metronidazole has been researched along with Hemorrhoids in 24 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Hemorrhoids: Swollen veins in the lower part of the RECTUM or ANUS. Hemorrhoids can be inside the anus (internal), under the skin around the anus (external), or protruding from inside to outside of the anus. People with hemorrhoids may or may not exhibit symptoms which include bleeding, itching, and pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " He had been receiving methotrexate (MTX) since boyhood for severe psoriasis." | 7.75 | [Prolonged fever and monocytosis after hemorrhoidectomy and treatment with methotrexate--listeriosis with cerebral abscess]. ( Krämer, S; Maarouf, M; Müller-Lung, U, 2009) |
| "To compare the effect of metronidazole on post conventional hemorrhoidectomy pain in patients with third and fourth degree hemorrhoids." | 5.12 | Post hemorrhoidectomy pain. A randomized controlled trial. ( Al-Masuod, N; Al-Mulhim, AS; Ali, AM; Alwahidi, A, 2006) |
| " He had been receiving methotrexate (MTX) since boyhood for severe psoriasis." | 3.75 | [Prolonged fever and monocytosis after hemorrhoidectomy and treatment with methotrexate--listeriosis with cerebral abscess]. ( Krämer, S; Maarouf, M; Müller-Lung, U, 2009) |
| "Of 1,184 patients who completed the follow-up protocol, 88 patients (male: female = 31:57) who had received metronidazole could be matched by gender, age, NSAIDs used, number of hemorrhoids resected and operation in the same period with 88 patients (male:female = 31:57) who had not." | 3.74 | Antibiotics and early post operative complications of closed hemorrhoidectomy: a retrospective matched pair study. ( Pattana-arun, J; Wesarachawit, W, 2007) |
| "Metronidazole has been shown to decrease postoperative pain but is not used widely." | 2.80 | Efficacy of metronidazole versus placebo in pain control after hemorrhoidectomy. Results of a controlled clinical trial. ( Chávez-Tostado, M; Cortés-Lares, JA; Cuesta-Márquez, LA; Fuentes Orozco, C; García-Rentería, J; González-Ojeda, A; Guerrero-Tarín, JE; Palomares-Chacón, UR; Rendón-Félix, J; Salazar-Parra, M; Solorio-López, S, 2015) |
| "Oral metronidazole has been previously demonstrated to decrease postoperative pain after open diathermy hemorrhoidectomy." | 2.71 | Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing. ( Armstrong, D; Nicholson, TJ, 2004) |
| "Metronidazole has been shown to reduce pain after open hemorrhoidectomy." | 2.70 | A randomized, double-blind trial of the effect of metronidazole on pain after closed hemorrhoidectomy. ( Balfour, L; Botterill, ID; Burke, DA; Finan, PJ; Sagar, PM; Stojkovic, SG, 2002) |
| "Metronidazole is a cheap, safe and effective intervention for reducing postoperative pain following conventional haemorrhoidectomy." | 2.55 | Systematic review and meta-analysis of the role of metronidazole in post-haemorrhoidectomy pain relief. ( Charters, P; Cornille, JB; Daniels, IR; Lyons, NJR; Pathak, S; Smart, NJ, 2017) |
| "Metronidazole use was associated with a significantly shorter time to return to normal activities (standardized mean difference, -0." | 2.55 | Systemic Metronidazole May Not Reduce Posthemorrhoidectomy Pain: A Meta-Analysis of Randomized Controlled Trials. ( Coughlin, S; Emmerton-Coughlin, HM; Foley, N; Vinden, C; Wanis, KN, 2017) |
| "Among these, a minimal anastomotic leakage may lead to gas spreading into surrounding soft tissues." | 1.43 | Pneumoretroperitoneum and pneumomediastinum after Stapled Anopexy Is conservative treatment possible? ( Frassani, S; Gabrielli, F; Guttadauro, A; Macchini, D; Maternini, M, 2016) |
