Page last updated: 2024-09-28

Rhinophyma

A manifestation of severe ROSACEA resulting in significant enlargement of the NOSE and occurring primarily in men. It is caused by hypertrophy of the SEBACEOUS GLANDS and surrounding CONNECTIVE TISSUE. The nose is reddened and marked with TELANGIECTASIS.

Synonyms(1)

Synonym
Rhinophyma

Research Excerpts

Overview

ExcerptReference
"Rhinophyma is the end stage of acne rosacea, which results in a large nose due to a proliferation of sebaceous glands and fibrous tissue."( Roenigk, RK, 1987)
"Rhinophyma is an uncommon condition that often results in both functional as well as cosmetic impairment."( Hoasjoe, DK; Stucker, FJ, 1995)
"Rhinophyma is a slowly progressive, disfiguring disorder of the nose which represents the end stage of acne rosacea."( Sharma, VL; Simo, R, 1996)
"Rhinophyma is a benign, disfiguring disorder of the nose which presents the end stage of acne rosacea, and can also occasionally result in nasal airway obstruction."( Frand, J; Haik, J; Kaplan, H; Orenstein, A; Tamir, J; Winkler, E; Zilinsky, I, 2001)
"Rhinophyma is the commonest among them."( Jansen, T; Plewig, G, 1998)
"Laser ablation of rhinophyma is a stress-minimizing procedure for the surgeon and the patient, as it is nearly bloodless and can be performed under local anesthesia."( Jovanovic, S; Sedlmaier, B, 1998)
"Rhinophyma is a slowly progressive disfiguring disorder of the nose that represents the end stage of acne rosacea."( Sharma, VL; Simo, R, 1998)
"Rhinophyma is a common condition in the west of Scotland."( Choudhary, S; Curnier, A, 2002)
"Rhinophyma is an uncommon progressively disfiguring process of the nose which occurs most often in middle-aged white men."( Bier, J; Klein, M; Raguse, JD; Schrader, T; Schwerdtner, O, 2004)
"Rhinophyma is a relatively common condition in the west of Scotland."( Choudhary, S; Curnier, A, 2004)
"Rhinophyma is an uncommon disease of the nose characterized by irregular skin thickening and nodular deformation."( Aberer, W; Arbab, E; Scharnagl, E; Schintler, MV; Spendel, S, 2006)
"Rhinophyma is a slowly progressive, benign dermatological disorder of the nose."( Baptista, A; Guedes, R; Leite, I; Moreira, A; Mota, G, 2010)
"Rhinophyma is characterized by a slow progressive enlargement of the nasal skin that cannot resolve spontaneously."( Arikan, OK; Cirpar, O; Muluk, NB, 2010)
"Rhinophyma is a subtype of rosacea which develops at the advanced stage of rosacea and is characterized by an excessive enlargement of the sebaceous glands."( Aytekin, AH; Elmas, O; Erbatur, S; Firat, C, 2012)
"Rhinophyma is characterized by slowly progressive tumour-like enlargement of the nasal skin that will not resolve spontaneously."( Agostini, T; Grassetti, L; Huemer, GM; Larcher, L; Lazzeri, D; Li, Q; Pantaloni, M; Riml, S; Spinelli, G; Zhang, YX, 2013)
"Rhinophyma is a progressive nasal deformity resulting from hyperplasia of the sebaceous glands and connective tissue, with a negative effect on quality of life."( Averbeck, M; Kendler, M; Simon, JC; Wetzig, T, 2013)
"Rhinophyma is a swelling of the soft tissue of the nose due to sebaceous gland hypertrophy, lymphoedema and fibrosis."( Lakhani, R; Panesar, J; Shah, A, 2013)
"Rhinophyma is a disfiguring condition etiologically related to rosacea and due to hypertrophy of the sebaceous glands of the nose."( Arnež, ZM; Franchi, A; Novati, FC; Ramella, V; Roggio, T, 2015)
"Whereas early rhinophyma is histopathologically thought to resemble fully developed rosacea, a fibromatous variant has previously been described for severe rhinophyma."( Kreuz, M; Schüürmann, M; Wetzig, T; Wickenhauser, C; Ziemer, M; Ziepert, M, 2015)
"Rhinophyma is a form of rosacea and is often cosmetically disfiguring."( Karsai, S; Pohl, L; Raulin, C, 2018)
"Rhinophyma is a rare disease characterized by chronic inflammation and hypertrophy of sebaceous glands, blood vessels, and fibrous tissue, associated with end-stage severe acne rosacea."( Cui, MY; Guo, S; Jin, SF; Lv, MZ; Wang, CC, 2019)
"Rhinophyma is a rare manifestation of rosacea."( Borzęcki, A; Sajdak-Wojtaluk, A; Strus-Rosińska, B; Turska, M, 2019)
"Rhinophyma is a skin disorder which causes nose enlargement and deformation due to proliferation of sebaceous glands and connective tissue."( Borzęcki, A; Turska, M, 2020)
"Although rhinophyma is considered to be a subtype of rosacea, here we hypothesise whether it is a separate disease with mechanical trauma as a main reason of the disease progress."( Borzęcki, A; Turska, M, 2020)
"Rhinophyma is a progressive and disfiguring thickening of the nasal skin."( Daoud, M; Kumar, R; Raghavan, U; Ullas, G, 2021)
"Rhinophyma is a progressive disease of the nose, which is characterised by skin thickening and sebaceous hyperplasia."( Goh, M; Gönen, ZB; Ilankovan, V; Sayan, A, 2021)
"Rhinophyma is a benign disease involving the skin of the nose, which is characterized by skin thickening and hypertrophy of the sebaceous glands and connective tissue."( Huseynov, J; Mozet, C, 2020)
"Rhinophyma is a rare and benign pathological condition affecting the nose."( Abbate, V; Arena, A; Bonavolontà, P; Califano, L; Giovanni, DO; Goglia, F; Iaconetta, G; Romano, A, 2020)
"Rhinophyma is a disfiguring disorder that is characterized by an erythematous, hypertrophied, and inflamed lower two-thirds of the nose."( Gotkin, RH; Kassirer, SS; Sarnoff, DS, 2021)

