periodontal pockets after 1 application of a 25% gel." | 3.68 | Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. ( Stoltze, K, 1992) |
| "Systemic absorption of metronidazole was studied after one application of a metronidazole 25% dental gel into inflamed periodontal pockets." | 3.68 | Systemic absorption of metronidazole after application of a metronidazole 25% dental gel. ( Stellfeld, M; Stoltze, K, 1992) |
| "The present study was performed to assess the effect of topical metronidazole therapy on ligature-induced periodontitis in beagle dogs." | 3.68 | The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. ( Attström, R; Edwardsson, S; Kalfas, S; Klinge, B; Kuvatanasuhati, J, 1992) |
| "This study investigated the effects of root planing and/or the placement of acrylic strips containing chlorhexidine, metronidazole or tetracycline on the composition and antimicrobial susceptibility of the subgingival flora in chronic periodontitis." | 3.68 | The effects of antimicrobial acrylic strips on the subgingival microflora in chronic periodontitis. ( Addy, M; Moran, J; Morgan, JR; Newcombe, R; Wade, WG, 1992) |
| "Chemical and biological assessment was done in vitro of a form of metronidazole for application into deep pouches in periodontal diseases." | 3.68 | [In vitro assessment of metronidazole adapted to the treatment of periodontopathies]. ( Chomyszyn-Gajewska, M; Kasprowicz, A; Kluczykowska, B, 1990) |
| " This study attempts to measure changes in flora by a number of methods following the placement of 40% metronidazole acrylic strips into periodontal pockets." | 3.67 | Simple bacteriological methods to assess changes in subgingival microflora produced by metronidazole-containing acrylic strips placed into periodontal pockets. ( Addy, M; Alam, L; Rawle, L, 1984) |
| "The purpose of this study was to develop a sustained release device containing metronidazole for insertion within periodontal pockets and to examine the release kinetics in vitro and in vivo." | 3.67 | Sustained release device containing metronidazole for periodontal use. ( Friedman, M; Golomb, G; Sela, MN; Soskolne, A; Stabholz, A, 1984) |
| "5%) and the other high (40%) dose metronidazole locally in periodontal pockets once a week for 4 weeks." | 3.67 | Slow release metronidazole and a simplified mechanical oral hygiene regimen in the control of chronic periodontitis. ( Addy, M; Newman, HN; wan Yusof, WZ; Yeung, FI, 1984) |
| "5% metronidazole solutions on the clinical and microbiologic parameters of adult periodontitis as compared with scaling and root planing." | 3.67 | Clinical and microbiologic changes following the irrigation of periodontal pockets with metronidazole or stannous fluoride. ( Bissada, NF; Lazzaro, AJ, 1989) |
| "The present study evaluated the effect of systemic metronidazole on advanced periodontitis in 10 patients with inadequate oral hygiene." | 3.67 | Systemic metronidazole in the treatment of periodontitis. ( Gilmour, WH; Jenkins, WM; MacFarlane, TW; MacKenzie, D; Ramsay, I, 1989) |
| "The aim of this study was to evaluate the effects of a gel containing 4% metronidazole and collagen in periodontal pockets deeper than 4 mm." | 3.67 | [Experimental study of a metronidazole gel inserted in periodontal pockets]. ( Bitton-Sebag, C; Charbit, Y; Hitzig, C; Lapougeas, JC; Teboul, M, 1989) |
| "The potential use of an adjunctive therapy of metronidazole plus amoxycillin for the subgingival elimination of Actinobacillus actinomycetemcomitans in periodontitis patients was investigated." | 3.67 | Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. ( Abbas, F; de Graaff, J; Goené, RJ; Rodenburg, JP; van Winkelhoff, AJ; Winkel, EG, 1989) |
| "Niridazole, metronidazole and tetracycline were compared for their activity against subgingival bacteria from patients with chronic periodontitis." | 3.67 | Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. ( Addy, M; Wade, WG, 1987) |
| " Two double blind studies are reviewed which indicate that metronidazole plus mechanical debridement of the root surfaces is significantly better than placebo plus mechanical debridement in the treatment of advanced cases of periodontitis especially when the periodontal pockets are 6 mm or more in depth." | 3.67 | The therapeutic use of antimicrobial agents in patients with periodontal disease. ( Loesche, WJ, 1985) |
| "In this study, 178 chronic periodontitis subjects were recruited and clinically monitored at baseline, 3, 6, 12, 18 and 24 months after therapy." | 2.78 | Effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. I. Overall effect and kinetics of change. ( Bogren, A; Goodson, JM; Haffajee, AD; Hasturk, H; Lindhe, J; Socransky, SS; Teles, R; van Dyke, T; Wang, X; Wennstrom, JL, 2013) |
| "Twenty-seven chronic periodontitis (CP) patients were randomly divided into three parallel groups each comprising nine individuals with at least four teeth having at least one approximal site with a probing depth (PD) of ≥5 mm and gingival index (GI) of ≥2 in each quadrant." | 2.77 | Er:YAG laser versus systemic metronidazole as an adjunct to nonsurgical periodontal therapy: a clinical and microbiological study. ( Eren-Kuru, B; Gursoy, H; Kadir, T; Kut, B; Noyan, U; Yilmaz, S, 2012) |
| "Metronidazole was applied to the free gingival margins and/or over the exposed membrane at every prophylactic visit (EG)." | 2.71 | Guided tissue regeneration in smokers: effect of aggressive anti-infective therapy in Class II furcation defects. ( Machtei, EE; Oettinger-Barak, O; Peled, M, 2003) |
| "Twenty-five localized juvenile periodontitis (LJP) patients from a Brazilian population were randomly allocated into an experimental group receiving mechanical treatment and antibiotics, and a control group receiving mechanical treatment and placebo." | 2.69 | Clinical and microbiological effects of adjunctive antibiotics in treatment of localized juvenile periodontitis. A controlled clinical trial. ( Beldi, MI; Bellini, HT; Campedelli, F; Gjermo, P; Lana, M; Loureiro, CA; Preus, HR; Rams, TE; Tinoco, EM; Tinoco, NM, 1998) |
