metronidazole has been researched along with Leukemia in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (50.00) | 18.7374 |
1990's | 2 (50.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Aguado, JM | 1 |
Gómez Berne, J | 1 |
Figuera, A | 1 |
de Villalobos, E | 1 |
Fernández-Guerrero, ML | 1 |
Sanchez Fayos, J | 1 |
Barrett, AP | 1 |
Schifter, M | 1 |
Dworczyński, A | 1 |
Sokół, B | 1 |
Meisel-Mikołajczyk, F | 1 |
Taylor, JA | 1 |
4 other studies available for metronidazole and Leukemia
Article | Year |
---|---|
Visceral leishmaniasis (kala-azar) complicating acute leukaemia.
Topics: Acute Disease; Adolescent; Humans; Leishmaniasis, Visceral; Leukemia; Male; Metronidazole | 1983 |
Antibiotic strategy in orofacial/head and neck infections in severe neutropenia.
Topics: Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Clinical Prot | 1994 |
Antibiotic resistance of Clostridium difficile isolates.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Clindamycin; Clostridioides difficile; D | 1991 |
Metronidazole and transient leukopenia.
Topics: Aged; Agranulocytosis; Bone Marrow Examination; Humans; Leukemia; Leukocyte Count; Male; Metronidazo | 1965 |