metronidazole has been researched along with Pus in 32 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To demonstrate the efficacy of oral metronidazole (OM) in simple or complicated appendicitis with localized peritonitis, a randomized prospective study was carried out in 1083 patients, ranging in age from 4 to 50 years (mean age, 21." | 9.09 | Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. ( Banani, SA; Talei, A, 1999) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 7.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| "We have studied the penetration of aztreonam into pus with a low mortality intra-abdominal abscess model in the Wistar rat." | 7.67 | The penetration of aztreonam, a monobactam antibiotic, into intra-abdominal abscesses. ( Burdon, DW; Keighley, MR; Youngs, DJ, 1989) |
| "Several studies have reported adjunctive benefits to scaling and root planing (SRP) of systemic amoxycillin and metronidazole in the treatment of periodontal diseases." | 5.10 | Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study. ( Addy, M; Newcombe, RG; Rooney, J; Sprague, SV; Wade, WG, 2002) |
| "To demonstrate the efficacy of oral metronidazole (OM) in simple or complicated appendicitis with localized peritonitis, a randomized prospective study was carried out in 1083 patients, ranging in age from 4 to 50 years (mean age, 21." | 5.09 | Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. ( Banani, SA; Talei, A, 1999) |
| " histolytica negative and positive (asymptomatic) individuals, and from pre- and post-metronidazole-treated healthy volunteers and pus samples from ALA patients were tested for the presence of various bacterial genera using 16S rRNA-based primers." | 3.73 | Changes in bacterial profile during amebiasis: demonstration of anaerobic bacteria in ALA pus samples. ( Ahuja, V; Bhattacharya, S; Murthy, RS; Paul, J; Rani, R; Rizvi, MA, 2006) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 3.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| "Specimens of abdominal adhesions and bowels of rats were examined at light microscopy in treatment of diffuse purulent peritonitis (DPP) by kanamycin and artificial carbomineral sorbent SUMS-2p with metronidazolum or lipoorizinum adsorbed on the surface." | 3.70 | [Structural formation of adhesions in abdominal cavity and bowel walls in treatment of peritonitis by sorbent with absorbed metrinidazole or lipoorizinum (experimental study)]. ( Maĭborodin, IV; Pleshakov, VP; Velichko, IaI, 1999) |
| "We have studied the penetration of aztreonam into pus with a low mortality intra-abdominal abscess model in the Wistar rat." | 3.67 | The penetration of aztreonam, a monobactam antibiotic, into intra-abdominal abscesses. ( Burdon, DW; Keighley, MR; Youngs, DJ, 1989) |
| "Amebic liver abscess is more common than pyogenic liver abscess on a global scale." | 2.38 | Pyogenic and amebic liver abscess. ( Richter, JM; Rustgi, AK, 1989) |
| "Primary cutaneous amoebiasis occurs from contamination of pre-existing wounds." | 1.36 | Amoebiasis cutis: clinical suspicion is the key to early diagnosis. ( Jindal, N; Kaushik, R; Mahajan, VK; Shanker, V; Sharma, NL; Verma, GK; Verma, S, 2010) |
| "As otogenic cerebral abscesses constitute a major proportion of all cerebral abscesses, the use of metronidazole against obligate anaerobic bacteria, which tend to dominate in such abscesses, should reduce the high mortality from this condition." | 1.26 | Bacteriological study of otogenic cerebral abscesses: chemotherapeutic role of metronidazole. ( Ingham, HR; Roxby, CM; Slekon, JB, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (43.75) | 18.7374 |
| 1990's | 9 (28.13) | 18.2507 |
| 2000's | 6 (18.75) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bali, R | 1 |
| Sharma, P | 1 |
| Gaba, S | 1 |
| Verma, GK | 1 |
| Sharma, NL | 1 |
| Shanker, V | 1 |
| Mahajan, VK | 1 |
