metronidazole has been researched along with Precursor T-Cell Lymphoblastic Leukemia-Lymphoma in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma: A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Busulfan is a cytotoxic agent used in preconditioning for hematopoietic stem cell transplantation." | 1.46 | A Significant Influence of Metronidazole on Busulfan Pharmacokinetics: A Case Report of Therapeutic Drug Monitoring. ( Choi, JY; Chung, H; Hong, CR; Hong, KT; Kang, HJ; Lee, S; Park, KD; Shin, HY; Yu, KS, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, H | 1 |
| Yu, KS | 1 |
| Hong, KT | 1 |
| Choi, JY | 1 |
| Hong, CR | 1 |
| Kang, HJ | 1 |
| Park, KD | 1 |
| Shin, HY | 1 |
| Lee, S | 1 |
1 other study available for metronidazole and Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
A Significant Influence of Metronidazole on Busulfan Pharmacokinetics: A Case Report of Therapeutic Drug Monitoring.
Topics: Busulfan; Child, Preschool; Drug Monitoring; Female; Hematopoietic Stem Cell Transplantation; Humans | 2017 |