metronidazole has been researched along with Astrocytoma, Grade IV in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used "high-dose" metronidazole, an "in vitro" and "in vivo" specific radiosensitizer of hypoxic cells, in a controlled trial to evaluate possible enhancement of radiation effect in patients with supratentorial glioblastomas." | 9.04 | Radiation and high-dose metronidazole in supratentorial glioblastomas. ( Band, P; Chapman, JD; Feldstein, ML; Fryer, C; Mielke, B; Urtasun, R, 1976) |
| "We used "high-dose" metronidazole, an "in vitro" and "in vivo" specific radiosensitizer of hypoxic cells, in a controlled trial to evaluate possible enhancement of radiation effect in patients with supratentorial glioblastomas." | 5.04 | Radiation and high-dose metronidazole in supratentorial glioblastomas. ( Band, P; Chapman, JD; Feldstein, ML; Fryer, C; Mielke, B; Urtasun, R, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stewart, DJ | 2 |
| Benoit, B | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Dennery, J | 1 |
| Russell, N | 1 |
| Peterson, E | 1 |
| Grahovac, Z | 1 |
| Belanger, G | 1 |
| Maroun, JA | 1 |
| Gutin, PH | 1 |
| Wara, WM | 1 |
| Phillips, TL | 1 |
| Wilson, CB | 1 |
| Urtasun, R | 2 |
| Feldstein, ML | 3 |
| Partington, J | 1 |
| Tanasichuk, H | 1 |
| Miller, JD | 1 |
| Russell, DB | 1 |
| Agboola, O | 2 |
| Mielke, B | 2 |
| Dahrouge, S | 1 |
| Girard, A | 1 |
| Band, P | 1 |
| Chapman, JD | 3 |
| Fryer, C | 1 |
| Belli, JA | 1 |
| Hellman, S | 1 |
| Urtasun, RC | 1 |
| Band, PR | 1 |
| Fowler, JF | 1 |
1 review available for metronidazole and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Hypoxic sensitizers--implications for radiation therapy.
Topics: Animals; Female; Glioblastoma; Humans; Metronidazole; Misonidazole; Neoplasms; Oxygen Consumption; R | 1979 |
3 trials available for metronidazole and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Radiation and nitroimidazoles in supratentorial high grade gliomas: a second clinical trial.
Topics: Adult; Aged; Cerebellar Neoplasms; Clinical Trials as Topic; Glioblastoma; Humans; Metronidazole; Mi | 1982 |
Cranial radiation and concomitant cisplatin and mitomycin-C plus resistance modulators for malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; beta Carotene; Brain Neoplasms; Cisplat | 1997 |
Radiation and high-dose metronidazole in supratentorial glioblastomas.
Topics: Administration, Oral; Adult; Aged; Brain Neoplasms; Cobalt Radioisotopes; Evaluation Studies as Topi | 1976 |
5 other studies available for metronidazole and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Treatment of malignant gliomas in adults with BCNU plus metronidazole.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Female; Gliobl | 1984 |
Hypoxic cell radiosensitizers in the treatment of malignant brain tumors.
Topics: Animals; Brain Neoplasms; Cricetinae; DNA; Glioblastoma; Humans; Hypoxia; In Vitro Techniques; Metro | 1980 |
Editorial: Hypoxic cell radiosensitizers.
Topics: Brain Neoplasms; Glioblastoma; Male; Metronidazole; Oxygen; Radiation-Sensitizing Agents | 1976 |
Radiation plus metronidazole for glioblastoma.
Topics: Brain Neoplasms; Glioblastoma; Humans; Metronidazole; Radiation-Sensitizing Agents | 1977 |
Developments in radiotherapy other than heavy particle beams.
Topics: Animals; Brain Neoplasms; Energy Transfer; Fast Neutrons; Female; Glioblastoma; Hot Temperature; Hum | 1977 |