Context

ExcerptReference
"Four patients with rhinophyma have been successfully treated with the carbon dioxide laser."( Anastasi, GW; Shapshay, SM; Strong, MS; Vaughan, CW, 1980)
"Although rhinophyma has been traditionally associated with alcoholism, there is no evidence to support this association."( Jansen, T; Plewig, G, 1998)

Treatment

ExcerptReference
"Surgery is the generally accepted treatment for rhinophyma."( Anastasi, GW; Shapshay, SM; Strong, MS; Vaughan, CW, 1980)
"The ideal surgical method for treatment of rhinophyma is still unclear and controversial."( Aytekin, AH; Elmas, O; Erbatur, S; Firat, C, 2012)

Research

Studies (116)

TimeframeStudies, This Condition (%)All Conditions %
pre-199034 (29.31)23.3326
1990's21 (18.10)12.5806
2000's22 (18.97)18.1394
2010's26 (22.41)28.8240
2020's13 (11.21)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminolevulinic acid0low10
niacinamide0low10
phenytoin0low10
azelaic acid0low10
fluconazole0low10
fluorouracil0low10
lidocaine0low20
khellin0low50
metronidazole0low20
sulfacetamide0low20
spironolactone0low10
prednisone0low10
trichloroacetic acid0low20
meglumine0low10
neodymium0low20
silver0low10
titanium0low10
argon0low20
erbium0medium11
yttrium0low30
silver nitrate0low10
triamcinolone0low10
meglumine antimoniate0low10
nicotine0low10
fibrinogen0low10
glucuronic acid0low10
potassium titanylphosphate0low10
ropivacaine0low10
cortisone0low10
inositol 3-phosphate0low10
tretinoin0low10
bromochloroacetic acid0low20
tamoxifen0low10
isotretinoin0low90
phenylephrine hydrochloride0medium571
aluminum0low10
tetracycline0low20
minocycline0low10
transforming growth factor beta0low30
hyaluronoglucosaminidase0low10
orabase0low10
eye0low20

