metronidazole and disulfiram

metronidazole has been researched along with disulfiram in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (56.10)	18.7374
1990's	2 (4.88)	18.2507
2000's	4 (9.76)	29.6817
2010's	10 (24.39)	24.3611
2020's	2 (4.88)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Hart, CJS; Riches, A; Skinner-Adams, TS; Trenholme, KR	1
Ban, TA	1
Bieder, L; Kitson, TM	1
Grabovskiĭ, IaA	1
Edwards, DL; Fink, PC; Van Dyke, PO	1
Mottin, JL	1
Gross, MM; Kissin, B	1
Guttman, M; Kalant, H; Khanna, JM; LeBlanc, AE	1
Wilson, CW	1
Dow, J; Goldberg, A; Krasner, N; MacDonald, CM; Moore, MR	1
Chaftez, ME	1
Clancy, DD; Rothstein, E	3
Ewing, JA	1
Goodhue, WW	1
Nitelea, I; Sauvard, S; Stănescu, C; Theodorescu, M; Winter, D; Winter, J	1
Sauvard, S; Stănescu, C; Winter, D	1
Miliani, B; Sogliani, G	1
Deitrich, RA	1
Matthew, JR	1
Fried, R	1
Hjelle, JJ; Petersen, DR	1
Czarnecka, E	1
Ackers, JP; Bouma, MJ; Fairlamb, AH; Snowdon, D	1
Williams, CS; Woodcock, KR	1
Kaihovaara, PS; Salaspuro, MP; Tillonen, JS; Visapää, JP	1
Dirckx, M; Luykx, JJ; Tijdink, JK; Van Hecke, J; Vinkers, CH; Vis, R	1
Alffenaar, JW; Alsaad, N; de Lange, WC; Kosterink, JG; van Altena, R; van der Werf, TS; Wilffert, B	1
Chen, CZ; Galkin, A; Herzberg, O; Kulakova, L; Lim, K; Turko, IV; Zheng, W	1
Fjeld, H; Raknes, G	1
Feldman, R; Jaszczenski, R	1

Reviews

10 review(s) available for metronidazole and disulfiram

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Anti- Journal of medicinal chemistry, 2020, 11-25, Volume: 63, Issue:22 Topics: Animals; Antiprotozoal Agents; Benzimidazoles; Drug Delivery Systems; Drug Discovery; Drug Therapy, Combination; Gastrointestinal Tract; Giardia; Giardiasis; Humans; Nitroimidazoles	2020
Alcoholism and schizophrenia: diagnostic and therapeutic considerations. Alcoholism, clinical and experimental research, 1977, Volume: 1, Issue:2 Topics: Alcoholism; Brain; Disulfiram; Dopamine; Humans; Methyltyrosines; Metronidazole; NAD; Norepinephrine; Schizophrenia; Tyrosine	1977
Drug-induced attenuation of alcohol consumption. A review and evaluation of claimed, potential or current therapies. Quarterly journal of studies on alcohol, 1973, Volume: 34, Issue:2 Topics: Alcohol Deterrents; Alcohol Drinking; Alcoholism; Aversive Therapy; Conditioning, Classical; Conditioning, Operant; Disulfiram; Emetics; Evaluation Studies as Topic; Hallucinogens; Humans; Lysergic Acid Diethylamide; Metronidazole; Neuromuscular Nondepolarizing Agents; Placebos; Research; Sympathomimetics; Tranquilizing Agents	1973
The pharmacological actions of alcohol in relation to nutrition. The Proceedings of the Nutrition Society, 1972, Volume: 31, Issue:2 Topics: Absorption; Adult; Alcohol Drinking; Animals; Barbiturates; Behavior, Animal; Diffusion; Disulfiram; Drug Interactions; Ethanol; Fenfluramine; Humans; Intestinal Absorption; Metronidazole; Mouth; Nutritional Physiological Phenomena; Rats; Taste	1972
Drugs in the treatment of alcoholism. The Medical clinics of North America, 1967, Volume: 51, Issue:5 Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Chlordiazepoxide; Chlorpromazine; Disulfiram; Humans; Imipramine; Metronidazole; Tranquilizing Agents	1967
Biochemical actions of anti-alcoholic agents. Substance and alcohol actions/misuse, 1980, Volume: 1, Issue:1 Topics: Alcoholism; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Behavior; Carbon Disulfide; Cyanamide; Diethylamines; Disulfiram; Ditiocarb; Drug Implants; Glutamine; Humans; Metronidazole	1980
Do ethanol and metronidazole interact to produce a disulfiram-like reaction? The Annals of pharmacotherapy, 2000, Volume: 34, Issue:2 Topics: Alcohol Deterrents; Antitrichomonal Agents; Central Nervous System Depressants; Disulfiram; Drug Interactions; Ethanol; Humans; Metronidazole	2000
Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis. The European respiratory journal, 2014, Volume: 43, Issue:3 Topics: Anti-Infective Agents; Antitubercular Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Disulfiram; Doxycycline; Drug Design; Humans; Metronidazole; Minocycline; Mycobacterium tuberculosis; Phenothiazines; Tigecycline; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculosis, Multidrug-Resistant	2014
[Is combining metronidazole and alcohol really hazardous?]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2014, Sep-16, Volume: 134, Issue:17 Topics: Alcohol Deterrents; Anti-Infective Agents; Central Nervous System Depressants; Disulfiram; Drug Interactions; Ethanol; Humans; Metronidazole	2014

