Cavernous Sinus Thrombophlebitis

Formation or presence of a blood clot (THROMBUS) in the CAVERNOUS SINUS of the brain. Infections of the paranasal sinuses and adjacent structures, CRANIOCEREBRAL TRAUMA, and THROMBOPHILIA are associated conditions. Clinical manifestations include dysfunction of cranial nerves III, IV, V, and VI, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)

Synonym
Septic Phlebitis, Cavernous Sinus
Cavernous Sinus Thrombosis
Thrombosis, Cavernous Sinus
Caverous Sinus Septic Phlebitis
Cavernous Sinus, Phlebitis, Septic
Cavernous Sinus Thrombophlebitis
Phlebitis, Cavernous Sinus, Septic

Excerpt	Reference
"Septic cavernous sinus thrombosis is a rare clinical condition."	( Dinaker, M; Kattula, SR; Kommalapati, V; Sharabu, C, 2014)
"Cavernous Sinus Thrombosis is a rare but serious condition."	( AlKhani, R; Battistin, U; Hallak, F; Hallak, O; Hallak, YO, 2020)
"Cavernous sinus thrombosis is a rare and often fatal condition, usually associated with infections in the head and neck region."	( Guileyardo, JM; Podduturi, V, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	20 (24.69)	23.3326
1990's	1 (1.23)	12.5806
2000's	22 (27.16)	18.1394
2010's	33 (40.74)	28.8240
2020's	5 (6.17)	9.53

Drug	Relationship Strength	Studies
coumarin	low	1
salicylic acid	low	1
dalteparin	low	3
aspirin	low	2
azathioprine	low	1
cefuroxime	low	1
gentamicin	low	2
2-propanol	low	1
ketoconazole	low	1
metronidazole	low	4
sulfadiazine	low	1
sulfanilamide	low	3
temozolomide	low	1
prednisolone	low	3
penicillin g	low	1
chloramphenicol	low	2
methicillin	low	3
cloxacillin	low	1
colchicine	low	1
methylprednisolone	low	4
quinoxalines	low	1
nafcillin	low	1
fusarium	low	1
carinamide	low	1
methamphetamine	low	1
erythromycin	low	1
vancomycin	low	5
streptomycin	low	2
gadolinium	low	2
timolol	low	1
propiconazole	low	18
paroxetine	low	1
cephalosporin c	low	1
triazoles	low	2
bendamustine hydrochloride	low	1
homocysteine	low	1
methotrexate	low	1
inositol 3-phosphate	low	1
meropenem	low	1
clindamycin	low	1
posaconazole	low	2
amphotericin b	low	7
phenylephrine hydrochloride	low	5
latanoprost	low	1
cefotaxime	low	1
apixaban	low	1
brimonidine tartrate	low	1
technetium tc 99m exametazime	low	1
ro13-9904	low	5
chlortetracycline	low	1
dicumarol	low	1
warfarin	low	5
phenprocoumon	low	1
rolitetracycline	low	1
hirudin	low	1
refludan	low	1
rifampin	low	2
dacarbazine	low	1
eye	low	9

