metronidazole has been researched along with Carcinoma, Anaplastic in 15 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed this meta-analysis to assess the metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma." | 8.91 | Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials. ( Liu, J; Niu, L; Song, F; Wang, L; Wei, S; Wu, F; Xing, Y; Yang, C; Yang, X; Yang, Y, 2015) |
| "Metronidazole (Flagyl) was introduced into The United States in the 1960's for the treatment of trichomoniasis (1)." | 5.27 | Occurrence of three cases of carcinoma in individuals with Crohn's disease treated with metronidazole. ( Ayuyang, HQ; Ellis, LD; Krause, JR, 1985) |
| "Results are reported of a clinical trial on the effect of metronidazole as an adjuvant radiosensitizer in the radiation treatment of cervix carcinomas in advanced stages." | 5.06 | Anaemia as a prognostic factor for the therapeutic effect of radiosensitizers. ( Balmukhanov, SB; Révész, L, 1987) |
| "We performed this meta-analysis to assess the metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma." | 4.91 | Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials. ( Liu, J; Niu, L; Song, F; Wang, L; Wei, S; Wu, F; Xing, Y; Yang, C; Yang, X; Yang, Y, 2015) |
| "Advanced vulvovaginal cancers have a survival of less than 25% in 5 years when treated with radiotherapy alone." | 1.27 | Metronidazole as a radiosensitizer and high-dose radiation in advanced vulvovaginal malignancies, a pilot study. ( Cain, JM; Hilaris, BS; Jones, WB; Lewis, JL; Nori, D, 1983) |
| "Metronidazole (Flagyl) was introduced into The United States in the 1960's for the treatment of trichomoniasis (1)." | 1.27 | Occurrence of three cases of carcinoma in individuals with Crohn's disease treated with metronidazole. ( Ayuyang, HQ; Ellis, LD; Krause, JR, 1985) |
| "Pathological examination showed pseudomembranous colitis confined to the cecum." | 1.27 | Localized pseudomembranous colitis simulating carcinoma of the cecum. ( Amir, G; Arber, N; Nissan, S; Udassin, R; Zamir, O, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Rodríguez, RT | 1 |
| Solís Marquínez, MN | 1 |
| Álvarez, MDCC | 1 |
| Fernández Suárez, J | 1 |
| Fernández Domínguez, J | 1 |
| Rodríguez, BI | 1 |
| Rodríguez Álvarez, FJ | 1 |
| Wei, S | 1 |
| Xing, Y | 1 |
| Liu, J | 1 |
| Wang, L | 1 |
| Yang, X | 1 |
| Song, F | 1 |
| Yang, C | 1 |
| Niu, L | 1 |
| Yang, Y | 1 |
| Wu, F | 1 |
| He, ZY | 1 |
| Li, FY | 1 |
| Tong, Q | 1 |
| Liao, ZW | 1 |
| Guan, XX | 1 |
| Wang, Y | 1 |
| Simşek, H | 1 |
| Elsürer, R | 1 |
| Sökmensüer, C | 1 |
| Balaban, HY | 1 |
| Tatar, G | 1 |
| Neklasova, NIu | 1 |
| Zharinov, GM | 1 |
| Vinokurov, VL | 1 |
| Skrynditsa, GM | 1 |
| Nori, D | 1 |
| Cain, JM | 1 |
| Hilaris, BS | 1 |
| Jones, WB | 1 |
| Lewis, JL | 1 |
| Lowenthal, RM | 1 |
| Cooper, DA | 1 |
| Thomas, GM | 1 |
| Rauth, AM | 1 |
| Bush, RS | 1 |
| Black, BE | 1 |
| Cummings, BJ | 1 |
| Hüskes, KP | 1 |
| Hardt, KU | 1 |
| Krause, JR | 1 |
| Ayuyang, HQ | 1 |
| Ellis, LD | 1 |
| Révész, L | 1 |
| Balmukhanov, SB | 1 |
| Arber, N | 1 |
| Udassin, R | 1 |
| Amir, G | 1 |
| Zamir, O | 1 |
| Nissan, S | 1 |
| Stone, HB | 1 |
| Withers, HR | 1 |
| Drazancić, A | 1 |
| Krstulović, B | 1 |
| Ivić, J | 1 |
2 reviews available for metronidazole and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Metronidazole amino acidum natrium combined with radiation in the treatment of nasopharyngeal carcinoma: A meta-analysis based on randomized controlled trials.
