metronidazole has been researched along with Osteoradionecrosis in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Osteoradionecrosis: Necrosis of bone following radiation injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A regimen of ultrasound with local debridement and metronidazole has proved to be an effective and practicable treatment for osteoradionecrosis, achieving healing in 10/21 (48%) cases without the need for surgery or sophisticated technology." | 3.68 | The conservative management of osteoradionecrosis of the mandible with ultrasound therapy. ( Harris, M, 1992) |
| "Conventional treatment of osteoradionecrosis of mandible is by antibiotics combined if necessary with a hemimandibulectomy." | 1.27 | [Current treatment of osteoradionecrosis]. ( Blanc, JL; Cheynet, F; Lachard, A; Lachard, J; Lagier, JP; Rakotobe, P, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harris, M | 1 |
| Millett, DT | 1 |
| Chapple, IL | 1 |
| Hirschmann, PN | 1 |
| Corrigan, AM | 1 |
| Lagier, JP | 1 |
| Blanc, JL | 1 |
| Lachard, A | 1 |
| Cheynet, F | 1 |
| Rakotobe, P | 1 |
| Lachard, J | 1 |
3 other studies available for metronidazole and Osteoradionecrosis
| Article | Year |
|---|---|
The conservative management of osteoradionecrosis of the mandible with ultrasound therapy.
Topics: Brachytherapy; Cephalexin; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Humans; Male; | 1992 |
Septic osteoradionecrosis of the mandible associated with pathological fracture: report of two cases.
Topics: Aged; Female; Fractures, Spontaneous; Humans; Mandibular Diseases; Mandibular Fractures; Metronidazo | 1990 |
[Current treatment of osteoradionecrosis].
Topics: Combined Modality Therapy; Drug Therapy, Combination; Humans; Mandible; Mandibular Diseases; Metroni | 1986 |