Abscess, Intracranial, Subdural

An intracranial or rarely intraspinal suppurative process invading the space between the inner surface of the DURA MATER and the outer surface of the ARACHNOID.

Synonym
Subdural Empyema
Empyema, Subdural
Abscess, Intracranial, Subdural

Excerpt	Reference
"Subdural empyema is a known yet infrequent complication of bacterial meningitis."	( Chapman, PH; McGrail, K; Ogilvy, CS, 1992)
"The occurrence of subdural empyema is an uncommon but possible sequela of a complicated tooth extraction."	( Ferrara, S; Gambino, A; Martines, F; Mucia, M; Salvago, P; Sireci, F, 2014)
"Subdural empyema is infrequently reported in cats and has high mortality rates even following surgical treatment."	( Cardy, TJ; De Decker, S; Lam, R; Matas Riera, M; McLaren, PJ; Peters, LM, 2017)

Excerpt	Reference
"Subdural empyema has not been reported previously as a complication of cerebrospinal fluid (CSF) shunt surgery."	( Dickerman, RD; Frank, EH; Hsu, F; Piatt, JH, 1999)

Excerpt	Reference
"Imipenem was successfully used to treat a case of subdural empyema complicated by multiple cerebral abscesses, in which surgery and therapy with other antibiotics had previously failed."	( Carton, JA; Maradona, JA; Mendez, FJ; Perez, F, 1987)
"Recurring subdural empyema despite adequate surgical drainage and antibiotic treatment is still a life-threatening disease."	( Bruder, N; Dufour, H; Lefebvre, L; Metellus, P, 2009)
"We report 2 cases of recurring subdural empyema due to Streptococcus, after repeat surgery and high-dose antibiotic treatment including beta-lactamines and vancomycin."	( Bruder, N; Dufour, H; Lefebvre, L; Metellus, P, 2009)
"Off-label use of linezolid for treatment of subdural empyema due to gram-positive bacteria should be considered after failure of conventional antibiotic treatment."	( Bruder, N; Dufour, H; Lefebvre, L; Metellus, P, 2009)
"Non-surgical treatment of small subdural empyemas with prolonged intravenous antibiotic therapy is a therapeutic option."	( Armano, R; Ghais, A; Mathot, M; Menten, R; Nassogne, MC; Zech, F, 2009)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	12 (14.12)	23.3326
1990's	24 (28.24)	12.5806
2000's	18 (21.18)	18.1394
2010's	25 (29.41)	28.8240
2020's	6 (7.06)	9.53

Drug	Relationship Strength	Studies
citric acid, anhydrous	low	1
salicylic acid	low	4
pyrazinamide	low	1
pyridoxine	low	1
phenytoin	low	1
acetaminophen	low	1
cefuroxime	low	1
ciprofloxacin	low	3
clonazepam	low	1
pentetic acid	low	3
fluconazole	low	2
flucytosine	low	1
gentamicin	low	1
isoniazid	low	1
metronidazole	low	10
prednisone	low	1
penicillin g	low	1
chloramphenicol	low	5
methicillin	low	1
ampicillin	low	6
framycetin	low	1
nafcillin	low	1
vancomycin	low	11
fluorescein	low	1
streptomycin	low	2
gadolinium	low	3
thiamphenicol	low	1
cephalexin	low	1
cefazolin	low	1
amoxicillin	low	2
amikacin	low	2
propiconazole	low	1
moxalactam	low	1
pefloxacin	low	1
cefotetan	low	1
cephalosporin c	low	5
triazoles	low	1
voriconazole	low	1
oxazolidin-2-one	low	3
imipenem, anhydrous	low	3
moxifloxacin	low	1
trimethoprim, sulfamethoxazole drug combination	low	2
meropenem	low	6
linezolid	low	3
fosfomycin	low	2
amphotericin b	low	1
clavulanic acid	low	1
phenylephrine hydrochloride	low	1
cefotaxime	low	6
gadolinium dtpa	low	5
amoxicillin-potassium clavulanate combination	low	1
mocetinostat	low	1
indocyanine green	low	1
virginiamycin	low	1
cosyntropin	low	1
ro13-9904	low	10
novobiocin	low	1
minocycline	low	1
calca protein, human	low	1
lactoferrin	low	1
rifampin	low	3
eye	low	1

