metronidazole has been researched along with Empyema in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Empyema: Presence of pus in a hollow organ or body cavity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred forty patients with pleuropulmonary amebiasis were classified radiographically in order to rationalize therapy based on the use of metronidazole." | 7.66 | The treatment of pleuropulmonary amebiasis with metronidazole. ( Cameron, EW, 1978) |
| "One hundred forty patients with pleuropulmonary amebiasis were classified radiographically in order to rationalize therapy based on the use of metronidazole." | 3.66 | The treatment of pleuropulmonary amebiasis with metronidazole. ( Cameron, EW, 1978) |
| "Of 33 patients with amoebic liver abscess (ALA) seen over a 5-year period, 24 had intrathoracic complications." | 1.27 | Intrathoracic complications of amoebic liver abscess. ( Aderounmu, A; Adeyemo, AO, 1984) |
| "Metronidazole also has been used either alone or in combination, most frequently with amoxicillin, to treat many other anaerobic infections: head and neck, pleuropulmonary, genital tract, bone and joint, skin and soft tissue, and cases of fusobacterial septicemia (necrobacillosis)." | 1.27 | The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital. ( Eykyn, SJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sadarangani, SP | 1 |
| Cunningham, SA | 1 |
| Jeraldo, PR | 1 |
| Wilson, JW | 1 |
| Khare, R | 1 |
| Patel, R | 1 |
| Adeyemo, AO | 1 |
| Aderounmu, A | 1 |
| Brodrick, TW | 1 |
| Eykyn, SJ | 1 |
| Abeysundere, RL | 1 |
| Hodson, ME | 1 |
| Szawatkowski, M | 1 |
| Noone, P | 1 |
| Fazlullah, S | 1 |
| Cameron, EW | 1 |
| Smith, BJ | 1 |
| Wellingham, J | 1 |
| Buchman, AL | 1 |
| Ponsillo, M | 1 |
| Nagami, PH | 1 |
9 other studies available for metronidazole and Empyema
| Article | Year |
|---|---|
Metronidazole- and carbapenem-resistant bacteroides thetaiotaomicron isolated in Rochester, Minnesota, in 2014.
Topics: Abscess; Adult; Anti-Bacterial Agents; Bacterial Proteins; Bacteroides; Bacteroides Infections; beta | 2015 |
Intrathoracic complications of amoebic liver abscess.
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Drainage; Empyema; Female; Fistula; Human | 1984 |
Treatment of empyema in a cat.
Topics: Animals; Cat Diseases; Cats; Empyema; Male; Metronidazole | 1983 |
The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital.
Topics: Adult; Aged; Bacterial Infections; Bone Diseases; Empyema; Female; Fusobacterium Infections; Gastroi | 1983 |
Pleuropulmonary lung infection by anaerobic bacteria.
Topics: Adult; Bacteroides fragilis; Bacteroides Infections; Chloramphenicol; Empyema; Humans; Lung Abscess; | 1978 |
Pleuro-pulmonary lesions in amebic liver abscess.
Topics: Adult; Drug Therapy, Combination; Emetine; Empyema; Female; Humans; Liver Abscess, Amebic; Metronida | 1978 |
The treatment of pleuropulmonary amebiasis with metronidazole.
Topics: Adolescent; Adult; Aged; Amebiasis; Child; Child, Preschool; Empyema; Female; Humans; Lung Diseases; | 1978 |
Letter: Metronidazole in treatment of empyema.
Topics: Aged; Bacteroides Infections; Clindamycin; Empyema; Humans; Male; Metronidazole | 1976 |
Empyema caused by Clostridium sordellii, a rare form of pleuropulmonary disease.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Clostridium Infections; Empyema; Female; Humans; Lac | 1991 |