Colitis, Lymphocytic

A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).

Synonym
Colitis, Lymphocytic

Excerpt	Reference
"Lymphocytic colitis is a cause of chronic diarrhea."	( Chande, N; Macdonald, JK; McDonald, JW, 2007)
"Lymphocytic colitis is a cause of chronic diarrhea."	( Chande, N; Macdonald, JK; McDonald, JW, 2008)
"Lymphocytic colitis is a disease characterised by chronic watery diarrhoea that can only be diagnosed histologically, since colonoscopy reveals macroscopically normal mucosa."	( Kusnik, B; Stolte, M, 2010)
"Lymphocytic colitis is a chronic inflammatory disease affecting the bowel."	( Hui, CK, 2015)
"Lymphocytic colitis is a cause of chronic diarrhea."	( Al Yatama, N; Bhanji, T; Chande, N; MacDonald, JK; McDonald, JW; Nguyen, TM, 2017)
"Lymphocytic colitis is a common cause of chronic, nonbloody diarrhea."	( Armerding, P; Aust, D; Böhm, G; Bonderup, O; Fernández-Bañares, F; Greinwald, R; Kupcinskas, J; Miehlke, S; Mihaly, E; Münch, A; Munck, LK; Nacak, T; Rehbehn, KU, 2018)

Excerpt	Reference
"Larger trials studying treatments for lymphocytic colitis are warranted."	( Chande, N; Macdonald, JK; McDonald, JW, 2007)
"In conclusion, an untreated lymphocytic colitis may result in the formation of an inflammatory mass lesion."	( Hui, CK, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	22 (30.56)	18.1394
2010's	36 (50.00)	28.8240
2020's	14 (19.44)	9.53

Drug	Relationship Strength	Studies	Trials
kynurenine	low	1	0
hydroxyindoleacetic acid	low	1	0
azathioprine	low	3	0
carbamazepine	low	3	0
diclofenac	low	1	0
lansoprazole	low	3	0
leflunomide	low	1	0
loperamide	low	5	0
losartan	low	1	0
meperidine	low	1	0
metronidazole	low	1	0
mianserin	low	1	0
omeprazole	low	1	0
pentoxifylline	low	1	0
rizatriptan	low	1	0
sulfasalazine	low	2	0
ticlopidine	low	1	0
prednisolone	low	2	0
thyroxine	low	1	0
levodopa	low	2	0
tryptophan	low	1	0
methylprednisolone	low	3	0
thiophenes	low	2	0
isoxazoles	low	1	0
thiazoles	low	1	0
2,2-bis(bromomethyl)-1,3-propanediol	low	1	0
trolamine salicylate	low	1	0
carbimazole	low	1	0
oxetorone	low	1	0
nitazoxanide	low	1	0
duloxetine hydrochloride	low	3	0
triazoles	low	1	0
sertraline	low	1	0
moprolol	low	1	0
methotrexate	low	3	0
olmesartan	low	2	0
mycophenolic acid	low	1	0
indigo carmine	low	1	0
entacapone	low	3	0
bismuth	low	6	0
gastrins	low	1	0
(9R)-9-chloro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one	low	1	0
bismuth subsalicylate	low	5	0
salicylates	low	5	0
teriflunomide	low	2	0
dolutegravir	low	1	0
cyclosporine	low	1	0
peptide yy	low	1	0
muramidase	low	1	0
exudates	low	1	0
cholestyramine resin	medium	8	1

