metronidazole has been researched along with Encephalitozoonosis in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Encephalitozoonosis: Infection with FUNGI of the genus ENCEPHALITOZOON. Lesions commonly occur in the BRAIN and KIDNEY tubules. Other sites of infection in MAMMALS are the LIVER; ADRENAL GLANDS; OPTIC NERVES; RETINA; and MYOCARDIUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Microsporidiosis is recognized as an increasingly important infection, particularly in patients with human immunodeficiency virus (HIV) infection." | 2.40 | Microsporidial disease in HIV-infected patients: a report of 42 patients and review of the literature. ( Crowe, SM; Leder, K; Ryan, N; Spelman, D, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lallo, MA | 1 |
| da Costa, LF | 1 |
| de Castro, JM | 1 |
| He, Q | 1 |
| Leitch, GJ | 1 |
| Visvesvara, GS | 1 |
| Wallace, S | 1 |
| Leder, K | 1 |
| Ryan, N | 1 |
| Spelman, D | 1 |
| Crowe, SM | 1 |
1 review available for metronidazole and Encephalitozoonosis
| Article | Year |
|---|---|
Microsporidial disease in HIV-infected patients: a report of 42 patients and review of the literature.
Topics: Adult; Aged; Albendazole; Animals; Anti-Infective Agents; Antiprotozoal Agents; Apansporoblastina; E | 1998 |
2 other studies available for metronidazole and Encephalitozoonosis
| Article | Year |
|---|---|
Effect of three drugs against Encephalitozoon cuniculi infection in immunosuppressed mice.
Topics: Albendazole; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclophosphamide; Cycl | 2013 |
Effects of nifedipine, metronidazole, and nitric oxide donors on spore germination and cell culture infection of the microsporidia Encephalitozoon hellem and Encephalitozoon intestinalis.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antitrichomonal Agents; Calcium Channel Blockers; Cells | 1996 |