Protein Targets (726)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	11	0	0	11
GLI family zinc finger 3	12	0	0	12
AR protein	18	0	0	18
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	11	0	0	11
estrogen nuclear receptor alpha	22	0	0	22
peroxisome proliferator-activated receptor delta	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Histone H2A.x	5	0	0	5
thyroid hormone receptor beta isoform a	6	0	0	6
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
lamin isoform A-delta10	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
Glutamate receptor 2	10	0	0	10
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, Cruzipain	2	0	0	2
interleukin 8	7	0	0	7
phosphopantetheinyl transferase	4	0	0	4
GLS protein	3	0	0	3
glucocorticoid receptor [Homo sapiens]	15	0	0	15
farnesoid X nuclear receptor	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	5	0	0	5
peripheral myelin protein 22	7	0	0	7
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 3A4	0	8	0	9
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C9	0	7	0	7
Cytochrome P450 2C19	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
EWS/FLI fusion protein	8	0	0	8
Coagulation factor X	0	1	0	1
Prothrombin	0	1	0	1
Coagulation factor X	0	2	0	2
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Spike glycoprotein	6	0	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
thioredoxin reductase	8	0	0	8
thyroid stimulating hormone receptor	8	0	0	8
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
estrogen-related nuclear receptor alpha	18	0	0	18
cytochrome P450 2D6	6	0	0	6
glucocerebrosidase	2	0	0	2
Rac1 protein	0	0	1	1
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	8	0	0	8
Bloom syndrome protein isoform 1	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	6	0	0	6
DNA polymerase kappa isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	19
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Bile salt export pump	0	25	0	25
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	9	0	11
Carbonic anhydrase 2	0	9	2	13
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	2	1	0	3
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	2	1	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	2
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	1	6
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Canalicular multispecific organic anion transporter 1	0	17	0	17
Sigma non-opioid intracellular receptor 1	0	3	1	4
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Ferritin light chain	4	0	0	4
acetylcholinesterase	2	0	0	2
SMAD family member 2	3	0	0	3
ATAD5 protein, partial	4	0	0	4
Fumarate hydratase	3	0	0	3
SMAD family member 3	3	0	0	3
TDP1 protein	13	0	0	13
Microtubule-associated protein tau	4	0	0	4
thioredoxin glutathione reductase	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
pregnane X nuclear receptor	12	0	0	12
G	7	0	0	7
polyprotein	3	0	0	3
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	11	0	0	11
arylsulfatase A	2	0	0	2
aryl hydrocarbon receptor	6	0	0	6
thyroid stimulating hormone receptor	5	0	0	5
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	11	0	0	11
geminin	12	0	0	12
survival motor neuron protein isoform d	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	4	0	1	5
Bile salt export pump	0	8	0	8
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Cellular tumor antigen p53	12	0	0	12
Gamma-aminobutyric acid receptor subunit beta-1	4	0	1	5
Gamma-aminobutyric acid receptor subunit delta	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	1	5
Gamma-aminobutyric acid receptor subunit beta-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit beta-2	4	0	1	5
GABA theta subunit	4	0	1	5
Inositol hexakisphosphate kinase 1	7	0	0	7
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	8	0	0	8
Gamma-aminobutyric acid receptor subunit epsilon	4	0	1	5
Protein-arginine deiminase type-4	0	7	0	7
cytochrome P450 2C9, partial	7	0	0	7
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	1	4
Metallo-beta-lactamase VIM-11	0	0	0	3
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	2
Albumin	0	1	5	6
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase	0	0	0	3
Kappa-type opioid receptor	0	0	0	2
Solute carrier family 15 member 1	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 7	0	1	0	2
Metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-b-lactamase	0	0	0	4
BlaVIM-1	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 8	0	3	0	4
Beta-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	3
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	1	5
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	2	0	3
Beta-lactamase VIM-1	0	0	0	3
Solute carrier family 22 member 7	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
streptokinase A precursor	0	0	4	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
50S ribosomal protein L36 2	0	2	1	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 8	0	4	0	5
Beta-lactamase OXA-7	0	0	0	1
Beta-lactamase TEM	0	2	0	4
Efflux transporter	0	1	0	2
Beta-lactamase	0	1	0	2
Chain A, Beta-lactamase	6	0	0	6
Luciferase	2	0	0	2
endonuclease IV	1	0	0	1
PAX8	0	0	0	1
pregnane X receptor	3	0	0	3
USP1 protein, partial	4	0	0	4
PPM1D protein	3	0	0	3
Thrombopoietin	1	0	0	1
Smad3	2	0	0	2
estrogen receptor 2 (ER beta)	6	0	0	6
67.9K protein	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
cytochrome P450 2D6 isoform 1	2	0	0	2
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
chromobox protein homolog 1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
flap endonuclease 1	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	5	0	5
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	6	0	7
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Histamine H2 receptor	4	0	0	4
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
ATP-dependent phosphofructokinase	5	0	0	5
GALC protein	2	0	0	2
glycogen synthase kinase-3 alpha	0	0	0	1
Exportin-1	0	1	0	1
Carbonic anhydrase 12	0	4	0	5
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	3	0	3
Cytochrome P450 2A6	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Cytochrome P450 2A5	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase 6	0	5	0	5
Carbonic anhydrase 5A, mitochondrial	0	4	0	5
UDP-glucuronosyltransferase 2B10	0	1	0	1
Carbonic anhydrase 7	0	3	0	3
Quinone oxidoreductase	0	0	0	1
Beta-secretase 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Carbonic anhydrase 9	0	5	0	6
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	2	0	2
Carbonic anhydrase 15	0	3	0	3
Carbonic anhydrase 13	0	3	0	3
Carbonic anhydrase 14	0	3	0	3
Carbonic anhydrase 5B, mitochondrial	0	3	0	4
Matrix metalloproteinase-9	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Isocitrate lyase	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
NAD	0	1	0	1
Cholinesterase	0	2	0	2
Urease	0	1	0	1
NAD	0	1	0	2
Mitogen-activated protein kinase 1	0	1	0	1
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Integrase	0	2	0	2
G-protein coupled receptor 35	0	1	1	2
Motilin receptor	0	0	1	1
acid sphingomyelinase	2	0	0	2
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	3	0	3
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	3	0	3
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	3	0	3
Lanosterol 14-alpha demethylase	0	5	1	6
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Multidrug and toxin extrusion protein 1	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Estrogen receptor beta	0	1	0	2
Solute carrier family 22 member 1	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	3	0	3
Epoxide hydrolase 1	0	0	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	0	4
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Alpha-2A adrenergic receptor	0	3	0	3
Cytochrome P450 2C8	0	1	0	1
Aromatase	0	3	0	3
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Translocator protein	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Estrogen receptor	0	1	0	2
Substance-K receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	2	6
Thromboxane-A synthase	0	1	0	1
Histamine H2 receptor	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	4	2	6
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 4F2	0	1	0	1
Sodium-dependent dopamine transporter	0	4	1	5
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
beta-2 adrenergic receptor	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	1	3
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
progesterone receptor	7	0	0	7
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	3
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nonstructural protein 1	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	4	1	10
Glycine receptor subunit alpha-1	0	4	0	4
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	0	1	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Quinolone resistance protein NorA	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	3	1	4
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
P2X purinoceptor 4	0	1	0	1
Envelope glycoprotein	0	0	1	1
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
P2X purinoceptor 4	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Transporter	0	3	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
glp-1 receptor, partial	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Sterol 14-alpha-demethylase	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
14-alpha sterol demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
heat shock protein 90, putative	0	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	3
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Insulin-degrading enzyme	0	1	0	1
DNA repair protein RAD52 homolog	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Aurora kinase A	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Protein argonaute-2	0	0	1	1
polyadenylate-binding protein 1	0	1	0	1
Tyrosine-protein kinase ABL2	0	1	0	1
NFKB1 protein, partial	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
Beta-2 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Cavernous Sinus Thrombophlebitis

Synonyms(7)

Research Excerpts

Overview

Research

Studies (81)

Protein Targets (726)

Cavernous Sinus Thrombophlebitis

Synonyms(7)

Research Excerpts

Overview

Research

Studies (81)

Drugs Studied (63)

Protein Targets (726)