Protein Targets (619)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase4004
bromodomain adjacent to zinc finger domain 2B4004
geminin180018
Gamma-aminobutyric acid receptor subunit rho-10101
Glutamate receptor 10101
Glutamate receptor 20101
Glutamate receptor 30101
Glutamate receptor ionotropic, kainate 30101
Solute carrier family 15 member 10101
Glutamate receptor 40101
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, Diaminopimelate decarboxylase0101
Chain B, Diaminopimelate decarboxylase0101
Chain A, Ferritin light chain4004
phosphopantetheinyl transferase4004
RAR-related orphan receptor gamma110011
NFKB1 protein, partial2002
GLI family zinc finger 3170017
thyroid stimulating hormone receptor5005
estrogen receptor 2 (ER beta)7007
cytochrome P450 family 3 subfamily A polypeptide 46006
estrogen-related nuclear receptor alpha110011
estrogen nuclear receptor alpha200020
arylsulfatase A6006
euchromatic histone-lysine N-methyltransferase 2120012
peripheral myelin protein 22 isoform 16006
muscleblind-like protein 1 isoform 14004
lamin isoform A-delta10100010
TAR DNA-binding protein 436006
ATP-dependent phosphofructokinase3003
AR protein150015
aldehyde dehydrogenase 1 family, member A1120012
nuclear receptor subfamily 1, group I, member 3100010
retinoic acid nuclear receptor alpha variant 1130013
thyroid stimulating hormone receptor5005
nuclear factor erythroid 2-related factor 2 isoform 1130013
Cellular tumor antigen p53110011
Nuclear receptor ROR-gamma3115
Chain A, JmjC domain-containing histone demethylation protein 3A2002
USP1 protein, partial5005
TDP1 protein150015
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
glucocorticoid receptor [Homo sapiens]150015
G5005
cytochrome P450 2D63003
67.9K protein5005
cytochrome P450 2D6 isoform 13003
vitamin D3 receptor isoform VDRA6006
chromobox protein homolog 1130013
potassium voltage-gated channel subfamily H member 2 isoform d3003
transcriptional regulator ERG isoform 34004
thyroid hormone receptor beta isoform 28008
importin subunit beta-1 isoform 12002
mitogen-activated protein kinase 14004
mitogen-activated protein kinase kinase kinase kinase 2 isoform 10011
eyes absent homolog 2 isoform a1001
snurportin-12002
GTP-binding nuclear protein Ran isoform 12002
peripheral myelin protein 225005
streptokinase A precursor0022
mitogen-activated protein kinase kinase kinase 3 isoform 10011
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010010
Bile salt export pump013013
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 5005
Estrogen receptor0023
ATP-dependent translocase ABCB10516
Spike glycoprotein0011
5-hydroxytryptamine receptor 1A0415
Cruzipain0101
Spike glycoprotein4015
C-terminal-binding protein 11001
Estrogen receptor beta0023
Inositol hexakisphosphate kinase 15005
Canalicular multispecific organic anion transporter 1010010
Broad substrate specificity ATP-binding cassette transporter ABCG20101
cytochrome P450 2C9, partial5005
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
endonuclease IV3003
dopamine D1 receptor1001
thioredoxin reductase9009
pregnane X receptor5005
GLS protein5005
progesterone receptor6006
regulator of G-protein signaling 46006
retinoid X nuclear receptor alpha9009
pregnane X nuclear receptor120012
peroxisome proliferator-activated receptor delta7007
peroxisome proliferator activated receptor gamma8008
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)4004
atrial natriuretic peptide receptor 1 precursor2002
heat shock protein beta-15005
flap endonuclease 14004
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 17007
M-phase phosphoprotein 83003
muscarinic acetylcholine receptor M13003
Gamma-aminobutyric acid receptor subunit pi7108
Glucocorticoid receptor08210
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10808
Corticosteroid-binding globulin0101
Gamma-aminobutyric acid receptor subunit beta-17108
Gamma-aminobutyric acid receptor subunit delta7108
Gamma-aminobutyric acid receptor subunit gamma-27108
Gamma-aminobutyric acid receptor subunit alpha-57108
Gamma-aminobutyric acid receptor subunit alpha-37108
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Gamma-aminobutyric acid receptor subunit gamma-17108
Gamma-aminobutyric acid receptor subunit alpha-27108
Glycine receptor subunit alpha-30808
Gamma-aminobutyric acid receptor subunit alpha-47108
Gamma-aminobutyric acid receptor subunit gamma-37108
Gamma-aminobutyric acid receptor subunit alpha-67108
Gamma-aminobutyric acid receptor subunit alpha-17108
Gamma-aminobutyric acid receptor subunit beta-37108
Gamma-aminobutyric acid receptor subunit beta-27108
