metronidazole has been researched along with Injuries, Leg in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tumram, NK | 1 |
| Bardale, RV | 1 |
| Dixit, PG | 1 |
| Deshmukh, AY | 1 |
| Ankra-Badu, GA | 1 |
| Warren, RA | 1 |
| Warren, MA | 1 |
| Buswell, WA | 1 |
| Shanson, DC | 1 |
1 trial available for metronidazole and Injuries, Leg
| Article | Year |
|---|---|
Wound healing and infection in pretibial lacerations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Drug Therapy, Combination; Female; Floxacillin; Humans; | 1991 |
2 other studies available for metronidazole and Injuries, Leg
| Article | Year |
|---|---|
A fatal mongoose bite.
Topics: Animals; Anti-Infective Agents; Bites and Stings; Cefoperazone; Drug Therapy, Combination; Fatal Out | 2012 |
Sickle cell leg ulcers in Ghana.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Anti-Bacterial Agents; Borates; Drug Therapy, Combination; F | 1992 |