metronidazole has been researched along with Tonsillitis in 19 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Tonsillitis: Inflammation of the tonsils, especially the PALATINE TONSILS but the ADENOIDS (pharyngeal tonsils) and lingual tonsils may also be involved. Tonsillitis usually is caused by bacterial infection. Tonsillitis may be acute, chronic, or recurrent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "16 patients with the anginose type of infectious mononucleosis were treated with metronidazole, and another 3 patients were given clindamycin." | 9.04 | Treatment of anginose infectious mononucleosis with metronidazole. ( Hedström, SA; Mårdh, PA; Ripa, T, 1978) |
| "Metronidazole treatment resulted in a more rapid regression of tonsillitis note on the 4th day in both treated groups and a faster defervescence noted on the 3rd day compared to controls." | 7.75 | Treatment of anginose infectious mononucleosis with metronidazole. A controlled clinical and laboratory study. ( Hedström, SA, 1980) |
| "The potential role of anaerobic bacteria in acute tonsillitis was investigated in a retrospective study that evaluated the efficacy of antimicrobial therapy with metronidazole on the management of acute episodes of non-beta-hemolytic streptococcal tonsillitis (NST)." | 7.73 | Treatment of non-streptococcal tonsillitis with metronidazole. ( Brook, I; Gober, AE, 2005) |
| "16 patients with the anginose type of infectious mononucleosis were treated with metronidazole, and another 3 patients were given clindamycin." | 5.04 | Treatment of anginose infectious mononucleosis with metronidazole. ( Hedström, SA; Mårdh, PA; Ripa, T, 1978) |
| "Metronidazole treatment resulted in a more rapid regression of tonsillitis note on the 4th day in both treated groups and a faster defervescence noted on the 3rd day compared to controls." | 3.75 | Treatment of anginose infectious mononucleosis with metronidazole. A controlled clinical and laboratory study. ( Hedström, SA, 1980) |
| "The potential role of anaerobic bacteria in acute tonsillitis was investigated in a retrospective study that evaluated the efficacy of antimicrobial therapy with metronidazole on the management of acute episodes of non-beta-hemolytic streptococcal tonsillitis (NST)." | 3.73 | Treatment of non-streptococcal tonsillitis with metronidazole. ( Brook, I; Gober, AE, 2005) |
| "Patients with confirmed Lemierre syndrome were included in our retrospective monocentric study." | 2.50 | Lemierre syndrome: study of 11 cases and literature review. ( Atallah, I; Karkas, A; N'Gouan, JM; Reyt, E; Righini, CA; Schmerber, S; Tourniaire, R, 2014) |
| "All patients with acute tonsillitis, peritonsillar abscess (PTA), and parapharyngeal abscess admitted to the Ear-Nose-Throat Department, Aarhus University Hospital, in the 2001-2014 period were included in the study." | 1.51 | Adherence to antibiotic guidelines in the treatment of acute pharyngeal infections. ( Danstrup, CS; Klug, TE; Øhrstrøm, MT, 2019) |
| "For cases of peritonsillar abscess, benzylpenicillin with metronidazole was the most common antibiotic combination chosen." | 1.36 | National UK survey of antibiotics prescribed for acute tonsillitis and peritonsillar abscess. ( Nix, P; Visvanathan, V, 2010) |
| "In the routine management of peritonsillar abscess, bacteriologic studies are unnecessary on initial presentation." | 1.34 | [The microbiology of peritonsillar abscesses]. ( Gajda, M; Zagólski, O, 2007) |
| "Necrobacillosis is a potentially life-threatening septicaemic illness occurring in the previously fit and healthy." | 1.29 | Necrobacillosis--an unusual case of pharyngotonsillitis. ( Carrie, S; Fenton, PA, 1994) |
| "24 days after the onset of infectious mononucleosis, clinically and serologically confirmed, an otherwise healthy 18-year-old schoolboy developed a fulminant septicaemia with acute meningitis and loss of consciousness, consumptive coagulopathy and acute renal failure." | 1.29 | [Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis]. ( Busch, N; Haase, G; Kierdorf, H; Marschall, HU; Matern, S; Mertens, PR; Nguyen, H; Schönfelder, T; Sieberth, HG; Urhahn, R, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Øhrstrøm, MT | 1 |
| Danstrup, CS | 1 |
| Klug, TE | 1 |
| Righini, CA | 1 |
| Karkas, A | 1 |
| Tourniaire, R | 1 |
| N'Gouan, JM | 1 |
| Schmerber, S | 1 |
| Reyt, E | 1 |
| Atallah, I | 1 |
| Collis, DH | 1 |
| Sanu, A | 1 |
| Zagólski, O | 1 |
| Gajda, M | 1 |
| Visvanathan, V | 1 |
| Nix, P | 1 |
| Brook, I | 1 |
| Gober, AE | 1 |
| Georgopoulos, S | 1 |
| Korres, S | 1 |
| Riga, M | 1 |
| Balatsouras, D | 1 |
| Kotsis, G | 1 |
| Ferekidis, E | 1 |
| Reilly, S | 2 |
| Willis, AT | 2 |
| Spelman, DW | 1 |
| Newton-John, HF | 1 |
| Hedström, SA | 2 |
| Mann, W | 1 |
| Pelz, K | 1 |
| Davidson, S | 1 |
| Kaplinsky, C | 1 |
| Frand, M | 1 |
| Rotem, J | 1 |
| Timmis, P | 1 |
| Beeden, AG | 1 |
| de Miguel, I | 1 |
| Muñoz, JL | 1 |
| Ramos, A | 1 |
| García-Rodríguez, JA | 1 |
| Carrie, S | 1 |
| Fenton, PA | 1 |
| Busch, N | 1 |
| Mertens, PR | 1 |
| Schönfelder, T | 1 |
| Nguyen, H | 1 |
| Marschall, HU | 1 |
| Kierdorf, H | 1 |
| Haase, G | 1 |
| Urhahn, R | 1 |
| Sieberth, HG | 1 |
| Matern, S | 1 |
| Bouton, F | 1 |
| Cotils, M | 1 |
| Genard, M | 1 |
| Hubert, C | 1 |
| Maheshwar, AA | 1 |
| Jones, MB | 1 |
| Evans, RA | 1 |
| Mårdh, PA | 1 |
| Ripa, T | 1 |
4 reviews available for metronidazole and Tonsillitis
| Article | Year |
|---|---|
Lemierre syndrome: study of 11 cases and literature review.
