metronidazole has been researched along with Empyema, Gall Bladder in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Adverse events were reported by 9% of patients in the isepamicin group (16/178) and 10% of patients in the amikacin group (9/89)." | 2.68 | The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections. ( Leal del Rosal, P, 1995) |
| "Cholecystitis is an important cause of hospital admission." | 1.51 | [Biliary microbiote in cholecystectomized patients: Review of empirical antibiotherapy]. ( Escrig Sos, J; Gil Fortuño, M; Granel Villach, L; Igual Adell, R; Martínez Ramos, D; Moreno Muñoz, R; Sabater Vidal, S; Soria Martín, R, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gil Fortuño, M | 1 |
| Granel Villach, L | 1 |
| Sabater Vidal, S | 1 |
| Soria Martín, R | 1 |
| Martínez Ramos, D | 1 |
| Escrig Sos, J | 1 |
| Moreno Muñoz, R | 1 |
| Igual Adell, R | 1 |
| Pekova, L | 1 |
| Shomov, G | 1 |
| Mladenova, I | 1 |
| Pellicano, R | 1 |
| Leal del Rosal, P | 1 |
| Andåker, L | 1 |
| Höjer, H | 1 |
| Kihlström, E | 1 |
| Lindhagen, J | 1 |
| Prada Lorenzo, D | 1 |
| García Fernández, S | 1 |
| Ortega Bevia, JM | 1 |
| Jiménez García, A | 1 |
| García Díaz, S | 1 |
| Smirnova, KM | 1 |
2 trials available for metronidazole and Empyema, Gall Bladder
| Article | Year |
|---|---|
The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Cholecystitis; Drug Administration Schedule; Escherichia col | 1995 |
Stratified duration of prophylactic antimicrobial treatment in emergency abdominal surgery. Metronidazole-fosfomycin vs. metronidazole-gentamicin in 381 patients.
Topics: Abdomen, Acute; Adolescent; Adult; Aged; Appendicitis; Cholecystitis; Clinical Trials as Topic; Drug | 1987 |
4 other studies available for metronidazole and Empyema, Gall Bladder
| Article | Year |
|---|---|
[Biliary microbiote in cholecystectomized patients: Review of empirical antibiotherapy].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin-Potassium Clavulanate Combination; Anti-Bact | 2019 |
Clostridium difficile-associated disease with lethal outcome in a 77-year-old woman. A case report.
Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Cholecy | 2007 |
[Antibiotic prophylaxis in biliary surgery. Indications and results].
Topics: Bacterial Infections; Biliary Tract Surgical Procedures; Cholecystitis; Cholestasis; Drug Administra | 1985 |
[The use of metronidazole in children with lambliasis].
Topics: Adolescent; Child; Cholecystitis; Female; Giardiasis; Humans; Male; Metronidazole | 1967 |