Protein Targets (703)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
IDH1	9	0	0	9
chromobox protein homolog 1	10	0	0	10
geminin	20	0	0	20
RAR-related orphan receptor gamma	19	0	0	19
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
thyroid stimulating hormone receptor	10	0	0	10
glucocorticoid receptor [Homo sapiens]	20	0	0	20
retinoic acid nuclear receptor alpha variant 1	20	0	0	20
retinoid X nuclear receptor alpha	17	0	0	17
farnesoid X nuclear receptor	11	0	0	11
peroxisome proliferator-activated receptor delta	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	14	0	0	14
Cellular tumor antigen p53	17	0	0	17
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, Ferritin light chain	4	0	0	4
interleukin 8	1	0	0	1
acetylcholinesterase	11	0	0	11
thioredoxin reductase	10	0	0	10
phosphopantetheinyl transferase	13	0	0	13
SMAD family member 2	7	0	0	7
ATAD5 protein, partial	10	0	0	10
Fumarate hydratase	7	0	0	7
SMAD family member 3	7	0	0	7
TDP1 protein	19	0	0	19
GLI family zinc finger 3	16	0	0	16
Microtubule-associated protein tau	9	0	0	9
AR protein	21	0	0	21
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
EWS/FLI fusion protein	14	0	0	14
estrogen-related nuclear receptor alpha	22	0	0	22
pregnane X nuclear receptor	18	0	0	18
estrogen nuclear receptor alpha	29	0	0	29
G	14	0	0	14
polyprotein	7	0	0	7
P53	2	0	0	2
peroxisome proliferator activated receptor gamma	15	0	0	15
arylsulfatase A	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
aryl hydrocarbon receptor	13	0	0	13
thyroid stimulating hormone receptor	7	0	0	7
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
Histone H2A.x	10	0	0	10
Bloom syndrome protein isoform 1	5	0	0	5
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	5	0	0	5
thyroid hormone receptor beta isoform 2	15	0	0	15
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
DNA polymerase iota isoform a (long)	8	0	0	8
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	9	0	0	9
cytochrome P450 3A4 isoform 1	11	0	0	11
M-phase phosphoprotein 8	6	0	0	6
muscleblind-like protein 1 isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	6	0	0	6
lamin isoform A-delta10	19	0	0	19
Gamma-aminobutyric acid receptor subunit pi	11	1	0	12
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	18	0	19
Bile salt export pump	0	5	0	6
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
Bile salt export pump	0	26	0	27
Interferon beta	19	0	0	19
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
Gamma-aminobutyric acid receptor subunit beta-1	11	1	0	12
Gamma-aminobutyric acid receptor subunit delta	11	1	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	11	1	0	12
Glutamate receptor 2	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	11	1	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	11	1	0	12
Gamma-aminobutyric acid receptor subunit gamma-1	11	1	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	11	1	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	11	1	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	11	1	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	11	1	0	12
Nuclear receptor ROR-gamma	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	11	1	0	12
Gamma-aminobutyric acid receptor subunit beta-3	11	1	0	12
Gamma-aminobutyric acid receptor subunit beta-2	11	1	0	12
GABA theta subunit	11	1	0	12
Inositol hexakisphosphate kinase 1	14	0	0	14
Canalicular multispecific organic anion transporter 1	0	16	0	16
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	15	0	0	15
Gamma-aminobutyric acid receptor subunit epsilon	11	1	0	12
Protein-arginine deiminase type-4	0	4	0	4
cytochrome P450 2C9, partial	14	0	0	14
Luciferase	12	0	0	12
Spike glycoprotein	13	0	1	14
Chain A, Beta-lactamase	6	0	0	6
USP1 protein, partial	11	0	0	11
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
mitogen-activated protein kinase 1	4	0	0	4
Vpr	1	0	0	1
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	13	0	14
UDP-glucuronosyltransferase 2B7	0	2	0	4
Cytochrome P450 2B6	0	2	1	3
Sodium channel protein type 4 subunit alpha	0	1	0	2
Cytochrome P450 2J2	0	9	0	9
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Lactoperoxidase	0	1	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	6	0	7
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 1	0	4	0	6
Carbonic anhydrase 2	0	4	1	7
Fatty acid-binding protein, liver	0	2	0	2
Transthyretin	0	1	1	5
Albumin	0	1	2	3
Prostaglandin G/H synthase 1	0	2	0	2
Cytochrome P450 3A4	0	6	0	6
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	5	0	7
UDP-glucuronosyltransferase 1A4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 9	0	2	0	4
Solute carrier family 22 member 6	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	2
UDP-glucuronosyltransferase 1A10	0	1	0	2
Chain A, PFV integrase	0	1	0	1
Chain A, PFV integrase	0	1	0	1
Chain A, PFV integrase	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
ATP-dependent translocase ABCB1	0	5	1	8
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C19	0	6	0	7
Integrase	0	0	1	1
