metronidazole has been researched along with Endotoxemia in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion." | 7.73 | Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect. ( Barreto, R; Fesce, E; Gelosa, F; Lorenzetti, A; Marotta, F; Naito, Y; Wu, CC; Yoshioka, M, 2005) |
| "In this proof-of-principle intervention trial, 16 healthy young men received either no treatment or broad-spectrum antibiotics (ciprofloxacin, vancomycin and metronidazole) for 7 days, after which all were administered lipopolysaccharide intravenously to induce a transient sepsis-like syndrome." | 5.24 | Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study. ( Belzer, C; Cranendonk, DR; de Vos, AF; de Vos, WM; Lankelma, JM; van der Poll, T; Wiersinga, WJ, 2017) |
| "The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion." | 3.73 | Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect. ( Barreto, R; Fesce, E; Gelosa, F; Lorenzetti, A; Marotta, F; Naito, Y; Wu, CC; Yoshioka, M, 2005) |
| "To explore the effects of metronidazole (Me) on intestinal microcirculation in septic rats, intravital microscopy (IVM) following 16 hours of colon ascendens stent peritonitis (CASP model) was used." | 3.73 | Metronidazole improves intestinal microcirculation in septic rats independently of bacterial burden. ( Bac, VH; Feyerherd, F; Gründling, M; Haase, H; Heidecke, CD; Jünger, M; Lehmann, Ch; Lustig, M; Maier, S; Meissner, K; Pavlovic, D; Usichenko, TI; Wendt, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lankelma, JM | 1 |
| Cranendonk, DR | 1 |
| Belzer, C | 1 |
| de Vos, AF | 1 |
| de Vos, WM | 1 |
| van der Poll, T | 1 |
| Wiersinga, WJ | 1 |
| Marotta, F | 1 |
| Barreto, R | 1 |
| Wu, CC | 1 |
| Naito, Y | 1 |
| Gelosa, F | 1 |
| Lorenzetti, A | 1 |
| Yoshioka, M | 1 |
| Fesce, E | 1 |
| Lehmann, Ch | 1 |
| Bac, VH | 1 |
| Pavlovic, D | 1 |
| Lustig, M | 1 |
| Maier, S | 1 |
| Feyerherd, F | 1 |
| Usichenko, TI | 1 |
| Meissner, K | 1 |
| Haase, H | 1 |
| Jünger, M | 1 |
| Wendt, M | 1 |
| Heidecke, CD | 1 |
| Gründling, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia[NCT02127749] | 16 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and Endotoxemia
| Article | Year |
|---|---|
Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study.
Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Drug Monitoring; Endotoxemia; Escherichia coli; Gastroi | 2017 |
2 other studies available for metronidazole and Endotoxemia
| Article | Year |
|---|---|
Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect.
Topics: Acute Disease; Animals; Bacterial Translocation; Bifidobacterium; Ceruletide; Disease Models, Animal | 2005 |
Metronidazole improves intestinal microcirculation in septic rats independently of bacterial burden.
Topics: Animals; Anti-Infective Agents; Bacteria, Anaerobic; Cell Adhesion; Cytokines; Endotoxemia; Intestin | 2006 |