| Kaushik, R | 1 |
| Verma, S | 1 |
| Jindal, N | 1 |
| Kim, YS | 1 |
| Kwon, H | 1 |
| Choi, DH | 1 |
| Hofmann, GE | 1 |
| Warikoo, P | 1 |
| Jacobs, W | 1 |
| Rani, R | 1 |
| Murthy, RS | 1 |
| Bhattacharya, S | 1 |
| Ahuja, V | 1 |
| Rizvi, MA | 1 |
| Paul, J | 1 |
| Parija, SC | 1 |
| Khairnar, K | 1 |
| Perera, MR | 1 |
| Kirk, A | 1 |
| Noone, P | 1 |
| McLean, A | 1 |
| Ioannides-Demos, L | 1 |
| Somogyi, A | 1 |
| Tong, N | 1 |
| Spicer, J | 1 |
| Tarshis, VE | 1 |
| Bronskaia, LK | 1 |
| Bogomolova, NS | 1 |
| Khromov, IaA | 1 |
| O'Sullivan, GC | 1 |
| Murphy, D | 1 |
| O'Brien, MG | 1 |
| Ireland, A | 1 |
| Nieminen, A | 1 |
| Asikainen, S | 1 |
| Torkko, H | 1 |
| Kari, K | 1 |
| Uitto, VJ | 1 |
| Saxén, L | 1 |
| Ziuzio, S | 1 |
| Sakson, B | 1 |
| Simo, R | 1 |
| Hartley, C | 1 |
| Rapado, F | 1 |
| Zarod, AP | 1 |
| Sanyal, D | 1 |
| Rothera, MP | 1 |
| Desiaterik, VI | 1 |
| Krivitskiĭ, IuM | 1 |
| Svetlovskiĭ, AA | 1 |
| Shapovaliuk, VV | 1 |
| Brook, I | 1 |
| Frazier, EH | 1 |
| Maĭborodin, IV | 1 |
| Velichko, IaI | 1 |
| Pleshakov, VP | 1 |
| Banani, SA | 1 |
| Talei, A | 1 |
| Feres, M | 1 |
| Haffajee, AD | 1 |
| Allard, K | 1 |
| Som, S | 1 |
| Socransky, SS | 1 |
| Rooney, J | 1 |
| Wade, WG | 1 |
| Sprague, SV | 1 |
| Newcombe, RG | 1 |
| Addy, M | 1 |
| Ogutcen-Toller, M | 1 |
| Alkan, A | 1 |
| Baris, S | 1 |
| Cakir, N | 1 |
| Eykyn, SJ | 1 |
| Phillips, I | 1 |
| Piéron, R | 1 |
| Debure, A | 1 |
| Mafart, Y | 1 |
| Lesobre, B | 1 |
| Bryskier, A | 1 |
| Vergez, P | 1 |
| Ingham, HR | 1 |
| Slekon, JB | 1 |
| Roxby, CM | 1 |
| Sridharan, GV | 1 |
| Wilkinson, SP | 1 |
| Primrose, WR | 1 |
| Rustgi, AK | 1 |
| Richter, JM | 1 |
| Youngs, DJ | 1 |
| Burdon, DW | 1 |
| Keighley, MR | 1 |
| Meier, R | 1 |
| Vögtlin, J | 1 |
| Gyr, K | 1 |
| Brousil, L | 1 |
| Paavonen, J | 1 |
| Lehtinen, M | 1 |
| Teisala, K | 1 |
| Heinonen, PK | 1 |
| Punnonen, R | 1 |
| Aine, R | 1 |
| Miettinen, A | 1 |
| Grönroos, P | 1 |
| Saha, SK | 1 |
| Halvorson, GD | 1 |
| Halvorson, JE | 1 |
| Iserson, KV | 1 |
| Sowmini, CN | 1 |
| Vijayalakshmi, K | 1 |
| Chellamuthiah, C | 1 |
| Sundaram, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Laparoscopic Lavage for Acute Non-Faeculant Diverticulitis[NCT01019239] | 300 participants (Anticipated) | Interventional | 2010-01-31 | Enrolling by invitation | |||
| Management and Evolution of Acute Diverticulitis With Pericolic Free Gas - a Multicentre Observational Study[NCT04311385] | 1,000 participants (Actual) | Observational | 2020-06-01 | Completed | |||
| Trimethoprim-sulfamethoxazole Versus Placebo in the Treatment of Cutaneous Abscesses in the Emergency Department[NCT00867789] | 140 participants (Actual) | Interventional | 2009-03-31 | Terminated (stopped due to Slow enrollment due to subjects not meeting inclusion/exclusion criteria) | |||
| A Randomized Trial of Intranasal Fentanyl Versus Placebo as an Adjunct to Lidocaine Infiltration in Adults Undergoing Abscess Incision and Drainage in the Emergency[NCT03872700] | Phase 3 | 49 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00867789)
Timeframe: two years
| Intervention | Percentage of outcomes assessed (Number) |
|---|---|
| Trimethoprim-sulfamethaxazole | 0 |
| Sugar Pill | 0 |
Patient reported NRS pain scores after Blunt Dissection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.1 |
| Placebo | 4.4 |
Patient reported NRS pain scores after Irrigation. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.4 |
| Placebo | 2.6 |
Patient reported NRS pain scores after Lidocaine injection. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Following Lidocaine injection measured once anytime up to 12 minutes after intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.4 |
| Placebo | 8.0 |
Patient reported pain after Packing of abscess. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once at the time of completion of application of the bandage, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 4.5 |