| "Day-case rate, postoperative pain (measured by a visual analogic scale, 1-10), admissions, re-admissions, early postoperative situation and recurrence were evaluated in the study." | 1.38 | Day case stapled anopexy for the treatment of haemorrhoids and rectal mucosal prolapse. ( Carbonell Roure, J; Estrada Ferrer, O; García Torralbo, E; Heredia Budó, A; Hidalgo Grau, LA; Llorca Cardeñosa, S; Suñol Sala, X, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Wilkie, BD | 1 |
| Chandra, R | 1 |
| Chua, J | 1 |
| Lam, DCS | 1 |
| Paratz, ED | 1 |
| An, V | 1 |
| Keck, JO | 1 |
| Gao, H | 1 |
| Cheng, X | 1 |
| Liu, R | 1 |
| Wang, X | 1 |
| Wang, W | 1 |
| Gong, F | 1 |
| Pan, R | 1 |
| Hu, J | 1 |
| Rabelo, FEF | 1 |
| Lacerda-Filho, A | 1 |
| Mansur, ES | 1 |
| de Oliveira, FH | 1 |
| de Queiroz, FL | 1 |
| França-Neto, PR | 1 |
| Misson, N | 1 |
| Lyons, NJR | 1 |
| Cornille, JB | 1 |
| Pathak, S | 1 |
| Charters, P | 1 |
| Daniels, IR | 1 |
| Smart, NJ | 1 |
| Li, HZ | 1 |
| Cheng, YS | 1 |
| Liu, XF | 1 |
| Zhu, XN | 1 |
| Khan, KI | 1 |
| Akmal, M | 1 |
| Waqas, A | 1 |
| Mahmood, S | 1 |
| Solorio-López, S | 1 |
| Palomares-Chacón, UR | 1 |
| Guerrero-Tarín, JE | 1 |
| González-Ojeda, A | 1 |
| Cortés-Lares, JA | 1 |
| Rendón-Félix, J | 1 |
| García-Rentería, J | 1 |
| Chávez-Tostado, M | 1 |
| Cuesta-Márquez, LA | 1 |
| Salazar-Parra, M | 1 |
| Fuentes Orozco, C | 1 |
| Macchini, D | 1 |
| Guttadauro, A | 1 |
| Frassani, S | 1 |
| Maternini, M | 1 |
| Gabrielli, F | 1 |
| Wanis, KN | 1 |
| Emmerton-Coughlin, HM | 1 |
| Coughlin, S | 1 |
| Foley, N | 1 |
| Vinden, C | 1 |
| Krämer, S | 1 |
| Maarouf, M | 1 |
| Müller-Lung, U | 1 |
| Hidalgo Grau, LA | 1 |
| Heredia Budó, A | 1 |
| Llorca Cardeñosa, S | 1 |
| Carbonell Roure, J | 1 |
| Estrada Ferrer, O | 1 |
| García Torralbo, E | 1 |
| Suñol Sala, X | 1 |
| Balfour, L | 1 |
| Stojkovic, SG | 1 |
| Botterill, ID | 1 |
| Burke, DA | 1 |
| Finan, PJ | 1 |
| Sagar, PM | 1 |
| La Torre, F | 1 |
| Nicolai, AP | 1 |
| Nicholson, TJ | 1 |
| Armstrong, D | 1 |
| Al-Mulhim, AS | 1 |
| Ali, AM | 1 |
| Al-Masuod, N | 1 |
| Alwahidi, A | 1 |
| Uraiqat, A | 1 |
| Wesarachawit, W | 1 |
| Pattana-arun, J | 1 |
| Ala, S | 1 |
| Saeedi, M | 1 |
| Eshghi, F | 1 |
| Mirzabeygi, P | 1 |
| Carapeti, EA | 1 |
| Kamm, MA | 1 |
| McDonald, PJ | 1 |
| Phillips, RK | 1 |
| Maw, A | 1 |
| Eu, KW | 1 |
| Seow-Choen, F | 1 |
| Ribbans, WJ | 1 |
| Radcliffe, AG | 1 |
| Sweeney, JL | 1 |
| Hewett, P | 1 |
| Riddell, P | 1 |
| Hoffmann, DC | 1 |
| Luger, A | 1 |
| Biswas, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomised, Double-blind, Placebo-controlled, Parallel-group, Multicentre, Interventional Clinical Trial to Assess the Efficacy and Safety of the Food Supplement Microsmin® Plus in the Symptomatic Treatment of Haemorrhoids[NCT05750563] | 80 participants (Anticipated) | Interventional | 2023-02-28 | Not yet recruiting | |||
| Randomised, Double-blind, Placebo-controlled Trial Evaluating the Effects of Metronidazole Ointment in Facilitating Resolution of Non-healing Pilonidal Sinus Wounds.[NCT04273997] | Phase 2 | 80 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metronidazole and Hemorrhoids
| Article | Year |
|---|---|
Systematic review and meta-analysis of the role of metronidazole in post-haemorrhoidectomy pain relief.
Topics: Adult; Aged; Analgesics; Female; Hemorrhoidectomy; Hemorrhoids; Humans; Male; Metronidazole; Middle | 2017 |
Systemic Metronidazole May Not Reduce Posthemorrhoidectomy Pain: A Meta-Analysis of Randomized Controlled Trials.
Topics: Administration, Oral; Analgesics; Anti-Infective Agents; Hemorrhoidectomy; Hemorrhoids; Humans; Metr | 2017 |
10 trials available for metronidazole and Hemorrhoids
| Article | Year |
|---|---|
Efficacy of postoperative oral metronidazole for haemorrhoidectomy pain: a randomized double-blind, placebo-controlled trial.