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Integrase	0	1	1	2
Solute carrier organic anion transporter family member 1B3	0	5	0	9
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Solute carrier organic anion transporter family member 1B1	0	5	0	9
glp-1 receptor, partial	6	0	0	6
Smad3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	8	0	0	8
progesterone receptor	14	0	0	14
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
cytochrome P450 2D6	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
caspase-3	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
Alpha-synuclein	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
GLS protein	8	0	0	8
vitamin D3 receptor isoform VDRA	10	0	0	10
histone deacetylase 9 isoform 3	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
DNA polymerase kappa isoform 1	8	0	0	8
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Catechol O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Adenosine receptor A2a	0	1	0	1
UDP-glucuronosyltransferase 2B15	0	0	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
ATP-dependent phosphofructokinase	9	0	0	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 4	0	1	0	3
Carbonic anhydrase 6	0	1	0	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase 7	0	1	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 5B, mitochondrial	0	1	0	3
endonuclease IV	2	0	0	2
NFKB1 protein, partial	3	0	0	3
hypothetical protein, conserved	2	0	0	2
regulator of G-protein signaling 4	6	0	0	6
alpha-galactosidase	3	0	0	3
cytochrome P450 2C9 precursor	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
neuropeptide S receptor isoform A	3	0	0	3
Histamine H2 receptor	7	1	0	10
Uracil nucleotide/cysteinyl leukotriene receptor	0	3	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
nuclear receptor ROR-gamma isoform 1	7	0	0	7
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
15-lipoxygenase, partial	5	0	0	5
apical membrane antigen 1, AMA1	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Replicase polyprotein 1ab	0	1	2	3
cytochrome P450 2D6 isoform 1	3	0	0	3
lysosomal alpha-glucosidase preproprotein	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
cytochrome P450 2C19 precursor	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
ras-related protein Rab-9A	6	0	0	6
serine/threonine-protein kinase PLK1	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Amyloid-beta precursor protein	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Replicase polyprotein 1ab	0	2	1	3
Microtubule-associated protein tau	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	0	1
Fatty acid synthase	0	4	0	4
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
WD repeat-containing protein 5	0	2	0	2
Histone-lysine N-methyltransferase 2A	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Cytosolic endo-beta-N-acetylglucosaminidase	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
matrix metalloproteinase 1, partial	0	0	1	1
PPM1D protein	7	0	0	7
Thrombopoietin	3	0	0	3
nonstructural protein 1	3	0	0	3
pyruvate kinase	3	0	0	3
huntingtin isoform 2	5	0	0	5
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	2	0	2
Integrin beta-3	2	0	0	2
Aldo-keto reductase family 1 member B1	0	7	0	7
Integrin alpha-IIb	2	0	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin receptor type B	2	1	0	3
Sodium-dependent noradrenaline transporter	0	6	1	7
Endothelin-1 receptor	2	0	0	2
Sodium-dependent dopamine transporter	0	4	1	5
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	3	1	4
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
dopamine D1 receptor	3	0	0	3
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
flap endonuclease 1	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	3	0	0	3
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	0	0	2
Epidermal growth factor receptor	0	1	0	1
Plasma kallikrein	0	0	0	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Carbonic anhydrase 3	0	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Tyrosinase	0	1	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	2
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 15	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Carbonic anhydrase 14	0	0	0	2
phosphoglycerate kinase	1	0	0	1
Spike glycoprotein	0	0	1	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Menin	0	1	0	1
Cocaine esterase	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Transmembrane protease serine 2	0	0	1	1
Beta-2 adrenergic receptor	0	2	0	2
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
D(2) dopamine receptor	0	3	0	3
D(4) dopamine receptor	0	2	0	2
Histamine H2 receptor	0	4	0	4
Sodium-dependent serotonin transporter	0	6	1	7
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	1	4
D(3) dopamine receptor	0	4	0	4
Delta-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	3	0	3
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	6	0	6
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Calmodulin	0	1	1	2
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Mu-type opioid receptor	0	1	1	2