Trials

3 trial(s) available for metronidazole and disulfiram

Article	Year
Toxicity of disulfiram combined with metronidazole. The New England journal of medicine, 1969, May-01, Volume: 280, Issue:18 Topics: Alcoholism; Clinical Trials as Topic; Disulfiram; Drug Synergism; Humans; Male; Metronidazole; Psychoses, Substance-Induced	1969
Combined use of disulfiram and metronidazole in treatment of alcoholism. Quarterly journal of studies on alcohol, 1970, Volume: 31, Issue:2 Topics: Alcoholism; Clinical Trials as Topic; Disulfiram; Hospitalization; Hospitals, Psychiatric; Humans; Male; Metronidazole; Neurotic Disorders; Personality Disorders; Placebos; Psychotherapy	1970
Lack of disulfiram-like reaction with metronidazole and ethanol. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:6 Topics: Acetaldehyde; Adult; Alcohol Deterrents; Blood Pressure; Body Temperature; Disulfiram; Double-Blind Method; Drug Interactions; Ethanol; Heart Rate; Humans; Male; Metronidazole; Surveys and Questionnaires	2002

Other Studies

28 other study(ies) available for metronidazole and disulfiram

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Drugs which interfere with alcohol metabolism. The New Zealand medical journal, 1977, Aug-10, Volume: 86, Issue:593 Topics: Alcohol Deterrents; Alcoholism; Amines; Chloral Hydrate; Cyanides; Disulfiram; Ethanol; Humans; Hypoglycemic Agents; Metronidazole	1977
[Sensitization treatment of alcoholism in the out-patient narcological practice]. Vrachebnoe delo, 1975, Issue:9 Topics: Adult; Alcoholism; Ambulatory Care; Disulfiram; Furazolidone; Humans; Metronidazole; Middle Aged	1975
Disulfiram-like reaction associated with intravenous trimethoprim-sulfamethoxazole and metronidazole. Clinical pharmacy, 1986, Volume: 5, Issue:12 Topics: Adolescent; Disulfiram; Drug Combinations; Drug Interactions; Humans; Male; Metronidazole; Postoperative Complications; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1986
Drug therapy in alcoholism. Current psychiatric therapies, 1970, Volume: 10 Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepoxide; Chronic Disease; Depression; Disulfiram; Female; Humans; Imipramine; Male; Metronidazole; Pentobarbital; Psychoses, Alcoholic; Sleep, REM; Substance Withdrawal Syndrome; Tranquilizing Agents	1970
Metabolic and pharmacologic interaction of ethanol and metronidazole in the rat. Canadian journal of physiology and pharmacology, 1972, Volume: 50, Issue:6 Topics: Acetaldehyde; Alcohol Oxidoreductases; Animals; Behavior, Animal; Chemical Phenomena; Chemistry; Chromatography, Gas; Disulfiram; Drug Synergism; Ethanol; Liver; Male; Metronidazole; Motor Activity; NAD; Rats; Reflex; Sleep	1972
Clinical and experimental studies on alcoholism. Health bulletin, 1973, Volume: 31, Issue:6 Topics: Alcohol Deterrents; Alcoholism; Animals; Disulfiram; Ethanol; Fenfluramine; Humans; Liver Diseases; Metronidazole; Nervous System; Nutrition Disorders; Rats; Scotland; Suicide	1973
How to help the chronic alcoholic. American family physician, 1972, Volume: 6, Issue:2 Topics: Alcohol Drinking; Alcoholism; Antidepressive Agents; Chronic Disease; Disulfiram; Humans; Metronidazole; Phenothiazines; Physicians, Family; Psychotherapy	1972
Disulfiram-metronidazole (well identified) toxicity. The New England journal of medicine, 1969, Jun-26, Volume: 280, Issue:26 Topics: Disulfiram; Humans; Metronidazole; Psychoses, Substance-Induced; Xanthine Oxidase	1969
Disulfiram-metronidazole. The New England journal of medicine, 1969, Aug-07, Volume: 281, Issue:6 Topics: Disulfiram; Drug Synergism; Humans; Metronidazole; Psychoses, Substance-Induced	1969
