metronidazole has been researched along with Dermatitis, Contact in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 68-year-old woman developed allergic contact dermatitis to topical metronidazole gel as proven by positive patch tests to the gel and to metronidazole." | 3.72 | Co-existing sensitivity to metronidazole and isothiazolinone. ( Matz, H; Orion, E; Wolf, R, 2003) |
| "Rosacea is a common, recurrent, inflammatory dermatologic disorder characterized by the presence of facial erythema, visible blood vessels, papules, and pustules." | 2.72 | A look at the safety of metronidazole 1% gel: cumulative irritation, contact sensitization, phototoxicity, and photoallergy potential. ( Beutner, KR; Calvarese, B; Lemke, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, KE | 1 |
| Park, TJ | 1 |
| Son, SW | 1 |
| Kim, IH | 1 |
| Moon, HR | 1 |
| Wolf, R | 1 |
| Orion, E | 1 |
| Matz, H | 1 |
| Kirkland, CR | 1 |
| Yelverton, CB | 1 |
| Fleischer, AB | 1 |
| Camacho, FT | 1 |
| Feldman, SR | 1 |
| Beutner, KR | 1 |
| Lemke, S | 1 |
| Calvarese, B | 1 |
| Izu, R | 1 |
| Aguirre, A | 1 |
| González, M | 1 |
| Díaz-Pérez, JL | 1 |
2 trials available for metronidazole and Dermatitis, Contact
| Article | Year |
|---|---|
Gel vehicles are not inherently more irritating than creams.
Topics: Administration, Cutaneous; Adult; Chemistry, Pharmaceutical; Dermatitis, Contact; Dermatologic Agent | 2006 |
A look at the safety of metronidazole 1% gel: cumulative irritation, contact sensitization, phototoxicity, and photoallergy potential.
Topics: Dermatitis, Contact; Dermatitis, Photoallergic; Dermatitis, Phototoxic; Dermatologic Agents; Erythem | 2006 |
3 other studies available for metronidazole and Dermatitis, Contact
| Article | Year |
|---|---|
Fiberglass-induced granulomatous periorificial dermatitis.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Biopsy; Dermatitis, Contact; Dermatitis, Occ | 2019 |
Co-existing sensitivity to metronidazole and isothiazolinone.
Topics: Aged; Anti-Infective Agents; Dermatitis, Contact; Drug Combinations; Drug Eruptions; Drug Interactio | 2003 |
Contact dermatitis from tioconazole with cross-sensitivity to other imidazoles.
Topics: Adult; Antifungal Agents; Cross Reactions; Dermatitis, Contact; Drug Eruptions; Female; Humans; Imid | 1992 |