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metronidazole and Leukemia

metronidazole has been researched along with Leukemia in 4 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aguado, JM1
Gómez Berne, J1
Figuera, A1
de Villalobos, E1
Fernández-Guerrero, ML1
Sanchez Fayos, J1
Barrett, AP1
Schifter, M1
Dworczyński, A1
Sokół, B1
Meisel-Mikołajczyk, F1
Taylor, JA1

Other Studies

4 other studies available for metronidazole and Leukemia

ArticleYear
Visceral leishmaniasis (kala-azar) complicating acute leukaemia.
    The Journal of infection, 1983, Volume: 7, Issue:3

    Topics: Acute Disease; Adolescent; Humans; Leishmaniasis, Visceral; Leukemia; Male; Metronidazole

1983
Antibiotic strategy in orofacial/head and neck infections in severe neutropenia.
    Oral surgery, oral medicine, and oral pathology, 1994, Volume: 77, Issue:4

    Topics: Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Clinical Prot

1994
Antibiotic resistance of Clostridium difficile isolates.
    Cytobios, 1991, Volume: 65, Issue:262-263

    Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Clindamycin; Clostridioides difficile; D

1991
Metronidazole and transient leukopenia.
    JAMA, 1965, Dec-20, Volume: 194, Issue:12

    Topics: Aged; Agranulocytosis; Bone Marrow Examination; Humans; Leukemia; Leukocyte Count; Male; Metronidazo

1965