metronidazole has been researched along with Immunologic Deficiency Syndromes in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Immunologic Deficiency Syndromes: Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
Excerpt | Relevance | Reference |
---|---|---|
"Treatment with metronidazole induced the disappearance of coccidia from the stool and clinical remission." | 1.26 | Malabsorption syndrome, coccidiosis, combined immune deficiency, and fulminant lymphoproliferative disease. ( Adar, U; Hallak, A; Ratan, Y; Yust, I, 1982) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (75.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (25.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kampitak, T | 1 |
Hallak, A | 1 |
Yust, I | 1 |
Ratan, Y | 1 |
Adar, U | 1 |
Webster, AD | 1 |
Ochs, HD | 1 |
Ament, ME | 1 |
Davis, SD | 1 |
4 other studies available for metronidazole and Immunologic Deficiency Syndromes
Article | Year |
---|---|
Selective immunoglobulin M deficiency in a patient with refractory giardiasis.
Topics: Adolescent; Antiprotozoal Agents; Diarrhea; Duodenitis; Giardia lamblia; Giardiasis; Humans; Immunog | 2010 |
Malabsorption syndrome, coccidiosis, combined immune deficiency, and fulminant lymphoproliferative disease.
Topics: Adult; Coccidiosis; Humans; Immunologic Deficiency Syndromes; Lymphoma; Malabsorption Syndromes; Mal | 1982 |
Giardiasis and immunodeficiency diseases.
Topics: Adolescent; Agammaglobulinemia; Bacteria; Diarrhea; Giardiasis; Humans; Immunologic Deficiency Syndr | 1980 |
Structure and function of the gastrointestinal tract in primary immunodeficiency syndromes (IDS) and in granulocyte dysfunction.
Topics: Carotenoids; Crohn Disease; Digestive System; Disaccharidases; Feces; Female; Folic Acid; Gastrointe | 1975 |