| "Twenty adult patients with untreated periodontitis and subgingival colonization of A." | 2.69 | Clonal infection with Actinobacillus actinomycetemcomitans following periodontal therapy. ( Beikler, T; Ehmke, B; Flemmig, TF; Karch, H; Klaiber, B; Kopp, C; Schmidt, H, 1999) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 2.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| "Metronidazole (MET) has been suggested as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis." | 2.50 | Effectiveness of metronidazole as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis. ( Gatto, R; Monaco, A; Petrucci, A; Severino, M; Sgolastra, F, 2014) |
| "Periodontal diseases are common oral diseases that afflict all humans to some degree." | 2.37 | Current concepts in periodontal diseases. ( Higgins, TJ; Hunter, N; Knox, KW, 1985) |
| "Patients with chronic periodontitis (CP) may yield multiple species of putative periodontal bacterial pathogens that vary in their antibiotic drug susceptibility." | 1.40 | Antibiotic resistance in human chronic periodontitis microbiota. ( Degener, JE; Rams, TE; van Winkelhoff, AJ, 2014) |
| "gingivalis in patients with chronic periodontitis and to assess antimicrobial susceptibility in terms of minimum inhibitory concentration (MIC) of clinical isolates to metronidazole and tetracycline." | 1.40 | Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis. ( Acosta, A; Araya, N; Gamboa, F; García, DA; Ledergerber, R; Velosa, J, 2014) |
| "Metronidazole was effective against all isolates except for a few strains of B." | 1.28 | Identification, and susceptibility to seven antimicrobial agents, of 61 gram-negative anaerobic rods from periodontal pockets. ( Abu-Fanas, SH; Drucker, DB; Ganguli, LA; Hull, PS; Reeder, JC, 1991) |
| "Metronidazole was significantly more effective than tetracycline or chlorhexidine on spirochaetes." | 1.27 | Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline. ( Addy, M; Langeroudi, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (12.94) | 18.7374 |
| 1990's | 62 (30.85) | 18.2507 |
| 2000's | 49 (24.38) | 29.6817 |
| 2010's | 58 (28.86) | 24.3611 |
| 2020's | 6 (2.99) | 2.80 |
| Authors | Studies |
|---|---|
| Collins, JR | 1 |
| Ogando, G | 1 |
| González, R | 1 |
| Figuero, E | 1 |
| Marín, MJ | 1 |
| Sanz, M | 2 |
| Herrera, D | 1 |
| Zussman, M | 1 |
| Zilberman, M | 2 |
| Eickholz, P | 6 |
| Koch, R | 3 |
| Göde, M | 1 |
| Nickles, K | 2 |
| Kocher, T | 3 |
| Lorenz, K | 1 |
| Kim, TS | 4 |
| Meyle, J | 3 |
| Kaner, D | 5 |
| Schlagenhauf, U | 3 |
| Harks, I | 3 |
| Ehmke, B | 4 |
| Ardila, CM | 3 |
| Flórez-Flórez, J | 1 |
| Castañeda-Parra, LD | 1 |
| Guzmán, IC | 2 |
| Bedoya-García, JA | 2 |
| Mensi, M | 1 |
| Feres, M | 9 |
| Calza, S | 1 |
| Sordillo, A | 1 |
| Scotti, E | 1 |
| Garzetti, G | 1 |
| Hernández-Casas, C | 1 |
| Usin, MM | 1 |
| Tabares, SM | 1 |
| Menso, J | 1 |
| de Albera, ER | 1 |
| Sembaj, A | 1 |
| Mei, L | 1 |
| Huang, X | 1 |
| Xie, Y | 1 |
| Chen, J | 1 |
| Huang, Y | 1 |
| Wang, B | 1 |
| Wang, H | 1 |
| Pan, X | 1 |
| Wu, C | 1 |
| Mombelli, A | 7 |
| Souto, MLS | 1 |
| Rovai, ES | 1 |
| Ganhito, JA | 1 |
| Holzhausen, M | 1 |
| Chambrone, L | 2 |
| Pannuti, CM | 2 |
| Hoffmann, T | 2 |
| Harmsen, D | 1 |
| Gonçalves, PF | 2 |
| Huang, H | 2 |
| McAninley, S | 1 |
| Alfant, B | 1 |
| Harrison, P | 2 |
| Aukhil, I | 3 |
| Walker, C | 1 |
| Shaddox, LM | 3 |
| Zhou, K | 1 |
| Ji, PH | 1 |
| Yu, LY | 1 |
| Chen, Q | 1 |
| Xu, QL | 1 |
| Sgolastra, F | 1 |
| Severino, M | 1 |
| Petrucci, A | 1 |
| Gatto, R | 1 |
| Monaco, A | 1 |
| Rams, TE | 5 |
| Degener, JE | 3 |
| van Winkelhoff, AJ | 10 |
| Socransky, SS | 8 |
| Haffajee, AD | 5 |
| Teles, R | 4 |
| Wennstrom, JL | 1 |
| Lindhe, J | 4 |
| Bogren, A | 2 |
| Hasturk, H | 2 |
| van Dyke, T | 2 |
| Wang, X | 2 |
| Goodson, JM | 3 |
| Vovk, A | 2 |
| Allin, N | 1 |
| Hou, W | 1 |
| Wallet, SM | 1 |
| Faveri, M | 6 |
| Rebello, A | 1 |
| de Oliveira Dias, R | 1 |
| Borges-Junior, I | 1 |
| Duarte, PM | 3 |
| Figueiredo, LC | 6 |
| Arweiler, NB | 1 |
| Pietruska, M | 1 |
| Skurska, A | 1 |
| Dolińska, E | 1 |
| Pietruski, JK | 1 |
| Bläs, M | 1 |
| Auschill, TM | 1 |
| Sculean, A | 4 |
| Kilicarslan, M | 1 |
| Koerber, M | 1 |
| Bodmeier, R | 1 |
| Preus, HR | 5 |
| Sandvik, L | 2 |
| Gjermo, P | 5 |
| Baelum, V | 4 |
| Labib, GS | 1 |
| Aldawsari, HM | 1 |
| Badr-Eldin, SM | 1 |
| Soares, GM | 3 |
| Mendes, JA | 3 |
| Silva, MP | 3 |
| Miranda, TS | 2 |
| Perez-Chaparro, PJ | 1 |
| Tamashiro, NS | 1 |
| Bastos, MF | 1 |
| Guerrero, A | 2 |
| Nibali, L | 2 |
| Lambertenghi, R | 1 |
| Ready, D | 1 |
| Suvan, J | 3 |
| Griffiths, GS | 3 |
| Wilson, M | 1 |
| Tonetti, MS | 2 |
| Merchant, SN | 1 |
| Kalash, D | 1 |
| Hovencamp, N | 1 |
| Zapert, E | 1 |
| Bidwell, J | 1 |
| Varnado, P | 1 |
| Almaghlouth, A | 2 |
| Cionca, N | 4 |
| Courvoisier, DS | 2 |
| Giannopoulou, C | 5 |
| Kolakovic, M | 1 |
| Held, U | 1 |
| Schmidlin, PR | 1 |
| Sahrmann, P | 1 |
| Gamboa, F | 1 |
| Acosta, A | 1 |
| García, DA | 1 |
| Velosa, J | 1 |
| Araya, N | 1 |
| Ledergerber, R | 1 |
| Scheie, AA | 1 |
| Dahlen, G | 1 |
| Bergamaschi, CC | 1 |
| Santamaria, MP | 1 |
| Berto, LA | 1 |
| Cogo-Müller, K | 1 |
| Motta, RH | 1 |
| Salum, EA | 1 |
| Nociti Júnior, FH | 1 |
| Groppo, FC | 1 |
| Neering, SH | 1 |
| Adyani-Fard, S | 1 |
| Klocke, A | 1 |
| Rüttermann, S | 1 |
| Flemmig, TF | 2 |
| Beikler, T | 2 |
| Siqueira, SJ | 1 |
| Ribeiro, FV | 2 |
| Villalpando, KT | 1 |
| Cirano, FR | 1 |
| Pimentel, SP | 1 |
| Rabelo, CC | 1 |
| Gonçalves, C | 1 |
| Tu, YK | 1 |
| Pulikkotil, SJ | 1 |
| Nath, S | 1 |
| Jepsen, K | 1 |
| Jepsen, S | 1 |
| Laine, ML | 1 |
| Anssari Moin, D | 1 |
| Pilloni, A | 1 |
| Zeza, B | 1 |
| Ortiz-Vigon, A | 1 |
| Roos-Jansåker, AM | 1 |
| Renvert, S | 1 |
| Khan, G | 1 |
| Yadav, SK | 1 |
| Patel, RR | 1 |
| Nath, G | 1 |
| Bansal, M | 1 |
| Mishra, B | 1 |
| Zandbergen, D | 1 |
| Slot, DE | 1 |
| Niederman, R | 1 |
| Van der Weijden, FA | 1 |
| Doering, S | 1 |
| Gravemeier, M | 1 |
| Akincibay, H | 1 |
| Orsal, SO | 1 |
| Sengün, D | 1 |
| Tözüm, TF | 1 |
| Shifrovitch, Y | 1 |
| Binderman, I | 1 |
| Bahar, H | 1 |
| Berdicevsky, I | 1 |
| Ugolotti, G | 2 |
| Romeo, E | 1 |
| Lops, D | 1 |
| Storelli, S | 1 |
| Ghisolfi, M | 1 |
| Ribeiro, Edel P | 1 |
| Bittencourt, S | 1 |
| Zanin, IC | 1 |
| Bovi Ambrosano, GM | 1 |
| Sallum, EA | 2 |
| Nociti, FH | 2 |
| Gonçalves, RB | 2 |
| Casati, MZ | 2 |
| Winkel, EG | 6 |
| Yek, EC | 1 |
| Cintan, S | 1 |
| Topcuoglu, N | 1 |
| Kulekci, G | 1 |
| Issever, H | 1 |
| Kantarci, A | 1 |
| Buchmann, R | 2 |
| Conrads, G | 1 |
