metronidazole has been researched along with Endophthalmitis in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Endophthalmitis: Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sexually transmitted diseases were reduced: Trichomonas vaginalis (rate ratio, 0." | 2.70 | Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. ( Abramowsky, C; Gray, RH; Kigozi, G; Meehan, M; Moulton, LH; O'Brien, KL; Quinn, TC; Robb, M; Serwadda, D; Sewankambo, NK; Wabwire-Mangen, F; Wawer, MJ, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pollett, S | 1 |
| McMullan, B | 1 |
| Lam, VW | 1 |
| Qureshi, C | 1 |
| Kok, J | 1 |
| Chheda, LV | 1 |
| Sobol, WM | 1 |
| Buerk, BM | 1 |
| Kurz, PA | 1 |
| Gray, RH | 1 |
| Wabwire-Mangen, F | 1 |
| Kigozi, G | 1 |
| Sewankambo, NK | 1 |
| Serwadda, D | 1 |
| Moulton, LH | 1 |
| Quinn, TC | 1 |
| O'Brien, KL | 1 |
| Meehan, M | 1 |
| Abramowsky, C | 1 |
| Robb, M | 1 |
| Wawer, MJ | 1 |
| Kelly, LD | 1 |
| Gaynon, M | 1 |
1 review available for metronidazole and Endophthalmitis
| Article | Year |
|---|---|
Bacteroides fragilis endophthalmitis: a case report.
Topics: Aged; Aged, 80 and over; Bacteroides fragilis; Bacteroides Infections; Cataract Extraction; Endophth | 1990 |
1 trial available for metronidazole and Endophthalmitis
| Article | Year |
|---|---|
Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda.
Topics: Azithromycin; Birth Weight; Cefixime; Drug Therapy, Combination; Endophthalmitis; Female; Folic Acid | 2001 |
2 other studies available for metronidazole and Endophthalmitis
| Article | Year |
|---|---|
A 68-year-old type 2 diabetic man of Korean ethnicity with fever, abdominal pain, and right eye visual disturbance.
Topics: Abdominal Pain; Aged; Anti-Bacterial Agents; Bacteremia; Diabetes Mellitus, Type 2; Endophthalmitis; | 2015 |
Endogenous endophthalmitis with brain abscesses caused by Streptococcus constellatus.
Topics: Anti-Bacterial Agents; Brain Abscess; Ceftriaxone; Drug Therapy, Combination; Endophthalmitis; Eye I | 2011 |