| Placebo | 3.9 |
Patient reported NRS pain scores following Incision. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once anytime up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 3.9 |
| Placebo | 3.9 |
Patient reported pain scores at baseline. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Baseline
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 8.3 |
| Placebo | 8.1 |
Patient reported pain scores for overall Procedure assessed immediately after placement of dressing at the end of procedure. The NRS for pain is a reliable and validated measure of pain intensity ranging from 0 - no pain, to 10 - worst pain imaginable. (NCT03872700)
Timeframe: Measured once following placement of dressing at completion of procedure, up to 60 minutes following intranasal administration
| Intervention | score on a scale (Mean) |
|---|---|
| Intranasal Fentanyl | 6.2 |
| Placebo | 7.0 |
1 review available for metronidazole and Pus
| Article | Year |
|---|---|
Pyogenic and amebic liver abscess.
Topics: Adult; Animals; Diagnosis, Differential; Drainage; Entamoeba histolytica; Humans; Liver Abscess; Liv | 1989 |
4 trials available for metronidazole and Pus
| Article | Year |
|---|---|
Use of metronidazole as part of an empirical antibiotic regimen after incision and drainage of infections of the odontogenic spaces.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Bacteriological Techniq | 2015 |
Value of some laboratory and clinical measurements in the treatment plan for advanced periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Anti-Bacterial Agents; Denta | 1996 |
Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Appendicitis; Ceftizo | 1999 |
Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Capsules; Chronic Disease; Colony C | 2002 |
27 other studies available for metronidazole and Pus
| Article | Year |
|---|---|
Amoebiasis cutis: clinical suspicion is the key to early diagnosis.
Topics: Adult; Amebiasis; Entamoeba histolytica; Humans; Male; Metronidazole; Skin Ulcer; Suppuration; Troph | 2010 |
Ruptured pyosalpinx following a fetal reduction procedure.
Topics: Abdominal Pain; Adult; Anti-Bacterial Agents; C-Reactive Protein; Cephalosporins; Fallopian Tubes; F | 2012 |
Ultrasound detection of pyometra at the time of embryo transfer after ovum retrieval for in vitro fertilization.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; | 2003 |
Changes in bacterial profile during amebiasis: demonstration of anaerobic bacteria in ALA pus samples.
Topics: Animals; Bacteria, Anaerobic; DNA, Protozoan; Drug Resistance, Bacterial; Entamoeba histolytica; Ent | 2006 |
Detection of excretory Entamoeba histolytica DNA in the urine, and detection of E. histolytica DNA and lectin antigen in the liver abscess pus for the diagnosis of amoebic liver abscess.
Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Antiprotozoal Agents; DNA Primers; DNA, Protozo | 2007 |
Presentation, diagnosis and management of liver abscess.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Drug Therapy, Combination; Female; Humans; Liver Abs | 1980 |
Successful substitution of rectal metronidazole administration for intravenous use.
Topics: Anaerobiosis; Bacteria; Humans; Injections, Intravenous; Metronidazole; Suppositories; Suppuration; | 1983 |
[Treatment with metronidazole in patients with destructive appendicitis].
Topics: Adult; Aged; Appendicitis; Female; Humans; Male; Metronidazole; Middle Aged; Peritonitis; Suppuratio | 1983 |
Laparoscopic management of generalized peritonitis due to perforated colonic diverticula.
Topics: Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Diverticulum, Colon; Female; Follow-Up Studies; | 1996 |
Laparoscopic management of generalized peritonitis due to perforated colonic diverticula.
