metronidazole has been researched along with Infertility, Male in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rosmarinic acid (RA) is a natural antioxidant that has many biological activities." | 1.46 | Rosmarinic acid reverses the effects of metronidazole-induced infertility in male albino rats. ( Al-Alami, ZM; Shraideh, ZA; Taha, MO, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Alami, ZM | 1 |
| Shraideh, ZA | 1 |
| Taha, MO | 1 |
| Hsu, CC | 1 |
| Hou, MF | 1 |
| Hong, JR | 1 |
| Wu, JL | 1 |
| Her, GM | 1 |
| Wiesenfeld, HC | 1 |
| Gopalkrishnan, K | 1 |
| Hinduja, IN | 1 |
| Kumar, TC | 1 |
| Korelitz, BI | 1 |
| Haschek, H | 1 |
| Kofler, K | 1 |
| Marberger, H | 1 |
| Decristoforo, A | 1 |
| Swoboda, HP | 1 |
| Walther, H | 1 |
| Bánk, EB | 1 |
1 review available for metronidazole and Infertility, Male
| Article | Year |
|---|---|
[Trichomonas vaginalis infection in the male].
Topics: Chronic Disease; Coitus; Epididymitis; Humans; Infertility, Male; Male; Metronidazole; Prostatitis; | 1973 |
8 other studies available for metronidazole and Infertility, Male
| Article | Year |
|---|---|
Rosmarinic acid reverses the effects of metronidazole-induced infertility in male albino rats.
Topics: Animals; Antioxidants; Cinnamates; Depsides; Infertility, Male; Male; Metronidazole; Rats; Rosmarini | 2017 |
Inducible male infertility by targeted cell ablation in zebrafish testis.
Topics: Ablation Techniques; Amino Acid Sequence; Animals; Animals, Genetically Modified; Anti-Infective Age | 2010 |
Male infertility.
Topics: Doxycycline; Humans; Infertility, Male; Male; Metronidazole; Trichomonas Infections | 1995 |
Semen characteristics of asymptomatic males affected by Trichomonas vaginalis.
Topics: Female; Humans; Infertility, Male; Male; Metronidazole; Semen; Sperm Count; Sperm Motility; Trichomo | 1990 |
Pregnancy, fertility, and inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Fe | 1985 |
[Fertility disorders due to inflammatory male adnexal diseases].
Topics: Abscess; Adult; Fructose; Genital Diseases, Male; Humans; Infertility, Male; Male; Metronidazole; Mi | 1972 |
[Trichomonas infection in clinical picture, therapy and significance to fertility and sterility].
Topics: Adult; Child; Female; Humans; Infertility, Female; Infertility, Male; Male; Metronidazole; Trichomon | 1973 |
[On the role of trichomonas infection of the sperm in sterility].
Topics: Female; Humans; Infertility, Female; Infertility, Male; Male; Metronidazole; Spermatozoa; Trichomona | 1966 |