metronidazole has been researched along with Bone Diseases in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Bone Diseases: Diseases of BONES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole also has been used either alone or in combination, most frequently with amoxicillin, to treat many other anaerobic infections: head and neck, pleuropulmonary, genital tract, bone and joint, skin and soft tissue, and cases of fusobacterial septicemia (necrobacillosis)." | 1.27 | The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital. ( Eykyn, SJ, 1983) |
| "Anaerobic infections are reviewed with emphasis on management." | 1.25 | Management of anaerobic infections. ( Bartlett, JG; Chow, AW; Finegold, SM; Flora, DJ; Gorbach, SL; Harder, EJ; Tally, FP, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Czarnobaj, K | 2 |
| Prokopowicz, M | 2 |
| Sawicki, W | 1 |
| Greber, K | 1 |
| Eykyn, SJ | 1 |
| Finegold, SM | 2 |
| Bartlett, JG | 1 |
| Chow, AW | 1 |
| Flora, DJ | 1 |
| Gorbach, SL | 1 |
| Harder, EJ | 1 |
| Tally, FP | 1 |
| Nielsen, R | 1 |
| Bülow, S | 1 |
| Moesgaard, F | 1 |
| Rosenblatt, JE | 1 |
6 other studies available for metronidazole and Bone Diseases
| Article | Year |
|---|---|
Formulation and In Vitro Characterization of Bioactive Mesoporous Silica with Doxorubicin and Metronidazole Intended for Bone Treatment and Regeneration.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Bone Diseases; Delayed-Action Preparations; Doxorub | 2017 |
Use of Materials Based on Polymeric Silica as Bone-Targeted Drug Delivery Systems for Metronidazole.
Topics: Adsorption; Bone Diseases; Drug Carriers; Humans; Metronidazole; Porosity; Silicon Dioxide; Surface | 2019 |
The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital.
Topics: Adult; Aged; Bacterial Infections; Bone Diseases; Empyema; Female; Fusobacterium Infections; Gastroi | 1983 |
Management of anaerobic infections.
Topics: Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Bacteroides Infections; Bone Diseases; Br | 1975 |
Contaminated fistula following J-pouch ileoanal reservoir. Treatment with a collagen sponge containing gentamicin and metronidazole. Case report.
Topics: Anal Canal; Anastomosis, Surgical; Bacterial Infections; Bone Diseases; Collagen; Female; Gentamicin | 1991 |
Practical aspects of anaerobic sepsis.
Topics: Abscess; Anaerobiosis; Arthritis, Infectious; Bacterial Infections; Bacteroides; Bone Diseases; Brai | 1973 |