metronidazole has been researched along with Mandibular Diseases in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Mandibular Diseases: Diseases involving the MANDIBLE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A regimen of ultrasound with local debridement and metronidazole has proved to be an effective and practicable treatment for osteoradionecrosis, achieving healing in 10/21 (48%) cases without the need for surgery or sophisticated technology." | 3.68 | The conservative management of osteoradionecrosis of the mandible with ultrasound therapy. ( Harris, M, 1992) |
| " Treatment with penicillin G was very effective in the acute stage, and chronic administration of metronidazole prevented relapse of the disease." | 1.35 | An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis. ( Fujimuro, M; Jackson, M; Kawarabayashi, T; Kimura, T; Matsubara, E; Nakahata, N; Seino, Y; Shirahama, I; Shoji, M; Suzuki, C; Takamura, A; Tomiyama, M; Wakasaya, Y; Watanabe, M; Yamamoto-Watanabe, Y, 2009) |
| "Circumscribed osteitis of a child's mandibula, with no dental etiology occurs around 7-years of age, adjacent to a healthy first molar." | 1.30 | [Circumscribed mandibular osteitis in children due to hematogenous dissemination. Apropos of 5 clinical cases]. ( Buis, J; Diner, PA; Franchi, G; Karcenty, B; Soupre, V; Vazquez, MP, 1999) |
| "Conventional treatment of osteoradionecrosis of mandible is by antibiotics combined if necessary with a hemimandibulectomy." | 1.27 | [Current treatment of osteoradionecrosis]. ( Blanc, JL; Cheynet, F; Lachard, A; Lachard, J; Lagier, JP; Rakotobe, P, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, K | 1 |
| Greenstein, A | 1 |
| Mahmood, S | 1 |
| Lowe, T | 1 |
| Yamamoto, Y | 1 |
| Asai, N | 1 |
| Furuhashi, A | 1 |
| Ono, T | 1 |
| Yamagishi, Y | 1 |
| Mikamo, H | 1 |
| Kazaoka, Y | 1 |
| Wakasaya, Y | 1 |
| Watanabe, M | 1 |
| Tomiyama, M | 1 |
| Suzuki, C | 1 |
| Jackson, M | 1 |
| Fujimuro, M | 1 |
| Kimura, T | 1 |
| Seino, Y | 1 |
| Kawarabayashi, T | 1 |
| Yamamoto-Watanabe, Y | 1 |
| Matsubara, E | 1 |
| Shirahama, I | 1 |
| Takamura, A | 1 |
| Nakahata, N | 1 |
| Shoji, M | 1 |
| Borysenko, AV | 1 |
| Nesin, OF | 1 |
| Piechkovs'kyĭ, KIe | 1 |
| Rakhniĭ, ZhI | 1 |
| Franchi, G | 1 |
| Soupre, V | 1 |
| Karcenty, B | 1 |
| Buis, J | 1 |
| Diner, PA | 1 |
| Vazquez, MP | 1 |
| Ogutcen-Toller, M | 1 |
| Alkan, A | 1 |
| Baris, S | 1 |
| Cakir, N | 1 |
| Harris, M | 1 |
| Millett, DT | 1 |
| Chapple, IL | 1 |
| Hirschmann, PN | 1 |
| Corrigan, AM | 1 |
| Lagier, JP | 1 |
| Blanc, JL | 1 |
| Lachard, A | 1 |
| Cheynet, F | 1 |
| Rakotobe, P | 1 |
| Lachard, J | 1 |
9 other studies available for metronidazole and Mandibular Diseases
| Article | Year |
|---|---|
Acute on chronic parotitis causing osteomyelitis and pathological fracture of the mandible.
Topics: Administration, Intravenous; Chronic Disease; Female; Floxacillin; Fractures, Bone; Humans; Mandibul | 2020 |
Metronidazole-induced encephalopathy caused by hyperbaric oxygen therapy in a patient with mandibular osteomyelitis.
Topics: Aged; Anti-Bacterial Agents; Cerebellar Ataxia; Cerebellar Nuclei; Chemoradiotherapy; Drug Therapy, | 2019 |
An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis.
Topics: Anti-Bacterial Agents; Chronic Disease; Gallium Radioisotopes; Head and Neck Neoplasms; Humans; Lymp | 2009 |
[The effect of a combined transplant on reparative osteogenesis in experimental defects of the jaw (the late results)].
Topics: Animals; Anti-Infective Agents; Bone Transplantation; Combined Modality Therapy; Drug Carriers; Fura | 1998 |
[Circumscribed mandibular osteitis in children due to hematogenous dissemination. Apropos of 5 clinical cases].
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Child; Curettage; Focal Infec | 1999 |
An unusual form of Actinomycosis of the mandible with a resultant gross sequester in a 4-year-old child: a case report.
Topics: Actinomycosis; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Child, Preschool; Follow-Up | 2001 |
The conservative management of osteoradionecrosis of the mandible with ultrasound therapy.
Topics: Brachytherapy; Cephalexin; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Humans; Male; | 1992 |
Septic osteoradionecrosis of the mandible associated with pathological fracture: report of two cases.
Topics: Aged; Female; Fractures, Spontaneous; Humans; Mandibular Diseases; Mandibular Fractures; Metronidazo | 1990 |
[Current treatment of osteoradionecrosis].
Topics: Combined Modality Therapy; Drug Therapy, Combination; Humans; Mandible; Mandibular Diseases; Metroni | 1986 |