metronidazole has been researched along with Monkey Diseases in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Monkey Diseases: Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nonspecific diarrhea was successfully treated with metronidazole in 76% (13/17) of cases in adult rhesus macaques (Macaca mulatta)." | 7.67 | Treatment of nonspecific diarrhea with metronidazole in rhesus macaques. ( Eisele, SG; Hempel, MJ; Houser, WD; Reinhardt, V; Sadoff, DA; Scheffler, J, 1987) |
| "Nonspecific diarrhea was successfully treated with metronidazole in 76% (13/17) of cases in adult rhesus macaques (Macaca mulatta)." | 3.67 | Treatment of nonspecific diarrhea with metronidazole in rhesus macaques. ( Eisele, SG; Hempel, MJ; Houser, WD; Reinhardt, V; Sadoff, DA; Scheffler, J, 1987) |
| "A case of amebic dysentery due to a natural infection of Entamoeba histolytica in the rhesus macaque (Macaca mullata) was reported." | 1.35 | A case report: Entamoeba histolytica infections in the rhesus macaque, China. ( Bi, FJ; Cheng, AC; Jiang, B; Yang, GY; Yu, XM, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, B | 1 |
| Yang, GY | 1 |
| Yu, XM | 1 |
| Cheng, AC | 1 |
| Bi, FJ | 1 |
| Reinhardt, V | 2 |
| Houser, WD | 1 |
| Sadoff, DA | 1 |
| Scheffler, J | 1 |
| Eisele, SG | 1 |
| Hempel, MJ | 1 |
3 other studies available for metronidazole and Monkey Diseases
| Article | Year |
|---|---|
A case report: Entamoeba histolytica infections in the rhesus macaque, China.
Topics: Animals; Antiprotozoal Agents; China; DNA, Protozoan; Dysentery, Amebic; Entamoeba histolytica; Enta | 2008 |
Empirical use of metronidazole for treatment of diarrhea in laboratory rhesus macaques: an evaluation.
Topics: Animals; Diarrhea; Drug Evaluation; Macaca mulatta; Metronidazole; Monkey Diseases; Recurrence | 1993 |
Treatment of nonspecific diarrhea with metronidazole in rhesus macaques.
Topics: Animals; Diarrhea; Female; Macaca mulatta; Male; Metronidazole; Monkey Diseases | 1987 |