Topics: Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Diverticulum, Colon; Female; Follow-Up Studies; | 1996 |
Laparoscopic management of generalized peritonitis due to perforated colonic diverticula.
Topics: Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Diverticulum, Colon; Female; Follow-Up Studies; | 1996 |
Laparoscopic management of generalized peritonitis due to perforated colonic diverticula.
Topics: Adult; Aged; Anti-Bacterial Agents; Cephalosporins; Diverticulum, Colon; Female; Follow-Up Studies; | 1996 |
[Results of conservative treatment of chronic purulent sinusitis].
Topics: Adult; Amikacin; Anti-Bacterial Agents; Antitrichomonal Agents; Child; Child, Preschool; Chronic Dis | 1995 |
Microbiology and antibiotic treatment of head and neck abscesses in children.
Topics: Abscess; Adolescent; Anti-Bacterial Agents; Bacteria, Anaerobic; Child; Child, Preschool; Drainage; | 1998 |
[Surgical treatment of putrid neck phlegmon].
Topics: Adult; Anti-Bacterial Agents; Antitrichomonal Agents; Cellulitis; Female; Humans; Hyperbaric Oxygena | 1998 |
Aerobic and anaerobic microbiology of axillary hidradenitis suppurativa.
Topics: Adult; Aged; Anti-Bacterial Agents; Axilla; Bacteria, Aerobic; Bacteria, Anaerobic; Drainage; Female | 1999 |
[Structural formation of adhesions in abdominal cavity and bowel walls in treatment of peritonitis by sorbent with absorbed metrinidazole or lipoorizinum (experimental study)].
Topics: Abdomen; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Colon; Disease Models, Animal; Drug | 1999 |
Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole.
Topics: Actinomyces; Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Bacteria; Bacteroides; | 2001 |
An unusual form of Actinomycosis of the mandible with a resultant gross sequester in a 4-year-old child: a case report.
Topics: Actinomycosis; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Child, Preschool; Follow-Up | 2001 |
Metronidazole in surgical infections.
Topics: Adolescent; Adult; Aged; Anaerobiosis; Child; Chromatography, Gas; Drainage; Female; Fluorescence; H | 1978 |
[Treatment of purulent anaerobic pleurisy by local injections of metronidazole].
Topics: Bacteroides Infections; Humans; Injections; Male; Metronidazole; Middle Aged; Pleurisy; Suppuration | 1977 |
Bacteriological study of otogenic cerebral abscesses: chemotherapeutic role of metronidazole.
Topics: Adolescent; Adult; Bacteroides fragilis; Bacteroides Infections; Brain Abscess; Ear Diseases; Female | 1977 |
Pyogenic liver abscess in the elderly.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Cholelithiasis; Diagnosis, Differential; Diverticuli | 1990 |
The penetration of aztreonam, a monobactam antibiotic, into intra-abdominal abscesses.
Topics: Abdomen; Abscess; Animals; Aztreonam; beta-Lactamases; Escherichia coli; Hydrogen-Ion Concentration; | 1989 |
[Therapy of pyogenic liver abscess].
Topics: Anti-Bacterial Agents; Drainage; Humans; Liver Abscess; Metronidazole; Suppuration | 1987 |
[Rectal administration of metronidazole in the prevention of suppurative complications after appendectomy].
Topics: Adolescent; Adult; Appendectomy; Bacteria, Anaerobic; Bacterial Infections; Humans; Metronidazole; M | 1986 |
Haemophilus influenzae causes purulent salpingitis.
Topics: Adult; Doxycycline; Fallopian Tubes; Female; Haemophilus Infections; Haemophilus influenzae; Humans; | 1985 |
Peritoneal lavage with metronidazole.
Topics: Adolescent; Adult; Aged; Cephradine; Child; Child, Preschool; Drug Therapy, Combination; Feces; Fema | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Abscess incision and drainage in the emergency department--Part I.
Topics: Abscess; Bacteria, Aerobic; Bacteria, Anaerobic; Cellulitis; Clindamycin; Drainage; Emergency Servic | 1985 |
Infections of the median raphe of the penis. Report of three cases.
Topics: Adult; Gonorrhea; Humans; Male; Metronidazole; Penicillins; Penile Diseases; Penis; Radiography; Str | 1973 |