| Fu, XY | 1 |
| Li, GF | 1 |
| Granada, MI | 1 |
| Heller, D | 2 |
| Varela, VM | 2 |
| Silva-Senem, MX | 2 |
| Torres, MC | 2 |
| Feres-Filho, EJ | 2 |
| Colombo, AP | 2 |
| Bernimoulin, JP | 4 |
| Dietrich, T | 1 |
| Kleber, BM | 2 |
| Friedmann, A | 2 |
| Bono, A | 1 |
| Brunotto, M | 1 |
| Sirotto, TA | 1 |
| Baltacioglu, E | 1 |
| Aslan, M | 1 |
| Saraç, Ö | 1 |
| Saybak, A | 1 |
| Yuva, P | 1 |
| Kumari, N | 1 |
| Pathak, K | 1 |
| Rodrigues, AS | 1 |
| Lourenção, DS | 1 |
| Lima Neto, LG | 1 |
| Hirata, RD | 1 |
| Hirata, MH | 1 |
| Lotufo, RF | 1 |
| De Micheli, G | 1 |
| Casarin, RC | 1 |
| Peloso Ribeiro, ED | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Adjunctive Use of Antimicrobial Photodynamic Therapy, Light-emitting-diode Photobiomodulation, and Ozone Therapy in Regenerative Treatment of Stage III Grade C Periodontitis[NCT05447026] | 48 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery[NCT05027893] | 157 participants (Actual) | Interventional | 2019-06-07 | Active, not recruiting | |||
| Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization[NCT00707369] | Phase 4 | 540 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| Mechanisms and Treatment Response of Aggressive Periodontitis in Children: Aberrant Immunological Phenotypes/Functions in the Progression of AgP[NCT01330719] | 514 participants (Actual) | Interventional | 2006-12-31 | Active, not recruiting | |||
| Timing of Administration of Systemic Antibiotics Associated With Scaling and Root Planing in the Treatment of Periodontitis: Clinical and Microbiological Evaluation[NCT06177119] | 72 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | |||
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial[NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Clinical Effects of Doxycycline in the Treatment of Aggressive Periodontitis: Comparative Clinical Study[NCT03727620] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| Comparing the Effect of 0,06 % -, 0,12 % and 0,2 % Chlorhexidine on Plaque, Bleeding and Side Effects in an Experimental Gingivitis Model. A Parallel, Double Masked, Randomized, Placebo-controlled Clinical Trial[NCT02911766] | Phase 4 | 59 participants (Anticipated) | Interventional | 2016-11-30 | Not yet recruiting | ||
| The Plaque- and Gingivitis Inhibiting Capacity of a Commercially Available Mouthwash Containing Essential Oils and Ethyl Lauroyl Arginate: A Parallel, Split-mouth, Double Blind, Randomized, Placebo-controlled Clinical Study[NCT02884817] | Phase 4 | 59 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Reconstructive Surgical Therapy of Peri-implantitis-related Osseous Defects. A Multicenter Randomized Controlled Clinical Trial[NCT03077061] | 140 participants (Actual) | Interventional | 2017-04-01 | Active, not recruiting | |||
| Reconstructive Surgical Treatment of Peri-implant Intra-osseous Defects - A MULTICENTER RANDOMIZED PROSPECTIVE CLINICAL STUDY[NCT02406001] | 70 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy: A Randomized Controlled Clinical Trial With Biochemical Analysis[NCT05657015] | Phase 4 | 30 participants (Actual) | Interventional | 2021-09-01 | Completed | ||
| Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial[NCT02135952] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | ||
| Effect of Non Surgical Therapy on Calprotectin and Periostin Levels in Patients With Periodontitis and Cardiovascular Diseases - An Interventional Study[NCT05618743] | 45 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | |||
| Clarithromycin as Adjuvant to Periodontal Debridement in the Treatment of Generalized Aggressive Periodontitis: Randomized Clinical Trial[NCT02829983] | 40 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| Influence of Moment of Systemic Metronidazole and Amoxicillin Administration in the Treatment of Chronic Periodontitis: a Randomized Clinical Trial.[NCT02954393] | 180 participants (Anticipated) | Interventional | 2015-05-31 | Active, not recruiting | |||
| Clinical, Microbiological and Immunological Evaluation of the Effects of Systemic Probiotics in the Periodontal Treatment[NCT03733379] | Phase 3 | 176 participants (Anticipated) | Interventional | 2018-11-05 | Recruiting | ||
| Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone[NCT00296881] | Phase 4 | 80 participants (Actual) | Interventional | 2006-04-30 | Active, not recruiting | ||
| A Multicenter, Randomized, Blinded Study of Two Treatments of Photoactivated Disinfection With SRP Against One Treatment of Photoactivated Disinfection With SRP Against SRP Alone in the Treatment of Chronic Periodontitis[NCT00336661] | Phase 3 | 105 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis[NCT00297531] | Phase 4 | 120 participants (Anticipated) | Interventional | 2006-04-30 | Active, not recruiting | ||
| A Multicenter, Randomized, Examiner Blinded Study of Photoactivated Disinfection With Scaling and Root Planing in the Treatment of Chronic Periodontitis[NCT00297518] | Phase 4 | 40 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| EFFECT OF LOCALLY DELIVERED ALOE VERA GEL AS AN ADJUNCT TO SCALING AND ROOT PLANING IN THE TREATMENT OF CHRONIC PERIODONTITIS: A SPLIT-MOUTH CLINICAL AND MICROBIOLOGICAL STUDY[NCT02462993] | Phase 2/Phase 3 | 12 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| Effectiveness of Metronidazole Gel and Mobile Telephone Short- Message Service Reminders on Gingivitis in Orthodontic Patients: A Randomized Controlled Trial[NCT03508999] | Phase 4 | 63 participants (Actual) | Interventional | 2018-05-23 | Completed | ||
| Vital Root-resective Therapy in Furcation-involved Maxillary Molars[NCT05259982] | 10 participants (Anticipated) | Interventional | 2022-03-04 | Active, not recruiting | |||
| Short & Medium Term Outcomes of Periodontal Regenerative Procedures. A Two-part Study With a) Analysis of Periodontal Records of a Cohort of Periodontitis Patients and b) a Single Visit Recall and Comprehensive Periodontal Re-evaluation[NCT04971174] | 200 participants (Anticipated) | Observational | 2022-09-30 | Enrolling by invitation | |||
| Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial[NCT02223702] | Phase 4 | 39 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Observational Study on Cytokine Production by Leukocytes of Papillon-Lefèvre Syndrome Patients and Healthy Probands in Whole Blood Cultures[NCT01116934] | 17 participants (Actual) | Observational | 2006-07-31 | Completed | |||