Protein Targets (638)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	7	0	0	7
ATAD5 protein, partial	2	0	0	2
GLS protein	7	0	0	7
Microtubule-associated protein tau	5	0	0	5
Smad3	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
thyroid stimulating hormone receptor	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
progesterone receptor	4	0	0	4
EWS/FLI fusion protein	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	9	0	0	9
estrogen nuclear receptor alpha	21	0	0	21
peroxisome proliferator activated receptor gamma	7	0	0	7
aryl hydrocarbon receptor	6	0	0	6
chromobox protein homolog 1	8	0	0	8
thyroid hormone receptor beta isoform 2	8	0	0	8
peripheral myelin protein 22	5	0	0	5
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	3	0	6
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	19
Solute carrier family 22 member 6	0	7	0	7
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	9	0	9
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Bile salt export pump	0	26	0	26
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	0	4
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	4	0	6
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	11	0	12
Cytochrome P450 2D6	0	5	0	6
Cytochrome P450 2C9	0	9	0	10
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	3	3	0	6
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	3	3	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	3	3	0	6
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	3	3	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	3	3	0	6
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	3	3	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	3	3	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	3	3	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	3	3	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	3	3	0	6
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
Carbonic anhydrase 7	0	2	0	2
Nuclear receptor ROR-gamma	3	0	0	3
Cytochrome P450 2J2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	3	3	0	6
Gamma-aminobutyric acid receptor subunit beta-3	3	3	0	6
Gamma-aminobutyric acid receptor subunit beta-2	3	3	0	6
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	3	3	0	6
Canalicular multispecific organic anion transporter 1	0	17	0	17
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	3	3	0	6
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
toxin B	0	0	0	1
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lamin isoform A-delta10	11	0	0	11
Aminoglycoside 3'-phosphotransferase	0	0	0	2
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Beta-lactamase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	5
Beta-lactamase	0	0	0	5
Beta-lactamase	0	1	0	5
AR protein	13	0	0	13
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	8	0	0	8
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
DNA polymerase kappa isoform 1	4	0	0	4
Beta-lactamase SHV-1	0	1	0	4
Beta-lactamase SHV-1	0	2	0	7
Beta-lactamase	0	1	0	6
Kappa-type opioid receptor	0	0	0	4
Solute carrier family 15 member 1	0	9	0	9
Solute carrier family 15 member 1	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	6
Solute carrier family 15 member 2	0	5	0	5
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Solute carrier family 15 member 2	0	6	0	7
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	4
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, Cruzipain	4	0	0	4
interleukin 8	3	0	0	3
phosphopantetheinyl transferase	6	0	0	6
glucocorticoid receptor [Homo sapiens]	11	0	0	11
farnesoid X nuclear receptor	6	0	0	6
peroxisome proliferator-activated receptor delta	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
Cytochrome P450 2C19	0	6	0	7
Potassium voltage-gated channel subfamily H member 2	0	7	0	9
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Beta-lactamase	0	1	0	4
acid sphingomyelinase	1	0	0	1
GLI family zinc finger 3	12	0	0	12
Beta-lactamase	0	2	0	5
Beta-lactamase	0	0	0	5
Metallo-beta-lactamase type 2	0	0	1	6
Metallo-beta-lactamase VIM-11	0	0	0	5
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Metallo-beta-lactamase VIM-2	0	0	0	5