Topics: Antineoplastic Agents; Carcinoma; Combined Modality Therapy; Humans; Metronidazole; Nasopharyngeal C | 2015 |
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs | 1976 |
2 trials available for metronidazole and Carcinoma, Anaplastic
| Article | Year |
|---|---|
[Concurrent chemoradiotherapy with sodium glycididazole and cisplatin for local advanced nasopharyngeal carcinoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Cobalt Radioisotopes; C | 2008 |
Anaemia as a prognostic factor for the therapeutic effect of radiosensitizers.
Topics: Anemia; Carcinoma; Female; Humans; Metronidazole; Prognosis; Radiation-Sensitizing Agents; Uterine C | 1987 |
11 other studies available for metronidazole and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Clostridium paraputrificum bacteremia in a 64-year-old woman with colon carcinoma.
Topics: Anti-Bacterial Agents; Bacteremia; Carcinoma; Clostridium; Clostridium Infections; Colon; Female; Hu | 2023 |
Ameboma mimicking carcinoma of the cecum: case report.
Topics: Abdominal Pain; Aged; Amebiasis; Animals; Biopsy, Needle; Carcinoma; Cecal Neoplasms; Colonoscopy; D | 2004 |
[Combined use of local and systemic radiomodifiers as a new modality of cervical carcinoma therapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Dimethyl Sulfoxide; Female; | 2006 |
Metronidazole as a radiosensitizer and high-dose radiation in advanced vulvovaginal malignancies, a pilot study.
Topics: Adult; Aged; Carcinoma; Female; Humans; Metronidazole; Middle Aged; Pilot Projects; Radiotherapy Dos | 1983 |
Complete regression of locally-advanced breast cancer with chemotherapy.
Topics: Aged; Breast Neoplasms; Carcinoma; Drug Therapy, Combination; Female; Humans; Metronidazole; Tobramy | 1981 |
A toxicity study of daily dose metronidazole with pelvic irradiation.
Topics: Administration, Oral; Adolescent; Adult; Aged; Carcinoma; Diarrhea; Dose-Response Relationship, Drug | 1980 |
[Primary wound healing of the sacral cavity following rectum amputation, also a comment on the discussion contribution by G. Jatzko and D. Schlapper, Chirurg (1988) 59: 855].
Topics: Aged; Aged, 80 and over; Carcinoma; Cephalosporins; Colectomy; Crohn Disease; Enema; Female; Follow- | 1989 |
Occurrence of three cases of carcinoma in individuals with Crohn's disease treated with metronidazole.
Topics: Adenoma, Bile Duct; Adult; Bile Duct Neoplasms; Breast Neoplasms; Carcinoma; Crohn Disease; Female; | 1985 |
Localized pseudomembranous colitis simulating carcinoma of the cecum.
Topics: Aged; Carcinoma; Cecal Neoplasms; Colonoscopy; Diagnosis, Differential; Enterocolitis, Pseudomembran | 1987 |
Tumor and normal tissue response to metronidazole and irradiation in mice.
Topics: Animals; Carcinoma; Cesium Isotopes; Dose-Response Relationship, Radiation; Epithelium; Female; Hypo | 1974 |
[Vaginal trichomoniasis and cervix uteri changes].
Topics: Antitrichomonal Agents; Biopsy; Carcinoma; Cervix Uteri; Colposcopy; Diagnosis, Differential; Female | 1969 |