| The Effect of Preoperative Antibiotics on Peri-implant Crestal Bone Remodelling and Postoperative Pain: A Randomized Controlled Trial[NCT04280406] | Phase 1 | 50 participants (Anticipated) | Interventional | 2020-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Distance from bottom of pocket to the cement-enamel junction (CEJ). (NCT02829983)
Timeframe: 6 months
| Intervention | milimeter (Mean) |
|---|---|
| Clarithromycin Group | 2.71 |
| Placebo Group | 3.03 |
Distance from the bottom of sulcus/pocket to gingival margin (NCT02829983)
Timeframe: 6 months
| Intervention | milimeter (Mean) |
|---|---|
| Clarithromycin Group | 2.53 |
| Placebo Group | 2.86 |
Attachment loss were recorded at baseline, 1st, 3rd and 6th months as millimeters. The data were compared among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 5.03 | 4.37 | 4.41 | 4.33 |
| Moxifloxacin | 4.94 | 4.14 | 3.98 | 4.30 |
We measured the probing depth at baseline, 1st, 3rd and 6th months. The changes were evaluated among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 4.57 | 3.12 | 3.11 | 3.15 |
| Moxifloxacin | 4.18 | 2.91 | 2.79 | 3.01 |
Concentrations of IL-8, IL-6, IP-10, interferon (IFN)-gamma, and IL-1 beta, in plasma/RPMI samples were determined by enzyme linked immunosorbent assay (ELISA) according to the manufacturers' instructions (NCT01116934)
Timeframe: 2006
| Intervention | pg/ml (Median) | ||||
|---|---|---|---|---|---|
| interleukin-1 beta | interleukin-6 | interferon-inducible protein-10 | interferon gamma | interleukin-8 | |
| Healthy Controls | 896.21 | 45734 | 11563 | 3317.4 | 44390 |
| Papillon-Lefèvre Syndrome (PLS) Patients | 1100.00 | 65559 | 12902.5 | 3704.5 | 50520 |
16 reviews available for metronidazole and Pocket, Periodontal
| Article | Year |
|---|---|
Microbial colonization of the periodontal pocket and its significance for periodontal therapy.
Topics: Amoxicillin; Anti-Bacterial Agents; Bacteria; Bacterial Physiological Phenomena; Biodiversity; Denta | 2018 |
Efficacy of systemic antibiotics in nonsurgical periodontal therapy for diabetic subjects: a systematic review and meta-analysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Diabetes Mellitus; Doxycycline; Drug Therapy, Co | 2018 |
Effectiveness of metronidazole as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis.
Topics: Anti-Infective Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling; Humans; Met | 2014 |
An estimate of pocket closure and avoided needs of surgery after scaling and root planing with systemic antibiotics: a systematic review.
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modali | 2014 |
Systemic antibiotics in the treatment of aggressive periodontitis. A systematic review and a Bayesian Network meta-analysis.
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Bayes Theorem; Combined Modality Thera | 2015 |
The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Perio | 2016 |
The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Perio | 2016 |
The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Perio | 2016 |
The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Perio | 2016 |
Amoxicillin/metronidazole or scaling and root planing in the treatment of chronic periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodontitis; Dental Plaque Inde | 2010 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of local metronidazole in the treatment of chronic periodontitis.
Topics: Administration, Topical; Adult; Anti-Infective Agents, Local; Chronic Disease; Dental Scaling; Human | 2004 |
Pharmacological control of periodontal disease. II. Antimicrobial agents.
Topics: Adult; Anti-Bacterial Agents; Child; Humans; Metronidazole; Periodontal Diseases; Periodontal Pocket | 1995 |
The role of antibiotics in the treatment of periodontitis (Part 2--Controlled drug delivery).
Topics: Anti-Bacterial Agents; Delayed-Action Preparations; Drug Delivery Systems; Gels; Humans; Metronidazo | 1995 |
The role of antibiotics in the treatment of periodontitis. (Part I--Systemic delivery.
Topics: Adult; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Metron | 1994 |
Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis.
Topics: Adult; Anti-Infective Agents; Combined Modality Therapy; Confidence Intervals; Dental Scaling; Dose- | 1997 |
Locally delivered antimicrobials in periodontal therapy.
Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antitrichomonal Agents | 1997 |
Local antimicrobial therapies in periodontal disease.
Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents; Biocompatible Materials; Cell | 2000 |
Current concepts in periodontal diseases.
Topics: Acute Disease; Adult; Child; Chronic Disease; Dental Plaque; Gingivitis; Gingivitis, Necrotizing Ulc | 1985 |
113 trials available for metronidazole and Pocket, Periodontal
| Article | Year |
|---|---|
Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Double-Blind Method; Humans; Metronidazole; Peri | 2022 |
Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis stage and grade: An exploratory sub-analysis of the ABPARO trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Male; Metronidazole; Periodontal Pocket; | 2023 |
Moxifloxacin versus amoxicillin plus metronidazole as adjunctive therapy for generalized aggressive periodontitis: a pilot randomized controlled clinical trial.
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; | 2020 |
Effects on clinical outcomes of adjunctive moxifloxacin versus amoxicillin plus metronidazole in periodontitis patients harboring Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia: exploratory analyses from a clinic
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Humans; Metronidaz | 2021 |
Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Attachment Lo | 2019 |
Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis.
Topics: Adolescent; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Black or African American; | 2013 |
Effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. I. Overall effect and kinetics of change.
Topics: Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Bacteroides; Biofilms; Capnocytophaga; Chronic P | 2013 |
LPS-induced inflammatory response after therapy of aggressive periodontitis.