Beta-lactamase	0	0	0	5
Metallo-beta-lactamase	0	0	0	5
Beta-lactamase	0	2	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA polymerase beta	1	0	0	1
geminin	12	0	0	12
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	1
Spike glycoprotein	4	0	0	4
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	4
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	5
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	4
Beta-lactamase Toho-1	0	0	0	3
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	1	0	3
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	4
Beta-lactamase	0	1	0	5
Beta-lactamase	0	0	1	5
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	7
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	7
Histamine H3 receptor	0	0	0	4
Beta-lactamase class B VIM-2	0	0	1	8
Beta-lactamase VIM-1	0	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Luciferase	2	0	0	2
thioredoxin reductase	5	0	0	5
cytochrome P450 2D6	5	0	0	5
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 8	0	4	0	4
Solute carrier family 22 member 11	0	2	0	2
Solute carrier family 22 member 8	0	4	0	5
Beta-lactamase	0	1	0	3
Beta-lactamase	0	2	0	4
Metallo-beta-lactamase VIM-19	0	0	0	4
Beta-lactamase	0	1	0	3
Albumin	0	1	5	6
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase VIM-2	0	0	0	4
Solute carrier family 22 member 7	0	1	0	2
BlaVIM-1	0	0	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	5
Solute carrier family 22 member 7	0	1	0	1
thioredoxin glutathione reductase	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3A isoform a	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
TDP1 protein	12	0	0	12
mitogen-activated protein kinase 1	3	0	0	3
Interferon beta	8	0	0	8
pregnane X nuclear receptor	8	0	0	8
G	7	0	0	7
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
heat shock protein beta-1	2	0	0	2
streptokinase A precursor	0	0	5	5
lethal factor (plasmid)	2	0	0	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
30S ribosomal protein S6	0	3	0	3
30S ribosomal protein S7	0	3	0	3
50S ribosomal protein L15	0	3	0	3
Cellular tumor antigen p53	9	0	0	9
50S ribosomal protein L10	0	3	0	3
50S ribosomal protein L11	0	3	0	3
50S ribosomal protein L7/L12	0	3	0	3
50S ribosomal protein L19	0	3	0	3
50S ribosomal protein L1	0	3	0	3
50S ribosomal protein L20	0	3	0	3
50S ribosomal protein L27	0	3	0	3
50S ribosomal protein L28	0	3	0	3
50S ribosomal protein L29	0	3	0	3
50S ribosomal protein L31	0	3	0	3
50S ribosomal protein L31 type B	0	3	0	3
50S ribosomal protein L32	0	3	0	3
50S ribosomal protein L33	0	3	0	3
50S ribosomal protein L34	0	3	0	3
50S ribosomal protein L35	0	3	0	3
50S ribosomal protein L36	0	3	0	3
30S ribosomal protein S10	0	3	0	3
30S ribosomal protein S11	0	3	0	3
30S ribosomal protein S12	0	3	0	3
30S ribosomal protein S13	0	3	0	3
30S ribosomal protein S16	0	3	0	3
30S ribosomal protein S18	0	3	0	3
30S ribosomal protein S19	0	3	0	3
30S ribosomal protein S20	0	3	0	3
30S ribosomal protein S2	0	3	0	3
30S ribosomal protein S3	0	3	0	3
30S ribosomal protein S4	0	3	0	3
30S ribosomal protein S5	0	3	0	3
30S ribosomal protein S8	0	3	0	3
30S ribosomal protein S9	0	3	0	3
50S ribosomal protein L13	0	3	0	3
50S ribosomal protein L14	0	3	0	3
50S ribosomal protein L16	0	3	0	3
50S ribosomal protein L23	0	3	0	3
30S ribosomal protein S15	0	3	0	3
50S ribosomal protein L17	0	3	0	3
50S ribosomal protein L21	0	3	0	3
50S ribosomal protein L30	0	3	0	3
50S ribosomal protein L6	0	3	0	3
30S ribosomal protein S14	0	3	0	3
30S ribosomal protein S17	0	3	0	3
30S ribosomal protein S1	0	3	0	3
50S ribosomal protein L18	0	3	0	3
50S ribosomal protein L2	0	3	0	3
50S ribosomal protein L3	0	3	0	3
50S ribosomal protein L24	0	3	0	3
50S ribosomal protein L4	0	3	0	3
50S ribosomal protein L22	0	3	0	3
50S ribosomal protein L5	0	3	0	3
30S ribosomal protein S21	0	3	0	3
50S ribosomal protein L25	0	3	0	3
50S ribosomal protein L36 2	0	3	0	3
Inositol hexakisphosphate kinase 1	7	0	0	7
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	7	0	0	7
cytochrome P450 2C9 precursor	2	0	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	4	0	6