Topics: Abscess; Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agen | 2014 |
Treatment of anginose infectious mononucleosis with metronidazole. A controlled clinical and laboratory study.
Topics: Adolescent; Adult; C-Reactive Protein; Clinical Trials as Topic; Female; Humans; Infectious Mononucl | 1980 |
[Anerobic infections in otolaryngology (author's transl)].
Topics: Adult; Anaerobiosis; Bacteria; Bacterial Infections; Carcinoma, Squamous Cell; Cephalosporins; Chron | 1981 |
[Septic thrombophlebitis of the internal jugular vein and Lemierre syndrome].
Topics: Abscess; Acute Disease; Aged; Amoxicillin-Potassium Clavulanate Combination; Angina Pectoris; Anti-B | 1998 |
4 trials available for metronidazole and Tonsillitis
| Article | Year |
|---|---|
Metronidazole in the treatment of anginose infectious mononucleosis.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Double-Blind Method; Female; Herpesvirus 4, Huma | 1982 |
Treatment of anginose infectious mononucleosis with metronidazole. A controlled clinical and laboratory study.
Topics: Adolescent; Adult; C-Reactive Protein; Clinical Trials as Topic; Female; Humans; Infectious Mononucl | 1980 |
[Importance of anaerobic bacteria in recurrent childhood non-streptococcal tonsillitis].
Topics: Bacteria, Anaerobic; Bacterial Infections; beta-Lactamases; Child; Child, Preschool; Drug Therapy, C | 1995 |
Treatment of anginose infectious mononucleosis with metronidazole.
Topics: Adolescent; Adult; Body Temperature; Child; Clindamycin; Deglutition; Drug Evaluation; Female; Human | 1978 |
12 other studies available for metronidazole and Tonsillitis
| Article | Year |
|---|---|
Adherence to antibiotic guidelines in the treatment of acute pharyngeal infections.
Topics: Acute Disease; Adult; Anti-Bacterial Agents; Denmark; Drug Prescriptions; Female; Guideline Adherenc | 2019 |
Zygomatic haematoma in an 11-month-old helps diagnose retropharyngeal abscess, with concurrent tonsillitis and subsequent infant tonsillectomy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anorexia; Anti-Bacterial Agents; Cefotaxime; Dexamethasone; | 2016 |
[The microbiology of peritonsillar abscesses].
Topics: Acute Disease; Adult; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Humans; Male; Metro | 2007 |
National UK survey of antibiotics prescribed for acute tonsillitis and peritonsillar abscess.
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Cefuroxime; Drug Therapy, Comb | 2010 |
Treatment of non-streptococcal tonsillitis with metronidazole.
Topics: Adolescent; Anti-Infective Agents; Bacteria, Anaerobic; Child; Female; Fever; Humans; Lymphadenitis; | 2005 |
Lemierre's syndrome associated with consumption coagulopathy and acute renal failure: a case report.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Disseminated Intravascular Coagulation; Drug Ther | 2008 |
beta-Lactamase-producing anaerobes.
Topics: Anaerobiosis; Bacteria; beta-Lactamases; Child; Humans; Metronidazole; Palatine Tonsil; Streptococcu | 1980 |
Treatment of infectious mononucleosis with metronidazole in the pediatric age group.
Topics: Adolescent; Child; Child, Preschool; Humans; Infectious Mononucleosis; Metronidazole; Prospective St | 1982 |
Possible role of the anaerobe in tonsillitis.
Topics: Acute Disease; Adolescent; Anaerobiosis; Bacteria; Bacterial Infections; Child; Child, Preschool; Hu | 1981 |
Necrobacillosis--an unusual case of pharyngotonsillitis.
Topics: Adult; Drug Therapy, Combination; Fusobacterium Infections; Fusobacterium necrophorum; Humans; Kidne | 1994 |
[Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis].
Topics: Acute Kidney Injury; Adolescent; Anti-Bacterial Agents; Bacteremia; Chloramphenicol; Disseminated In | 1996 |
Efficacy and safety of 'hot' tonsillectomy.
Topics: Acute Disease; Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Biopsy, Needl | 2001 |