Topics: Adolescent; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Chemokine CCL2; Chemokine | 2013 |
Clinical and microbiologic effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized chronic periodontitis: smokers versus non-smokers.
Topics: Actinomyces; Adult; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Cohort Studies; Combi | 2014 |
Nonsurgical treatment of aggressive periodontitis with photodynamic therapy or systemic antibiotics. Three-month results of a randomized, prospective, controlled clinical study.
Topics: Administration, Oral; Adult; Aggressive Periodontitis; Amoxicillin; Analysis of Variance; Anti-Bacte | 2013 |
Baseline adjustment and change revisited: effect of smoking on change in periodontal status following periodontal therapy.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Anti-Infective Agents; Bias; Combined Modality Thera | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1-year outcomes of a randomized placebo-controlled clinical trial.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Chronic Periodonti | 2014 |
Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: an exploratory analysis from a randomized controlled clinical trial.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; | 2014 |
Localized aggressive periodontitis treatment response in primary and permanent dentitions.
Topics: Adolescent; Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Child; Child, Presc | 2014 |
Differential benefits of amoxicillin-metronidazole in different phases of periodontal therapy in a randomized controlled crossover clinical trial.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Combined Mod | 2015 |
The effect of metronidazole on the presence of P. gingivalis and T. forsythia at 3 and 12 months after different periodontal treatment strategies evaluated in a randomized, clinical trial.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Anti-Infective Agents; Anti-Infective Agents, Lo | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: A pilot study.
Topics: Chronic Periodontitis; Dental Scaling; Follow-Up Studies; Humans; Metronidazole; Periodontal Attachm | 2016 |
Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis.
Topics: Administration, Topical; Adolescent; Adult; Anti-Infective Agents; Anti-Infective Agents, Local; Ant | 2015 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Is furcation involvement affected by adjunctive systemic amoxicillin plus metronidazole? A clinical trials exploratory subanalysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Double-Blind Method; Follow-Up Studies; Humans; | 2016 |
Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: a clinical and microbiologic study.
Topics: Administration, Oral; Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Ba | 2008 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Full-mouth ultrasonic debridement associated with amoxicillin and metronidazole in the treatment of severe chronic periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacteroides; | 2009 |
Microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin/metronidazole in chronic periodontitis.
Topics: Adult; Amoxicillin; Anti-Infective Agents; Antibiotic Prophylaxis; Bacteria; Chronic Periodontitis; | 2010 |
Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Ant | 2010 |
Short-term effects of systemic antibiotics during periodontal healing.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; A | 2010 |
[Therapeutic effects of three topical remedies on periodontitis].
Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Iodine; Male; Metronida | 2010 |
Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Ant | 2011 |
Calprotectin levels in gingival crevicular fluid predict disease activity in patients treated for generalized aggressive periodontitis.
Topics: Administration, Topical; Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Anti-I | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Load; Chemotherapy, Adjuvant; Chronic Periodont | 2011 |
Analysis of clinical results of systemic antimicrobials combined with nonsurgical periodontal treatment for generalized aggressive periodontitis: a pilot study.
Topics: Administration, Oral; Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Chi-Squar | 2011 |
Dual controlled release, in situ gelling periodontal sol of metronidazole benzoate and serratiopeptidase: statistical optimization and mechanistic evaluation.
Topics: Adhesiveness; Administration, Oral; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-St | 2012 |
The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2012 |
Surgical and non-surgical therapy with systemic antimicrobials for residual pockets in type 2 diabetics with chronic periodontitis: a pilot study.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Cytokines; Dental Scaling; D | 2012 |
Er:YAG laser versus systemic metronidazole as an adjunct to nonsurgical periodontal therapy: a clinical and microbiological study.
Topics: Administration, Oral; Adult; Aged; Chronic Periodontitis; Combined Modality Therapy; Dental Plaque I | 2012 |
Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites.
Topics: Amoxicillin; Analysis of Variance; Anti-Infective Agents; Cellulose; Chemotherapy, Adjuvant; Chlorhe | 2012 |
Are there specific benefits of amoxicillin plus metronidazole in Aggregatibacter actinomycetemcomitans-associated periodontitis? Double-masked, randomized clinical trial of efficacy and safety.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infecti | 2013 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chlorhexidi | 2012 |
A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Combined Modality T | 2013 |
Clinical and microbiological effects of systemic antimicrobials combined to an anti-infective mechanical debridement for the management of aggressive periodontitis: a 12-month randomized controlled trial.
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective | 2013 |
Local antimicrobial therapy after initial periodontal treatment.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Analysis of Variance; Anti-Bacterial Agents; Ant | 2002 |
Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results.
Topics: Administration, Topical; Adult; Analysis of Variance; Anti-Bacterial Agents; Colony Count, Microbial | 2001 |
Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Combined Modality Therapy; Dental Plaqu | 2000 |
Clinical outcome observed in subjects with recurrent periodontal disease following local treatment with 25% metronidazole gel.
Topics: Adult; Anti-Infective Agents; Dental Plaque Index; Dental Scaling; Follow-Up Studies; Gels; Gingival | 2003 |
Guided tissue regeneration in smokers: effect of aggressive anti-infective therapy in Class II furcation defects.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Cl | 2003 |
Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients.
Topics: Adult; Anti-Infective Agents, Local; Case-Control Studies; Chlorhexidine; Chronic Disease; Colony Co | 2004 |
Enamel matrix proteins and systemic antibiotics as adjuncts to non-surgical periodontal treatment: clinical effects.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bone Density; Chronic Diseas | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Local oxygen therapy for treating acute necrotizing periodontal disease in smokers.
Topics: Acute Disease; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin-Po | 2006 |
Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Case-Control Studi | 2006 |
Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study.
Topics: Adult; Anti-Infective Agents; Dental Scaling; Epidemiologic Methods; Female; Humans; Male; Metronida | 2006 |
Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results.
Topics: Adult; Aged; Anti-Bacterial Agents; Azithromycin; Chronic Disease; Combined Modality Therapy; Dental | 2007 |
Topical use of a metronidazole gel in the treatment of sites with symptoms of recurring chronic inflammation.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Chronic Disease; Delayed-Action Prepara | 2007 |
Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chlorhexidine; Delayed-Acti | 2007 |
Effect of metronidazole on chronic periodontal disease in subjects using a topically applied chlorhexidine gel.
Topics: Administration, Topical; Adult; Chlorhexidine; Clinical Trials as Topic; Dental Plaque; Double-Blind | 1984 |
A comparative clinical study: the use of human type I collagen with and without the addition of metronidazole in the GTR method of treatment of periodontal disease.
Topics: Adult; Anti-Infective Agents, Local; Collagen; Dental Plaque Index; Dental Prophylaxis; Dental Scali | 1995 |
Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Clinical findings.
Topics: Administration, Topical; Adult; Alveolar Bone Loss; Dental Plaque; Female; Gels; Gingival Hemorrhage | 1994 |
Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Microbiological findings.
Topics: Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Colony Co | 1994 |
Metronidazole in periodontitis V: debridement should precede medication.
Topics: Adult; Analysis of Variance; Bacteria, Anaerobic; Clinical Protocols; Dental Plaque; Dental Scaling; | 1994 |
Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis.
