metronidazole has been researched along with Tooth Loss in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Tooth Loss: The failure to retain teeth as a result of disease or injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tooth loss is the ultimate negative consequence of periodontitis, and reports of the extent to which different treatment strategies may influence long-term tooth loss are hard to find." | 2.84 | A Randomized Double-Masked Clinical Trial Comparing Four Periodontitis Treatment Strategies: 5-Year Tooth Loss Results. ( Baelum, V; Gjermo, P; Preus, HR, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Preus, HR | 1 |
| Gjermo, P | 1 |
| Baelum, V | 1 |
| Leininger, M | 1 |
| Tenenbaum, H | 1 |
| Davideau, JL | 1 |
| Sixou, JL | 1 |
| Robert, JC | 1 |
| Bonnaure-Mallet, M | 1 |
| De Vree, H | 1 |
| Steenackers, K | 1 |
| De Boever, JA | 1 |
| Loesche, WJ | 1 |
| Giordano, JR | 1 |
| Hujoel, P | 1 |
| Schwarcz, J | 1 |
| Smith, BA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Treatment of Periodontal Diseases. A Randomized, Blinded, Five Years Follow-up, Four-arm, Placebo Controlled Clinical Intervention Trial[NCT01318928] | Phase 4 | 184 participants (Actual) | Interventional | 2008-01-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for metronidazole and Tooth Loss
| Article | Year |
|---|---|
A Randomized Double-Masked Clinical Trial Comparing Four Periodontitis Treatment Strategies: 5-Year Tooth Loss Results.
Topics: Adult; Aged; Anti-Infective Agents, Local; Chlorhexidine; Dental Scaling; Disinfection; Double-Blind | 2017 |
Metronidazole in periodontitis: reduced need for surgery.
Topics: Adult; Alveolar Bone Loss; Bacteria; Bacteroidaceae; Bacteroides; Colony Count, Microbial; Combined | 1992 |
3 other studies available for metronidazole and Tooth Loss
| Article | Year |
|---|---|
Modified periodontal risk assessment score: long-term predictive value of treatment outcomes. A retrospective study.
Topics: Aggressive Periodontitis; Anti-Infective Agents, Local; Chronic Periodontitis; Dental Scaling; Disea | 2010 |
Loss of deciduous teeth and germs of permanent incisors in a 4-year-old child. An atypic prepubertal periodontitis? A clinical, microbiological, immunological and ultrastructural study.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Anti-Bacterial Agents; Basement Mem | 1997 |
Periodontal treatment of rapid progressive periodontitis in 2 siblings with Papillon-Lefèvre syndrome: 15-year follow-up.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Anti-Bacterial Agents; Anti-Infecti | 2000 |