metronidazole has been researched along with Lassitude in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-eight patients with active Crohn's disease participated in a randomized, double-blind, cross-over trial." | 2.65 | A comparative study of metronidazole and sulfasalazine for active Crohn's disease: the cooperative Crohn's disease study in Sweden. II. Result. ( Alm, T; Bárány, F; Bergelin, I; Ganrot-Norlin, K; Hoevels, J; Huitfeldt, B; Järnerot, G; Krause, U; Krook, A; Lindström, B; Nordle, O; Rosén, A; Ursing, B, 1982) |
| "To review our experience in managing pyogenic liver abscesses to aid in the current management of this complex condition." | 1.46 | Pyogenic Liver Abscess: A Retrospective Study of 105 Cases in an Emergency Department from East China. ( Chen, W; Liu, L; Lu, X; Zhang, K; Zhu, C, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L | 1 |
| Chen, W | 1 |
| Lu, X | 1 |
| Zhang, K | 1 |
| Zhu, C | 1 |
| Aijaz, B | 1 |
| Beckman, TJ | 1 |
| Ursing, B | 1 |
| Alm, T | 1 |
| Bárány, F | 1 |
| Bergelin, I | 1 |
| Ganrot-Norlin, K | 1 |
| Hoevels, J | 1 |
| Huitfeldt, B | 1 |
| Järnerot, G | 1 |
| Krause, U | 1 |
| Krook, A | 1 |
| Lindström, B | 1 |
| Nordle, O | 1 |
| Rosén, A | 1 |
| Ahmed, DS | 1 |
| Fecik, S | 1 |
| Matveev, VF | 1 |
| Vorob'ev, VS | 1 |
| Khambatta, RB | 1 |
1 trial available for metronidazole and Lassitude
| Article | Year |
|---|---|
A comparative study of metronidazole and sulfasalazine for active Crohn's disease: the cooperative Crohn's disease study in Sweden. II. Result.
Topics: Adult; Anorexia; Blood Sedimentation; Clinical Trials as Topic; Crohn Disease; Double-Blind Method; | 1982 |
5 other studies available for metronidazole and Lassitude
| Article | Year |
|---|---|
Pyogenic Liver Abscess: A Retrospective Study of 105 Cases in an Emergency Department from East China.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; C-Reactive Protein; Calcitonin; Carbapenems; Cephalo | 2017 |
25-year-old man with abdominal pain, nausea, and fatigue.
Topics: Abdominal Pain; Adult; Antiprotozoal Agents; Diagnosis, Differential; Fatigue; Giardiasis; Humans; M | 2007 |
The fatigue factor. When long shifts harm patients.
Topics: Adult; Alcohol Drinking; Anti-Infective Agents; Drug Interactions; Fatigue; Female; Humans; Medicati | 1999 |
[Experience with treatment of chronic alcoholism patients with large doses of metronidazole in psychoneurologic dispensaries].
Topics: Adult; Alcoholism; Apomorphine; Chronic Disease; Fatigue; Feeding and Eating Disorders; Humans; Male | 1969 |
Metronidazole in giardiasis.
Topics: Adult; Electrocardiography; Fatigue; Feeding and Eating Disorders; Giardiasis; Humans; Metronidazole | 1971 |