Potassium voltage-gated channel subfamily A member 10011
GABA theta subunit7108
Multidrug and toxin extrusion protein 10404
Gamma-aminobutyric acid receptor subunit epsilon7108
Chain A, BCL-2-RELATED PROTEIN A10011
acetylcholinesterase3003
apical membrane antigen 1, AMA12002
unnamed protein product0101
heat shock protein HSP 90-alpha isoform 20102
DNA polymerase iota isoform a (long)2002
bcl-2-like protein 11 isoform 10011
Histone deacetylase 30101
Rap guanine nucleotide exchange factor 31001
Chymotrypsinogen A0101
Beta-lactamase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Heme oxygenase 1 0101
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40415
Lanosterol 14-alpha demethylase0112
Aromatase0202
Cytochrome P450 2C9 0516
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
ATP-dependent translocase ABCB10101
Heme oxygenase 20101
Malate dehydrogenase, cytoplasmic0101
Histone deacetylase 40101
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
Histone deacetylase 10101
Lanosterol 14-alpha demethylase0213
Sterol 14-alpha demethylase0011
Sterol 14-alpha demethylase0112
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
14-alpha sterol demethylase 0011
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
heat shock protein 90, putative0001
likely tRNA 2'-phosphotransferase0101
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase3003
interleukin 83003
glp-1 receptor, partial6006
Skn7p0001
hypoxia-inducible factor 1 alpha subunit5005
ATAD5 protein, partial3003
Microtubule-associated protein tau7007
Thrombopoietin1001
EWS/FLI fusion protein4004
nonstructural protein 13003
farnesoid X nuclear receptor7007
IDH15005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
Histone H2A.x5005
hemoglobin subunit beta1001
nuclear factor erythroid 2-related factor 2 isoform 24004
huntingtin isoform 21001
serine/threonine-protein kinase mTOR isoform 13003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Vpr3003
Voltage-dependent calcium channel gamma-2 subunit5005
Solute carrier family 22 member 80001
Epidermal growth factor receptor0202
Amyloid-beta precursor protein1102
Thymidylate synthase0101
Glutamate receptor 25005
ATPase family AAA domain-containing protein 56006
Ataxin-26006
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, Cruzipain2002
Parkin2002
activating transcription factor 66006
Caspase-74004
Bloom syndrome protein isoform 15005
thyroid hormone receptor beta isoform a5005
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
caspase-34004
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
Ornithine decarboxylase0002
Adenosine receptor A30606
Retinoic acid receptor alpha0224
Alpha-1B adrenergic receptor0707
Alpha-2B adrenergic receptor0404
Retinoic acid receptor gamma0224
Retinoic acid receptor beta0224
Cellular retinoic acid-binding protein 20022
Mitogen-activated protein kinase 10202
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10203
5-hydroxytryptamine receptor 2B0606
Alpha-1A adrenergic receptor0707
Cellular retinoic acid-binding protein 10022
Mitogen-activated protein kinase 140101
Rap guanine nucleotide exchange factor 41001
Olfactory receptor 51E20101
GALC protein2002
aryl hydrocarbon receptor4004
cytochrome P450 2C19 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
histone acetyltransferase KAT2A isoform 13003
Cytochrome P450 1A10202
Cytochrome P450 1A20314
Cytochrome P450 2D60112
Cytochrome P450 2C190213
Cytochrome P450 1B10101
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0203
Potassium voltage-gated channel subfamily H member 20505
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0202
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0202
Thioredoxin reductase 0101
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Albumin0011
Stromelysin-10202
Matrilysin0101
Multidrug transporter MdfA0202
Matrix metalloproteinase-90101
Cytochrome P450 2J20202
Protein mono-ADP-ribosyltransferase PARP150202
Protein-arginine deiminase type-40303
Chain A, NAD-dependent deacetylase0101
Poly [ADP-ribose] polymerase 20101
NAD-dependent histone deacetylase SIR20101
Coagulation factor VII0101
Poly [ADP-ribose] polymerase 10101
Tissue factor0101
Cytochrome P450 3A50101
NAD-dependent protein deacetylase HST20101
Fatty-acid amide hydrolase 10101
NAD(+) hydrolase SARM10101
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase sirtuin-60101
NAD-dependent protein deacetylase sirtuin-10101
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
NAD-dependent protein deacetylase 0101
5-hydroxytryptamine receptor 3E0101
Smad33003
D(1A) dopamine receptor2002
