metronidazole has been researched along with Bladder Cancer in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors presented short-term and immediate results of radiation therapy of bladder cancer by a conventional method and optimized program, combining accelerated hyperfractionation and local radiomodification with metronidazole." | 7.68 | [The radiation therapy of bladder cancer in a regimen of nontraditional fractionation with local radiomodification by metronidazole]. ( Mufazalov, FF; Pereslegin, IA, 1991) |
| "The paper is devoted to the description of the combined methods of radiotherapy of urinary bladder cancer and the local use of metronidazole." | 7.67 | [Dynamic fractionation of the radiation dosage combined with the local use of metronidazole in bladder cancer]. ( Mufazalov, FF; Pereslegin, IA; Vinogradskiĭ, AG, 1989) |
| "The authors presented short-term and immediate results of radiation therapy of bladder cancer by a conventional method and optimized program, combining accelerated hyperfractionation and local radiomodification with metronidazole." | 3.68 | [The radiation therapy of bladder cancer in a regimen of nontraditional fractionation with local radiomodification by metronidazole]. ( Mufazalov, FF; Pereslegin, IA, 1991) |
| "The paper is devoted to the description of the combined methods of radiotherapy of urinary bladder cancer and the local use of metronidazole." | 3.67 | [Dynamic fractionation of the radiation dosage combined with the local use of metronidazole in bladder cancer]. ( Mufazalov, FF; Pereslegin, IA; Vinogradskiĭ, AG, 1989) |
| "Four patients had had cervical cancer, five had uterine cancer, one had prostatic cancer, one had vesical cancer and one had vaginal cancer." | 1.37 | A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration. ( Atittharnsakul, P; Patiwongpaisarn, A; Rojanasakul, A; Sahakitrungruang, C; Thum-Umnuaysuk, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sahakitrungruang, C | 1 |
| Thum-Umnuaysuk, S | 1 |
| Patiwongpaisarn, A | 1 |
| Atittharnsakul, P | 1 |
| Rojanasakul, A | 1 |
| Fowler, JF | 1 |
| Pereslegin, IA | 2 |
| Mufazalov, FF | 2 |
| Kob, D | 1 |
| Lilienthal, A | 1 |
| Bauhardt, H | 1 |
| Merkle, K | 1 |
| Schröder, E | 2 |
| Hentschel, M | 1 |
| Vinogradskiĭ, AG | 1 |
5 other studies available for metronidazole and Bladder Cancer
| Article | Year |
|---|---|
A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Ga | 2011 |
Developments in radiotherapy other than heavy particle beams.
Topics: Animals; Brain Neoplasms; Energy Transfer; Fast Neutrons; Female; Glioblastoma; Hot Temperature; Hum | 1977 |
[The radiation therapy of bladder cancer in a regimen of nontraditional fractionation with local radiomodification by metronidazole].
Topics: Administration, Intravesical; Aged; Carcinoma, Transitional Cell; Combined Modality Therapy; Female; | 1991 |
[The radiation-sensitizing effect of isometronidazole following its intravesical application in bladder carcinoma. A clinical phase-II study].
Topics: Administration, Intravesical; Combined Modality Therapy; Drug Evaluation; Female; Humans; Male; Metr | 1991 |
[Dynamic fractionation of the radiation dosage combined with the local use of metronidazole in bladder cancer].
Topics: Administration, Intravesical; Aged; Combined Modality Therapy; Female; Gamma Rays; Humans; Metronida | 1989 |