metronidazole has been researched along with Osteonecrosis in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The preliminary results seem to suggest that biphosphonate-associated osteonecrosis can be well controlled by a nonsurgical protocol consisting in long-term administration of antibiotics." | 2.73 | Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management. ( Felicetti, L; Gissi, DB; Marchetti, C; Montebugnoli, L; Pelliccioni, GA; Pizzigallo, A, 2007) |
| "Osteopetrosis is a hereditary disorder of bone characterized by sclerosis of bone and decreased marrow spaces." | 1.42 | Oral Manifestations of Osteopetrosis. ( Ishfaq, M; Khan, SR; Liaqat, S; Pervez, N; Ullah, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ullah, A | 1 |
| Pervez, N | 1 |
| Khan, SR | 1 |
| Ishfaq, M | 1 |
| Liaqat, S | 1 |
| Montebugnoli, L | 1 |
| Felicetti, L | 1 |
| Gissi, DB | 1 |
| Pizzigallo, A | 1 |
| Pelliccioni, GA | 1 |
| Marchetti, C | 1 |
| Siegel, MA | 1 |
| Migliorati, CA | 1 |
| Velez, I | 1 |
| Forrest, M | 1 |
| Holmes, S | 1 |
| Hardee, P | 1 |
| Anand, P | 1 |
1 trial available for metronidazole and Osteonecrosis
| Article | Year |
|---|---|
Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management.
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Analysis of Variance; Anti-Bacterial Agents; Bo | 2007 |
3 other studies available for metronidazole and Osteonecrosis
| Article | Year |
|---|---|
Oral Manifestations of Osteopetrosis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Blood Transfusion; Child, Preschool; Chlorhexidine; Cu | 2015 |
Exposed bone in the palate.
Topics: Aged, 80 and over; Anti-Infective Agents, Local; Bone Density Conservation Agents; Chlorhexidine; Cl | 2007 |
Use of an orthopaedic fixator for external fixation of the mandible.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bone Plates; Bone Transplantation; | 2002 |