Topics: Adult; Aged; Chronic Disease; Collagen; Delayed-Action Preparations; Dental Plaque Index; Female; Hu | 1994 |
Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters.
Topics: Alveolar Bone Loss; Colony Count, Microbial; Dental Plaque; Dental Scaling; Double-Blind Method; Fem | 1993 |
Metronidazole in the treatment of localized juvenile periodontitis.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Lo | 1993 |
Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents, Local; Bacteria; Colony Count, Microbia | 1996 |
Value of some laboratory and clinical measurements in the treatment plan for advanced periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Anti-Bacterial Agents; Denta | 1996 |
Comparison of 3 periodontal local antibiotic therapies in persistent periodontal pockets.
Topics: Administration, Topical; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuvant; Chi-Sq | 1996 |
The effect of subgingival antimicrobial therapy on the levels of stromelysin and tissue inhibitor of metalloproteinases in gingival crevicular fluid.
Topics: Administration, Topical; Adult; Aged; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adj | 1996 |
A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients.
Topics: Administration, Oral; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Anti-In | 1997 |
The effect of smoking on mechanical and antimicrobial periodontal therapy.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Dental Plaque Index; Dental Scaling; Female; Hum | 1997 |
Effects of combined topical metronidazole and mechanical treatment on the subgingival flora in deep periodontal pockets in cuspids and bicuspids.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aggregatibacter actinomycetemcomitans; A | 1997 |
Topical metronidazole application in recall patients. Long-term results.
Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Bacteria; Dental Plaque; Dental Scaling | 1997 |
Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery system.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antitrichomonal Agents; Cellulose; Colon | 1998 |
The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Biopsy; Combined M | 1998 |
Effects of topical metronidazole and tetracycline in treatment of adult periodontitis.
Topics: Administration, Topical; Adult; Aged; Aggregatibacter actinomycetemcomitans; Analysis of Variance; A | 1998 |
Local metronidazole application in maintenance patients. Clinical and microbiological evaluation.
Topics: Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Colony | 1998 |
Additional clinical and microbiological effects of amoxicillin and metronidazole after initial periodontal therapy.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial | 1998 |
Clinical and microbiological effects of adjunctive antibiotics in treatment of localized juvenile periodontitis. A controlled clinical trial.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Process | 1998 |
A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chronic Disease; D | 1999 |
Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuva | 1999 |
Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony periodontal defects. A split-mouth study.
Topics: Absorbable Implants; Alveolar Bone Loss; Amoxicillin; Anti-Infective Agents; Dental Enamel Proteins; | 1999 |
Bacteriological and clinical follow-up of periodontal pockets during a topically applied 1% metronidazole-gel therapy in patients with adult periodontitis.
Topics: Administration, Topical; Adult; Dental Plaque; Female; Follow-Up Studies; Gels; Gingival Hemorrhage; | 1999 |
Clonal infection with Actinobacillus actinomycetemcomitans following periodontal therapy.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacterial Outer Me | 1999 |
Repeated local metronidazole-therapy as adjunct to scaling and root planing in maintenance patients.
Topics: Administration, Topical; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Colony Count, | 1999 |
Repeated metronidazole and amoxicillin treatment of periodontitis. A follow-up study.
Topics: Adult; Aged; Amoxicillin; Analysis of Variance; Anti-Infective Agents; Chronic Disease; Disease Prog | 2000 |
Periodontal flap surgery with 25% metronidazole gel. (2). Effect on gingival crevicular fluid PGE2.
Topics: Administration, Topical; Adult; Analysis of Variance; Anti-Infective Agents; Combined Modality Thera | 2000 |
Periodontal flap surgery with 25% metronidazole gel. (1). Clinical outcomes.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Combined Modality Therapy; Confidence I | 2000 |
Topical metronidazole application as an adjunct to scaling and root planing.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Combined Modality Therapy; Dental Scali | 2000 |
[Adjuvant antibiotic therapy as a 2-step treatment concept in early-onset periodontitis: a strategy for eradication of bacteria that cause periodontitis].
Topics: Administration, Oral; Adolescent; Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria; Chemot | 2000 |
Comparison of clinical outcomes following treatment of chronic adult periodontitis with subgingival scaling or subgingival scaling plus metronidazole gel.
Topics: Adult; Anti-Infective Agents, Local; Chronic Disease; Dental Scaling; Double-Blind Method; Female; G | 2000 |
The effect of postsurgical antibiotics on the healing of intrabony defects following treatment with enamel matrix proteins.
Topics: Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bone Substitutes; Den | 2001 |
Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteroides; Dental Plaque; Double-Blind Method; Drug Com | 2001 |
A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Clindamycin; Clinical Protocols | 2001 |
[Metronidazole in the treatment of refractory periodontitis].
Topics: Adult; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Female; Humans; Male; Metro | 2000 |
The nonsurgical treatment of patients with periodontal disease: results after five years.
Topics: Age Factors; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; D | 2002 |
Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Capsules; Chronic Disease; Colony C | 2002 |
Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients.
Topics: Analysis of Variance; Anti-Infective Agents; Chi-Square Distribution; Cyclosporine; Dental Plaque In | 2002 |
Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Bacteria; Bacteroides; Delayed-Action Preparatio | 1992 |
3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults.
Topics: Adult; Aged; Delayed-Action Preparations; Dental Scaling; Drug Implants; Female; Follow-Up Studies; | 1992 |
Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis.
Topics: Adult; Aged; Delayed-Action Preparations; Dental Scaling; Drug Implants; Female; Follow-Up Studies; | 1992 |
Serial doxycycline and metronidazole in prevention of recurrent periodontitis in high-risk patients.
Topics: Bacteria; Dental Plaque Index; Dental Scaling; Doxycycline; Drug Therapy, Combination; Female; Human | 1992 |
Metronidazole in periodontitis: reduced need for surgery.
Topics: Adult; Alveolar Bone Loss; Bacteria; Bacteroidaceae; Bacteroides; Colony Count, Microbial; Combined | 1992 |
The effects of metronidazole administration on clinical and microbiologic parameters of periodontal disease.
Topics: Analysis of Variance; Biological Assay; Chi-Square Distribution; Dental Plaque; Dental Plaque Index; | 1991 |
The effects of subgingival irrigation with low dosage metronidazole on periodontal inflammation.
Topics: Administration, Topical; Adult; Chronic Disease; Dental Plaque Index; Double-Blind Method; Humans; M | 1991 |
The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults.
Topics: Adult; Bone Resorption; Clinical Trials as Topic; Dental Prophylaxis; Dental Scaling; Double-Blind M | 1990 |
[Simplified oral hygiene with subgingival pulsating jet irrigation with and without a dilute metronidazole solution as an adjunct for control of chronic periodontal disease].
Topics: Adult; Chronic Disease; Humans; Metronidazole; Oral Hygiene; Periodontal Diseases; Periodontal Pocke | 1989 |
[Influence of systemic metronidazole therapy on the flora of the periodontal gingival pocket].