The influence of metronidazol and disulfiram on the pharmacologic action of ethanol. Pharmacology, 1969, Volume: 2, Issue:1 Topics: Alcoholism; Animals; Disulfiram; Ethanol; Female; Humans; Lipids; Liver; Male; Metronidazole; Rabbits; Rats	1969
The effect of metronidazol on the toxicity of ethanol. Biochemical pharmacology, 1969, Volume: 18, Issue:5 Topics: Alcoholism; Animals; Disulfiram; Ethanol; Humans; Male; Metronidazole; Rats	1969
[Metronidazole in the treatment of alcoholism]. Minerva medica, 1967, Apr-25, Volume: 58, Issue:33 Topics: Adult; Aged; Alcoholism; Disulfiram; Humans; Metronidazole; Middle Aged; Psychoses, Alcoholic	1967
Effect of in vivo administration of cyanamide, disulfiram, and metronidazole on rabbit liver aldehyde oxidation. Proceedings of the Western Pharmacology Society, 1967, Volume: 10 Topics: Animals; Cyanides; Disulfiram; Fluorometry; Liver; Male; Metronidazole; Oxidoreductases; Rabbits	1967
An addition to the somatic treatment of alcoholism. The Journal of the Indiana State Medical Association, 1967, Volume: 60, Issue:12 Topics: Alcoholism; Disulfiram; Humans; Male; Metronidazole; Middle Aged	1967
Metabolic interactions of aldehyde dehydrogenase with therapeutic and toxic agents. Progress in clinical and biological research, 1982, Volume: 114 Topics: Alcohol Oxidoreductases; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Anti-Bacterial Agents; Benserazide; Carbon Tetrachloride; Chlorpropamide; Cyanamide; Disulfiram; Humans; Isoenzymes; Lactams; Liver; Malondialdehyde; Metronidazole; Pargyline; Pharmaceutical Preparations; Propranolol; Pyrogallol; Tolbutamide	1982
[Pharmacological evaluation of the central effect of ethyl alcohol after administration with disulfiram and metronidazole]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1981, May-25, Volume: 36, Issue:21 Topics: Action Potentials; Animals; Brain; Depression, Chemical; Disulfiram; Drug Synergism; Ethanol; Metronidazole; Mice; Rabbits	1981
[Metronidazole, alcohol and rosacea]. Ugeskrift for laeger, 1993, Jan-25, Volume: 155, Issue:4 Topics: Administration, Topical; Alcohol Drinking; Disulfiram; Drug Synergism; Ethanol; Humans; Metronidazole; Ointments; Rosacea	1993
Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:6 Topics: Aerobiosis; Anaerobiosis; Animals; Antiprotozoal Agents; Antitrichomonal Agents; Disulfiram; Ditiocarb; Drug Resistance; Metronidazole; Trichomonas vaginalis; Tritrichomonas foetus	1998
Psychotic symptoms after combined metronidazole-disulfiram use. Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:1 Topics: Alcohol Deterrents; Anti-Infective Agents; Disulfiram; Drug Interactions; Humans; Male; Metronidazole; Middle Aged; Paranoid Disorders; Psychoses, Substance-Induced	2013
Structural basis for inactivation of Giardia lamblia carbamate kinase by disulfiram. The Journal of biological chemistry, 2014, Apr-11, Volume: 289, Issue:15 Topics: Adenosine Triphosphate; Animals; Antiprotozoal Agents; Catalytic Domain; Cell Proliferation; Crystallography, X-Ray; Cysteine; Disulfiram; Drug Resistance; Enzyme Inhibitors; Female; Giardia lamblia; Giardiasis; Mass Spectrometry; Metronidazole; Mice; Mice, Inbred C57BL; Phosphotransferases (Carboxyl Group Acceptor); Trophozoites; Trypsin	2014
Can Metronidazole Cause a Disulfiram-Like Reaction? A Case-Control Study Propensity Matched by Age, Sex, and Ethanol Concentration. WMJ : official publication of the State Medical Society of Wisconsin, 2023, Volume: 122, Issue:3 Topics: Acetaldehyde; Animals; Case-Control Studies; Disulfiram; Ethanol; Female; Humans; Male; Metronidazole; Middle Aged; Retrospective Studies	2023