metronidazole has been researched along with Cancer of Mouth in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of radiation therapy were compared in 217 patients at advanced stages of cancer of the tongue (131) and fundus of the mouth (86) using split courses of conventional (SCF) and dynamic fractionation (SDF) and SDF combined with metronidazole." | 3.68 | [Probit analysis in assessing the results of radiation therapy of disseminated cancer of the tongue and floor of the mouth]. ( Limarova, IV; Ustinskov, VI; Vorob'ev, IuI, 1990) |
| "Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F." | 2.72 | Fusobacterium nucleatum and oral cancer: a critical review. ( Craig, SG; James, JA; Linden, GJ; Lundy, FT; McIlvanna, E, 2021) |
| "So a study was undertaken in various cancer patients to observe the role of metrnidazole as a selective radiosensitizer." | 2.67 | Role of metronidazole in radiation therapy (a review of 717 cancer cases). ( Acharya, DK, 1994) |
| " On the basis of pharmacokinetic investigations, administration of the antibiotic 30 min preoperatively fulfills this requirement." | 2.66 | [Bacteriological, clinical, and pharmacokinetic studies of perioperative antibiotic prophylaxis in head and neck surgery]. ( Anagnostou, M; Bleier, R; Borneff, M; Geyer, G; Hartmetz, G; Roser, F, 1987) |
| "In the patients with esophageal cancer after MZ administration via the gastrostoma, the nature and time course of drug accumulation in the blood was identical, however accumulation maximum was lower and reached 219 +/- 25 micrograms/ml." | 1.27 | [Pharmacokinetics and the effects of metronidazole during its use as a radiosensitizer]. ( Dar'ialova, SL; Kiseleva, ES; Poliakov, PIu; Zel'vin, BM; Zimina, ES, 1984) |
| "Proceeding from the clinical observation of 11 patients with cancer of the tongue, oral mucosa and stomatopharynx who received gamma-beam therapy according to the scheme of dynamic fractionation combined with metronidazole, it has been concluded that the drug enhances the degree of radiation injury of the above tumors." | 1.27 | [Cell kinetics of oral cancer during gamma teletherapy in combination with the administration of metronidazole]. ( Dar'ialova, SL; Karakulov, RK; Kiseleva, ES; Pelevina, II; Poliakov, PIu, 1983) |
| "Metronidazole was administered per os 3 = 4 h before irradiation with fractions I, III and V of each phase of a split course." | 1.27 | [Radiotherapy, using metronidazole, of regional lymph node metastases of cancer of the oral mucosa]. ( Limarova, IV, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (60.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| McIlvanna, E | 1 |
| Linden, GJ | 1 |
| Craig, SG | 1 |
| Lundy, FT | 1 |
| James, JA | 1 |
| Cloke, DJ | 1 |
| Green, JE | 1 |
| Khan, AL | 1 |
| Hodgkinson, PD | 1 |
| McLean, NR | 1 |
| Aiken, K | 1 |
| Koyuncu, M | 1 |
| Acuner, IC | 1 |
| Uyar, M | 1 |
| Kiseleva, ES | 5 |
| Dar'ialova, SL | 5 |
| Vorob'ev, IuI | 2 |
| Limarova, IV | 3 |
| Zel'vin, BM | 1 |
| Poliakov, PIu | 4 |
| Zimina, ES | 1 |
| Karakulov, RK | 3 |
| Pelevina, II | 3 |
| Zykov, AP | 1 |
| Kuznetsova, IP | 1 |
| Orr, LE | 1 |
| Puthawala, A | 1 |
| Syed, AM | 1 |
| Fleming, PA | 1 |
| Acharya, DK | 1 |
| Griffin, JP | 1 |
| Tandon, DA | 1 |
| Bahadur, S | 1 |
| Laldina, HC | 1 |
| Sundaram, KR | 1 |
| Ustinskov, VI | 1 |
| Borneff, M | 2 |
| Hartmetz, G | 2 |
| Roser, F | 1 |
| Geyer, G | 2 |
| Bleier, R | 1 |
| Anagnostou, M | 1 |
| Zazovskiĭ, LM | 1 |
| Brusis, T | 1 |
| Luckhaupt, H | 1 |
| Daryalova, SL | 1 |
| Zeljvin, BM | 1 |
| Kvasov, VA | 1 |
4 reviews available for metronidazole and Cancer of Mouth
| Article | Year |
|---|---|
Fusobacterium nucleatum and oral cancer: a critical review.
Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Cell Movement; Cell Proliferation; Col | 2021 |
Managing tissue necrosis associated with oral carcinoma.
Topics: Aged; Anti-Infective Agents; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Mouth Neoplasm | 2004 |
[Electron acceptor compounds as radiation sensitizers of hypoxic cells in human tumors].
Topics: Brain Neoplasms; Combined Modality Therapy; Esophageal Neoplasms; Female; Head and Neck Neoplasms; H | 1984 |
Drug-induced disorders of taste.
Topics: Adverse Drug Reaction Reporting Systems; Captopril; Humans; Metronidazole; Mouth Neoplasms; Penicill | 1992 |
3 trials available for metronidazole and Cancer of Mouth
| Article | Year |
|---|---|
Role of metronidazole in radiation therapy (a review of 717 cancer cases).
Topics: Female; Humans; Metronidazole; Mouth Neoplasms; Neoplasms; Uterine Cervical Neoplasms | 1994 |
Role of prophylactic antibiotics in surgery for advanced head and neck cancer.
Topics: Adult; Aged; Ampicillin; Anti-Bacterial Agents; Cephalexin; Combined Modality Therapy; Drug Therapy, | 1992 |
[Bacteriological, clinical, and pharmacokinetic studies of perioperative antibiotic prophylaxis in head and neck surgery].
Topics: Adult; Aged; Bacterial Infections; Female; Humans; Intraoperative Period; Laryngectomy; Male; Metron | 1987 |
13 other studies available for metronidazole and Cancer of Mouth
| Article | Year |
|---|---|
Factors influencing the development of wound infection following free-flap reconstruction for intra-oral cancer.
Topics: Adult; Aged; Aged, 80 and over; Cefuroxime; Drug Therapy, Combination; Female; Humans; Male; Metroni | 2004 |
Deep neck infection due to Lactococcus lactis cremoris: a case report.
Topics: Aged; Animals; Anti-Infective Agents; Biopsy; C-Reactive Protein; Ceftriaxone; Gram-Positive Bacteri | 2005 |
[Radiation treatment with metronidazole in patients with oral mucosa cancer in the late stages].
Topics: Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Gamma Rays; Humans; Male; Metroni | 1983 |
[Pharmacokinetics and the effects of metronidazole during its use as a radiosensitizer].
Topics: Adult; Esophageal Neoplasms; Humans; Inactivation, Metabolic; Intestinal Absorption; Kidney; Kidney | 1984 |
[Cell kinetics of oral cancer during gamma teletherapy in combination with the administration of metronidazole].
Topics: Administration, Oral; Adult; Carcinoma, Squamous Cell; Cell Division; Humans; Metronidazole; Middle | 1983 |
[Optimization of methods of radiotherapy of cancer of the tongue, mouth mucosa and oropharynx].
Topics: Adolescent; Adult; Humans; Hyperbaric Oxygenation; Methods; Metronidazole; Middle Aged; Mouth Neopla | 1982 |
Metronidazole and interstitial implantation in the treatment of extensive recurrent head and neck cancers.
Topics: Brachytherapy; Carcinoma, Squamous Cell; Drug Administration Schedule; Humans; Metronidazole; Middle | 1981 |
[Probit analysis in assessing the results of radiation therapy of disseminated cancer of the tongue and floor of the mouth].
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Dose-Response Relationship, Radiation; Female; | 1990 |
[Perioperative prophylaxis with cefmenoxime and metronidazole in patients with head and neck tumors].
Topics: Cefmenoxime; Cefotaxime; Drug Therapy, Combination; Female; Glossectomy; Humans; Laryngeal Neoplasms | 1987 |
[Use of the indicators of the proliferative activity of tumors of the oropharyngeal area as qualitative prognostic criteria of the radiotherapy].
Topics: Brachytherapy; Carcinoma, Squamous Cell; Humans; Hyperbaric Oxygenation; Metronidazole; Mouth Neopla | 1986 |
[Anaerobic infections in ulcerating tumors of the head and neck. A contribution to the problem of odors].
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Clindamycin; Head and Neck Neopla | 1986 |
[Radiotherapy, using metronidazole, of regional lymph node metastases of cancer of the oral mucosa].
Topics: Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Lymphatic Metastasis; Mal | 1986 |
Studies of metronidazole radiosensitizing effect in radiation treatment of patients with oral cavity cancer.
Topics: Adult; Aged; Cell Division; Female; Humans; Liver; Male; Metronidazole; Middle Aged; Mouth Neoplasms | 1985 |