Inositol monophosphatase 1	3	0	0	3
Angiopoietin-1 receptor	0	0	1	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	6	0	6
Angiotensin-converting enzyme 2	0	0	1	1
Chain A, Cruzipain	1	0	0	1
Neprilysin	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Atrial natriuretic peptide receptor 3	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	0	3
Thromboxane A2 receptor	0	1	0	2
Type-1A angiotensin II receptor	0	2	1	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	1	5
Type-1 angiotensin II receptor	0	1	1	2
Type-2 angiotensin II receptor	0	4	0	4
Type-2 angiotensin II receptor	0	1	0	1
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Platelet glycoprotein VI	0	1	2	4
Type-1 angiotensin II receptor	0	1	1	2
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent dopamine transporter	0	3	0	3
Sodium-dependent serotonin transporter	0	5	0	5
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	4
Tumor necrosis factor	0	2	1	3
Neuraminidase	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Caspase-7	2	0	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	2	0	0	2
ClpP	2	0	0	2
67.9K protein	4	0	0	4
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
DNA polymerase beta	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	3	0	4
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	4
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	2	0	4
Solute carrier family 22 member 11	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	7	0	7
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
5-hydroxytryptamine receptor 3E	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 4	0	4	0	4
5-hydroxytryptamine receptor 3B	0	2	0	2
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	4	0	4
5-hydroxytryptamine receptor 1A	0	4	1	5
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	7	0	7
Muscarinic acetylcholine receptor M1	0	4	0	4
Alpha-1B adrenergic receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	7	0	7
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-1D adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 3A	0	3	0	3
Endothelin receptor type B	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Endothelin-1 receptor	0	1	0	1
5-hydroxytryptamine receptor 1D	0	3	1	4
5-hydroxytryptamine receptor 2A	0	5	0	5
5-hydroxytryptamine receptor 2C	0	5	0	5
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 3A	0	3	0	3
Alpha-1A adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 3A	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
5-hydroxytryptamine receptor 6	0	2	0	3
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3D	0	2	0	2
5-hydroxytryptamine receptor 3C	0	2	0	2
5-hydroxytryptamine receptor 3B	0	3	0	3
5-hydroxytryptamine receptor 3B	0	3	0	3
G-protein coupled receptor	0	1	0	1
Transporter	0	3	0	3
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
lethal factor (plasmid)	2	0	0	2
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	1
pregnane X receptor	1	0	0	1
pyruvate kinase PKM isoform a	2	0	0	2
Signal transducer and activator of transcription 3	0	1	0	1
Pyruvate-flavodoxin oxidoreductase	0	1	0	1
Anoctamin-1	0	1	0	1
Mcl-1	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Glutathione S-transferase omega-1	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
Cholinesterase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Adenosine receptor A2b	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
luciferase	0	0	0	1
Estrogen receptor	0	3	0	3
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	3	2	5
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	0	3
glucocerebrosidase	1	0	0	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	1
Genome polyprotein	0	1	0	1
Neuraminidase	0	2	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Lysine-specific histone demethylase 1A	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Albumin	0	1	0	1
Neuraminidase	0	1	0	1
Beta-lactamase	0	1	0	1
Sialidase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Dipeptidyl peptidase 4	0	1	0	1
Substance-P receptor	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Substance-K receptor	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Envelope glycoprotein	0	0	1	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Sodium/bile acid cotransporter	0	2	0	3
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Solute carrier family 22 member 6	0	1	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Sodium/bile acid cotransporter	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
Ileal sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Stromal interaction molecule 1	0	1	0	1
Dihydroorotate dehydrogenase	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Myeloperoxidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Phospholipase A-2-activating protein	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (72)

Protein Targets (703)

Colitis, Lymphocytic

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (72)

Drugs Studied (56)

Protein Targets (703)