metronidazole has been researched along with Retinal Diseases in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Retinal Diseases: Diseases involving the RETINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0) years) with active or past giardiasis diagnosed on the basis of microscopic examination of stool specimens or duodenal secretions--53 were newly diagnosed and untreated (group A), 50 had active infections in spite of metronidazole therapy (group B), and 38 had been successfully treated, with negative stool specimens for 1-3 years (group C)." | 3.70 | Ocular changes associated with Giardia lamblia infection in children. ( Ardenti Morini, F; Bulgarini, D; Corsi, A; De Risi, F; Di Iorio, L; Knafelz, D; Nucci, C; Paone, FM; Polito, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Corsi, A | 1 |
| Nucci, C | 1 |
| Knafelz, D | 1 |
| Bulgarini, D | 1 |
| Di Iorio, L | 1 |
| Polito, A | 1 |
| De Risi, F | 1 |
| Ardenti Morini, F | 1 |
| Paone, FM | 1 |
1 other study available for metronidazole and Retinal Diseases
| Article | Year |
|---|---|
Ocular changes associated with Giardia lamblia infection in children.
Topics: Adolescent; Animals; Antiprotozoal Agents; Case-Control Studies; Child; Child, Preschool; Eye Infect | 1998 |