Solute carrier family 22 member 1 0001
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10011
5-hydroxytryptamine receptor 3B0101
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-30225
Acetylcholine receptor subunit gamma0213
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-41226
Muscarinic acetylcholine receptor M20101
Acetylcholine receptor subunit beta0213
Cytochrome P450 2A60213
Neuronal acetylcholine receptor subunit alpha-20225
Neuronal acetylcholine receptor subunit beta-21226
Neuronal acetylcholine receptor subunit beta-30225
Neuronal acetylcholine receptor subunit beta-40225
Translocator protein0101
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-50225
Cytochrome P450 2A50101
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40213
Muscarinic acetylcholine receptor M40101
Neuronal acetylcholine receptor subunit alpha-30213
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Neuronal acetylcholine receptor subunit alpha-70224
Neuronal acetylcholine receptor subunit alpha-60225
Neuronal acetylcholine receptor subunit alpha-90225
Neuronal acetylcholine receptor subunit alpha-40213
5-hydroxytryptamine receptor 3A0101
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Mu-type opioid receptor0101
Inositol monophosphatase 12002
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-70225
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
Solute carrier family 22 member 10101
5-hydroxytryptamine receptor 3D0101
Transient receptor potential cation channel subfamily A member 10011
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
5-hydroxytryptamine receptor 3C0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-100225
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
Transporter0113
Chain A, 2-oxoglutarate Oxygenase2002
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Gamma-aminobutyric acid 0101
cytochrome P450 2C9 precursor1001
nuclear receptor ROR-gamma isoform 14004
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Dihydrofolate reductase 0202
Gamma-aminobutyric acid receptor subunit alpha-10101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Sodium channel protein type 1 subunit alpha0101
Histamine H2 receptor2002
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0101
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
thioredoxin glutathione reductase3003
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
SMAD family member 23003
SMAD family member 33003
Estrogen receptor0427
Progesterone receptor0314
Mineralocorticoid receptor 0203
Androgen receptor0213
Androgen receptor0405
Sodium-dependent serotonin transporter0101
Estrogen receptor beta0325
Dihydrofolate reductase0101
Serum paraoxonase/arylesterase 10101
Chain A, CES1 protein0101
Fumarate hydratase1001
PPM1D protein1001
DNA polymerase III, partial1001
caspase 7, apoptosis-related cysteine protease1001
polyprotein1001
glucocerebrosidase1001
caspase-31001
thyrotropin-releasing hormone receptor2002
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor1001
cellular tumor antigen p53 isoform a2002
interferon gamma precursor0001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
lethal factor (plasmid)1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Integrin beta-32002
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Procathepsin L0011
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40202
Integrin alpha-IIb2002
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Protein kinase C alpha type0101
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Alpha-synuclein1203
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Protein kinase C iota type0101
Melanocortin receptor 30202
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Sodium-dependent dopamine transporter 0202
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Sigma non-opioid intracellular receptor 10202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
72 kDa type IV collagenase0101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0202
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
Solute carrier family 22 member 80001
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Solute carrier family 22 member 70001
Chain A, Nuclear Receptor ROR-beta0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
DNA polymerase kappa isoform 11001
Ornithine decarboxylase0001
60 kDa chaperonin0101
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor RXR-beta0224
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
procathepsin L isoform 1 preproprotein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]