metronidazole has been researched along with Liver Steatosis in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Drenick, EJ | 1 |
| Fisler, J | 1 |
| Johnson, D | 1 |
| Freund, HR | 1 |
| Muggia-Sullam, M | 1 |
| LaFrance, R | 1 |
| Enrione, EB | 1 |
| Popp, MB | 1 |
| Bjornson, HS | 1 |
2 other studies available for metronidazole and Liver Steatosis
| Article | Year |
|---|---|
Hepatic steatosis after intestinal bypass--prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition.
Topics: Adult; Amino Acids; Body Weight; Fatty Liver; Female; Humans; Ileum; Jejunum; Liver; Male; Metronida | 1982 |
A possible beneficial effect of metronidazole in reducing TPN-associated liver function derangements.
Topics: Amino Acids; Animals; Bacteria; Cholestasis, Intrahepatic; Fatty Liver; Injections, Intravenous; Int | 1985 |