Topics: Humans; Metronidazole; Periodontal Pocket; Periodontitis | 1989 |
Use of antimicrobial containing acrylic strips in the treatment of chronic periodontal disease. A three month follow-up study.
Topics: Adult; Aged; Chlorhexidine; Chronic Disease; Dental Scaling; Drug Implants; Female; Follow-Up Studie | 1988 |
The effects of a simplified mechanical oral hygiene regime plus supragingival irrigation with chlorhexidine or metronidazole on subgingival plaque.
Topics: Adult; Bacteria; Chlorhexidine; Dental Devices, Home Care; Dental Plaque; Equipment Design; Female; | 1986 |
The value of systemically administered metronidazole in the modified Widman flap procedure.
Topics: Adult; Bacteria; Double-Blind Method; Epithelial Attachment; Female; Humans; Male; Metronidazole; Mi | 1987 |
A follow-up study 3 years after metronidazole therapy for chronic periodontal disease.
Topics: Chronic Disease; Dental Plaque; Dental Scaling; Follow-Up Studies; Gingival Hemorrhage; Humans; Metr | 1986 |
Effects of short-term administration of metronidazole on the subgingival microflora.
Topics: Adult; Aged; Bacteria; Dental Scaling; Female; Gingiva; Gingival Crevicular Fluid; Humans; Male; Met | 1985 |
72 other studies available for metronidazole and Pocket, Periodontal
| Article | Year |
|---|---|
Injectable metronidazole-eluting gelatin-alginate hydrogels for local treatment of periodontitis.
Topics: Alginates; Gelatin; Humans; Hydrogels; Metronidazole; Periodontal Pocket | 2022 |
One-Stage Full Mouth Instrumentation (OSFMI): Clinical Outcomes of an Innovative Protocol for the Treatment of Severe Periodontitis.
Topics: Dental Plaque Index; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Periodontitis; Treat | 2020 |
Generalized aggressive periodontitis: microbiological composition and clinical parameters in non-surgical therapy.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2016 |
An injectable in situ gel with cubic and hexagonal nanostructures for local treatment of chronic periodontitis.
Topics: Chronic Periodontitis; Drug Liberation; Humans; Metronidazole; Nanostructures; Periodontal Pocket | 2017 |
[Detection of anaerobes and drug sensitivity from the periodontal pockets of patients with combined periodontal-endodontic lesions].
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Clindamycin; Humans; Metronidazole; Periodontal Pocket; | 2013 |
Antibiotic resistance in human chronic periodontitis microbiota.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacterial Lo | 2014 |
In situ forming implants for the delivery of metronidazole to periodontal pockets: formulation and drug release studies.
Topics: Absorbable Implants; Adhesiveness; Anti-Infective Agents; Chemistry, Pharmaceutical; Delayed-Action | 2014 |
Metronidazole and Pentoxifylline films for the local treatment of chronic periodontal pockets: preparation, in vitro evaluation and clinical assessment.
Topics: Acrylates; Adult; Anti-Infective Agents; Calorimetry, Differential Scanning; Chitosan; Delayed-Actio | 2014 |
Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Load; Bacteriological Techniques; Chronic | 2014 |
Periodontitis associated with plasminogen deficiency: a case report.
Topics: Adolescent; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Conju | 2015 |
Maintenance periodontal therapy after systemic antibiotic and regenerative therapy of generalized aggressive periodontitis. A case report with 10-year follow-up.
Topics: Adult; Aggressive Periodontitis; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Combined Mo | 2015 |
Development and Evaluation of Biodegradable Chitosan Films of Metronidazole and Levofloxacin for the Management of Periodontitis.
Topics: Adult; Anti-Bacterial Agents; Chitosan; Drug Carriers; Drug Delivery Systems; Drug Liberation; Esche | 2016 |
Metronidazole-loaded bioabsorbable films as local antibacterial treatment of infected periodontal pockets.
Topics: Absorbable Implants; Anti-Infective Agents, Local; Bacteroides fragilis; Bacteroides Infections; Cel | 2009 |
Clinical peri-implant sounding accuracy in the presence of chronic inflammation of peri-implant tissues. Clinical observation study.
Topics: Alveolar Bone Loss; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Debride | 2009 |
Antibiotics in periodontics: right or wrong?
Topics: Amoxicillin; Anti-Bacterial Agents; Bacteroidaceae Infections; Combined Modality Therapy; Dental Pla | 2009 |
Antibiotic resistance of subgingival species in chronic periodontitis patients.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicillin-Potassium Clavulanate C | 2010 |
Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2012 |
Local concentration of systemic amoxicillin and metronidazole in healthy and inflamed gingiva: a comparative in vivo study.
Topics: Administration, Oral; Amoxicillin; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Drug | 2012 |
Therapeutic management of a case of generalised aggressive periodontitis in an 8-year old child: 18-month results.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Loss; Amoxicillin; An | 2012 |
Antibiotic susceptibility of periodontal Enterococcus faecalis.
Topics: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; Anti- | 2013 |
Prevalence of β-lactamase-producing bacteria in human periodontitis.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bac | 2013 |
[Assessment of feasibility of formulation of a preparation for growth inhibition of metronidazole-resistant strains isolated from periodontal pockets].
Topics: Administration, Topical; Anti-Bacterial Agents; Drug Resistance, Microbial; Gels; Humans; Hydrogels; | 2005 |
Periodontal therapy in siblings with Papillon-Lefèvre syndrome and tinea capitis: a report of two cases.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Ch | 2006 |
The efficacy of non-surgical and systemic antibiotic treatment on smoking and non-smoking periodontitis patients.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Dental Plaque Index; Humans; | 2006 |
Clinical and microbiological effects of a combined mechanic-antibiotic therapy in subjects with Actinobacillus actinomycetemcomitans-associated periodontitis.
Topics: Actinobacillus Infections; Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Ch | 2007 |
Simple bacteriological methods to assess changes in subgingival microflora produced by metronidazole-containing acrylic strips placed into periodontal pockets.
Topics: Acrylic Resins; Bacteria; Bacteriological Techniques; Delayed-Action Preparations; Gingiva; Humans; | 1984 |
Treatment of an isolated deep defect.
Topics: Combined Modality Therapy; Humans; Male; Metronidazole; Periodontal Pocket; Periodontitis | 1983 |
Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline.
Topics: Acrylic Resins; Administration, Topical; Bacteria; Chlorhexidine; Dental Plaque; Humans; Metronidazo | 1984 |
Sustained release device containing metronidazole for periodontal use.
Topics: Bacteroides fragilis; Cellulose; Delayed-Action Preparations; Equipment Design; Humans; In Vitro Tec | 1984 |
Slow release metronidazole and a simplified mechanical oral hygiene regimen in the control of chronic periodontitis.
Topics: Chronic Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Evaluation; Hum | 1984 |
Treatment of periodontal infections due to anaerobic bacteria with short-term treatment with metronidazole.
Topics: Adolescent; Adult; Bacteroides; Dental Plaque; Epithelial Attachment; Female; Humans; Male; Metronid | 1981 |
The development and in vitro evaluation of acrylic strips and dialysis tubing for local drug delivery.