DNA gyrase subunit A	0	6	0	10
DNA gyrase subunit B	0	6	1	10
DNA topoisomerase 4 subunit A	0	2	0	2
DNA topoisomerase 4 subunit B	0	2	0	3
DNA topoisomerase 4 subunit A	0	3	0	4
DNA topoisomerase 2-alpha	0	2	0	6
DNA gyrase subunit A	0	4	0	6
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	5	0	0	5
DNA gyrase subunit B	0	5	0	6
DNA gyrase subunit A	0	5	0	6
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	6
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	5	0	0	5
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	2	0	2
Beta-lactamase	0	1	0	4
Neutrophil elastase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
Cytochrome P450 2B6	0	2	1	3
Beta-lactamase TEM	0	3	0	7
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	0	3
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acetylcholinesterase	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	3	0	3
Rap guanine nucleotide exchange factor 3	2	0	0	2
Chymotrypsinogen A	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	2	3
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	2	0	2
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	3	0	3
Lanosterol 14-alpha demethylase	0	3	1	4
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
14-alpha sterol demethylase	0	0	2	2
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	3	0	0	3
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Ferritin light chain	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
estrogen receptor 2 (ER beta)	5	0	0	5
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Bloom syndrome protein isoform 1	4	0	0	4
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	2	2
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
arylsulfatase A	4	0	0	4
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	3
Beta-lactamase	0	0	0	3
67.9K protein	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	4	0	0	4
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	2	0	3
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Estrogen receptor	0	0	2	2
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	2	2
Renin	0	1	0	1
Solute carrier family 22 member 8	0	3	0	4
Thioredoxin reductase	0	1	0	1
Histone H2A.x	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Flavodoxin	0	0	0	1
Stromelysin-1	0	1	1	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	4	0	4
PPM1D protein	1	0	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
DNA gyrase subunit B	0	2	0	2
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Chain A, Gyrase	0	0	1	1
Genome polyprotein	0	1	1	2
DNA gyrase subunit B	0	1	0	1
interferon gamma precursor	0	0	0	1
Heat shock protein HSP 90-alpha	0	0	2	2
Heat shock protein HSP 90-beta	0	1	2	4
DNA gyrase subunit B	0	1	0	1
Cell division inhibitor SulA	0	0	0	1
Heat shock protein HSP 90	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
DNA topoisomerase	0	1	0	1
Microtubule-associated proteins 1A/1B light chain 3B	0	2	1	3
Microtubule-associated proteins 1A/1B light chain 3A	0	2	1	3
Vpr	2	0	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
endonuclease IV	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
USP1 protein, partial	2	0	0	2
GALC protein	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
flap endonuclease 1	2	0	0	2
M-phase phosphoprotein 8	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
glp-1 receptor, partial	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
IDH1	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Gamma-aminobutyric acid	0	1	0	1
regulator of G-protein signaling 4	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
pregnane X receptor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
dopamine D1 receptor	1	0	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
Pyridoxal kinase	0	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Abscess, Intracranial, Subdural

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (85)

Protein Targets (638)

Abscess, Intracranial, Subdural

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (85)

Drugs Studied (68)

Protein Targets (638)