Topics: Double-Blind Method; Hemorrhoidectomy; Hemorrhoids; Humans; Metronidazole; Pain, Postoperative; Qual | 2021 |
Benefits of flavonoid and metronidazole use after excisional hemorrhoidectomy: a randomized double-blind clinical trial.
Topics: Double-Blind Method; Flavonoids; Hemorrhoidectomy; Hemorrhoids; Humans; Metronidazole; Pain Measurem | 2021 |
Role of prophylactic antibiotics in Milligan Morgan hemorrhoidectomy - a randomized control trial.
Topics: Adult; Analgesics; Anti-Bacterial Agents; Antibiotic Prophylaxis; Ceftriaxone; Female; Hemorrhoidect | 2014 |
Efficacy of metronidazole versus placebo in pain control after hemorrhoidectomy. Results of a controlled clinical trial.
Topics: Adult; Aged; Female; Hemorrhoidectomy; Hemorrhoids; Humans; Male; Metronidazole; Middle Aged; Pain M | 2015 |
A randomized, double-blind trial of the effect of metronidazole on pain after closed hemorrhoidectomy.
Topics: Analgesics; Double-Blind Method; Female; Hemorrhoids; Humans; Male; Metronidazole; Middle Aged; Pain | 2002 |
Clinical use of micronized purified flavonoid fraction for treatment of symptoms after hemorrhoidectomy: results of a randomized, controlled, clinical trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combinati | 2004 |
Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing.
Topics: Administration, Topical; Adult; Analgesics; Hemorrhoids; Humans; Metronidazole; Middle Aged; Pain Me | 2004 |
Post hemorrhoidectomy pain. A randomized controlled trial.
Topics: Adult; Anti-Infective Agents; Antibiotic Prophylaxis; Female; Hemorrhoids; Humans; Male; Metronidazo | 2006 |
Topical metronidazole can reduce pain after surgery and pain on defecation in postoperative hemorrhoidectomy.
Topics: Administration, Topical; Adult; Anti-Infective Agents; Defecation; Digestive System Surgical Procedu | 2008 |
Double-blind randomised controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy.
Topics: Ambulatory Surgical Procedures; Analgesics; Double-Blind Method; Female; Hemorrhoids; Humans; Male; | 1998 |
12 other studies available for metronidazole and Hemorrhoids
| Article | Year |
|---|---|
Clinical study of herbal mixture "Diding Oral Medicine" as an alternative to preventative antibiotics in perioperative hemorrhoids: A CARE-compliant article.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefazolin; Drugs, Chines | 2021 |
Metronidazole for Posthemorrhoidectomy Pain: Does No Statistical Significance Mean Insignificant Effect on Pain Relief?
Topics: Hemorrhoids; Humans; Metronidazole; Pain; Pain Management; Pain Measurement; Pain, Postoperative | 2017 |
Pneumoretroperitoneum and pneumomediastinum after Stapled Anopexy Is conservative treatment possible?
Topics: Anastomotic Leak; Anti-Bacterial Agents; Combined Modality Therapy; Conservative Treatment; Hemorrho | 2016 |
[Prolonged fever and monocytosis after hemorrhoidectomy and treatment with methotrexate--listeriosis with cerebral abscess].
Topics: Anti-Infective Agents; Biopsy, Needle; Brain; Brain Abscess; Diagnosis, Differential; Drug Therapy, | 2009 |
Day case stapled anopexy for the treatment of haemorrhoids and rectal mucosal prolapse.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Anti-Bacterial Agents; Anti-Infective Agents; Antib | 2012 |
Post hemorrhoidectomy pain. A randomized controlled trial.
Topics: Hemorrhoids; Humans; Length of Stay; Metronidazole; Pain, Postoperative; Randomized Controlled Trial | 2007 |
Antibiotics and early post operative complications of closed hemorrhoidectomy: a retrospective matched pair study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis | 2007 |
Retroperitoneal sepsis complicating stapled hemorrhoidectomy: report of a case and review of the literature.
Topics: Adult; Anti-Infective Agents; Cefuroxime; Cephalosporins; Hemorrhoids; Humans; Male; Metronidazole; | 2002 |
Retroperitoneal abscess following sclerotherapy for hemorrhoids.
Topics: Abscess; Adult; Erythromycin; Gentamicins; Hemorrhoids; Humans; Intestinal Perforation; Male; Metron | 1985 |
Rectal gangrene: a complication of phosphate enema.
Topics: Aged; Constipation; Debridement; Drug Therapy, Combination; Enema; Female; Gangrene; Gentamicins; He | 1986 |
[Syphilis diagnosis in the age of antibiotics].
Topics: Adult; Aged; Alopecia; Anti-Bacterial Agents; Balanitis; Biopsy; Child; Child, Preschool; Chloramphe | 1971 |
Metronidazole in haemorrhoids.
Topics: Female; Hemorrhoids; Humans; Male; Metronidazole | 1968 |