Topics: Chlorhexidine; Delayed-Action Preparations; Dialysis; Dosage Forms; Humans; Intubation; Methylmethac | 1982 |
Mitsuokella dentalis in human periodontitis.
Topics: Adolescent; Adult; Age Distribution; Aged; Amoxicillin; Anti-Bacterial Agents; Bacteroides; Ciproflo | 1994 |
Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets.
Topics: Absorption; Adult; Chromatography, High Pressure Liquid; Dental Scaling; Female; Gels; Gingival Crev | 1995 |
Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood.
Topics: Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria; Drug Combinations; Female; Gingival Crev | 1994 |
Campylobacter rectus in human periodontitis.
Topics: Adolescent; Adult; Age Distribution; Aged; Campylobacter; Chi-Square Distribution; Ciprofloxacin; Cr | 1993 |
[Antibacterial therapy in the combined treatment of periodontitis].
Topics: 4-Quinolones; Adolescent; Adult; Anti-Bacterial Agents; Bacteria; Chronic Disease; Dose-Response Rel | 1996 |
Development of resistance to metronidazole and minocycline in vitro.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Bacteria, Anaerobic; Campylobacter; Do | 1997 |
Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anaerobiosis; Anti-Bacterial Agents; Bacteroidaceae In | 1997 |
Re: Non-surgical treatment of patients with periodontitis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Double-Bl | 1997 |
Periodontitis patient and the spouse: periodontal bacteria before and after treatment.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Bacteria; Campylobacter; Dental Calcul | 1997 |
Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial | 1998 |
[A biocompatibility study and the effects of slow-release antibiotic materials in the treatment of periodontal disease. II. The biocompatibility and behavior of polyhydroxyethyl methacrylate (pHEMA) as a slow-release material for tetracycline of metronida
Topics: Anti-Bacterial Agents; Biocompatible Materials; Delayed-Action Preparations; Drug Combinations; Drug | 1998 |
The use of antimicrobial acrylic strips in the nonsurgical management of chronic periodontitis.
Topics: Acrylic Resins; Adult; Bacterial Infections; Chlorhexidine; Chronic Disease; Drug Delivery Systems; | 1990 |
Resistance profile survey of 50 periodontal strains of Actinobacillus actinomyectomcomitans.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicillin-Potassium Clavulanate Combina | 1999 |
The role of controlled drug delivery for periodontitis. The Research, Science and Therapy Committee of the American Academy of Periodontology.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Delayed-A | 2000 |
Actinobacillus actinomycetemcomitans in destructive periodontal disease. Three-year follow-up results.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial | 2000 |
Cost-effectiveness analysis of periodontal disease control.
Topics: Alveoloplasty; Anti-Bacterial Agents; Anti-Infective Agents; Cost-Benefit Analysis; Decision Support | 1987 |
A multidisciplinary approach to the diagnosis and treatment of early-onset periodontitis: a case report.
Topics: Adolescent; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacte | 2001 |
Combined mechanical and antibiotic periodontal therapy in a case of Papillon-Lefèvre syndrome.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; | 2001 |
The effect of systemic antibiotics in the treatment of patients with recurrent periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents | 2001 |
Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole.
Topics: Actinomyces; Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Bacteria; Bacteroides; | 2001 |
Treatment of Papillon-Lefèvre syndrome periodontitis.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti- | 2002 |
Statistical modeling of tooth mobility after treating adult periodontitis.
Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Colony Count, Microbial; Dental Plaque Index; Electro | 2002 |
Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis.
Topics: Adult; Age Factors; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Bacteroi | 1992 |
A preliminary study on the use of a combination of tetracycline and metronidazole in the treatment of refractory periodontitis.
Topics: Aggressive Periodontitis; Drug Therapy, Combination; Female; Humans; Male; Metronidazole; Middle Age | 1992 |
Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel.
Topics: Adult; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Implants; Female; Gel | 1992 |
Systemic absorption of metronidazole after application of a metronidazole 25% dental gel.
Topics: Absorption; Adult; Biological Availability; Delayed-Action Preparations; Drug Implants; Female; Gels | 1992 |
The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog.
Topics: Animals; Bacteria, Aerobic; Bacteria, Anaerobic; Colony Count, Microbial; Delayed-Action Preparation | 1992 |
The effects of antimicrobial acrylic strips on the subgingival microflora in chronic periodontitis.
Topics: Acrylic Resins; Adult; Bacteria; Bacteria, Aerobic; Bacteria, Anaerobic; Chlorhexidine; Chronic Dise | 1992 |
Identification, and susceptibility to seven antimicrobial agents, of 61 gram-negative anaerobic rods from periodontal pockets.
Topics: Amoxicillin; Anaerobiosis; Anti-Bacterial Agents; Bacteriological Techniques; Bacteroides; Clavulani | 1991 |
[In vitro assessment of metronidazole adapted to the treatment of periodontopathies].
Topics: Evaluation Studies as Topic; Humans; Metronidazole; Periodontal Diseases; Periodontal Pocket | 1990 |
[The absorbent metronidazole gelatin sponge used in treating periodontal disease].
Topics: Adolescent; Adult; Aged; Bacteria, Anaerobic; Female; Gelatin Sponge, Absorbable; Humans; Male; Metr | 1990 |
Clinical and microbiologic changes following the irrigation of periodontal pockets with metronidazole or stannous fluoride.
Topics: Fluorides; Humans; Metronidazole; Periodontal Pocket; Periodontitis; Therapeutic Irrigation; Tin Flu | 1989 |
Systemic metronidazole in the treatment of periodontitis.
Topics: Administration, Oral; Adult; Bacteria; Bacteroides; Dental Plaque; Dental Prophylaxis; Dental Scalin | 1989 |
[Experimental study of a metronidazole gel inserted in periodontal pockets].
Topics: Adult; Analysis of Variance; Dental Scaling; Female; Gels; Humans; Male; Metronidazole; Middle Aged; | 1989 |
Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis.
Topics: Actinobacillus; Adolescent; Adult; Aggressive Periodontitis; Amoxicillin; Bacteroides; Drug Combinat | 1989 |
Combined antibiotic (metronidazole) and mechanical treatment effects on the subgingival bacterial flora of sites with recurrent periodontal disease.
Topics: Adult; Bacteria; Dental Prophylaxis; Dental Scaling; Humans; Metronidazole; Middle Aged; Periodontal | 1988 |
Microbial and clinical measurements of periodontal pockets during sequential periods of non-treatment, mechanical debridement and metronidazole therapy.
Topics: Adult; Bacteria; Bacteroides; Combined Modality Therapy; Eikenella corrodens; Fusobacterium; Humans; | 1987 |
Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis.
Topics: Bacteria, Anaerobic; Dental Plaque; Humans; Metronidazole; Niridazole; Periodontal Pocket; Periodont | 1987 |
The development and clinical use of acrylic strips containing anti-microbial agents in the management of chronic periodontitis.
Topics: Acrylic Resins; Anti-Bacterial Agents; Bacteria; Bacterial Physiological Phenomena; Bacteroides; Chl | 1985 |
The therapeutic use of antimicrobial agents in patients with periodontal disease.
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Combined Modality Therapy; Debrid | 1985 |